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Interleukin-5 (IL-5) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)

 IL5_MACMU               Reviewed;         134 AA.
P48093;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
12-AUG-2020, entry version 102.
RecName: Full=Interleukin-5;
Short=IL-5;
AltName: Full=Eosinophil differentiation factor;
AltName: Full=T-cell replacing factor;
Short=TRF;
Flags: Precursor;
Name=IL5;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Blood;
PubMed=7561102;
Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.;
"Comparative sequence analysis of cytokine genes from human and nonhuman
primates.";
J. Immunol. 155:3946-3954(1995).
-!- FUNCTION: Factor that induces terminal differentiation of late-
developing B-cells to immunoglobulin secreting cells. {ECO:0000250}.
-!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-5 family. {ECO:0000305}.
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EMBL; U19848; AAA86710.1; -; mRNA.
RefSeq; NP_001040598.1; NM_001047133.1.
SMR; P48093; -.
STRING; 9544.ENSMMUP00000004183; -.
eggNOG; ENOG502RWD8; Eukaryota.
InParanoid; P48093; -.
Proteomes; UP000006718; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005137; F:interleukin-5 receptor binding; IEA:InterPro.
GO; GO:0006955; P:immune response; IEA:InterPro.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000186; IL-5.
Pfam; PF02025; IL5; 1.
PRINTS; PR00432; INTERLEUKIN5.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
Secreted; Signal.
SIGNAL 1..19
/evidence="ECO:0000250"
CHAIN 20..134
/note="Interleukin-5"
/id="PRO_0000015562"
CARBOHYD 22
/note="O-linked (GalNAc...) threonine"
/evidence="ECO:0000250"
CARBOHYD 47
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 90
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 63
/note="Interchain (with C-105)"
/evidence="ECO:0000250"
DISULFID 105
/note="Interchain (with C-63)"
/evidence="ECO:0000250"
SEQUENCE 134 AA; 15150 MW; DC985ECF4BAB86A3 CRC64;
MRMLLHLSLL ALGAAYVYAI PTEIPASALV KETLALLSTH RTLLIANETL RIPVPVHKNH
QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIGG QKKKCGEERR RVNQFLDYLQ
EFLGVMNTEW IIES


Related products :

Catalog number Product name Quantity
E0078h ELISA kit B-cell differentiation factor I,Eosinophil differentiation factor,Homo sapiens,Human,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
E0078h ELISA B-cell differentiation factor I,Eosinophil differentiation factor,Homo sapiens,Human,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
U0078h CLIA B-cell differentiation factor I,Eosinophil differentiation factor,Homo sapiens,Human,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
E0078r ELISA B-cell growth factor II,BCGF-II,Cytotoxic T-lymphocyte inducer,Eosinophil differentiation factor,Il5,IL-5,Il-5,Interleukin-5,Rat,Rattus norvegicus,T-cell replacing factor,TRF 96T
U0078m CLIA B-cell growth factor II,BCGF-II,Cytotoxic T-lymphocyte inducer,Eosinophil differentiation factor,Il5,IL-5,Il-5,Interleukin-5,Mouse,Mus musculus,T-cell replacing factor,TRF 96T
E0078r ELISA kit B-cell growth factor II,BCGF-II,Cytotoxic T-lymphocyte inducer,Eosinophil differentiation factor,Il5,IL-5,Il-5,Interleukin-5,Rat,Rattus norvegicus,T-cell replacing factor,TRF 96T
E0078m ELISA B-cell growth factor II,BCGF-II,Cytotoxic T-lymphocyte inducer,Eosinophil differentiation factor,Il5,IL-5,Il-5,Interleukin-5,Mouse,Mus musculus,T-cell replacing factor,TRF 96T
U0078r CLIA B-cell growth factor II,BCGF-II,Cytotoxic T-lymphocyte inducer,Eosinophil differentiation factor,Il5,IL-5,Il-5,Interleukin-5,Rat,Rattus norvegicus,T-cell replacing factor,TRF 96T
E0078m ELISA kit B-cell growth factor II,BCGF-II,Cytotoxic T-lymphocyte inducer,Eosinophil differentiation factor,Il5,IL-5,Il-5,Interleukin-5,Mouse,Mus musculus,T-cell replacing factor,TRF 96T
10-663-45082 Interleukin-5 (IL-5) Human - IL-5; T-cell replacing factor; TRF; Eosinophil differentiation factor; B cell differentiation factor I N_A 0.002 mg
10-663-45082 Interleukin-5 (IL-5) Human - IL-5; T-cell replacing factor; TRF; Eosinophil differentiation factor; B cell differentiation factor I N_A 0.01 mg
10-663-45082 Interleukin-5 (IL-5) Human - IL-5; T-cell replacing factor; TRF; Eosinophil differentiation factor; B cell differentiation factor I N_A 1 mg
U0078p CLIA Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,Pig,Sus scrofa,T-cell replacing factor,TRF 96T
E0078p ELISA kit Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,Pig,Sus scrofa,T-cell replacing factor,TRF 96T
E0078p ELISA Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,Pig,Sus scrofa,T-cell replacing factor,TRF 96T
10-663-45215 Interleukin-5 Rat - IL-5; T-cell replacing factor; TRF; Eosinophil differentiation factor; B cell differentiation factor I N_A 0.002 mg
10-663-45215 Interleukin-5 Rat - IL-5; T-cell replacing factor; TRF; Eosinophil differentiation factor; B cell differentiation factor I N_A 0.01 mg
10-663-45215 Interleukin-5 Rat - IL-5; T-cell replacing factor; TRF; Eosinophil differentiation factor; B cell differentiation factor I N_A 1 mg
E0078b ELISA kit Bos taurus,Bovine,Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
E0078b ELISA Bos taurus,Bovine,Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
U0078b CLIA Bos taurus,Bovine,Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
M10-046 IL-5 Mouse Host: E. coli Il5; Il-5; B-cell growth factor II Short name=BCGF-II Cytotoxic T-lymphocyte inducer Eosinophil differentiation factor T-cell replacing factor 25
U0078c CLIA Canis familiaris,Canis lupus familiaris,Dog,Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
E0078c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
E0078c ELISA Canis familiaris,Canis lupus familiaris,Dog,Eosinophil differentiation factor,IL5,IL-5,Interleukin-5,T-cell replacing factor,TRF 96T
Pathways :
WP2029: Cell Differentiation - Index
WP2076: miRs in Muscle Cell Differentiation
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2276: Glial Cell Differentiation
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP2023: Cell Differentiation - meta
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP2082: Cell Differentiation - Index
WP2148: Brain derived neurotrophic factor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP2012: miRs in Muscle Cell Differentiation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP272: Blood Clotting Cascade
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1011: T Cell Receptor Signaling Pathway
WP1838: Interleukin-1 processing
WP2375: miRNAs and TFs in iPS Cell Generation
WP844: Cell cycle

Related Genes :
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[Il2 Il-2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[Il6 Il-6] Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)
[IL4] Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[NFIL3 E4BP4 IL3BP1] Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)
[IL33 C9orf26 IL1F11 NFHEV] Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
[Cebpb Crp2 Nf-il6 Sfb] CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B)
[TERF2IP DRIP5 RAP1 PP8000] Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[CEBPB TCF5 PP9092] CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
[IL16] Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]
[Cd40lg Cd40l Tnfsf5] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[CD40LG CD40L TNFSF5 TRAP] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il17a Ctla8 Il17] Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)
[ITK EMT LYK] Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL2] Interleukin-2 (IL-2) (T-cell growth factor) (TCGF)
[IL36RN FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 UNQ1896/PRO4342] Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)

Bibliography :
[25566252] Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5.
[12372126] Genetic variation of Der p 2 allergens: effects on T cell responses and immunoglobulin E binding.
[8244211] [Cytokine and inflammation: role of IL-5 and its receptor system in inflammation].
[2025616] The role of interleukin 4 in specific antibody responses by human B cells.
[2215480] Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity.
[2518658] Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5.
[3263924] Interleukin 2 and low molecular weight B cell growth factor are T cell-replacing factors for different subpopulations of human B cells.
[3073429] [Molecular mechanisms regulating B cell growth and differentiation--special reference to TRF/IL-5 and its receptor].
[3262707] Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication.
[3260684] Biological characterization of T cell-replacing factor in the synovial fluid of rheumatoid arthritis patients.