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Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)

 IL17_HUMAN              Reviewed;         155 AA.
Q16552; Q5T2P0;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
17-JUN-2020, entry version 180.
RecName: Full=Interleukin-17A;
Short=IL-17;
Short=IL-17A;
AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8;
Short=CTLA-8;
Flags: Precursor;
Name=IL17A; Synonyms=CTLA8, IL17;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=8676080; DOI=10.1084/jem.183.6.2593;
Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C.,
Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C.,
Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S.;
"T cell interleukin-17 induces stromal cells to produce proinflammatory and
hematopoietic cytokines.";
J. Exp. Med. 183:2593-2603(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=T-cell;
PubMed=7499828;
Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K.,
Armitage R.J.;
"Human IL-17: a novel cytokine derived from T cells.";
J. Immunol. 155:5483-5486(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 24-38.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified
cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[8]
SUBUNIT.
PubMed=17355969; DOI=10.1074/jbc.m700499200;
Wright J.F., Guo Y., Quazi A., Luxenberg D.P., Bennett F., Ross J.F.,
Qiu Y., Whitters M.J., Tomkinson K.N., Dunussi-Joannopoulos K.,
Carreno B.M., Collins M., Wolfman N.M.;
"Identification of an interleukin 17F/17A heterodimer in activated human
CD4+ T cells.";
J. Biol. Chem. 282:13447-13455(2007).
[9]
FUNCTION.
PubMed=17911633; DOI=10.4049/jimmunol.179.8.5462;
Kuestner R.E., Taft D.W., Haran A., Brandt C.S., Brender T., Lum K.,
Harder B., Okada S., Ostrander C.D., Kreindler J.L., Aujla S.J.,
Reardon B., Moore M., Shea P., Schreckhise R., Bukowski T.R., Presnell S.,
Guerra-Lewis P., Parrish-Novak J., Ellsworth J.L., Jaspers S., Lewis K.E.,
Appleby M., Kolls J.K., Rixon M., West J.W., Gao Z., Levin S.D.;
"Identification of the IL-17 receptor related molecule IL-17RC as the
receptor for IL-17F.";
J. Immunol. 179:5462-5473(2007).
[10]
FUNCTION.
PubMed=18684971; DOI=10.4049/jimmunol.181.4.2799;
Wright J.F., Bennett F., Li B., Brooks J., Luxenberg D.P., Whitters M.J.,
Tomkinson K.N., Fitz L.J., Wolfman N.M., Collins M.,
Dunussi-Joannopoulos K., Chatterjee-Kishore M., Carreno B.M.;
"The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-
17RA/IL-17RC receptor complex.";
J. Immunol. 181:2799-2805(2008).
[11]
X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 20-155 IN COMPLEX WITH ANTIBODY,
DISULFIDE BONDS, AND SUBUNIT.
PubMed=19835883; DOI=10.1016/j.jmb.2009.10.008;
Gerhardt S., Abbott W.M., Hargreaves D., Pauptit R.A., Davies R.A.,
Needham M.R., Langham C., Barker W., Aziz A., Snow M.J., Dawson S.,
Welsh F., Wilkinson T., Vaugan T., Beste G., Bishop S., Popovic B.,
Rees G., Sleeman M., Tuske S.J., Coales S.J., Hamuro Y., Russell C.;
"Structure of IL-17A in complex with a potent, fully human neutralizing
antibody.";
J. Mol. Biol. 394:905-921(2009).
-!- FUNCTION: Ligand for IL17RA and IL17RC (PubMed:17911633). The
heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric
complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in
inducing stromal cells to produce proinflammatory and hematopoietic
cytokines (PubMed:8676080). {ECO:0000269|PubMed:17911633,
ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:8676080}.
-!- SUBUNIT: Homodimer (PubMed:19835883). Heterodimer with IL17F
(PubMed:17355969). {ECO:0000269|PubMed:17355969,
ECO:0000269|PubMed:19835883}.
-!- INTERACTION:
Q16552; Q9BQC3: DPH2; NbExp=3; IntAct=EBI-10237926, EBI-10237931;
Q16552; Q6PIL6: KCNIP4; NbExp=3; IntAct=EBI-10237926, EBI-1051469;
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Restricted to activated memory T-cells.
-!- PTM: Found both in glycosylated and nonglycosylated forms.
-!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry;
URL="https://en.wikipedia.org/wiki/Interleukin_17";
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il17/";
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/IL17AID40945ch6p12.html";
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EMBL; Z58820; CAA91233.1; -; mRNA.
EMBL; U32659; AAC50341.1; -; mRNA.
EMBL; AY460616; AAR23263.1; -; Genomic_DNA.
EMBL; AL391221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471081; EAX04362.1; -; Genomic_DNA.
EMBL; BC066251; AAH66251.1; -; mRNA.
EMBL; BC066252; AAH66252.1; -; mRNA.
EMBL; BC067503; AAH67503.1; -; mRNA.
EMBL; BC067504; AAH67504.1; -; mRNA.
EMBL; BC067505; AAH67505.1; -; mRNA.
CCDS; CCDS4937.1; -.
RefSeq; NP_002181.1; NM_002190.2.
PDB; 2VXS; X-ray; 2.63 A; A/B/C/D=20-155.
PDB; 4HR9; X-ray; 2.48 A; A/B=34-155.
PDB; 4HSA; X-ray; 3.15 A; A/B/D/E=34-155.
PDB; 4QHU; X-ray; 2.20 A; C/D=24-154.
PDB; 5HHV; X-ray; 2.20 A; A/B=34-155.
PDB; 5HHX; X-ray; 3.00 A; A/B=20-155.
PDB; 5HI3; X-ray; 2.15 A; A/B=24-155.
PDB; 5HI4; X-ray; 1.80 A; A/B=24-155.
PDB; 5HI5; X-ray; 1.80 A; A/B=24-155.
PDB; 5N7W; X-ray; 1.96 A; X/Y=1-155.
PDB; 5N92; X-ray; 2.30 A; A=24-155.
PDB; 5NAN; X-ray; 3.30 A; A/D=24-155.
PDB; 5VB9; X-ray; 1.70 A; A/B=38-155.
PDBsum; 2VXS; -.
PDBsum; 4HR9; -.
PDBsum; 4HSA; -.
PDBsum; 4QHU; -.
PDBsum; 5HHV; -.
PDBsum; 5HHX; -.
PDBsum; 5HI3; -.
PDBsum; 5HI4; -.
PDBsum; 5HI5; -.
PDBsum; 5N7W; -.
PDBsum; 5N92; -.
PDBsum; 5NAN; -.
PDBsum; 5VB9; -.
SMR; Q16552; -.
BioGRID; 109818; 10.
DIP; DIP-6014N; -.
IntAct; Q16552; 7.
STRING; 9606.ENSP00000344192; -.
BindingDB; Q16552; -.
ChEMBL; CHEMBL3390822; -.
DrugBank; DB11569; Ixekizumab.
DrugBank; DB09029; Secukinumab.
DrugCentral; Q16552; -.
iPTMnet; Q16552; -.
PhosphoSitePlus; Q16552; -.
BioMuta; IL17A; -.
DMDM; 2498481; -.
jPOST; Q16552; -.
PaxDb; Q16552; -.
PeptideAtlas; Q16552; -.
PRIDE; Q16552; -.
ProteomicsDB; 60910; -.
ABCD; Q16552; 76 sequenced antibodies.
Antibodypedia; 17132; 1742 antibodies.
DNASU; 3605; -.
Ensembl; ENST00000648244; ENSP00000497968; ENSG00000112115.
GeneID; 3605; -.
KEGG; hsa:3605; -.
UCSC; uc003pak.1; human.
CTD; 3605; -.
DisGeNET; 3605; -.
EuPathDB; HostDB:ENSG00000112115.5; -.
GeneCards; IL17A; -.
HGNC; HGNC:5981; IL17A.
HPA; ENSG00000112115; Group enriched (lymphoid tissue, tongue, urinary bladder).
MIM; 603149; gene.
neXtProt; NX_Q16552; -.
OpenTargets; ENSG00000112115; -.
PharmGKB; PA29794; -.
eggNOG; ENOG410J12P; Eukaryota.
eggNOG; ENOG410YS4N; LUCA.
GeneTree; ENSGT00940000161882; -.
HOGENOM; CLU_118641_0_0_1; -.
InParanoid; Q16552; -.
KO; K05489; -.
OMA; CPHSFRL; -.
OrthoDB; 1469254at2759; -.
PhylomeDB; Q16552; -.
TreeFam; TF314701; -.
Reactome; R-HSA-448424; Interleukin-17 signaling.
Reactome; R-HSA-6785807; Interleukin-4 and Interleukin-13 signaling.
SIGNOR; Q16552; -.
BioGRID-ORCS; 3605; 0 hits in 785 CRISPR screens.
EvolutionaryTrace; Q16552; -.
GeneWiki; IL17A; -.
GenomeRNAi; 3605; -.
Pharos; Q16552; Tclin.
PRO; PR:Q16552; -.
Proteomes; UP000005640; Chromosome 6.
RNAct; Q16552; protein.
Bgee; ENSG00000112115; Expressed in palpebral conjunctiva and 18 other tissues.
Genevisible; Q16552; HS.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; TAS:ProtInc.
GO; GO:0005125; F:cytokine activity; TAS:ProtInc.
GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
GO; GO:0008219; P:cell death; TAS:ProtInc.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO; GO:0050832; P:defense response to fungus; IEA:Ensembl.
GO; GO:0072537; P:fibroblast activation; IDA:BHF-UCL.
GO; GO:0097530; P:granulocyte migration; IEA:Ensembl.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0097400; P:interleukin-17-mediated signaling pathway; TAS:Reactome.
GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IDA:ARUK-UCL.
GO; GO:0050725; P:positive regulation of interleukin-1 beta biosynthetic process; IDA:ARUK-UCL.
GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IDA:ARUK-UCL.
GO; GO:0045377; P:positive regulation of interleukin-16 biosynthetic process; IDA:ARUK-UCL.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IDA:BHF-UCL.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IDA:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IDA:ARUK-UCL.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR020440; IL-17_chr.
InterPro; IPR010345; IL-17_fam.
Pfam; PF06083; IL17; 1.
PRINTS; PR01932; INTRLEUKIN17.
SUPFAM; SSF57501; SSF57501; 1.
1: Evidence at protein level;
3D-structure; Cytokine; Direct protein sequencing; Disulfide bond;
Glycoprotein; Reference proteome; Secreted; Signal.
SIGNAL 1..23
/evidence="ECO:0000269|PubMed:15340161"
CHAIN 24..155
/note="Interleukin-17A"
/id="PRO_0000015423"
CARBOHYD 68
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 94..144
/evidence="ECO:0000269|PubMed:19835883"
DISULFID 99..146
/evidence="ECO:0000269|PubMed:19835883"
HELIX 35..39
/evidence="ECO:0000244|PDB:4QHU"
STRAND 44..48
/evidence="ECO:0000244|PDB:5N7W"
STRAND 50..52
/evidence="ECO:0000244|PDB:5HI5"
HELIX 60..62
/evidence="ECO:0000244|PDB:5HI5"
HELIX 66..69
/evidence="ECO:0000244|PDB:5VB9"
STRAND 70..72
/evidence="ECO:0000244|PDB:5VB9"
STRAND 74..80
/evidence="ECO:0000244|PDB:5VB9"
STRAND 84..86
/evidence="ECO:0000244|PDB:5VB9"
STRAND 88..95
/evidence="ECO:0000244|PDB:5VB9"
STRAND 97..100
/evidence="ECO:0000244|PDB:5VB9"
STRAND 104..107
/evidence="ECO:0000244|PDB:5VB9"
STRAND 110..126
/evidence="ECO:0000244|PDB:5VB9"
STRAND 133..147
/evidence="ECO:0000244|PDB:5VB9"
STRAND 151..153
/evidence="ECO:0000244|PDB:4HSA"
SEQUENCE 155 AA; 17504 MW; 2BCAE9CB2F4886D1 CRC64;
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP
KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL
VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA


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[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[SLC17A8 VGLUT3] Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
[COL17A1 BP180 BPAG2] Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]
[IL17F] Interleukin-17F (IL-17F) (Cytokine ML-1)
[Slc17a8 Vglut3] Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
[ABHD17A C19orf27 FAM108A1] Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22)
[IL17RA IL17R] Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)
[Slc17a8 Vglut3] Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
[CYP17A1 CYP17 S17AH] Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
[IL16] Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]
[Col17a1 Bp180 Bpag2] Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen homolog]
[IL2 CgPICR_002350 H671_1g3106 I79_014246] Interleukin-2 (IL-2)
[CD86 CD28LG2] T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
[CD80 CD28LG CD28LG1 LAB7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[TIMM17A MIMT17 TIM17 TIM17A TIMM17] Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a)
[IL36B IL1F8 IL1H2] Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[COL17A1 BP180 BPAG2] Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen homolog]
[Il21r Nilr] Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Lymphocyte receptor beta) (LR-beta) (Novel cytokine receptor 8) (NR8) (Novel interleukin receptor) (CD antigen CD360)
[CLEC17A] C-type lectin domain family 17, member A (Prolectin)
[LY9 CDABP0070] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[PAG1 PRC8 At2g27020 T20P8.7] Proteasome subunit alpha type-3 (EC 3.4.25.1) (20S proteasome alpha subunit G-1) (DiDi 17A-2a) (Proteasome component 8) (Proteasome subunit alpha type-7)
[GZMA CTLA3 HFSP] Granzyme A (EC 3.4.21.78) (CTL tryptase) (Cytotoxic T-lymphocyte proteinase 1) (Fragmentin-1) (Granzyme-1) (Hanukkah factor) (H factor) (HF)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)

Bibliography :
[32620468] Serum and ascitic fluid interleukin-17 in spontaneous bacterial peritonitis in Egyptian patients with HCV-related liver cirrhosis.
[32619071] Protective effect of microRNA-134-3p on multiple sclerosis through inhibiting PRSS57 and promotion of CD34 cell proliferation in rats.
[32617963] Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?
[32615662] Increased miR-223-3p in Leukocytes Positively Correlated with IL-17A in Plasma of Asthmatic Patients.
[32615450] Interleukin-2 maintains the survival of interleukin-17 gamma/delta T cells in inflammation and autoimmune diseases.
[32614049] Dysregulation of the interleukin-17A pathway in endometrial tissue from women with unexplained infertility affects pregnancy outcome following assisted reproductive treatment.
[32610110] REPLY TO: Interleukin-17: a potential therapeutic target in COVID-19.
[32605468] Interleukin-17 Gene Polymorphism (Rs2275913 G/A, Rs763780 C/T) in Rheumatoid arthritis´╝ÜMeta-analysis Based on Ethnicity.
[32600079] Th17 cell frequency and IL-17A production in peripheral blood of patients with non-small-cell lung cancer.
[32592813] Nuclear antigen-reactive CD4 T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys.