GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6) (Interleukin-1 homolog 1) (IL-1H1)

 IL36A_MOUSE             Reviewed;         160 AA.
Q9JLA2;
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
17-JUN-2020, entry version 130.
RecName: Full=Interleukin-36 alpha;
AltName: Full=FIL1 epsilon;
AltName: Full=Interleukin-1 epsilon;
Short=IL-1 epsilon;
AltName: Full=Interleukin-1 family member 6;
Short=IL-1F6;
AltName: Full=Interleukin-1 homolog 1;
Short=IL-1H1;
Flags: Precursor;
Name=Il36a; Synonyms=Fil1e, Il1e, Il1f6, Il1h1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E.,
Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R.;
"Identification and initial characterization of four novel members of the
interleukin-1 family.";
J. Biol. Chem. 275:10308-10314(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J.,
Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.;
"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an
antagonist and agonist of NF-kappa B activation through the orphan IL-1
receptor-related protein 2.";
J. Immunol. 167:1440-1446(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
TISSUE SPECIFICITY.
PubMed=20101239; DOI=10.1038/labinvest.2009.148;
Ichii O., Otsuka S., Sasaki N., Yabuki A., Ohta H., Takiguchi M.,
Hashimoto Y., Endoh D., Kon Y.;
"Local overexpression of interleukin-1 family, member 6 relates to the
development of tubulointerstitial lesions.";
Lab. Invest. 90:459-475(2010).
[5]
FUNCTION.
PubMed=21860022; DOI=10.1182/blood-2011-05-356873;
Vigne S., Palmer G., Lamacchia C., Martin P., Talabot-Ayer D.,
Rodriguez E., Ronchi F., Sallusto F., Dinh H., Sims J.E., Gabay C.;
"IL-36R ligands are potent regulators of dendritic and T cells.";
Blood 118:5813-5823(2011).
[6]
FUNCTION, AND PROCESSING.
PubMed=21965679; DOI=10.1074/jbc.m111.267922;
Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A.,
Sims J.E.;
"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-
36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity.";
J. Biol. Chem. 286:42594-42602(2011).
[7]
INDUCTION.
PubMed=21881584; DOI=10.1038/jid.2011.234;
Carrier Y., Ma H.L., Ramon H.E., Napierata L., Small C., O'Toole M.,
Young D.A., Fouser L.A., Nickerson-Nutter C., Collins M.,
Dunussi-Joannopoulos K., Medley Q.G.;
"Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in
vivo: implications in psoriasis pathogenesis.";
J. Invest. Dermatol. 131:2428-2437(2011).
[8]
FUNCTION.
PubMed=23029241; DOI=10.1371/journal.pone.0045784;
Ramadas R.A., Ewart S.L., Iwakura Y., Medoff B.D., LeVine A.M.;
"IL-36alpha exerts pro-inflammatory effects in the lungs of mice.";
PLoS ONE 7:E45784-E45784(2012).
[9]
FUNCTION.
PubMed=24829417; DOI=10.4049/jimmunol.1301481;
Foster A.M., Baliwag J., Chen C.S., Guzman A.M., Stoll S.W.,
Gudjonsson J.E., Ward N.L., Johnston A.;
"IL-36 promotes myeloid cell infiltration, activation, and inflammatory
activity in skin.";
J. Immunol. 192:6053-6061(2014).
-!- FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R
receptor which in turn activates NF-kappa-B and MAPK signaling pathways
in target cells linked to a pro-inflammatory response. Part of the IL-
36 signaling system that is thought to be present in epithelial
barriers and to take part in local inflammatory response; similar to
the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be
involved in skin inflammatory response by acting on keratinocytes,
dendritic cells and indirectly on T-cells to drive tissue infiltration,
cell maturation and cell proliferation. Induces the production of
proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha
and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in
dendritic cell maturation by stimulating the surface expression of
CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4
and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role
in proinflammatory effects in the lung: induces the expression of CXCL1
and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A,
IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar
macrophages. May be involved in T-cell maturation by stimulating the
surface expression of CD40 and modestly CD80 and CD86 in splenic
CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces
NF-kappa B activation in macrophages. {ECO:0000269|PubMed:21860022,
ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23029241,
ECO:0000269|PubMed:24829417}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- TISSUE SPECIFICITY: Highly expressed in embryonic tissue and in tissues
containing epithelial cells. Elevated expression levels are detected in
chronic kidney disease; expressed inepithelia from the distal
convoluted tubules (DCTs) to the cortical collecting ducts (CCDs) in
single nephrons (at protein level). {ECO:0000269|PubMed:11466363,
ECO:0000269|PubMed:20101239}.
-!- INDUCTION: By IL-22 in normal and psoriasis-like skin.
{ECO:0000269|PubMed:21881584}.
-!- PTM: N-terminal truncation leads to a dramatic enhancement of its
activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
-!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AF200493; AAF69249.1; -; mRNA.
EMBL; AF206697; AAG35671.1; -; mRNA.
EMBL; AK004061; BAB23147.1; -; mRNA.
CCDS; CCDS15734.1; -.
RefSeq; NP_062323.1; NM_019450.3.
SMR; Q9JLA2; -.
STRING; 10090.ENSMUSP00000028361; -.
PhosphoSitePlus; Q9JLA2; -.
PaxDb; Q9JLA2; -.
PRIDE; Q9JLA2; -.
Antibodypedia; 33315; 310 antibodies.
Ensembl; ENSMUST00000028361; ENSMUSP00000028361; ENSMUSG00000026984.
GeneID; 54448; -.
KEGG; mmu:54448; -.
UCSC; uc008ioq.1; mouse.
CTD; 54448; -.
MGI; MGI:1859324; Il1f6.
eggNOG; ENOG410JBMR; Eukaryota.
eggNOG; ENOG41118FS; LUCA.
GeneTree; ENSGT00950000182943; -.
HOGENOM; CLU_095373_1_0_1; -.
InParanoid; Q9JLA2; -.
KO; K05484; -.
OMA; PFLFYHN; -.
OrthoDB; 1502484at2759; -.
PhylomeDB; Q9JLA2; -.
TreeFam; TF300203; -.
Reactome; R-MMU-9014826; Interleukin-36 pathway.
BioGRID-ORCS; 54448; 0 hits in 12 CRISPR screens.
PRO; PR:Q9JLA2; -.
Proteomes; UP000000589; Chromosome 2.
RNAct; Q9JLA2; protein.
Bgee; ENSMUSG00000026984; Expressed in uterine cervix and 43 other tissues.
ExpressionAtlas; Q9JLA2; baseline and differential.
Genevisible; Q9JLA2; MM.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005125; F:cytokine activity; IGI:MGI.
GO; GO:0005149; F:interleukin-1 receptor binding; ISS:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IGI:MGI.
InterPro; IPR000975; IL-1_fam.
InterPro; IPR003297; IL-1RA/IL-36.
InterPro; IPR027163; IL-36_alpha.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR10078; PTHR10078; 1.
PANTHER; PTHR10078:SF25; PTHR10078:SF25; 1.
Pfam; PF00340; IL1; 1.
PRINTS; PR01360; INTRLEUKIN1X.
SUPFAM; SSF50353; SSF50353; 1.
1: Evidence at protein level;
Cytokine; Immunity; Inflammatory response; Innate immunity; Nitration;
Reference proteome; Secreted.
PROPEP 1..7
/evidence="ECO:0000269|PubMed:21965679"
/id="PRO_0000430546"
CHAIN 8..160
/note="Interleukin-36 alpha"
/id="PRO_0000153645"
MOD_RES 98
/note="Nitrated tyrosine"
/evidence="ECO:0000250|UniProtKB:Q9UHA7"
SEQUENCE 160 AA; 18015 MW; AA0434D68FF62F4A CRC64;
MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETN
RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFY HKKSGTTSTF
ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH


Related products :

Catalog number Product name Quantity
E2205h Homo sapiens,Human,IL-1 epsilon,IL1E,IL1F9,IL-1F9,IL1H1,IL-1H1,IL-1-related protein 2,IL1RP2,IL-1RP2,IL36G,Interleukin-1 epsilon,Interleukin-1 family member 9,Interleukin-1 homolog 1,Interleukin-36 ga
U2205h CLIA Homo sapiens,Human,IL-1 epsilon,IL1E,IL1F9,IL-1F9,IL1H1,IL-1H1,IL-1-related protein 2,IL1RP2,IL-1RP2,IL36G,Interleukin-1 epsilon,Interleukin-1 family member 9,Interleukin-1 homolog 1,Interleukin- 96T
E2205h ELISA Homo sapiens,Human,IL-1 epsilon,IL1E,IL1F9,IL-1F9,IL1H1,IL-1H1,IL-1-related protein 2,IL1RP2,IL-1RP2,IL36G,Interleukin-1 epsilon,Interleukin-1 family member 9,Interleukin-1 homolog 1,Interleukin 96T
U2205h CLIA kit Homo sapiens,Human,IL-1 epsilon,IL1E,IL1F9,IL-1F9,IL1H1,IL-1H1,IL-1-related protein 2,IL1RP2,IL-1RP2,IL36G,Interleukin-1 epsilon,Interleukin-1 family member 9,Interleukin-1 homolog 1,Interle 96T
E2205h ELISA kit Homo sapiens,Human,IL-1 epsilon,IL1E,IL1F9,IL-1F9,IL1H1,IL-1H1,IL-1-related protein 2,IL1RP2,IL-1RP2,IL36G,Interleukin-1 epsilon,Interleukin-1 family member 9,Interleukin-1 homolog 1,Interl 96T
IL1F8 IL1F6 Gene interleukin 1 family, member 6 (epsilon)
orb82722 Human IL1 RN protein Recombinant Human Interleukin-1 Receptor Antagonist is a member of the Interleukin-1cytokine family. IL1RN inhibits the activities of Interleukin-1 alpha (IL1A) and Interleukin-1 1 mg
101-M497 IL-1F6, Host: Mouse, Species: Anti-Human, Synonyms: IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON) 100 ug
101-M497 IL-1F6 Anti-Human Host: Mouse IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON) 100
E0065h ELISA kit CD121 antigen-like family member A,Homo sapiens,Human,IL1R,IL1R1,IL-1R-1,IL1RA,IL-1R-alpha,IL1RT1,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 r 96T
E0065h ELISA CD121 antigen-like family member A,Homo sapiens,Human,IL1R,IL1R1,IL-1R-1,IL1RA,IL-1R-alpha,IL1RT1,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 recept 96T
U0065h CLIA CD121 antigen-like family member A,Homo sapiens,Human,IL1R,IL1R1,IL-1R-1,IL1RA,IL-1R-alpha,IL1RT1,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 recepto 96T
CSB-EL011617HU Human interleukin 1 family, member 6 (epsilon) (IL1F6) ELISA kit, Species Human, Sample Type serum, plasma 96T
E0065m ELISA CD121 antigen-like family member A,Il1r1,Il-1r1,IL-1R-1,Il1ra,IL-1R-alpha,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 receptor type I,Mouse,Mus musc 96T
U0065m CLIA CD121 antigen-like family member A,Il1r1,Il-1r1,IL-1R-1,Il1ra,IL-1R-alpha,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 receptor type I,Mouse,Mus muscu 96T
U0065r CLIA CD121 antigen-like family member A,Il1r1,IL-1R-1,Il1ra,IL-1R-alpha,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 receptor type I,p80,Rat,Rattus norvegi 96T
E0065r ELISA CD121 antigen-like family member A,Il1r1,IL-1R-1,Il1ra,IL-1R-alpha,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 receptor type I,p80,Rat,Rattus norveg 96T
E0065m ELISA kit CD121 antigen-like family member A,Il1r1,Il-1r1,IL-1R-1,Il1ra,IL-1R-alpha,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 receptor type I,Mouse,Mus 96T
E0065r ELISA kit CD121 antigen-like family member A,Il1r1,IL-1R-1,Il1ra,IL-1R-alpha,IL-1RT1,IL-1RT-1,Interleukin-1 receptor alpha,Interleukin-1 receptor type 1,Interleukin-1 receptor type I,p80,Rat,Rattus n 96T
EIAAB31453 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1,Kiaa1516,Mouse,Mus musculus,Phosphoinositide phospholipase C-epsilon-1,Phospholipase C-epsilon-1,Plce,Plce1,PLC-epsilon-1
EIAAB31455 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1,Phosphoinositide phospholipase C-epsilon-1,Phospholipase C-epsilon-1,Plce,Plce1,PLC-epsilon-1,Rat,Rattus norvegicus
C94843Ra CLIA Kit for Interleukin 1 Epsilon (IL1e) Organism: Rattus norvegicus (Rat) 96T
SEE843Hu ELISA Kit for Interleukin 1 Epsilon (IL1e) Homo sapiens (Human) 96T
C94843Mu CLIA Kit for Interleukin 1 Epsilon (IL1e) Organism: Mus musculus (Mouse) 96T
E0066h ELISA kit CD121 antigen-like family member B,CDw121b,Homo sapiens,Human,IL1R2,IL-1R-2,IL1RB,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 recepto 96T