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Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Interleukin-13-binding protein) (Novel cytokine receptor 4) (NR4) (CD antigen CD213a1)

 I13R1_MOUSE             Reviewed;         424 AA.
O09030; Q7TT27;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
08-MAY-2019, entry version 148.
RecName: Full=Interleukin-13 receptor subunit alpha-1;
Short=IL-13 receptor subunit alpha-1;
Short=IL-13R subunit alpha-1;
Short=IL-13R-alpha-1;
Short=IL-13RA1;
AltName: Full=Interleukin-13-binding protein;
AltName: Full=Novel cytokine receptor 4;
Short=NR4;
AltName: CD_antigen=CD213a1;
Flags: Precursor;
Name=Il13ra1; Synonyms=Il13r, Il13ra;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8552669; DOI=10.1073/pnas.93.1.497;
Hilton D.J., Zhang J.-G., Metcalf D., Alexander W.S., Nicola N.A.,
Willson T.A.;
"Cloning and characterization of a binding subunit of the interleukin
13 receptor that is also a component of the interleukin 4 receptor.";
Proc. Natl. Acad. Sci. U.S.A. 93:497-501(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Brain, and Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Binds with low affinity to interleukin-13 (IL13).
Together with IL4RA can form a functional receptor for IL13. Also
serves as an alternate accessory protein to the common cytokine
receptor gamma chain for interleukin-4 (IL4) signaling, but cannot
replace the function of IL2RG in allowing enhanced interleukin-2
(IL2) binding activity (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interleukin-13 receptor is a complex of IL4R, IL13RA1,
and possibly other components. Interacts with TRAF3IP1 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Spleen, liver, thymus, heart, lung, kidney,
testis, stomach, brain, skin, and colon; but not skeletal muscle.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; S80963; AAB50695.1; -; mRNA.
EMBL; BC052425; AAH52425.2; -; mRNA.
EMBL; BC059939; AAH59939.1; -; mRNA.
CCDS; CCDS30057.1; -.
RefSeq; NP_598751.3; NM_133990.5.
SMR; O09030; -.
DIP; DIP-1167N; -.
STRING; 10090.ENSMUSP00000033418; -.
iPTMnet; O09030; -.
PhosphoSitePlus; O09030; -.
MaxQB; O09030; -.
PaxDb; O09030; -.
PRIDE; O09030; -.
Ensembl; ENSMUST00000033418; ENSMUSP00000033418; ENSMUSG00000017057.
GeneID; 16164; -.
KEGG; mmu:16164; -.
UCSC; uc009sxj.1; mouse.
CTD; 3597; -.
MGI; MGI:105052; Il13ra1.
eggNOG; ENOG410IH4K; Eukaryota.
eggNOG; ENOG410YM7M; LUCA.
GeneTree; ENSGT00940000160896; -.
HOGENOM; HOG000230941; -.
InParanoid; O09030; -.
KO; K05076; -.
OMA; TICFMVP; -.
OrthoDB; 1151666at2759; -.
PhylomeDB; O09030; -.
TreeFam; TF331549; -.
Reactome; R-MMU-6785807; Interleukin-4 and Interleukin-13 signaling.
PRO; PR:O09030; -.
Proteomes; UP000000589; Chromosome X.
Bgee; ENSMUSG00000017057; Expressed in 246 organ(s), highest expression level in jejunum.
Genevisible; O09030; MM.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0016515; F:interleukin-13 receptor activity; ISO:MGI.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR040566; Il13Ra_Ig.
InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF18001; Il13Ra_Ig; 1.
Pfam; PF09240; IL6Ra-bind; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 2.
PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 424 Interleukin-13 receptor subunit alpha-1.
/FTId=PRO_0000010940.
TOPO_DOM 26 340 Extracellular. {ECO:0000255}.
TRANSMEM 341 364 Helical. {ECO:0000255}.
TOPO_DOM 365 424 Cytoplasmic. {ECO:0000255}.
DOMAIN 32 121 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 224 336 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 324 328 WSXWS motif.
MOTIF 371 379 Box 1 motif.
CARBOHYD 35 35 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 59 59 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 103 103 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 136 136 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 262 262 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 338 338 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 44 93 {ECO:0000255}.
DISULFID 132 142 {ECO:0000250}.
DISULFID 171 183 {ECO:0000250}.
SEQUENCE 424 AA; 48402 MW; EB8330A0DC82C9F9 CRC64;
MARPALLGEL LVLLLWTATV GQVAAATEVQ PPVTNLSVSV ENLCTIIWTW SPPEGASPNC
TLRYFSHFDD QQDKKIAPET HRKEELPLDE KICLQVGSQC SANESEKPSP LVKKCISPPE
GDPESAVTEL KCIWHNLSYM KCSWLPGRNT SPDTHYTLYY WYSSLEKSRQ CENIYREGQH
IACSFKLTKV EPSFEHQNVQ IMVKDNAGKI RPSCKIVSLT SYVKPDPPHI KHLLLKNGAL
LVQWKNPQNF RSRCLTYEVE VNNTQTDRHN ILEVEEDKCQ NSESDRNMEG TSCFQLPGVL
ADAVYTVRVR VKTNKLCFDD NKLWSDWSEA QSIGKEQNST FYTTMLLTIP VFVAVAVIIL
LFYLKRLKII IFPPIPDPGK IFKEMFGDQN DDTLHWKKYD IYEKQSKEET DSVVLIENLK
KAAP


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