GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)

 IL2_RAT                 Reviewed;         155 AA.
P17108;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
07-APR-2021, entry version 149.
RecName: Full=Interleukin-2;
Short=IL-2;
AltName: Full=T-cell growth factor;
Short=TCGF;
Flags: Precursor;
Name=Il2; Synonyms=Il-2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2788130; DOI=10.1007/bf02421547;
McKnight A.J., Mason D.W., Barclay A.N.;
"Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin
2 cDNA probe to rat MHC class II-associated invariant chain mRNA.";
Immunogenetics 30:145-147(1989).
-!- FUNCTION: Produced by T-cells in response to antigenic or mitogenic
stimulation, this protein is required for T-cell proliferation and
other activities crucial to regulation of the immune response. Can
stimulate B-cells, monocytes, lymphokine-activated killer cells,
natural killer cells, and glioma cells.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; M22899; AAA41427.1; -; mRNA.
PIR; A45882; A31278.
RefSeq; NP_446288.1; NM_053836.1.
SMR; P17108; -.
STRING; 10116.ENSRNOP00000023327; -.
GlyGen; P17108; 1 site.
PaxDb; P17108; -.
Ensembl; ENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348.
GeneID; 116562; -.
KEGG; rno:116562; -.
UCSC; RGD:620047; rat.
CTD; 3558; -.
RGD; 620047; Il2.
eggNOG; ENOG502RVR5; Eukaryota.
GeneTree; ENSGT00390000003555; -.
HOGENOM; CLU_124210_0_0_1; -.
InParanoid; P17108; -.
OMA; FCQSIFS; -.
OrthoDB; 1491449at2759; -.
PhylomeDB; P17108; -.
TreeFam; TF338200; -.
PRO; PR:P17108; -.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000017348; Expressed in kidney and 15 other tissues.
Genevisible; P17108; RN.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0030246; F:carbohydrate binding; IDA:RGD.
GO; GO:0005125; F:cytokine activity; IDA:RGD.
GO; GO:0043208; F:glycosphingolipid binding; IDA:RGD.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005134; F:interleukin-2 receptor binding; IMP:RGD.
GO; GO:0031851; F:kappa-type opioid receptor binding; IMP:RGD.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISO:RGD.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:RGD.
GO; GO:0010467; P:gene expression; ISO:RGD.
GO; GO:0002366; P:leukocyte activation involved in immune response; ISO:RGD.
GO; GO:0002903; P:negative regulation of B cell apoptotic process; ISO:RGD.
GO; GO:0045822; P:negative regulation of heart contraction; IDA:RGD.
GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
GO; GO:0050672; P:negative regulation of lymphocyte proliferation; ISO:RGD.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IDA:RGD.
GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; ISO:RGD.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISO:RGD.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
GO; GO:0060999; P:positive regulation of dendritic spine development; IDA:RGD.
GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:RGD.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISO:RGD.
GO; GO:1900100; P:positive regulation of plasma cell differentiation; ISO:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IDA:RGD.
GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:RGD.
GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IMP:RGD.
GO; GO:0046013; P:regulation of T cell homeostatic proliferation; ISO:RGD.
GO; GO:0045471; P:response to ethanol; IDA:RGD.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000779; IL-2.
InterPro; IPR030477; IL-2_CS.
Pfam; PF00715; IL2; 1.
PRINTS; PR00265; INTERLEUKIN2.
SMART; SM00189; IL2; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00424; INTERLEUKIN_2; 1.
2: Evidence at transcript level;
Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
Immunity; Reference proteome; Secreted; Signal.
SIGNAL 1..20
/evidence="ECO:0000250"
CHAIN 21..155
/note="Interleukin-2"
/id="PRO_0000015500"
CARBOHYD 23
/note="O-linked (GalNAc...) threonine"
/evidence="ECO:0000250"
DISULFID 78..126
/evidence="ECO:0000250"
SEQUENCE 155 AA; 17633 MW; 67A8554A73BF30A0 CRC64;
MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN YKNLKLPMML
TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL EDAGNFISNI RVTVVKLKGS
ENKFECQFDD EPATVVEFLR RWIAICQSII STMTQ


Related products :

Catalog number Product name Quantity
10-663-45210 Interleukin-2 (IL-2) Rat - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 1 mg
10-663-45210 Interleukin-2 (IL-2) Rat - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.02 mg
10-663-45200 Interleukin-2 (IL-2) Murine - IL-2; T-cell growth factor; TCGF N_A 0.005 mg
10-663-45200 Interleukin-2 (IL-2) Murine - IL-2; T-cell growth factor; TCGF N_A 0.02 mg
10-663-45200 Interleukin-2 (IL-2) Murine - IL-2; T-cell growth factor; TCGF N_A 1 mg
10-663-45210 Interleukin-2 (IL-2) Rat - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.005 mg
10-663-45079 Interleukin-2 Human - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.05 mg
U0073p CLIA IL2,IL-2,Interleukin-2,Pig,Sus scrofa,T-cell growth factor,TCGF 96T
10-663-45079 Interleukin-2 Human - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.01 mg
0801017 Natural Human Interleukin-2 IL-2 per T-Cell Growth Factor TCGF 50 mL, 25,000 BRMP Units
10-663-45079 Interleukin-2 Human - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 1 mg
10-663-45224 Interleukin-2 (IL-2) Porcine - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.01 mg
15-288-22461F Interleukin-2 - IL-2; T-cell growth factor; TCGF; Aldesleukin Polyclonal 0.1 mg
E0073p ELISA IL2,IL-2,Interleukin-2,Pig,Sus scrofa,T-cell growth factor,TCGF 96T
10-663-45224 Interleukin-2 (IL-2) Porcine - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.1 mg
10-663-45224 Interleukin-2 (IL-2) Porcine - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.002 mg
E0073p ELISA kit IL2,IL-2,Interleukin-2,Pig,Sus scrofa,T-cell growth factor,TCGF 96T
15-288-22461F Interleukin-2 - IL-2; T-cell growth factor; TCGF; Aldesleukin Polyclonal 0.05 mg
10-002-38032 Interleukin-2 (C145S) human - IL-2; T-cell growth factor; TCGF; Aldesleukin N_A 0.05 mg
E0073m ELISA Il2,IL-2,Il-2,Interleukin-2,Mouse,Mus musculus,T-cell growth factor,TCGF 96T
U0073m CLIA Il2,IL-2,Il-2,Interleukin-2,Mouse,Mus musculus,T-cell growth factor,TCGF 96T
E0073r ELISA Il2,IL-2,Il-2,Interleukin-2,Rat,Rattus norvegicus,T-cell growth factor,TCGF 96T
E0073m ELISA kit Il2,IL-2,Il-2,Interleukin-2,Mouse,Mus musculus,T-cell growth factor,TCGF 96T
U0073r CLIA Il2,IL-2,Il-2,Interleukin-2,Rat,Rattus norvegicus,T-cell growth factor,TCGF 96T
E0073b ELISA kit Bos taurus,Bovine,IL2,IL-2,IL-2,Interleukin-2,T-cell growth factor,TCGF 96T
Pathways :
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP2005: Muscle cell TarBase
WP413: G1 to S cell cycle control
WP1011: T Cell Receptor Signaling Pathway
WP1793: Cell junction organization
WP2328: Allograft rejection
WP1833: Integrin cell surface interactions
WP2377: Integrated Pancreatic Cancer Pathway
WP840: G1 to S cell cycle control
WP1308: Endochondral Ossification
WP2023: Cell Differentiation - meta
WP1365: Calcium Regulation in the Cardiac Cell
WP2082: Cell Differentiation - Index
WP474: Endochondral Ossification

Related Genes :
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[IL2 IL-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[Il6 Il-6] Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2 IL-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
[ITK EMT LYK] Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[orf1ab ORF1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[Il1b] Interleukin-1 beta (IL-1 beta)

Bibliography :
[34549680] Effects of stem cell-derived exosomes on neuronal apoptosis and inflammatory cytokines in rats with cerebral ischemia-reperfusion injury via PI3K/AKT pathway-mediated mitochondrial apoptosis.
[34542267] Enhancing the Pharmacokinetic Profile of Interleukin 2 through Site-Specific Conjugation to a Selective Small-Molecule Transthyretin Ligand.
[34532097] Predictive values profiling of interleukin-2, interleukin-8, tumor necrosis factor-α, procalcitonin, and C-reactive protein in critical gastrointestinal cancer patients.
[34526990] Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives.
[34526984] Transcriptome Signature of Vγ9Vδ2 T Cells Treated With Phosphoantigens and Notch Inhibitor Reveals Interplay Between TCR and Notch Signaling Pathways.
[34526724] An engineered IL-2 partial agonist promotes CD8 T cell stemness.
[34522094] Increased Serum Soluble Interleukin-2 Receptor Associated with Severity of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
[34519213] Identification and Biological Activity of NFAT-133 Congeners from .
[34515780] Development of Graves' disease during drug-free remission of juvenile dermatomyositis.
[34515174] Survival Time among Young and Old Breast Cancer Patients in Relation to Circulating Blood-Based Biomarkers, Acute Radiation Skin Reactions, and Tumour Recurrence.