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Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)

 I13R1_HUMAN             Reviewed;         427 AA.
P78552; O95646; Q5JSL4; Q99656; Q9UDY5;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
17-JUN-2020, entry version 186.
RecName: Full=Interleukin-13 receptor subunit alpha-1;
Short=IL-13 receptor subunit alpha-1;
Short=IL-13R subunit alpha-1;
Short=IL-13R-alpha-1;
Short=IL-13RA1;
AltName: Full=Cancer/testis antigen 19;
Short=CT19;
AltName: CD_antigen=CD213a1;
Flags: Precursor;
Name=IL13RA1; Synonyms=IL13R, IL13RA;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Carcinoma;
PubMed=9013879; DOI=10.1016/s0014-5793(96)01462-7;
Miloux B., Laurent P., Bonnin O., Lupker J., Caput D., Vita N., Ferrara P.;
"Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R
alpha of a functional IL-4/IL-13 receptor complex.";
FEBS Lett. 401:163-166(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=B-cell;
Gauchat J.-F., Schlagenhauf E., Feng N.P., Moser R., Yamage M., Jeannin P.,
Alouani S., Elson G., Notarangelo L.D., Wells T., Eugster H.P.,
Bonnefoy J.-Y.;
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=T-cell;
PubMed=8910586; DOI=10.1074/jbc.271.46.29265;
Aman M.J., Tayebi N., Obiri N.I., Puri R.K., Modi W.S., Leonard W.J.;
"cDNA cloning and characterization of the human interleukin 13 receptor
alpha chain.";
J. Biol. Chem. 271:29265-29270(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Wada M., Hisano T., Kuwano M.;
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15772651; DOI=10.1038/nature03440;
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
INTERACTION WITH TRAF3IP1.
PubMed=10791955; DOI=10.1074/jbc.m001095200;
Ling L., Goeddel D.V.;
"MIP-T3, a novel protein linking tumor necrosis factor receptor-associated
factor 3 to the microtubule network.";
J. Biol. Chem. 275:23852-23860(2000).
[10]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 29-342 IN COMPLEXES WITH IL4;
IL4RA AND IL13, DISULFIDE BONDS, AND SUBUNIT.
PubMed=18243101; DOI=10.1016/j.cell.2007.12.030;
LaPorte S.L., Juo Z.S., Vaclavikova J., Colf L.A., Qi X., Heller N.M.,
Keegan A.D., Garcia K.C.;
"Molecular and structural basis of cytokine receptor pleiotropy in the
interleukin-4/13 system.";
Cell 132:259-272(2008).
-!- FUNCTION: Binds with low affinity to interleukin-13 (IL13). Together
with IL4RA can form a functional receptor for IL13. Also serves as an
alternate accessory protein to the common cytokine receptor gamma chain
for interleukin-4 (IL4) signaling, but cannot replace the function of
IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
-!- SUBUNIT: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and
possibly other components. Interacts with TRAF3IP1.
{ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:18243101}.
-!- INTERACTION:
P78552; P35225: IL13; NbExp=6; IntAct=EBI-1391535, EBI-1647828;
P78552; P05112: IL4; NbExp=3; IntAct=EBI-1391535, EBI-367025;
P78552; Q8TDR0: TRAF3IP1; NbExp=3; IntAct=EBI-1391535, EBI-928811;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P78552-1; Sequence=Displayed;
Name=2;
IsoId=P78552-2; Sequence=VSP_055587, VSP_055588;
-!- TISSUE SPECIFICITY: Ubiquitous. Highest levels in heart, liver,
skeletal muscle and ovary; lowest levels in brain, lung and kidney.
Also found in B-cells, T-cells and endothelial cells.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-surface
receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
subfamily. {ECO:0000305}.
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EMBL; Y10659; CAA71669.1; -; mRNA.
EMBL; Y09328; CAA70508.1; -; mRNA.
EMBL; U62858; AAB37127.1; -; mRNA.
EMBL; U81379; AAD00510.3; -; mRNA.
EMBL; U81380; AAD00511.2; -; mRNA.
EMBL; AK313467; BAG36253.1; -; mRNA.
EMBL; AL391280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471161; EAW89893.1; -; Genomic_DNA.
EMBL; BC009960; AAH09960.1; -; mRNA.
CCDS; CCDS14573.1; -. [P78552-1]
RefSeq; NP_001551.1; NM_001560.2. [P78552-1]
PDB; 3BPN; X-ray; 3.02 A; C=29-342.
PDB; 3BPO; X-ray; 3.00 A; C=29-342.
PDB; 4HWB; X-ray; 2.61 A; A=223-336.
PDB; 5E4E; X-ray; 3.00 A; C=23-340.
PDBsum; 3BPN; -.
PDBsum; 3BPO; -.
PDBsum; 4HWB; -.
PDBsum; 5E4E; -.
SMR; P78552; -.
BioGRID; 109811; 9.
CORUM; P78552; -.
DIP; DIP-3225N; -.
IntAct; P78552; 9.
STRING; 9606.ENSP00000360730; -.
ChEMBL; CHEMBL3831285; -.
GlyConnect; 2052; -.
iPTMnet; P78552; -.
PhosphoSitePlus; P78552; -.
BioMuta; IL13RA1; -.
DMDM; 2494718; -.
EPD; P78552; -.
jPOST; P78552; -.
MassIVE; P78552; -.
PaxDb; P78552; -.
PeptideAtlas; P78552; -.
PRIDE; P78552; -.
ProteomicsDB; 57649; -. [P78552-1]
ProteomicsDB; 84133; -.
ABCD; P78552; 1 sequenced antibody.
Antibodypedia; 385; 523 antibodies.
DNASU; 3597; -.
Ensembl; ENST00000371642; ENSP00000360705; ENSG00000131724. [P78552-2]
Ensembl; ENST00000371666; ENSP00000360730; ENSG00000131724. [P78552-1]
GeneID; 3597; -.
KEGG; hsa:3597; -.
UCSC; uc004eqr.2; human. [P78552-1]
CTD; 3597; -.
DisGeNET; 3597; -.
EuPathDB; HostDB:ENSG00000131724.10; -.
GeneCards; IL13RA1; -.
HGNC; HGNC:5974; IL13RA1.
HPA; ENSG00000131724; Low tissue specificity.
MIM; 300119; gene.
neXtProt; NX_P78552; -.
OpenTargets; ENSG00000131724; -.
PharmGKB; PA200; -.
eggNOG; ENOG410IH4K; Eukaryota.
eggNOG; ENOG410YM7M; LUCA.
GeneTree; ENSGT00940000160896; -.
HOGENOM; CLU_039945_1_0_1; -.
InParanoid; P78552; -.
KO; K05076; -.
OMA; IGCSFDL; -.
OrthoDB; 1151666at2759; -.
PhylomeDB; P78552; -.
TreeFam; TF331549; -.
Reactome; R-HSA-6785807; Interleukin-4 and Interleukin-13 signaling.
SignaLink; P78552; -.
SIGNOR; P78552; -.
BioGRID-ORCS; 3597; 2 hits in 414 CRISPR screens.
ChiTaRS; IL13RA1; human.
EvolutionaryTrace; P78552; -.
GeneWiki; Interleukin_13_receptor,_alpha_1; -.
GenomeRNAi; 3597; -.
Pharos; P78552; Tbio.
PRO; PR:P78552; -.
Proteomes; UP000005640; Chromosome X.
RNAct; P78552; protein.
Bgee; ENSG00000131724; Expressed in esophagus squamous epithelium and 230 other tissues.
ExpressionAtlas; P78552; baseline and differential.
Genevisible; P78552; HS.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0005898; C:interleukin-13 receptor complex; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0019976; F:interleukin-2 binding; IBA:GO_Central.
GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR040566; Il13Ra_Ig.
InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF18001; Il13Ra_Ig; 1.
Pfam; PF09240; IL6Ra-bind; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 3.
PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Disulfide bond; Glycoprotein; Membrane;
Receptor; Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1..21
/evidence="ECO:0000255"
CHAIN 22..427
/note="Interleukin-13 receptor subunit alpha-1"
/id="PRO_0000010939"
TOPO_DOM 22..343
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 344..367
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 368..427
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 34..123
/note="Fibronectin type-III 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 128..226
/note="Fibronectin type-III 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 227..339
/note="Fibronectin type-III 3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 327..331
/note="WSXWS motif"
MOTIF 374..382
/note="Box 1 motif"
CARBOHYD 37
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 61
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 105
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 138
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 157
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 235
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 265
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 293
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 329
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 341
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 62..102
/evidence="ECO:0000269|PubMed:18243101"
DISULFID 95..117
/evidence="ECO:0000269|PubMed:18243101"
DISULFID 134..144
/evidence="ECO:0000269|PubMed:18243101"
DISULFID 173..185
/evidence="ECO:0000269|PubMed:18243101"
DISULFID 257..320
/evidence="ECO:0000269|PubMed:18243101"
DISULFID 282..296
/evidence="ECO:0000269|PubMed:18243101"
VAR_SEQ 278..279
/note="QE -> RF (in isoform 2)"
/evidence="ECO:0000303|Ref.4"
/id="VSP_055587"
VAR_SEQ 280..427
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|Ref.4"
/id="VSP_055588"
CONFLICT 130
/note="T -> I (in Ref. 3; AAB37127)"
/evidence="ECO:0000305"
CONFLICT 358
/note="G -> D (in Ref. 3; AAB37127)"
/evidence="ECO:0000305"
STRAND 36..43
/evidence="ECO:0000244|PDB:3BPO"
TURN 44..46
/evidence="ECO:0000244|PDB:3BPO"
STRAND 47..53
/evidence="ECO:0000244|PDB:3BPO"
STRAND 66..68
/evidence="ECO:0000244|PDB:3BPO"
TURN 71..73
/evidence="ECO:0000244|PDB:5E4E"
STRAND 77..87
/evidence="ECO:0000244|PDB:3BPO"
STRAND 90..92
/evidence="ECO:0000244|PDB:5E4E"
STRAND 94..100
/evidence="ECO:0000244|PDB:3BPO"
STRAND 114..118
/evidence="ECO:0000244|PDB:3BPO"
TURN 125..127
/evidence="ECO:0000244|PDB:3BPN"
STRAND 130..137
/evidence="ECO:0000244|PDB:3BPO"
TURN 138..140
/evidence="ECO:0000244|PDB:3BPO"
STRAND 141..147
/evidence="ECO:0000244|PDB:3BPO"
STRAND 158..166
/evidence="ECO:0000244|PDB:3BPO"
STRAND 171..173
/evidence="ECO:0000244|PDB:5E4E"
STRAND 176..179
/evidence="ECO:0000244|PDB:3BPO"
STRAND 182..188
/evidence="ECO:0000244|PDB:3BPO"
STRAND 202..208
/evidence="ECO:0000244|PDB:3BPO"
STRAND 216..220
/evidence="ECO:0000244|PDB:3BPO"
STRAND 222..227
/evidence="ECO:0000244|PDB:3BPO"
STRAND 232..239
/evidence="ECO:0000244|PDB:4HWB"
STRAND 242..248
/evidence="ECO:0000244|PDB:4HWB"
HELIX 252..255
/evidence="ECO:0000244|PDB:4HWB"
STRAND 258..265
/evidence="ECO:0000244|PDB:4HWB"
STRAND 267..269
/evidence="ECO:0000244|PDB:4HWB"
STRAND 273..278
/evidence="ECO:0000244|PDB:4HWB"
STRAND 285..288
/evidence="ECO:0000244|PDB:4HWB"
STRAND 292..299
/evidence="ECO:0000244|PDB:3BPO"
STRAND 309..316
/evidence="ECO:0000244|PDB:4HWB"
HELIX 318..320
/evidence="ECO:0000244|PDB:4HWB"
STRAND 334..337
/evidence="ECO:0000244|PDB:3BPO"
SEQUENCE 427 AA; 48760 MW; 5983B3E8F554107B CRC64;
MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS
NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP
PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG
QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN
DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP
GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI
IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE
NLKKASQ


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Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1566: Citrate cycle (TCA cycle)
WP1655: Geraniol degradation
WP566: canonical wnt - zebrafish
WP1963: The effect of Glucocorticoids on target gene expression
WP2292: Chemokine signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP1003: Ovarian Infertility Genes
WP1835: Interferon alpha/beta signaling
WP929: TNF-alpha NF-kB Signaling Pathway
WP2100: AhR pathway
WP263: Ovarian Infertility Genes
WP1369: TNF-alpha NF-kB Signaling Pathway
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP1225: estrogen signalling
WP885: Ovarian Infertility Genes
WP2328: Allograft rejection
WP457: TNF-alpha NF-kB Signaling Pathway
WP210: Cytoplasmic Ribosomal Proteins
WP262: EBV LMP1 signaling
WP537: Translation Factors
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1224: EBV LMP1 signaling
WP219: Cytoplasmic tRNA Synthetases
WP811: TNF-alpha NF-kB Signaling Pathway

Related Genes :
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[IL13RA2 IL13R] Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
[Il13ra1 Il13r Il13ra] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Interleukin-13-binding protein) (Novel cytokine receptor 4) (NR4) (CD antigen CD213a1)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL10RA IL10R] Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il18r1] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[IL6R] Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[IL7R] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124)
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[IL15RA] Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]
[IL6ST] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL3RA IL3R] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[IL5RA IL5R] Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
[Il7r] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL11RA] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)

Bibliography :
No related Items