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Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)

 IL4_HUMAN               Reviewed;         153 AA.
P05112; Q14630; Q6NZ77;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
02-JUN-2021, entry version 232.
RecName: Full=Interleukin-4;
Short=IL-4;
AltName: Full=B-cell stimulatory factor 1;
Short=BSF-1;
AltName: Full=Binetrakin;
AltName: Full=Lymphocyte stimulatory factor 1;
AltName: Full=Pitrakinra;
Flags: Precursor;
Name=IL4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
PubMed=3016727; DOI=10.1073/pnas.83.16.5894;
Yokota T., Otsuka T., Mosmann T., Banchereau J., Defrance T., Blanchard D.,
de Vries J.E., Lee F., Arai K.;
"Isolation and characterization of a human interleukin cDNA clone,
homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and
T-cell-stimulating activities.";
Proc. Natl. Acad. Sci. U.S.A. 83:5894-5898(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2535858;
Arai N., Nomura D., Villaret D., Malefijt R.D., Seiki M., Yoshida M.,
Minoshima S., Fukuyama R., Maekawa M., Kudoh J., Shimizu N., Yokota K.,
Abe E., Yokota T., Takebe Y., Arai K.;
"Complete nucleotide sequence of the chromosomal gene for human IL-4 and
its expression.";
J. Immunol. 142:274-282(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=7806280; DOI=10.1007/bf00188440;
Klein S.C., Golverdingen J., Bouwens A.G.M., Tilanus M.G.J.;
"An alternatively spliced interleukin 4 form in lymphoid cells.";
Immunogenetics 41:57-57(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Blood;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45.
PubMed=3257560; DOI=10.1093/nar/16.2.772;
Eder A., Krafft-Czepa H., Krammer P.H.;
"The 5' region of the human interleukin 4 gene: structure and potential
regulatory elements.";
Nucleic Acids Res. 16:772-772(1988).
[7]
PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-62, AND DISULFIDE BONDS.
PubMed=1993171; DOI=10.1021/bi00220a011;
Carr C., Aykent S., Kimack N.M., Levine A.D.;
"Disulfide assignments in recombinant mouse and human interleukin 4.";
Biochemistry 30:1515-1523(1991).
[8]
X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
PubMed=1400355; DOI=10.2210/pdb2int/pdb;
Walter M.R., Cook W.J., Zhao B.G., Cameron R.P. Jr., Ealick S.E.,
Walter R.L. Jr., Reichert P., Nagabhushan T.L., Trotta P.P., Bugg C.E.;
"Crystal structure of recombinant human interleukin-4.";
J. Biol. Chem. 267:20371-20376(1992).
[9]
X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
PubMed=1511746; DOI=10.1016/0014-5793(92)80739-4;
Wlodaver A., Pavlovsky A., Gustchina A.;
"Crystal structure of human recombinant interleukin-4 at 2.25-A
resolution.";
FEBS Lett. 309:59-64(1992).
[10]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 25-153 IN COMPLEX WITH IL4RALPHA.
PubMed=10219247; DOI=10.1016/s0092-8674(00)80736-9;
Hage T., Sebald W., Reinemer P.;
"Crystal structure of the interleukin-4/receptor alpha chain complex
reveals a mosaic binding interface.";
Cell 97:271-281(1999).
[11]
STRUCTURE BY NMR.
PubMed=1932028; DOI=10.1021/bi00110a004;
Redfield C., Smith L.J., Boyd J., Lawrence G.M.P., Edwards R.G.,
Smith R.A.G., Dobson C.M.;
"Secondary structure and topology of human interleukin 4 in solution.";
Biochemistry 30:11029-11035(1991).
[12]
STRUCTURE BY NMR.
PubMed=1569578; DOI=10.1016/0022-2836(92)90457-u;
Smith L.J., Redfield C., Boyd J., Lawrence G.M.P., Edwards R.G.,
Smith R.A.G., Dobson C.M.;
"Human interleukin 4. The solution structure of a four-helix bundle
protein.";
J. Mol. Biol. 224:899-904(1992).
[13]
STRUCTURE BY NMR.
PubMed=1567880; DOI=10.1021/bi00132a026;
Powers R., Garret D.S., March C.J., Frieden E.A., Gronenborn A.M.,
Clore G.M.;
"1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-
dimensional double- and triple-resonance heteronuclear magnetic resonance
spectroscopy.";
Biochemistry 31:4334-4346(1992).
[14]
STRUCTURE BY NMR.
PubMed=1567881; DOI=10.1021/bi00132a027;
Garret D.S., Powers R., March C.J., Frieden E.A., Clore G.M.,
Gronenborn A.M.;
"Determination of the secondary structure and folding topology of human
interleukin-4 using three-dimensional heteronuclear magnetic resonance
spectroscopy.";
Biochemistry 31:4347-4353(1992).
[15]
STRUCTURE BY NMR.
PubMed=1609277; DOI=10.1126/science.256.5064.1673;
Powers R., Garret D.S., March C.J., Frieden E.A., Gronenborn A.M.,
Clore G.M.;
"Three-dimensional solution structure of human interleukin-4 by
multidimensional heteronuclear magnetic resonance spectroscopy.";
Science 256:1673-1677(1992).
[16]
DISULFIDE BONDS, AND 3D-STRUCTURE MODELING.
PubMed=1946344; DOI=10.1002/prot.340110204;
Curtis B.M., Presnell S.R., Srinivasan S., Sassenfeld H., Klinke R.,
Jeffery E., Cosman D., March C.J., Cohen F.E.;
"Experimental and theoretical studies of the three-dimensional structure of
human interleukin-4.";
Proteins 11:111-119(1991).
[17]
MUTAGENESIS, AND STRUCTURE BY NMR.
PubMed=8151703; DOI=10.1006/jmbi.1994.1245;
Mueller T., Dieckmann T., Sebald W., Oschkinat H.;
"Aspects of receptor binding and signalling of interleukin-4 investigated
by site-directed mutagenesis and NMR spectroscopy.";
J. Mol. Biol. 237:423-436(1994).
[18]
COMPARISON OF STRUCTURES.
PubMed=7664036; DOI=10.1038/nsb0594-301;
Smith L.J., Redfield C., Smith R.A.G., Dobson C.M., Clore G.M.,
Gronenborn A.M., Walter M.R., Naganbushan T.L., Wlodawer A.;
"Comparison of four independently determined structures of human
recombinant interleukin-4.";
Nat. Struct. Biol. 1:301-310(1994).
[19]
INVOLVEMENT IN SUSCEPTIBILITY TO ISCHSTR.
PubMed=14681304; DOI=10.1093/hmg/ddh039;
Zee R.Y.L., Cook N.R., Cheng S., Reynolds R., Erlich H.A., Lindpaintner K.,
Ridker P.M.;
"Polymorphism in the P-selectin and interleukin-4 genes as determinants of
stroke: a population-based, prospective genetic analysis.";
Hum. Mol. Genet. 13:389-396(2004).
-!- FUNCTION: Participates in at least several B-cell activation processes
as well as of other cell types (PubMed:3016727). It is a costimulator
of DNA-synthesis. It induces the expression of class II MHC molecules
on resting B-cells. It enhances both secretion and cell surface
expression of IgE and IgG1. It also regulates the expression of the low
affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Positively regulates IL31RA expression in macrophages (By similarity).
Stimulates autophagy in dendritic cells by interfering with mTORC1
signaling and through the induction of RUFY4 (By similarity).
{ECO:0000250|UniProtKB:P07750, ECO:0000269|PubMed:3016727}.
-!- INTERACTION:
P05112; P78552: IL13RA1; NbExp=3; IntAct=EBI-367025, EBI-1391535;
P05112; P24394: IL4R; NbExp=7; IntAct=EBI-367025, EBI-367009;
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Long;
IsoId=P05112-1; Sequence=Displayed;
Name=2; Synonyms=Short, IL-4delta2;
IsoId=P05112-2; Sequence=VSP_002672;
-!- DISEASE: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute
neurologic event leading to death of neural tissue of the brain and
resulting in loss of motor, sensory and/or cognitive function. Ischemic
strokes, resulting from vascular occlusion, is considered to be a
highly complex disease consisting of a group of heterogeneous disorders
with multiple genetic and environmental risk factors.
{ECO:0000269|PubMed:14681304}. Note=Disease susceptibility is
associated with variants affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il4/";
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EMBL; M13982; AAA59149.1; -; mRNA.
EMBL; M23442; AAA59150.1; -; Genomic_DNA.
EMBL; X81851; CAA57444.1; -; mRNA.
EMBL; AF395008; AAK71324.1; -; Genomic_DNA.
EMBL; BC066277; AAH66277.1; -; mRNA.
EMBL; BC067514; AAH67514.1; -; mRNA.
EMBL; BC070123; AAH70123.1; -; mRNA.
EMBL; X06750; CAA29925.1; -; Genomic_DNA.
CCDS; CCDS4158.1; -. [P05112-1]
CCDS; CCDS4159.1; -. [P05112-2]
PIR; A30546; A25946.
RefSeq; NP_000580.1; NM_000589.3. [P05112-1]
RefSeq; NP_758858.1; NM_172348.2. [P05112-2]
PDB; 1BBN; NMR; -; A=25-153.
PDB; 1BCN; NMR; -; A=25-153.
PDB; 1CYL; NMR; -; A=25-153.
PDB; 1HIJ; X-ray; 3.00 A; A=25-153.
PDB; 1HIK; X-ray; 2.60 A; A=25-153.
PDB; 1HZI; X-ray; 2.05 A; A=25-153.
PDB; 1IAR; X-ray; 2.30 A; A=25-153.
PDB; 1ILL; Model; -; 4=25-153.
PDB; 1ITE; Model; -; A=25-153.
PDB; 1ITI; NMR; -; A=25-153.
PDB; 1ITL; NMR; -; A=25-153.
PDB; 1ITM; NMR; -; A=25-153.
PDB; 1RCB; X-ray; 2.25 A; A=25-153.
PDB; 2B8U; X-ray; 1.80 A; A=25-153.
PDB; 2B8X; X-ray; 1.70 A; A=25-153.
PDB; 2B8Y; X-ray; 1.80 A; A=25-153.
PDB; 2B8Z; X-ray; 2.50 A; A=25-153.
PDB; 2B90; X-ray; 2.10 A; A=25-153.
PDB; 2B91; X-ray; 2.00 A; A=25-153.
PDB; 2CYK; NMR; -; A=25-153.
PDB; 2D48; X-ray; 1.65 A; A=25-153.
PDB; 2INT; X-ray; 2.35 A; A=25-153.
PDB; 3BPL; X-ray; 2.93 A; A=25-153.
PDB; 3BPN; X-ray; 3.02 A; A=25-153.
PDB; 3QB7; X-ray; 3.24 A; A/B=25-153.
PDB; 4YDY; X-ray; 2.00 A; I/J=25-153.
PDB; 5FHX; X-ray; 2.55 A; A=30-153.
PDB; 6OEL; X-ray; 3.10 A; A=25-153.
PDBsum; 1BBN; -.
PDBsum; 1BCN; -.
PDBsum; 1CYL; -.
PDBsum; 1HIJ; -.
PDBsum; 1HIK; -.
PDBsum; 1HZI; -.
PDBsum; 1IAR; -.
PDBsum; 1ILL; -.
PDBsum; 1ITE; -.
PDBsum; 1ITI; -.
PDBsum; 1ITL; -.
PDBsum; 1ITM; -.
PDBsum; 1RCB; -.
PDBsum; 2B8U; -.
PDBsum; 2B8X; -.
PDBsum; 2B8Y; -.
PDBsum; 2B8Z; -.
PDBsum; 2B90; -.
PDBsum; 2B91; -.
PDBsum; 2CYK; -.
PDBsum; 2D48; -.
PDBsum; 2INT; -.
PDBsum; 3BPL; -.
PDBsum; 3BPN; -.
PDBsum; 3QB7; -.
PDBsum; 4YDY; -.
PDBsum; 5FHX; -.
PDBsum; 6OEL; -.
BMRB; P05112; -.
SMR; P05112; -.
BioGRID; 109779; 3.
CORUM; P05112; -.
DIP; DIP-3222N; -.
IntAct; P05112; 3.
MINT; P05112; -.
STRING; 9606.ENSP00000231449; -.
ChEMBL; CHEMBL3712894; -.
DrugBank; DB06560; Pascolizumab.
DrugCentral; P05112; -.
GlyGen; P05112; 1 site.
iPTMnet; P05112; -.
PhosphoSitePlus; P05112; -.
BioMuta; IL4; -.
DMDM; 124337; -.
MassIVE; P05112; -.
PaxDb; P05112; -.
PeptideAtlas; P05112; -.
PRIDE; P05112; -.
ProteomicsDB; 51797; -. [P05112-1]
ProteomicsDB; 51798; -. [P05112-2]
ABCD; P05112; 1 sequenced antibody.
Antibodypedia; 14502; 1794 antibodies.
DNASU; 3565; -.
Ensembl; ENST00000231449; ENSP00000231449; ENSG00000113520. [P05112-1]
Ensembl; ENST00000350025; ENSP00000325190; ENSG00000113520. [P05112-2]
GeneID; 3565; -.
KEGG; hsa:3565; -.
UCSC; uc003kxk.3; human. [P05112-1]
CTD; 3565; -.
DisGeNET; 3565; -.
GeneCards; IL4; -.
HGNC; HGNC:6014; IL4.
HPA; ENSG00000113520; Tissue enriched (blood).
MIM; 147780; gene.
MIM; 601367; phenotype.
neXtProt; NX_P05112; -.
OpenTargets; ENSG00000113520; -.
PharmGKB; PA197; -.
VEuPathDB; HostDB:ENSG00000113520.10; -.
eggNOG; KOG3886; Eukaryota.
GeneTree; ENSGT00390000013108; -.
HOGENOM; CLU_154691_0_0_1; -.
InParanoid; P05112; -.
OMA; SCMELTV; -.
PhylomeDB; P05112; -.
TreeFam; TF336383; -.
PathwayCommons; P05112; -.
Reactome; R-HSA-6785807; Interleukin-4 and Interleukin-13 signaling.
Reactome; R-HSA-9012546; Interleukin-18 signaling.
SignaLink; P05112; -.
SIGNOR; P05112; -.
BioGRID-ORCS; 3565; 2 hits in 985 CRISPR screens.
EvolutionaryTrace; P05112; -.
GeneWiki; Interleukin_4; -.
GenomeRNAi; 3565; -.
Pharos; P05112; Tbio.
PRO; PR:P05112; -.
Proteomes; UP000005640; Chromosome 5.
RNAct; P05112; protein.
Bgee; ENSG00000113520; Expressed in oocyte and 101 other tissues.
ExpressionAtlas; P05112; baseline and differential.
Genevisible; P05112; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; NAS:UniProtKB.
GO; GO:0005136; F:interleukin-4 receptor binding; TAS:UniProtKB.
GO; GO:0042976; P:activation of Janus kinase activity; IGI:ARUK-UCL.
GO; GO:0031296; P:B cell costimulation; IBA:GO_Central.
GO; GO:0030183; P:B cell differentiation; TAS:UniProtKB.
GO; GO:0008203; P:cholesterol metabolic process; ISS:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO; GO:0097028; P:dendritic cell differentiation; IDA:DFLAT.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
GO; GO:0042116; P:macrophage activation; IGI:ARUK-UCL.
GO; GO:0001774; P:microglial cell activation; IBA:GO_Central.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IDA:UniProtKB.
GO; GO:0002674; P:negative regulation of acute inflammatory response; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:1903845; P:negative regulation of cellular response to transforming growth factor beta stimulus; IDA:UniProtKB.
GO; GO:0002677; P:negative regulation of chronic inflammatory response; IBA:GO_Central.
GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IMP:AgBase.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IMP:AgBase.
GO; GO:0010633; P:negative regulation of epithelial cell migration; IDA:CACAO.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0050728; P:negative regulation of inflammatory response; IGI:ARUK-UCL.
GO; GO:0043031; P:negative regulation of macrophage activation; IBA:GO_Central.
GO; GO:0150079; P:negative regulation of neuroinflammatory response; IC:ARUK-UCL.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IBA:GO_Central.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:ARUK-UCL.
GO; GO:0150076; P:neuroinflammatory response; ISS:ARUK-UCL.
GO; GO:1900223; P:positive regulation of amyloid-beta clearance; ISS:ARUK-UCL.
GO; GO:2001171; P:positive regulation of ATP biosynthetic process; ISS:ARUK-UCL.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IGI:ARUK-UCL.
GO; GO:0008284; P:positive regulation of cell population proliferation; IGI:ARUK-UCL.
GO; GO:1901857; P:positive regulation of cellular respiration; ISS:ARUK-UCL.
GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IBA:GO_Central.
GO; GO:0010628; P:positive regulation of gene expression; IGI:ARUK-UCL.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IGI:ARUK-UCL.
GO; GO:0032736; P:positive regulation of interleukin-13 production; IDA:UniProtKB.
GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISS:UniProtKB.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISS:UniProtKB.
GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
GO; GO:0071677; P:positive regulation of mononuclear cell migration; IBA:GO_Central.
GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISS:ARUK-UCL.
GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IGI:ARUK-UCL.
GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
GO; GO:0045191; P:regulation of isotype switching; TAS:UniProtKB.
GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
GO; GO:0042110; P:T cell activation; IGI:BHF-UCL.
GO; GO:0045064; P:T-helper 2 cell differentiation; IBA:GO_Central.
GO; GO:0042092; P:type 2 immune response; TAS:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002354; IL-4.
InterPro; IPR001325; IL-4/IL-13.
InterPro; IPR018096; IL-4/IL-13_CS.
PANTHER; PTHR47401; PTHR47401; 1.
Pfam; PF00727; IL4; 1.
PIRSF; PIRSF001941; Interleukin_4; 1.
PRINTS; PR00431; INTERLEUKIN4.
SMART; SM00190; IL4_13; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00838; INTERLEUKIN_4_13; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; B-cell activation; Cytokine;
Direct protein sequencing; Disulfide bond; Glycoprotein; Growth factor;
Reference proteome; Secreted; Signal.
SIGNAL 1..24
CHAIN 25..153
/note="Interleukin-4"
/id="PRO_0000015532"
CARBOHYD 62
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:1993171"
DISULFID 27..151
/evidence="ECO:0000269|PubMed:1993171"
DISULFID 48..89
/evidence="ECO:0000269|PubMed:1993171"
DISULFID 70..123
VAR_SEQ 46..61
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:7806280"
/id="VSP_002672"
VARIANT 27
/note="C -> R (in dbSNP:rs4986964)"
/id="VAR_020392"
TURN 26..29
/evidence="ECO:0007829|PDB:1BBN"
HELIX 30..41
/evidence="ECO:0007829|PDB:2D48"
HELIX 42..44
/evidence="ECO:0007829|PDB:5FHX"
HELIX 48..50
/evidence="ECO:0007829|PDB:2D48"
STRAND 51..54
/evidence="ECO:0007829|PDB:2D48"
HELIX 56..58
/evidence="ECO:0007829|PDB:2D48"
TURN 60..62
/evidence="ECO:0007829|PDB:1CYL"
HELIX 65..83
/evidence="ECO:0007829|PDB:2D48"
TURN 87..89
/evidence="ECO:0007829|PDB:2D48"
HELIX 94..118
/evidence="ECO:0007829|PDB:2D48"
STRAND 130..132
/evidence="ECO:0007829|PDB:2D48"
HELIX 133..151
/evidence="ECO:0007829|PDB:2D48"
SEQUENCE 153 AA; 17492 MW; 8725BF64B34D45F7 CRC64;
MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS
KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL
NSCPVKEANQ STLENFLERL KTIMREKYSK CSS


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E0077h ELISA B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
U0077h CLIA B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
E0077h ELISA kit B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45213 Interleukin-4 (IL-4) Rat - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45213 Interleukin-4 (IL-4) Rat - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45213 Interleukin-4 (IL-4) Rat - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
E0077m ELISA kit B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus muscul 96T
E0077m ELISA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
U0077m CLIA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
E0077r ELISA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077r ELISA kit B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
U0077r CLIA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077Rb ELISA kit B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
E0077Rb ELISA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
U0077Rb CLIA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
U0077b CLIA B-cell stimulatory factor 1,Bos taurus,Bovine,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1 96T
Pathways :
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP272: Blood Clotting Cascade
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP2148: Brain derived neurotrophic factor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP2076: miRs in Muscle Cell Differentiation
WP536: Calcium Regulation in the Cardiac Cell
WP1011: T Cell Receptor Signaling Pathway
WP1839: Interleukin-1 signaling
WP274: B Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP964: Cell cycle
WP1386: Integrin-mediated cell adhesion
WP2106: The Effect of Emodin on MDA-MB-231 cell lines
WP6: Integrin-mediated cell adhesion

Related Genes :
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1)
[BSG UNQ6505/PRO21383] Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
[Il6 Il-6] Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)
[USF1 BHLHB11 USF] Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)
[IL16] Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[ORF1ab ORF1a orf1ab] 3C-like proteinase (EC 3.4.19.12) (EC 3.4.22.69) (Growth factor-like peptide) (Leader protein) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (Papain-like proteinase) (p65 homolog)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[NFIL3 E4BP4 IL3BP1] Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)
[Usf1 Usf] Upstream stimulatory factor 1 (Major late transcription factor 1)
[USF2 BHLHB12] Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
[IL4I1 FIG1 UNQ636/PRO1265] L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[CLCF1 BSF3 CLC NNT1] Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)
[IL33 C9orf26 IL1F11 NFHEV] Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
[Usf2] Upstream stimulatory factor 2 (Major late transcription factor 2) (Upstream transcription factor 2)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Usf2] Upstream stimulatory factor 2 (Major late transcription factor 2) (Upstream transcription factor 2)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)

Bibliography :