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Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)

 I22R1_HUMAN             Reviewed;         574 AA.
Q8N6P7; A8K839; B2R9Y9; Q9HB22;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
17-JUN-2020, entry version 156.
RecName: Full=Interleukin-22 receptor subunit alpha-1;
Short=IL-22 receptor subunit alpha-1;
Short=IL-22R-alpha-1;
Short=IL-22RA1;
AltName: Full=Cytokine receptor class-II member 9;
AltName: Full=Cytokine receptor family 2 member 9;
Short=CRF2-9;
AltName: Full=ZcytoR11;
Flags: Precursor;
Name=IL22RA1; Synonyms=IL22R;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-518.
PubMed=10875937; DOI=10.1074/jbc.m005304200;
Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J.,
Wood W.I., Goddard A.D., Gurney A.L.;
"Interleukin (IL)-22, a novel human cytokine that signals through the
interferon receptor-related proteins CRF2-4 and IL-22R.";
J. Biol. Chem. 275:31335-31339(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-518.
TISSUE=Esophagus, and Liver;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adrenal cortex;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, AND SUBUNIT.
PubMed=11035029; DOI=10.1074/jbc.m007837200;
Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E.,
Dickensheets H., Donnelly R.P., Pestka S.;
"Identification of the functional interleukin-22 (IL-22) receptor complex:
the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-
22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor
complexes.";
J. Biol. Chem. 276:2725-2732(2001).
[7]
FUNCTION.
PubMed=11564763; DOI=10.4049/jimmunol.167.7.3545;
Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.;
"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes
of two types.";
J. Immunol. 167:3545-3549(2001).
[8]
TISSUE SPECIFICITY.
PubMed=12407026; DOI=10.1093/intimm/dxf096;
Lecart S., Morel F., Noraz N., Pene J., Garcia M., Boniface K.,
Lecron J.-C., Yssel H.;
"IL-22, in contrast to IL-10, does not induce Ig production, due to absence
of a functional IL-22 receptor on activated human B cells.";
Int. Immunol. 14:1351-1356(2002).
[9]
FUNCTION.
PubMed=11706020; DOI=10.1074/jbc.m106043200;
Wang M., Tan Z., Zhang R., Kotenko S.V., Liang P.;
"Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors,
IL-22R1/IL-20R2 and IL-20R1/IL-20R2.";
J. Biol. Chem. 277:7341-7347(2002).
[10]
FUNCTION.
PubMed=12351624; DOI=10.1074/jbc.m205114200;
Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C.,
Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S.,
Chandrasekher Y.A.;
"Interleukins 19, 20, and 24 signal through two distinct receptor
complexes. Differences in receptor-ligand interactions mediate unique
biological functions.";
J. Biol. Chem. 277:47517-47523(2002).
[11]
FUNCTION.
PubMed=12941841;
Ramesh R., Mhashilkar A.M., Tanaka F., Saito Y., Branch C.D., Sieger K.,
Mumm J.B., Stewart A.L., Boquoi A., Dumoutier L., Grimm E.A.,
Renauld J.-C., Kotenko S., Chada S.;
"Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel
ligand that regulates angiogenesis via the IL-22 receptor.";
Cancer Res. 63:5105-5113(2003).
[12]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=15308104; DOI=10.1016/j.immuni.2004.07.007;
Wolk K., Kunz S., Witte E., Friedrich M., Asadullah K., Sabat R.;
"IL-22 increases the innate immunity of tissues.";
Immunity 21:241-254(2004).
[13]
SUBUNIT.
PubMed=15120653; DOI=10.1016/j.intimp.2004.01.010;
Li J., Tomkinson K.N., Tan X.-Y., Wu P., Yan G., Spaulding V., Deng B.,
Annis-Freeman B., Heveron K., Zollner R., De Zutter G., Wright J.F.,
Crawford T.K., Liu W., Jacobs K.A., Wolfman N.M., Ling V., Pittman D.D.,
Veldman G.M., Fouser L.A.;
"Temporal associations between interleukin 22 and the extracellular domains
of IL-22R and IL-10R2.";
Int. Immunopharmacol. 4:693-708(2004).
[14]
FUNCTION.
PubMed=17204547; DOI=10.1152/ajpgi.00239.2006;
Brand S., Dambacher J., Beigel F., Zitzmann K., Heeg M.H.J., Weiss T.S.,
Pruefer T., Olszak T., Steib C.J., Storr M., Goeke B., Diepolder H.,
Bilzer M., Thasler W.E., Auernhammer C.J.;
"IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3
overexpression in vitro.";
Am. J. Physiol. 292:G1019-G1028(2007).
[15]
TISSUE SPECIFICITY.
PubMed=17900301; DOI=10.1111/j.1365-2249.2007.03511.x;
Boniface K., Guignouard E., Pedretti N., Garcia M., Delwail A.,
Bernard F.-X., Nau F., Guillet G., Dagregorio G., Yssel H., Lecron J.-C.,
Morel F.;
"A role for T cell-derived interleukin 22 in psoriatic skin inflammation.";
Clin. Exp. Immunol. 150:407-415(2007).
[16]
ASSOCIATION WITH CHRONIC RHINOSINUSITIS.
PubMed=17906500; DOI=10.1097/mlg.0b013e31811edd4f;
Ramanathan M. Jr., Spannhake E.W., Lane A.P.;
"Chronic rhinosinusitis with nasal polyps is associated with decreased
expression of mucosal interleukin 22 receptor.";
Laryngoscope 117:1839-1843(2007).
[17]
TISSUE SPECIFICITY.
PubMed=17828272; DOI=10.1038/nm1651;
Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R.,
Bernard M., Giuliani F., Arbour N., Becher B., Prat A.;
"Human TH17 lymphocytes promote blood-brain barrier disruption and central
nervous system inflammation.";
Nat. Med. 13:1173-1175(2007).
[18]
TISSUE SPECIFICITY.
PubMed=18061474; DOI=10.1016/j.cyto.2007.10.004;
Kragstrup T.W., Otkjaer K., Holm C., Jorgensen A., Hokland M., Iversen L.,
Deleuran B.;
"The expression of IL-20 and IL-24 and their shared receptors are increased
in rheumatoid arthritis and spondyloarthropathy.";
Cytokine 41:16-23(2008).
[19]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 18-228 IN COMPLEX WITH IL22,
MUTAGENESIS OF LYS-58 AND TYR-60, AND DISULFIDE BONDS.
PubMed=18675809; DOI=10.1016/j.febslet.2008.07.046;
Bleicher L., de Moura P.R., Watanabe L., Colau D., Dumoutier L.,
Renauld J.-C., Polikarpov I.;
"Crystal structure of the IL-22/IL-22R1 complex and its implications for
the IL-22 signaling mechanism.";
FEBS Lett. 582:2985-2992(2008).
-!- FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component
of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling
via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and
Akt kinases pathways. Component of one of the receptor for IL20 and
IL24 formed by IL22RA1 and IL20RB also signaling through STATs
activation. Mediates IL24 antiangiogenic activity as well as IL24
inhibitory effect on endothelial cell tube formation and
differentiation. {ECO:0000269|PubMed:11035029,
ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020,
ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841,
ECO:0000269|PubMed:17204547}.
-!- SUBUNIT: Heterodimer with IL10RB and with IL20RB. IL22 binding to
heterodimer is greater than binding to IL22RA1 alone.
{ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:15120653,
ECO:0000269|PubMed:18675809}.
-!- INTERACTION:
Q8N6P7; Q08334: IL10RB; NbExp=5; IntAct=EBI-3940749, EBI-11175900;
Q8N6P7; Q9GZX6: IL22; NbExp=9; IntAct=EBI-3940749, EBI-8040250;
Q8N6P7; PRO_0000015383 [Q9GZX6]: IL22; NbExp=5; IntAct=EBI-3940749, EBI-11315863;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- TISSUE SPECIFICITY: Expressed in colon, liver, lung, pancreas and
kidney. No expression in immune cells such as monocytes, T-cells, and
NK-cells. Expressed in keratinocytes of normal skin as well as in
psoriatic skin lesion. Detected in normal blood brain barrier
endothelial cells as well as in multiple sclerosis lesions; Strongly
expressed on central nervous system vessels within infiltrated multiple
sclerosis lesions. Overexpressed in synovial fluid cells from
rheumatoid arthritis and spondyloarthropathy patients.
{ECO:0000269|PubMed:12407026, ECO:0000269|PubMed:15308104,
ECO:0000269|PubMed:17828272, ECO:0000269|PubMed:17900301,
ECO:0000269|PubMed:18061474}.
-!- INDUCTION: By IFNG/IFN-gamma in keratinocytes.
{ECO:0000269|PubMed:15308104}.
-!- MISCELLANEOUS: Failure of medical and surgical therapy in Chronic
rhinosinusitis with nasal polyps is associated with decreased
expression of IL22RA1.
-!- SIMILARITY: Belongs to the type II cytokine receptor family.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/IL22RA1ID44568ch1p36.html";
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EMBL; AF286095; AAG22073.1; -; mRNA.
EMBL; AK292204; BAF84893.1; -; mRNA.
EMBL; AK313971; BAG36686.1; -; mRNA.
EMBL; AL590683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL591178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471134; EAW95111.1; -; Genomic_DNA.
EMBL; BC029273; AAH29273.1; -; mRNA.
CCDS; CCDS247.1; -.
RefSeq; NP_067081.2; NM_021258.3.
PDB; 3DGC; X-ray; 2.50 A; R/S=17-226.
PDB; 3DLQ; X-ray; 1.90 A; R=18-228.
PDB; 6DF3; X-ray; 2.15 A; L=24-228.
PDBsum; 3DGC; -.
PDBsum; 3DLQ; -.
PDBsum; 6DF3; -.
SMR; Q8N6P7; -.
BioGRID; 121855; 26.
DIP; DIP-42031N; -.
IntAct; Q8N6P7; 6.
MINT; Q8N6P7; -.
STRING; 9606.ENSP00000270800; -.
iPTMnet; Q8N6P7; -.
PhosphoSitePlus; Q8N6P7; -.
BioMuta; IL22RA1; -.
DMDM; 74751067; -.
MassIVE; Q8N6P7; -.
PaxDb; Q8N6P7; -.
PeptideAtlas; Q8N6P7; -.
PRIDE; Q8N6P7; -.
ProteomicsDB; 72209; -.
Antibodypedia; 15695; 432 antibodies.
DNASU; 58985; -.
Ensembl; ENST00000270800; ENSP00000270800; ENSG00000142677.
GeneID; 58985; -.
KEGG; hsa:58985; -.
UCSC; uc001biq.3; human.
CTD; 58985; -.
DisGeNET; 58985; -.
EuPathDB; HostDB:ENSG00000142677.3; -.
GeneCards; IL22RA1; -.
HGNC; HGNC:13700; IL22RA1.
HPA; ENSG00000142677; Tissue enriched (pancreas).
MIM; 605457; gene.
neXtProt; NX_Q8N6P7; -.
OpenTargets; ENSG00000142677; -.
PharmGKB; PA29823; -.
eggNOG; ENOG410IF2U; Eukaryota.
eggNOG; ENOG4111CQU; LUCA.
GeneTree; ENSGT00940000161366; -.
HOGENOM; CLU_033634_0_0_1; -.
InParanoid; Q8N6P7; -.
KO; K05138; -.
OMA; CNLTMET; -.
OrthoDB; 1078220at2759; -.
PhylomeDB; Q8N6P7; -.
TreeFam; TF334107; -.
Reactome; R-HSA-8854691; Interleukin-20 family signaling.
SignaLink; Q8N6P7; -.
SIGNOR; Q8N6P7; -.
BioGRID-ORCS; 58985; 2 hits in 780 CRISPR screens.
ChiTaRS; IL22RA1; human.
EvolutionaryTrace; Q8N6P7; -.
GenomeRNAi; 58985; -.
Pharos; Q8N6P7; Tbio.
PRO; PR:Q8N6P7; -.
Proteomes; UP000005640; Chromosome 1.
RNAct; Q8N6P7; protein.
Bgee; ENSG00000142677; Expressed in body of pancreas and 102 other tissues.
Genevisible; Q8N6P7; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0004904; F:interferon receptor activity; TAS:UniProtKB.
GO; GO:0042015; F:interleukin-20 binding; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
Pfam; PF01108; Tissue_fac; 1.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 1.
1: Evidence at protein level;
3D-structure; Disulfide bond; Glycoprotein; Membrane; Polymorphism;
Receptor; Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1..15
/evidence="ECO:0000255"
CHAIN 16..574
/note="Interleukin-22 receptor subunit alpha-1"
/id="PRO_0000324320"
TOPO_DOM 16..228
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 229..249
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 250..574
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 17..124
/note="Fibronectin type-III 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 141..221
/note="Fibronectin type-III 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
CARBOHYD 80
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 172
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 71..79
/evidence="ECO:0000269|PubMed:18675809"
DISULFID 128..217
/evidence="ECO:0000269|PubMed:18675809"
VARIANT 130
/note="S -> P (in dbSNP:rs34900099)"
/id="VAR_039699"
VARIANT 205
/note="V -> I (in dbSNP:rs16829204)"
/id="VAR_039700"
VARIANT 209
/note="A -> S (in dbSNP:rs34379702)"
/id="VAR_039701"
VARIANT 222
/note="L -> P (in dbSNP:rs34782294)"
/id="VAR_039702"
VARIANT 407
/note="M -> V (in dbSNP:rs35401673)"
/id="VAR_039703"
VARIANT 518
/note="R -> G (in dbSNP:rs3795299)"
/evidence="ECO:0000269|PubMed:10875937,
ECO:0000269|PubMed:14702039"
/id="VAR_039704"
MUTAGEN 58
/note="K->A: Strongly reduced response to IL22."
/evidence="ECO:0000269|PubMed:18675809"
MUTAGEN 60
/note="Y->A,R: Loss of response to IL22."
/evidence="ECO:0000269|PubMed:18675809"
CONFLICT 117
/note="Q -> R (in Ref. 2; BAF84893)"
/evidence="ECO:0000305"
HELIX 21..23
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 25..33
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 36..43
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 49..59
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 72..80
/evidence="ECO:0000244|PDB:3DLQ"
HELIX 83..85
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 92..100
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 105..109
/evidence="ECO:0000244|PDB:3DLQ"
HELIX 115..118
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 126..130
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 132..139
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 143..147
/evidence="ECO:0000244|PDB:6DF3"
STRAND 149..151
/evidence="ECO:0000244|PDB:6DF3"
STRAND 153..155
/evidence="ECO:0000244|PDB:6DF3"
HELIX 156..159
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 164..170
/evidence="ECO:0000244|PDB:3DLQ"
TURN 172..174
/evidence="ECO:0000244|PDB:6DF3"
STRAND 177..190
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 196..205
/evidence="ECO:0000244|PDB:3DLQ"
HELIX 206..208
/evidence="ECO:0000244|PDB:3DLQ"
STRAND 215..220
/evidence="ECO:0000244|PDB:3DLQ"
SEQUENCE 574 AA; 63077 MW; D46CC71D496F3420 CRC64;
MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD TVYSIEYKTY
GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS AGGRSATKMT DRFSSLQHTT
LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG
GKQREYEFFG LTPDTEFLGT IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG
FLVAVLCYLS YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ
YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG
PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS
SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV
LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK
DEAKSPAPET SDLEQPTELD SLFRGLALTV QWES


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Pathways :
WP2292: Chemokine signaling pathway
WP566: canonical wnt - zebrafish
WP1963: The effect of Glucocorticoids on target gene expression
WP2272: Pathogenic Escherichia coli infection
WP2328: Allograft rejection
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP274: B Cell Receptor Signaling Pathway
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP1284: EPO Receptor Signaling
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP878: EPO Receptor Signaling
WP1130: T Cell Receptor Signaling Pathway
WP886: Kit Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP304: Kit receptor signaling pathway
WP768: EPO Receptor Signaling
WP1011: T Cell Receptor Signaling Pathway
WP2079: Serotonin Receptor 2 and STAT3 Signaling
WP1045: TGF-beta Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP1781: Advanced glycosylation endproduct receptor signaling
WP480: T Cell Receptor Signaling Pathway

Related Genes :
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[Il18r1] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[IL10RA IL10R] Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il2rg] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL6R] Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)
[IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612] Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)
[IL15RA] Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]
[IL13RA2 IL13R] Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
[Csf2rb Aic2b Csf2rb1 Il3rb1] Cytokine receptor common subunit beta (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
[CSF2RB IL3RB IL5RB] Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
[IL6ST] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL11RA] Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL1RAPL1 OPHN4] Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)
[Il7r] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)

Bibliography :