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Interleukin-5 (Eosinophil differentiation factor)

 Q5SV01_MOUSE            Unreviewed;       133 AA.
Q5SV01; Q05A89;
21-DEC-2004, integrated into UniProtKB/TrEMBL.
20-FEB-2007, sequence version 2.
02-JUN-2021, entry version 134.
RecName: Full=Interleukin-5 {ECO:0000256|RuleBase:RU363136};
AltName: Full=Eosinophil differentiation factor {ECO:0000256|RuleBase:RU363136};
Name=Il5 {ECO:0000313|EMBL:AAI25367.1, ECO:0000313|MGI:MGI:96557};
Synonyms=IL5 {ECO:0000256|RuleBase:RU363136};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI25367.1};
[1] {ECO:0000313|EMBL:AAI25367.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain {ECO:0000313|EMBL:AAI25367.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Factor that induces terminal differentiation of late-
developing B-cells to immunoglobulin secreting cells.
{ECO:0000256|ARBA:ARBA00003693, ECO:0000256|RuleBase:RU363136}.
-!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
ECO:0000256|RuleBase:RU363136}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
ECO:0000256|RuleBase:RU363136}.
-!- SIMILARITY: Belongs to the IL-5 family. {ECO:0000256|ARBA:ARBA00006740,
ECO:0000256|RuleBase:RU363136}.
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EMBL; BC125366; AAI25367.1; -; mRNA.
EMBL; BC132066; AAI32067.1; -; mRNA.
RefSeq; NP_034688.1; NM_010558.1.
SMR; Q5SV01; -.
BindingDB; Q5SV01; -.
Antibodypedia; 4146; 806 antibodies.
DNASU; 16191; -.
GeneID; 16191; -.
KEGG; mmu:16191; -.
CTD; 3567; -.
MGI; MGI:96557; Il5.
HOGENOM; CLU_156269_0_0_1; -.
OMA; NTEWTME; -.
OrthoDB; 1469027at2759; -.
BioGRID-ORCS; 16191; 2 hits in 53 CRISPR screens.
Bgee; ENSMUSG00000036117; Expressed in retina and 51 other tissues.
ExpressionAtlas; Q5SV01; baseline and differential.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005137; F:interleukin-5 receptor binding; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0045645; P:positive regulation of eosinophil differentiation; IEA:Ensembl.
GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000186; IL-5.
Pfam; PF02025; IL5; 1.
PRINTS; PR00432; INTERLEUKIN5.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU363136};
Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
ECO:0000256|RuleBase:RU363136};
Growth factor {ECO:0000256|RuleBase:RU363136};
Secreted {ECO:0000256|ARBA:ARBA00022525};
Signal {ECO:0000256|RuleBase:RU363136}.
SIGNAL 1..20
/evidence="ECO:0000256|RuleBase:RU363136"
CHAIN 21..133
/note="Interleukin-5"
/evidence="ECO:0000256|RuleBase:RU363136"
/id="PRO_5014205901"
SEQUENCE 133 AA; 15410 MW; C6DC091682452AF4 CRC64;
MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ
LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE
FLGVMSTEWA MEG


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Related Genes :
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
[EPX EPER EPO EPP] Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]
[CCL11 SCYA11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Ccl11 Scya11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1)
[Ccl24 Scya24] C-C motif chemokine 24 (Eosinophil chemotactic protein 2) (Eotaxin-2) (Small-inducible cytokine A24)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il6 Il-6] Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Ccl11 Scya11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[NFIL3 E4BP4 IL3BP1] Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[TRAF6 RNF85] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
[TNFRSF11A RANK] Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
[Cebpb Crp2 Nf-il6 Sfb] CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B)
[ILF3 DRBF MPHOSPH4 NF90] Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)
[TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6] E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
[Mdk Mk] Midkine (MK) (Retanoic acid-responsive protein) (Retinoic acid-induced differentiation factor)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL33 C9orf26 IL1F11 NFHEV] Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[ASAP1 DDEF1 KIAA1249 PAG2] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[Cd84 Slamf5] SLAM family member 5 (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)

Bibliography :
[34306708] Benralizumab use in chronic eosinophilic pneumonia with eosinophilic bronchiolitis and chronic airway infection.
[34292606] A Phase 1 study of the long-acting anti-IL-5 monoclonal antibody GSK3511294 in patients with asthma.
[34287685] Multi-targeted therapy for refractory eosinophilic granulomatosis with polyangiitis characterized by intracerebral hemorrhage and cardiomyopathy: a case-based review.
[34285513] Real-World Multicenter Experience with Mepolizumab and Benralizumab in the Treatment of Uncontrolled Severe Eosinophilic Asthma Over 12 Months.
[34259869] Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction.
[34246445] Reply to "Mepolizumab in patients with eosinophilic granulomatosis with polyangiitis in remission: What is the right dose?"
[34246444] Mepolizumab in patients with eosinophilic granulomatosis with polyangiitis in remission: What is the right dose?
[34237420] IgG4-related disease and hypereosinophilic syndrome: Overlapping phenotypes.
[34221407] Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India.
[34203871] Searching for Noninvasive Predictors of the Diagnosis and Monitoring of Eosinophilic Esophagitis-The Importance of Biomarkers of the Inflammatory Reaction Involving Eosinophils.