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Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)

 IL2_RABIT               Reviewed;         153 AA.
O77620; Q0MS71;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
26-FEB-2020, entry version 104.
RecName: Full=Interleukin-2;
Short=IL-2;
AltName: Full=T-cell growth factor;
Short=TCGF;
Flags: Precursor;
Name=IL2;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymph node;
PubMed=10843729; DOI=10.1006/cyto.1999.0658;
Perkins H.D., van Leeuwen B.H., Hardy C.M., Kerr P.J.;
"The complete cDNA sequences of IL-2, IL-4, IL-6 and IL-10 from the
European rabbit (Oryctolagus cuniculus).";
Cytokine 12:555-565(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Huang D., Yang G., Gu X., Wu K., Hao G.;
"Cloning and sequence analysis of IL-2 gene in rabbit.";
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by T-cells in response to antigenic or mitogenic
stimulation, this protein is required for T-cell proliferation and
other activities crucial to regulation of the immune response. Can
stimulate B-cells, monocytes, lymphokine-activated killer cells,
natural killer cells, and glioma cells.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000305}.
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EMBL; AF068057; AAC23838.1; -; mRNA.
EMBL; DQ852342; ABH10827.1; -; mRNA.
RefSeq; NP_001156652.1; NM_001163180.1.
SMR; O77620; -.
STRING; 9986.ENSOCUP00000008701; -.
Ensembl; ENSOCUT00000010098; ENSOCUP00000008701; ENSOCUG00000010100.
GeneID; 100302458; -.
KEGG; ocu:100302458; -.
CTD; 3558; -.
eggNOG; ENOG410J049; Eukaryota.
eggNOG; ENOG41119SF; LUCA.
GeneTree; ENSGT00390000003555; -.
HOGENOM; CLU_124210_0_0_1; -.
InParanoid; O77620; -.
KO; K05429; -.
OMA; FCQSIFS; -.
OrthoDB; 1491449at2759; -.
TreeFam; TF338200; -.
Proteomes; UP000001811; Chromosome 15.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0010467; P:gene expression; IEA:Ensembl.
GO; GO:0002366; P:leukocyte activation involved in immune response; IEA:Ensembl.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IEA:Ensembl.
GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0051024; P:positive regulation of immunoglobulin secretion; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000779; IL-2.
InterPro; IPR030477; IL-2_CS.
Pfam; PF00715; IL2; 1.
PRINTS; PR00265; INTERLEUKIN2.
SMART; SM00189; IL2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00424; INTERLEUKIN_2; 1.
2: Evidence at transcript level;
Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
Immunity; Reference proteome; Secreted; Signal.
SIGNAL 1..20
/evidence="ECO:0000250"
CHAIN 21..153
/note="Interleukin-2"
/id="PRO_0000015499"
CARBOHYD 23
/note="O-linked (GalNAc...) threonine"
/evidence="ECO:0000250"
CARBOHYD 111
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 78..125
/evidence="ECO:0000250"
SEQUENCE 153 AA; 17256 MW; 8173536B2DDD8B86 CRC64;
MYKVQLLSCI ALTLALLTSS APTSSSTKET QEQLDQLLLD LQVLLKGVND YKNSKLSRML
TFKFYMPKKV TELKHLQCLE EELKPLEEVL NLAQGKNSHG GNTRESISNI NVTVLKLKGS
ETFMCEYDET VTIVEFLNRW ITFCQSIISA SSS


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Pathways :
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1011: T Cell Receptor Signaling Pathway
WP1793: Cell junction organization
WP2328: Allograft rejection
WP2005: Muscle cell TarBase
WP413: G1 to S cell cycle control
WP1308: Endochondral Ossification
WP2023: Cell Differentiation - meta
WP1833: Integrin cell surface interactions
WP2377: Integrated Pancreatic Cancer Pathway
WP840: G1 to S cell cycle control
WP1078: G1 to S cell cycle control
WP1840: Interleukin-3, 5 and GM-CSF signaling
WP272: Blood Clotting Cascade

Related Genes :
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[Il2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2 IL-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2 IL-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
[ITK EMT LYK] Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il1b] Interleukin-1 beta (IL-1 beta)
[IL1B] Interleukin-1 beta (IL-1 beta)
[Cebpb Crp2 Nf-il6 Sfb] CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL1B IL1F2] Interleukin-1 beta (IL-1 beta) (Catabolin)
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)

Bibliography :
[32226348] Getting Under the Skin: Targeting Cutaneous Autoimmune Disease.
[32226302] Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.
[32218197] Supplementation of Lactobacillus plantarum or Macleaya cordata Extract Alleviates Oxidative Damage Induced by Weaning in the Lower Gut of Young Goats.
[32218162] HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM).
[32217767] Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia.
[32217015] Long-Term Outcomes of Liver Transplantation in Patients With Pretransplant Renal Dysfunction Treated With Induction Therapy and Delayed Reduced De Novo Once-Daily Tacrolimus.
[32213060] Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity.
[32211314] Clinical and Immunological Outcomes in High-Risk Resected Melanoma Patients Receiving Peptide-Based Vaccination and Interferon Alpha, With or Without Dacarbazine Preconditioning: A Phase II Study.
[32211313] NLGP Attenuates Murine Melanoma and Carcinoma Metastasis by Modulating Cytotoxic CD8 T Cells.
[32210945] IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia.