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Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)

 I36RA_HUMAN             Reviewed;         155 AA.
Q9UBH0; A8K2I4; Q56AT9; Q7RTZ6;
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
16-OCT-2019, entry version 167.
RecName: Full=Interleukin-36 receptor antagonist protein;
Short=IL-36Ra {ECO:0000303|PubMed:21965679};
AltName: Full=FIL1 delta;
AltName: Full=IL-1-related protein 3;
Short=IL-1RP3;
AltName: Full=Interleukin-1 HY1;
Short=IL-1HY1;
AltName: Full=Interleukin-1 delta;
Short=IL-1 delta;
AltName: Full=Interleukin-1 family member 5;
Short=IL-1F5;
AltName: Full=Interleukin-1 receptor antagonist homolog 1;
Short=IL-1ra homolog 1;
AltName: Full=Interleukin-1-like protein 1;
Short=IL-1L1;
Name=IL36RN; Synonyms=FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3;
ORFNames=UNQ1896/PRO4342;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
Sims J.E.;
"Four new members expand the IL-1 superfamily.";
J. Biol. Chem. 275:1169-1175(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal skin;
PubMed=10512743; DOI=10.1006/bbrc.1999.1440;
Mulero J.J., Pace A.M., Nelken S.T., Loeb D.B., Correa T.R.,
Drmanac R., Ford J.E.;
"IL1HY1: a novel interleukin-1 receptor antagonist gene.";
Biochem. Biophys. Res. Commun. 263:702-706(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=11093146;
DOI=10.1002/1521-4141(200011)30:11<3299::aid-immu3299>3.0.co;2-s;
Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.;
"A tissue specific IL-1 receptor antagonist homolog from the IL-1
cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.";
Eur. J. Immunol. 30:3299-3308(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
PubMed=11466363; DOI=10.4049/jimmunol.167.3.1440;
Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
Kastelein R.A.;
"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
as an antagonist and agonist of NF-kappa B activation through the
orphan IL-1 receptor-related protein 2.";
J. Immunol. 167:1440-1446(2001).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10860666; DOI=10.1006/geno.2000.6184;
Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S.,
Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.;
"Identification and gene organization of three novel members of the
IL-1 family on human chromosome 2.";
Genomics 66:213-216(2000).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11991722; DOI=10.1006/geno.2002.6751;
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
Kornman K.;
"A sequence-based map of the nine genes of the human interleukin-1
cluster.";
Genomics 79:718-725(2002).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-47.
SeattleSNPs variation discovery resource;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[13]
FUNCTION, AND CLEAVAGE OF INITIATOR METHIONINE.
PubMed=21965679; DOI=10.1074/jbc.m111.267922;
Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M.,
Gabel C.A., Sims J.E.;
"Interleukin-36 (IL-36) ligands require processing for full agonist
(IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra)
activity.";
J. Biol. Chem. 286:42594-42602(2011).
[14]
FUNCTION, AND INDUCTION.
PubMed=23147407; DOI=10.1002/eji.201242711;
Gresnigt M.S., Roesler B., Jacobs C.W., Becker K.L., Joosten L.A.,
van der Meer J.W., Netea M.G., Dinarello C.A., van de Veerdonk F.L.;
"The IL-36 receptor pathway regulates Aspergillus fumigatus-induced
Th1 and Th17 responses.";
Eur. J. Immunol. 43:416-426(2013).
[15]
VARIANTS PSORS14 TRP-48 AND LEU-113.
PubMed=21839423; DOI=10.1016/j.ajhg.2011.07.022;
Onoufriadis A., Simpson M.A., Pink A.E., Di Meglio P., Smith C.H.,
Pullabhatla V., Knight J., Spain S.L., Nestle F.O., Burden A.D.,
Capon F., Trembath R.C., Barker J.N.;
"Mutations in IL36RN/IL1F5 are associated with the severe episodic
inflammatory skin disease known as generalized pustular psoriasis.";
Am. J. Hum. Genet. 89:432-437(2011).
[16]
VARIANT PSORS14 PRO-27, AND CHARACTERIZATION OF VARIANT PSORS14
PRO-27.
PubMed=21848462; DOI=10.1056/nejmoa1013068;
Marrakchi S., Guigue P., Renshaw B.R., Puel A., Pei X.Y., Fraitag S.,
Zribi J., Bal E., Cluzeau C., Chrabieh M., Towne J.E., Douangpanya J.,
Pons C., Mansour S., Serre V., Makni H., Mahfoudh N., Fakhfakh F.,
Bodemer C., Feingold J., Hadj-Rabia S., Favre M., Genin E.,
Sahbatou M., Munnich A., Casanova J.L., Sims J.E., Turki H.,
Bachelez H., Smahi A.;
"Interleukin-36-receptor antagonist deficiency and generalized
pustular psoriasis.";
N. Engl. J. Med. 365:620-628(2011).
[17]
VARIANT PSORS14 ARG-123, AND CHARACTERIZATION OF VARIANT PSORS14
ARG-123.
PubMed=22903787; DOI=10.1002/humu.22203;
Farooq M., Nakai H., Fujimoto A., Fujikawa H., Matsuyama A.,
Kariya N., Aizawa A., Fujiwara H., Ito M., Shimomura Y.;
"Mutation analysis of the IL36RN gene in 14 Japanese patients with
generalized pustular psoriasis.";
Hum. Mutat. 34:176-183(2013).
-!- FUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and
IL36G) by binding to receptor IL1RL2 and preventing its
association with the coreceptor IL1RAP for signaling. Part of the
IL-36 signaling system that is thought to be present in epithelial
barriers and to take part in local inflammatory response; similar
to the IL-1 system with which it shares the coreceptor. Proposed
to play a role in skin inflammation. May be involved in the innate
immune response to fungal pathogens, such as Aspergillus
fumigatus. May activate an anti-inflammatory signaling pathway by
recruiting SIGIRR. {ECO:0000269|PubMed:11466363,
ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
-!- INTERACTION:
Q04864:REL; NbExp=3; IntAct=EBI-465156, EBI-307352;
Q9BWW4:SSBP3; NbExp=5; IntAct=EBI-465156, EBI-2902395;
Q9BWG4:SSBP4; NbExp=3; IntAct=EBI-465156, EBI-744719;
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Predominantly expressed in skin keratinocytes
but not in fibroblasts, endothelial cells or melanocytes. Detected
also in the spleen, brain leukocyte and macrophage cell types.
Increased in lesional psoriasis skin.
{ECO:0000269|PubMed:11466363}.
-!- INDUCTION: By phorbol ester (PMA) and bacterial
lipopolysaccharides (LPS) treatment in macrophage cell line. By
Aspergillus fumigatus conidia in peripheral blood mnonocytes.
{ECO:0000269|PubMed:23147407}.
-!- DISEASE: Psoriasis 14, pustular (PSORS14) [MIM:614204]: A life-
threatening disease defined by repeated flares of sudden onset
consisting of diffuse erythematous skin eruption characterized by
rapid coverage with pustules, high-grade fever, asthenia, marked
leukocytosis, and elevated serum levels of C-reactive protein.
{ECO:0000269|PubMed:21839423, ECO:0000269|PubMed:21848462,
ECO:0000269|PubMed:22903787}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
URL="https://en.wikipedia.org/wiki/Interleukin_1";
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il1f5/";
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EMBL; AF201830; AAF25210.1; -; mRNA.
EMBL; AF186094; AAF02757.1; -; mRNA.
EMBL; AJ242737; CAB59822.1; -; mRNA.
EMBL; AJ242738; CAB59823.1; -; mRNA.
EMBL; AJ271338; CAB67704.1; -; Genomic_DNA.
EMBL; AF216693; AAF76981.1; -; Genomic_DNA.
EMBL; AF230377; AAF91274.1; -; mRNA.
EMBL; BN000002; CAD29877.1; -; Genomic_DNA.
EMBL; AY359117; AAQ89475.1; -; mRNA.
EMBL; AK290249; BAF82938.1; -; mRNA.
EMBL; AY972853; AAX59031.1; -; Genomic_DNA.
EMBL; AC016724; AAY14990.1; -; Genomic_DNA.
EMBL; CH471217; EAW73617.1; -; Genomic_DNA.
EMBL; BC024747; AAH24747.1; -; mRNA.
CCDS; CCDS2111.1; -.
PIR; JC7104; JC7104.
RefSeq; NP_036407.1; NM_012275.2.
RefSeq; NP_775262.1; NM_173170.1.
PDB; 4P0J; X-ray; 2.30 A; A/B=2-135, A/B=147-155.
PDB; 4P0K; X-ray; 1.70 A; A=2-49, A=55-135, A=147-155.
PDB; 4P0L; X-ray; 1.55 A; A=2-49, A=55-135, A=147-155.
PDBsum; 4P0J; -.
PDBsum; 4P0K; -.
PDBsum; 4P0L; -.
SMR; Q9UBH0; -.
BioGrid; 117728; 16.
IntAct; Q9UBH0; 25.
MINT; Q9UBH0; -.
STRING; 9606.ENSP00000376896; -.
iPTMnet; Q9UBH0; -.
PhosphoSitePlus; Q9UBH0; -.
BioMuta; IL36RN; -.
DMDM; 25008600; -.
MassIVE; Q9UBH0; -.
PaxDb; Q9UBH0; -.
PeptideAtlas; Q9UBH0; -.
PRIDE; Q9UBH0; -.
ProteomicsDB; 83968; -.
DNASU; 26525; -.
Ensembl; ENST00000346807; ENSP00000259212; ENSG00000136695.
Ensembl; ENST00000393200; ENSP00000376896; ENSG00000136695.
GeneID; 26525; -.
KEGG; hsa:26525; -.
UCSC; uc002tis.4; human.
CTD; 26525; -.
DisGeNET; 26525; -.
GeneCards; IL36RN; -.
HGNC; HGNC:15561; IL36RN.
HPA; HPA034542; -.
MalaCards; IL36RN; -.
MIM; 605507; gene.
MIM; 614204; phenotype.
neXtProt; NX_Q9UBH0; -.
OpenTargets; ENSG00000136695; -.
Orphanet; 163931; Acrodermatitis continua of Hallopeau.
Orphanet; 404546; DITRA.
Orphanet; 247353; Generalized pustular psoriasis.
Orphanet; 163927; Pustulosis palmaris et plantaris.
PharmGKB; PA38388; -.
eggNOG; ENOG410IZIW; Eukaryota.
eggNOG; ENOG41116AA; LUCA.
GeneTree; ENSGT00950000182943; -.
InParanoid; Q9UBH0; -.
KO; K05483; -.
OMA; NRWLDAR; -.
OrthoDB; 1410755at2759; -.
PhylomeDB; Q9UBH0; -.
TreeFam; TF300203; -.
Reactome; R-HSA-9014826; Interleukin-36 pathway.
ChiTaRS; IL36RN; human.
GeneWiki; IL1F5; -.
GenomeRNAi; 26525; -.
Pharos; Q9UBH0; -.
PRO; PR:Q9UBH0; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000136695; Expressed in 105 organ(s), highest expression level in amniotic fluid.
ExpressionAtlas; Q9UBH0; baseline and differential.
Genevisible; Q9UBH0; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005152; F:interleukin-1 receptor antagonist activity; TAS:ProtInc.
GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
GO; GO:0019732; P:antifungal humoral response; IMP:UniProtKB.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IMP:UniProtKB.
GO; GO:1902714; P:negative regulation of interferon-gamma secretion; IMP:UniProtKB.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IMP:UniProtKB.
GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IBA:GO_Central.
GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
InterPro; IPR020877; IL-1_CS.
InterPro; IPR000975; IL-1_fam.
InterPro; IPR003297; IL-1RA/IL-36.
InterPro; IPR027171; IL-36RA.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR10078:SF32; PTHR10078:SF32; 1.
Pfam; PF00340; IL1; 1.
PRINTS; PR00264; INTERLEUKIN1.
PRINTS; PR01360; INTRLEUKIN1X.
SUPFAM; SSF50353; SSF50353; 1.
PROSITE; PS00253; INTERLEUKIN_1; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Disease mutation;
Disulfide bond; Immunity; Innate immunity; Polymorphism;
Reference proteome; Secreted.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:21965679}.
CHAIN 2 155 Interleukin-36 receptor antagonist
protein.
/FTId=PRO_0000153642.
DISULFID 8 154 {ECO:0000250}.
VARIANT 27 27 L -> P (in PSORS14; expression of the
protein is severely impaired compared to
wild-type; the mutant protein is
substantially less able to inhibit IL1RL2
signaling than wild-type;
dbSNP:rs387906914).
{ECO:0000269|PubMed:21848462}.
/FTId=VAR_066646.
VARIANT 47 47 N -> S (in dbSNP:rs28938777).
{ECO:0000269|Ref.9}.
/FTId=VAR_023239.
VARIANT 48 48 R -> W (in PSORS14; dbSNP:rs151325121).
{ECO:0000269|PubMed:21839423}.
/FTId=VAR_066647.
VARIANT 113 113 S -> L (in PSORS14; dbSNP:rs144478519).
{ECO:0000269|PubMed:21839423}.
/FTId=VAR_066648.
VARIANT 123 123 T -> R (in PSORS14; shows impaired
expression of the mutant protein which
fails to antagonize the IL-36 signaling
pathway; dbSNP:rs397514629).
{ECO:0000269|PubMed:22903787}.
/FTId=VAR_068972.
STRAND 9 13 {ECO:0000244|PDB:4P0L}.
STRAND 18 22 {ECO:0000244|PDB:4P0L}.
STRAND 25 29 {ECO:0000244|PDB:4P0L}.
STRAND 42 46 {ECO:0000244|PDB:4P0L}.
HELIX 52 54 {ECO:0000244|PDB:4P0J}.
STRAND 55 61 {ECO:0000244|PDB:4P0L}.
TURN 62 65 {ECO:0000244|PDB:4P0L}.
STRAND 66 69 {ECO:0000244|PDB:4P0L}.
STRAND 72 75 {ECO:0000244|PDB:4P0L}.
STRAND 79 82 {ECO:0000244|PDB:4P0L}.
HELIX 85 89 {ECO:0000244|PDB:4P0L}.
HELIX 96 98 {ECO:0000244|PDB:4P0L}.
STRAND 99 102 {ECO:0000244|PDB:4P0L}.
STRAND 109 116 {ECO:0000244|PDB:4P0L}.
STRAND 120 123 {ECO:0000244|PDB:4P0L}.
STRAND 132 135 {ECO:0000244|PDB:4P0L}.
STRAND 149 153 {ECO:0000244|PDB:4P0L}.
SEQUENCE 155 AA; 16962 MW; B96DB5EFA2612E25 CRC64;
MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD


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