GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122)

 IL2RB_MACFA             Reviewed;         551 AA.
Q38J85;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
22-NOV-2005, sequence version 1.
26-FEB-2020, entry version 66.
RecName: Full=Interleukin-2 receptor subunit beta;
Short=IL-2 receptor subunit beta;
Short=IL-2R subunit beta;
Short=IL-2RB;
AltName: Full=High affinity IL-2 receptor subunit beta;
AltName: Full=p70-75;
AltName: CD_antigen=CD122;
Flags: Precursor;
Name=IL2RB;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Chen S., Yu L.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor for interleukin-2. This beta subunit is involved in
receptor mediated endocytosis and transduces the mitogenic signals of
IL2. Probably in association with IL15RA, involved in the stimulation
of neutrophil phagocytosis by IL15 (By similarity).
{ECO:0000250|UniProtKB:P14784}.
-!- SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists
in 3 different forms: a high affinity dimer, an intermediate affinity
monomer (beta subunit), and a low affinity monomer (alpha subunit). The
high and intermediate affinity forms also associate with a gamma
subunit. Interacts with SHB upon interleukin stimulation (By
similarity). {ECO:0000250|UniProtKB:P14784}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14784};
Single-pass type I membrane protein {ECO:0000255}. Cell surface
{ECO:0000250|UniProtKB:P14784}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-surface
receptor binding. {ECO:0000250}.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation. {ECO:0000250}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; DQ223724; ABB03908.1; -; mRNA.
RefSeq; NP_001274237.1; NM_001287308.1.
RefSeq; XP_005567439.1; XM_005567382.2.
SMR; Q38J85; -.
STRING; 9541.XP_005567439.1; -.
Ensembl; ENSMFAT00000024519; ENSMFAP00000005839; ENSMFAG00000002576.
GeneID; 102138714; -.
KEGG; mcf:102138714; -.
CTD; 3560; -.
GeneTree; ENSGT00510000049239; -.
KO; K05069; -.
OMA; QFTCFYN; -.
OrthoDB; 1322475at2759; -.
Proteomes; UP000233100; Chromosome 10.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042010; F:interleukin-15 receptor activity; ISS:UniProtKB.
GO; GO:0019976; F:interleukin-2 binding; IEA:Ensembl.
GO; GO:0004911; F:interleukin-2 receptor activity; IEA:Ensembl.
GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR040951; IL2RB_N1.
Pfam; PF18707; IL2RB_N1; 1.
SMART; SM00060; FN3; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
2: Evidence at transcript level;
Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..26
/evidence="ECO:0000250"
CHAIN 27..551
/note="Interleukin-2 receptor subunit beta"
/id="PRO_0000045409"
TOPO_DOM 27..240
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 241..265
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 266..551
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 134..234
/note="Fibronectin type-III"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 220..224
/note="WSXWS motif"
MOTIF 278..286
/note="Box 1 motif"
CARBOHYD 29
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 43
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 71
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 149
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 36..46
/evidence="ECO:0000250"
DISULFID 74..86
/evidence="ECO:0000250"
SEQUENCE 551 AA; 61224 MW; 5CEAEC1A802A1D50 CRC64;
MATLALSWCL PLLILLLPLA TSSASAAVNG TSRFTCFYNS RANISCVWSQ DGALQDTSCQ
VHAWPDRRRW NQTCELLPVS QASWACNLIL GTPDSQKLTA VDIVTLRVMC REGVRWRMMA
IQDFKPFENL RLMAPISLQV VHVETHRCNI SWKISQASHY FERHLEFEAR TLSPGHTWEE
APLMTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT
IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC HTPDPSKFFS QLTSEHGGDV
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPSSLS SNRSLTSCFT
NQGYFFFHLP DALEIEACQV YFTYDPCAEE EPDEGGADAP TGSSPQPLRP LSAEDDAYCT
FPSGDDLLLF SPSLLGGPSP PSTAPGGSGA GEERLPPSLQ ERVPRDWDPQ PLGPPTPGVP
DLVDFQPRPE LVLREAGEQV PDPGPREPFS FPWARPPGQG EVRALNARLP LNTDAYLSLQ
ELQDQDPTHL V


Related products :

Catalog number Product name Quantity
U1837h CLIA High affinity IL-2 receptor subunit beta,Homo sapiens,Human,IL-2 receptor subunit beta,IL-2R subunit beta,IL2RB,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,p75 96T
U1837h CLIA kit High affinity IL-2 receptor subunit beta,Homo sapiens,Human,IL-2 receptor subunit beta,IL-2R subunit beta,IL2RB,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,p75 96T
E1837h ELISA High affinity IL-2 receptor subunit beta,Homo sapiens,Human,IL-2 receptor subunit beta,IL-2R subunit beta,IL2RB,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,p75 96T
E1837h ELISA kit High affinity IL-2 receptor subunit beta,Homo sapiens,Human,IL-2 receptor subunit beta,IL-2R subunit beta,IL2RB,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,p75 96T
U1837m CLIA High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,Mouse,Mus musculus,p70-75 96T
E1837r ELISA kit High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,Rat,Rattus norvegicus 96T
E1837r ELISA High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,Rat,Rattus norvegicus 96T
U1837r CLIA kit High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,Rat,Rattus norvegicus 96T
E1837m ELISA High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,Mouse,Mus musculus,p70-75 96T
U1837m CLIA kit High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,Mouse,Mus musculus,p70-75 96T
U1837r CLIA High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,p70-75,Rat,Rattus norvegicus 96T
E1837m ELISA kit High affinity IL-2 receptor subunit beta,IL-2 receptor subunit beta,IL-2R subunit beta,Il2rb,IL-2RB,Interleukin-2 receptor subunit beta,Mouse,Mus musculus,p70-75 96T
E1761h ELISA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
U1761h CLIA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
E1761h ELISA kit Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
U1761r CLIA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
E1761m ELISA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
E1761r ELISA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
U1761m CLIA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
E1761r ELISA kit IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
E1761m ELISA kit IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
U0046r CLIA gp130,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,Il6st,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Oncostatin-M receptor sub 96T
E0046r ELISA gp130,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,Il6st,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Oncostatin-M receptor su 96T
E0046h ELISA kit CDw130,gp130,Homo sapiens,Human,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,IL6ST,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprote 96T
U0046h CLIA CDw130,gp130,Homo sapiens,Human,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,IL6ST,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130 96T