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Interleukin-2 (IL-2)

 Q13169_HUMAN            Unreviewed;       156 AA.
Q13169;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
26-FEB-2020, entry version 95.
RecName: Full=Interleukin-2 {ECO:0000256|RuleBase:RU363134};
Short=IL-2 {ECO:0000256|RuleBase:RU363134};
Name=IL2 {ECO:0000256|RuleBase:RU363134, ECO:0000313|EMBL:AAA70092.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA70092.1};
[1] {ECO:0000313|EMBL:AAA70092.1}
NUCLEOTIDE SEQUENCE.
Xu D., Wu Y., Chen J., Yu L., Zhong M., Hui Y., Qu H.;
"Expression of human IL-2 from gene transferred mouse melanoma cells and
its effect on the growth of mouse melanoma.";
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 13:78-82(1993).
[2] {ECO:0000313|EMBL:AAA70092.1}
NUCLEOTIDE SEQUENCE.
Xu L.;
Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by T-cells in response to antigenic or mitogenic
stimulation, this protein is required for T-cell proliferation and
other activities crucial to regulation of the immune response.
{ECO:0000256|RuleBase:RU363134}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU363134}.
-!- SIMILARITY: Belongs to the IL-2 family.
{ECO:0000256|RuleBase:RU363134}.
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EMBL; U25676; AAA70092.1; -; mRNA.
PeptideAtlas; Q13169; -.
PRIDE; Q13169; -.
ChiTaRS; IL2; human.
GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005134; F:interleukin-2 receptor binding; TAS:UniProtKB.
GO; GO:0019209; F:kinase activator activity; TAS:UniProtKB.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007267; P:cell-cell signaling; TAS:UniProtKB.
GO; GO:0006955; P:immune response; TAS:UniProtKB.
GO; GO:0030101; P:natural killer cell activation; TAS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
GO; GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; TAS:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000779; IL-2.
InterPro; IPR030477; IL-2_CS.
Pfam; PF00715; IL2; 1.
PRINTS; PR00265; INTERLEUKIN2.
SMART; SM00189; IL2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00424; INTERLEUKIN_2; 1.
2: Evidence at transcript level;
Adaptive immunity {ECO:0000256|RuleBase:RU363134};
Coiled coil {ECO:0000256|SAM:Coils};
Cytokine {ECO:0000256|RuleBase:RU363134};
Disulfide bond {ECO:0000256|RuleBase:RU363134};
Growth factor {ECO:0000256|RuleBase:RU363134};
Immunity {ECO:0000256|RuleBase:RU363134};
Secreted {ECO:0000256|RuleBase:RU363134};
Signal {ECO:0000256|RuleBase:RU363134}.
SIGNAL 1..20
/evidence="ECO:0000256|RuleBase:RU363134"
CHAIN 21..156
/note="Interleukin-2"
/evidence="ECO:0000256|RuleBase:RU363134"
/id="PRO_5009031468"
COILED 79..99
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 156 AA; 18002 MW; 8E0452D43B336389 CRC64;
MYRMQLLSCI ALILALVTNS APTSSSTKKT KKTQLQLEHL LLDLQMILNG INNYKNPKLT
RMLTFKFYMP KKATELKQLQ CLEEELKPLE EVLNLAQSKN FHLRPRDLIS NINVIVLELK
GSETTFMCEY ADETATIVEF LNRWITFCQS IISTLT


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Related Genes :
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IL36G IL1E IL1F9 IL1H1 IL1RP2 UNQ2456/PRO5737] Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1)
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[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
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[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[IL2RB IL15RB] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[IL13RA2 IL13R] Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
[IL1RAP C3orf13 IL1R3] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
[Il1rl2] Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2)
[IL1RAPL1 OPHN4] Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)
[Il18r1] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il1rap] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-33 receptot beta chain)
[Il12rb2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[IL12RB2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1)
[Il17re] Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE)
[Il1b] Interleukin-1 beta (IL-1 beta)
[IL1B] Interleukin-1 beta (IL-1 beta)
[Il2rg] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)

Bibliography :
[32228431] The Potential Protective Effect of Orange Peel and Selenium against 17β-Estradiol-Induced Chronic Non-Bacterial Prostatitis in Rats.
[32226348] Getting Under the Skin: Targeting Cutaneous Autoimmune Disease.
[32226302] Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.
[32218197] Supplementation of Lactobacillus plantarum or Macleaya cordata Extract Alleviates Oxidative Damage Induced by Weaning in the Lower Gut of Young Goats.
[32218162] HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM).
[32217767] Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia.
[32217015] Long-Term Outcomes of Liver Transplantation in Patients With Pretransplant Renal Dysfunction Treated With Induction Therapy and Delayed Reduced De Novo Once-Daily Tacrolimus.
[32213060] Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity.
[32211314] Clinical and Immunological Outcomes in High-Risk Resected Melanoma Patients Receiving Peptide-Based Vaccination and Interferon Alpha, With or Without Dacarbazine Preconditioning: A Phase II Study.
[32211313] NLGP Attenuates Murine Melanoma and Carcinoma Metastasis by Modulating Cytotoxic CD8 T Cells.