GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Interleukin-4 (IL-4) (B-cell IgG differentiation factor) (B-cell growth factor 1) (B-cell stimulatory factor 1) (BSF-1) (IGG1 induction factor) (Lymphocyte stimulatory factor 1)

 IL4_MOUSE               Reviewed;         140 AA.
P07750;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
16-OCT-2019, entry version 168.
RecName: Full=Interleukin-4;
Short=IL-4;
AltName: Full=B-cell IgG differentiation factor;
AltName: Full=B-cell growth factor 1;
AltName: Full=B-cell stimulatory factor 1;
Short=BSF-1;
AltName: Full=IGG1 induction factor;
AltName: Full=Lymphocyte stimulatory factor 1;
Flags: Precursor;
Name=Il4; Synonyms=Il-4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3005865; DOI=10.1038/319640a0;
Noma Y., Sideras P., Naito T., Bergstedt-Lindqvist S., Azuma C.,
Severinson E., Tanabe T., Kinashi T., Matsuda F., Yaoita Y., Honjo T.;
"Cloning of cDNA encoding the murine IgG1 induction factor by a novel
strategy using SP6 promoter.";
Nature 319:640-646(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ;
PubMed=3029676; DOI=10.1093/nar/15.1.333;
Otsuka T., Villaret D., Yokota T., Takebe Y., Lee F., Arai N.,
Arai K.;
"Structural analysis of the mouse chromosomal gene encoding
interleukin 4 which expresses B cell, T cell and mast cell stimulating
activities.";
Nucleic Acids Res. 15:333-344(1987).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=3083412; DOI=10.1073/pnas.83.7.2061;
Lee F., Yokota T., Otsuka T., Meyerson P., Villaret D., Coffman R.,
Mosmann T., Rennick D., Roehm N., Smith C., Zlotnik A., Arai K.;
"Isolation and characterization of a mouse interleukin cDNA clone that
expresses B-cell stimulatory factor 1 activities and T-cell- and mast-
cell-stimulating activities.";
Proc. Natl. Acad. Sci. U.S.A. 83:2061-2065(1986).
[4]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=3498301; DOI=10.1007/978-1-4684-5323-2_22;
Sideras P., Bergstedt-Lindqvist S., Severinson E., Noma Y., Naito T.,
Azuma C., Tanabe T., Kinashi T., Matsude F., Yaoita Y., Honjo T.;
"IgG1 induction factor: a single molecular entity with multiple
biological functions.";
Adv. Exp. Med. Biol. 213:227-236(1987).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Thymus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PARTIAL PROTEIN SEQUENCE, AND DISULFIDE BONDS.
PubMed=1993171; DOI=10.1021/bi00220a011;
Carr C., Aykent S., Kimack N.M., Levine A.D.;
"Disulfide assignments in recombinant mouse and human interleukin 4.";
Biochemistry 30:1515-1523(1991).
[7]
FUNCTION.
PubMed=25847241; DOI=10.1074/jbc.m114.622126;
Edukulla R., Singh B., Jegga A.G., Sontake V., Dillon S.R.,
Madala S.K.;
"Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent
IL-31RA Expression.";
J. Biol. Chem. 290:13510-13520(2015).
[8]
FUNCTION.
PubMed=26416964; DOI=10.1083/jcb.201501059;
Terawaki S., Camosseto V., Prete F., Wenger T., Papadopoulos A.,
Rondeau C., Combes A., Rodriguez Rodrigues C., Vu Manh T.P.,
Fallet M., English L., Santamaria R., Soares A.R., Weil T., Hammad H.,
Desjardins M., Gorvel J.P., Santos M.A., Gatti E., Pierre P.;
"RUN and FYVE domain-containing protein 4 enhances autophagy and
lysosome tethering in response to Interleukin-4.";
J. Cell Biol. 210:1133-1152(2015).
-!- FUNCTION: Participates in at least several B-cell activation
processes as well as of other cell types (PubMed:3083412). It is a
costimulator of DNA-synthesis. It induces the expression of class
II MHC molecules on resting B-cells (PubMed:3498301). It enhances
both secretion and cell surface expression of IgE and IgG1
(PubMed:3498301). It also regulates the expression of the low
affinity Fc receptor for IgE (CD23) on both lymphocytes and
monocytes. Positively regulates IL31RA expression in macrophages
(PubMed:25847241). Stimulates autophagy in dendritic cells by
interfering with mTORC1 signaling and through the induction of
RUFY4 (PubMed:26416964). {ECO:0000269|PubMed:25847241,
ECO:0000269|PubMed:26416964, ECO:0000269|PubMed:3083412,
ECO:0000269|PubMed:3498301}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X03532; CAA27233.1; -; mRNA.
EMBL; X05064; CAA28731.1; -; Genomic_DNA.
EMBL; X05252; CAA28873.1; ALT_SEQ; Genomic_DNA.
EMBL; X05253; CAA28874.1; ALT_SEQ; Genomic_DNA.
EMBL; M13238; AAA39307.1; -; mRNA.
EMBL; M25892; AAA39298.1; -; mRNA.
EMBL; BC027514; AAH27514.1; -; mRNA.
CCDS; CCDS24682.1; -.
PIR; A25870; IIMSG1.
RefSeq; NP_067258.1; NM_021283.2.
SMR; P07750; -.
IntAct; P07750; 1.
STRING; 10090.ENSMUSP00000000889; -.
PhosphoSitePlus; P07750; -.
PaxDb; P07750; -.
PRIDE; P07750; -.
ABCD; P07750; -.
Ensembl; ENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869.
GeneID; 16189; -.
KEGG; mmu:16189; -.
UCSC; uc007iwq.2; mouse.
CTD; 3565; -.
MGI; MGI:96556; Il4.
eggNOG; KOG3886; Eukaryota.
eggNOG; ENOG410XQ0R; LUCA.
GeneTree; ENSGT00390000013108; -.
HOGENOM; HOG000254781; -.
InParanoid; P07750; -.
KO; K05430; -.
OMA; SCMELTV; -.
OrthoDB; 1495672at2759; -.
PhylomeDB; P07750; -.
TreeFam; TF336383; -.
Reactome; R-MMU-6785807; Interleukin-4 and Interleukin-13 signaling.
ChiTaRS; Il4; mouse.
PRO; PR:P07750; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000000869; Expressed in 34 organ(s), highest expression level in brain.
ExpressionAtlas; P07750; baseline and differential.
Genevisible; P07750; MM.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
GO; GO:0042976; P:activation of Janus kinase activity; ISO:MGI.
GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
GO; GO:0031296; P:B cell costimulation; IDA:MGI.
GO; GO:0008203; P:cholesterol metabolic process; IMP:UniProtKB.
GO; GO:0042832; P:defense response to protozoan; IMP:MGI.
GO; GO:0097028; P:dendritic cell differentiation; ISO:MGI.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
GO; GO:0002227; P:innate immune response in mucosa; IDA:BHF-UCL.
GO; GO:0001774; P:microglial cell activation; ISO:MGI.
GO; GO:0043011; P:myeloid dendritic cell differentiation; ISO:MGI.
GO; GO:0002674; P:negative regulation of acute inflammatory response; ISO:MGI.
GO; GO:0002677; P:negative regulation of chronic inflammatory response; ISO:MGI.
GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; ISO:MGI.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISO:MGI.
GO; GO:0010633; P:negative regulation of epithelial cell migration; ISO:MGI.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IDA:MGI.
GO; GO:0043031; P:negative regulation of macrophage activation; ISO:MGI.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; ISO:MGI.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IDA:MGI.
GO; GO:0050868; P:negative regulation of T cell activation; IDA:MGI.
GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0042536; P:negative regulation of tumor necrosis factor biosynthetic process; IDA:ARUK-UCL.
GO; GO:0070351; P:negative regulation of white fat cell proliferation; IDA:CACAO.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IDA:MGI.
GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IDA:ARUK-UCL.
GO; GO:2001171; P:positive regulation of ATP biosynthetic process; IDA:ARUK-UCL.
GO; GO:0050871; P:positive regulation of B cell activation; IDA:MGI.
GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
GO; GO:1901857; P:positive regulation of cellular respiration; IDA:ARUK-UCL.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IDA:BHF-UCL.
GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
GO; GO:0002230; P:positive regulation of defense response to virus by host; ISO:MGI.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:BHF-UCL.
GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IDA:ARUK-UCL.
GO; GO:0002639; P:positive regulation of immunoglobulin production; IMP:MGI.
GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:MGI.
GO; GO:0032736; P:positive regulation of interleukin-13 production; ISO:MGI.
GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IDA:MGI.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IDA:MGI.
GO; GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IMP:MGI.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IDA:MGI.
GO; GO:0071677; P:positive regulation of mononuclear cell migration; ISO:MGI.
GO; GO:1901741; P:positive regulation of myoblast fusion; IDA:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.
GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; ISO:MGI.
GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IDA:ARUK-UCL.
GO; GO:0045582; P:positive regulation of T cell differentiation; ISO:MGI.
GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:MGI.
GO; GO:0050776; P:regulation of immune response; IDA:MGI.
GO; GO:0050727; P:regulation of inflammatory response; ISO:MGI.
GO; GO:0010155; P:regulation of proton transport; ISO:MGI.
GO; GO:0042110; P:T cell activation; ISO:MGI.
GO; GO:0002296; P:T-helper 1 cell lineage commitment; IGI:MGI.
GO; GO:0035745; P:T-helper 2 cell cytokine production; ISO:MGI.
GO; GO:0045064; P:T-helper 2 cell differentiation; IDA:MGI.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002354; IL-4.
InterPro; IPR001325; IL-4/IL-13.
InterPro; IPR018096; IL-4/IL-13_CS.
PANTHER; PTHR47401; PTHR47401; 1.
Pfam; PF00727; IL4; 1.
PIRSF; PIRSF001941; Interleukin_4; 1.
PRINTS; PR00431; INTERLEUKIN4.
SMART; SM00190; IL4_13; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00838; INTERLEUKIN_4_13; 1.
1: Evidence at protein level;
Autophagy; B-cell activation; Complete proteome; Cytokine;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 20
CHAIN 21 140 Interleukin-4.
/FTId=PRO_0000015538.
CARBOHYD 61 61 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 91 91 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 117 117 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 25 107 {ECO:0000269|PubMed:1993171}.
DISULFID 47 87 {ECO:0000269|PubMed:1993171}.
DISULFID 69 114 {ECO:0000269|PubMed:1993171}.
SEQUENCE 140 AA; 15834 MW; E43CE16195DE051F CRC64;
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM DVPNVLTATK
NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR LFRAFRCLDS SISCTMNESK
STSLKDFLES LKSIMQMDYS


Related products :

Catalog number Product name Quantity
E0077m ELISA kit B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus muscul 96T
E0077m ELISA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
U0077m CLIA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
10-271-82216 IL-4 Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; IGG1 induction factor; B-cell IgG differentiation factor; B-cell growth factor 1 0.002 mg
10-271-82216 IL-4 Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; IGG1 induction factor; B-cell IgG differentiation factor; B-cell growth factor 1 0.01 mg
20-663-48008 Interleukin-4 (rAmuIL-4) - Rat Anti-Mouse Interleukin-4 (rAmuIL-4); IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; IGG1 induction factor; B-cell IgG differentiation factor; 0.5 mg
20-663-48008 Interleukin-4 (rAmuIL-4) - Rat Anti-Mouse Interleukin-4 (rAmuIL-4); IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; IGG1 induction factor; B-cell IgG differentiation factor; 1 mg
E0077r ELISA kit B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
U0077r CLIA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077r ELISA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
20-663-48007 Interleukin-4 (mAHuIL-4) - Mouse Anti Human Interleukin-4 (mAHuIL-4); IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; IGG1 induction factor; B-cell IgG differentiation facto 0.5 mg
20-663-48007 Interleukin-4 (mAHuIL-4) - Mouse Anti Human Interleukin-4 (mAHuIL-4); IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; IGG1 induction factor; B-cell IgG differentiation facto 1 mg
10-664-50012 Interleukin-6 - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.1 mg
10-664-50012 Interleukin-6 - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.05 mg
10-663-45216 Interleukin-6 Rat - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.01 mg
10-663-45216 Interleukin-6 Rat - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.002 mg
10-663-45216 Interleukin-6 Rat - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 1 mg
10-663-45226 Interleukin-6 (IL-6) Porcine - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.002 mg
10-663-45181 Interleukin-6 (IL-6) Mouse - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 1 mg
10-663-45181 Interleukin-6 (IL-6) Mouse - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.002 mg
10-663-45226 Interleukin-6 (IL-6) Porcine - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.1 mg
10-663-45181 Interleukin-6 (IL-6) Mouse - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.01 mg
15-288-22495 Interleukin-6 - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF Polyclonal 0.05 mg
10-663-45226 Interleukin-6 (IL-6) Porcine - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 0.01 mg
10-663-45083 Interleukin-6 (IL-6) Human - IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF N_A 1 mg
Pathways :
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP2023: Cell Differentiation - meta
WP2082: Cell Differentiation - Index
WP2012: miRs in Muscle Cell Differentiation
WP2276: Glial Cell Differentiation
WP2029: Cell Differentiation - Index
WP2076: miRs in Muscle Cell Differentiation
WP2104: The Effect of Emodin on MCF-7 cell lines
WP445: G1 to S cell cycle control
WP1195: G1 to S cell cycle control
WP1900: Regulation of mitotic cell cycle

Related Genes :
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[Cxcl12 Sdf1] Stromal cell-derived factor 1 (SDF-1) (12-O-tetradecanoylphorbol 13-acetate repressed protein 1) (TPAR1) (C-X-C motif chemokine 12) (Pre-B cell growth-stimulating factor) (PBSF) (Thymic lymphoma cell-stimulating factor) (TLSF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
[NRG1 GGF HGL HRGA NDF SMDF] Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
[Il2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[CXCL12 SDF1 SDF1A SDF1B] Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]
[CLCF1 BSF3 CLC NNT1] Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[IL4 EGK_16838] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[TIF1 TIF41A YKR059W; TIF2 TIF41B YJL138C J0660] ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[USF1 BHLHB11 USF] Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[Neurod1 Neurod] Neurogenic differentiation factor 1 (NeuroD1) (Beta-cell E-box transcriptional activator 2) (Beta2)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); Non-structural protein 11 (nsp11)]
[Ms4a1 Cd20 Ly-44 Ms4a2] B-lymphocyte antigen CD20 (B-cell differentiation antigen Ly-44) (Lymphocyte antigen 44) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)
[Ebf2 Coe2 Mmot1] Transcription factor COE2 (Early B-cell factor 2) (EBF-2) (Metencephalon-mesencephalon-olfactory transcription factor 1) (MET-mesencephalon-olfactory TF1) (MET-mesencephalon-olfactory transcription factor 1) (Olf-1/EBF-like 3) (O/E-3) (OE-3)
[Ebf1 Coe1 Ebf] Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)
[PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1] Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[IL16] Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]
[USF2 BHLHB12] Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)
[I79_024441] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor)

Bibliography :
[2974056] IL-4 (B cell stimulatory factor 1) overcomes Fc gamma receptor-mediated inhibition of mouse B lymphocyte proliferation without affecting inhibition of c-myc mRNA induction.
[3260915] Differential regulation by Ly-5 and Lyb-2 of IgG production induced by lipopolysaccharide and B cell stimulatory factor-1 (IL-4).