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Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)

 IL6RB_MOUSE             Reviewed;         917 AA.
Q00560; G5E8D2;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
16-OCT-2019, entry version 181.
RecName: Full=Interleukin-6 receptor subunit beta;
Short=IL-6 receptor subunit beta;
Short=IL-6R subunit beta;
Short=IL-6R-beta;
Short=IL-6RB;
AltName: Full=Interleukin-6 signal transducer;
AltName: Full=Membrane glycoprotein 130;
Short=gp130;
AltName: Full=Oncostatin-M receptor subunit alpha;
AltName: CD_antigen=CD130;
Flags: Precursor;
Name=Il6st;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=ICR; TISSUE=Macrophage;
PubMed=1602143;
Saito M., Yoshida K., Hibi M., Taga T., Kishimoto T.;
"Molecular cloning of a murine IL-6 receptor-associated signal
transducer, gp130, and its regulated expression in vivo.";
J. Immunol. 148:4066-4071(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=8552649; DOI=10.1073/pnas.93.1.407;
Yoshida K., Taga T., Saito M., Suematsu S., Kumanogoh A., Tanaka T.,
Fujiwara H., Hirata M., Yamagami T., Nakahata T., Hirabayashi T.,
Yoneda Y., Tanaka K., Wang W.Z., Mori C., Shiota K., Yoshida N.,
Kishimoto T.;
"Targeted disruption of gp130, a common signal transducer for the
interleukin 6 family of cytokines, leads to myocardial and
hematological disorders.";
Proc. Natl. Acad. Sci. U.S.A. 93:407-411(1996).
[5]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=9348227; DOI=10.1210/endo.138.11.5534;
Kawasaki K., Gao Y.H., Yokose S., Kaji Y., Nakamura T., Suda T.,
Yoshida K., Taga T., Kishimoto T., Kataoka H., Yuasa T., Norimatsu H.,
Yamaguchi A.;
"Osteoclasts are present in gp130-deficient mice.";
Endocrinology 138:4959-4965(1997).
[6]
SUBUNIT.
PubMed=9920829;
Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A.,
Miyajima A.;
"Reconstitution of the functional mouse oncostatin M (OSM) receptor:
molecular cloning of the OSM receptor beta subunit.";
Blood 93:804-815(1999).
[7]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=10377352; DOI=10.1523/jneurosci.19-13-05429.1999;
Nakashima K., Wiese S., Yanagisawa M., Arakawa H., Kimura N.,
Hisatsune T., Yoshida K., Kishimoto T., Sendtner M., Taga T.;
"Developmental requirement of gp130 signaling in neuronal survival and
astrocyte differentiation.";
J. Neurosci. 19:5429-5434(1999).
[8]
FUNCTION.
PubMed=10661409; DOI=10.1016/s1074-7613(00)80162-4;
Ohtani T., Ishihara K., Atsumi T., Nishida K., Kaneko Y., Miyata T.,
Itoh S., Narimatsu M., Maeda H., Fukada T., Itoh M., Okano H.,
Hibi M., Hirano T.;
"Dissection of signaling cascades through gp130 in vivo: reciprocal
roles for STAT3- and SHP2-mediated signals in immune responses.";
Immunity 12:95-105(2000).
[9]
INTERACTION WITH INPP5D.
PubMed=17105399; DOI=10.1089/scd.2006.15.641;
Desponts C., Ninos J.M., Kerr W.G.;
"s-SHIP associates with receptor complexes essential for pluripotent
stem cell growth and survival.";
Stem Cells Dev. 15:641-646(2006).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[11]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225.
PubMed=19349973; DOI=10.1038/nbt.1532;
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
Schiess R., Aebersold R., Watts J.D.;
"Mass-spectrometric identification and relative quantification of N-
linked cell surface glycoproteins.";
Nat. Biotechnol. 27:378-386(2009).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[13]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=24339143; DOI=10.1002/jbmr.2159;
Johnson R.W., Brennan H.J., Vrahnas C., Poulton I.J., McGregor N.E.,
Standal T., Walker E.C., Koh T.T., Nguyen H., Walsh N.C.,
Forwood M.R., Martin T.J., Sims N.A.;
"The primary function of gp130 signaling in osteoblasts is to maintain
bone formation and strength, rather than promote osteoclast
formation.";
J. Bone Miner. Res. 29:1492-1505(2014).
[14]
FUNCTION.
PubMed=25228504; DOI=10.1530/joe-14-0424;
Standal T., Johnson R.W., McGregor N.E., Poulton I.J., Ho P.W.,
Martin T.J., Sims N.A.;
"gp130 in late osteoblasts and osteocytes is required for PTH-induced
osteoblast differentiation.";
J. Endocrinol. 223:181-190(2014).
[15]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=25057188; DOI=10.1523/jneurosci.5161-13.2014;
Malsch P., Andratsch M., Vogl C., Link A.S., Alzheimer C.,
Brierley S.M., Hughes P.A., Kress M.;
"Deletion of interleukin-6 signal transducer gp130 in small sensory
neurons attenuates mechanonociception and down-regulates TRPA1
expression.";
J. Neurosci. 34:9845-9856(2014).
[16]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=26255596; DOI=10.1016/j.bone.2015.08.005;
Johnson R.W., McGregor N.E., Brennan H.J., Crimeen-Irwin B.,
Poulton I.J., Martin T.J., Sims N.A.;
"Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in
osteoclasts promotes bone formation in periosteal and trabecular
bone.";
Bone 81:343-351(2015).
-!- FUNCTION: Signal-transducing molecule. The receptor systems for
IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for
initiating signal transmission. Binding of IL6 to IL6R induces
IL6ST homodimerization and formation of a high-affinity receptor
complex, which activates Janus kinases (PubMed:1602143). That
causes phosphorylation of IL6ST tyrosine residues which in turn
activates STAT3 (PubMed:10661409). Mediates signals which regulate
immune response, hematopoiesis, pain control and bone metabolism
(PubMed:10661409, PubMed:26255596, PubMed:25057188,
PubMed:8552649). Has a role in embryonic development
(PubMed:10661409). Does not bind IL6 (By similarity). Essential
for survival of motor and sensory neurons and for differentiation
of astrocytes (PubMed:10377352). Required for expression of TRPA1
in nociceptive neurons (PubMed:25057188). Required for the
maintenance of PTH1R expression in the osteoblast lineage and for
the stimulation of PTH-induced osteoblast differentiation
(PubMed:25228504). Required for normal trabecular bone mass and
cortical bone composition (PubMed:24339143, PubMed:9348227,
PubMed:26255596). {ECO:0000250|UniProtKB:P40189,
ECO:0000269|PubMed:10377352, ECO:0000269|PubMed:10661409,
ECO:0000269|PubMed:1602143, ECO:0000269|PubMed:24339143,
ECO:0000269|PubMed:25057188, ECO:0000269|PubMed:25228504,
ECO:0000269|PubMed:26255596, ECO:0000269|PubMed:8552649,
ECO:0000269|PubMed:9348227}.
-!- SUBUNIT: Component of a hexamer of two molecules each of IL6, IL6R
and IL6ST. Forms heterodimers composed of LIFR and IL6ST (type I
OSM receptor) which are activated by LIF and OSM. Also forms
heterodimers composed of OSMR and IL6ST (type II receptor) which
are activated by OSM but not by LIF. Interacts with HCK (By
similarity). Interacts with INPP5D/SHIP1 (PubMed:17105399).
{ECO:0000250|UniProtKB:P40189, ECO:0000269|PubMed:17105399,
ECO:0000269|PubMed:9920829}.
-!- INTERACTION:
P97378:Il12rb2; NbExp=2; IntAct=EBI-3862992, EBI-6253448;
O35718:Socs3; NbExp=2; IntAct=EBI-3862992, EBI-2659360;
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P40189}; Single-pass type I membrane
protein {ECO:0000255}.
-!- TISSUE SPECIFICITY: Found in tissues such as brain, heart, thymus,
spleen, kidney, lung and liver. Found in all the cell lines tested
except BaF-B03. Expression not restricted to IL6-responsive cells.
{ECO:0000269|PubMed:1602143}.
-!- DEVELOPMENTAL STAGE: In embryonic stem cells it is found from day
6 of gestation. It reaches a peak on day 8 and gradually declines
during the rest of embryogenesis. {ECO:0000269|PubMed:1602143}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- PTM: Phosphorylation of Ser-780 down-regulates cell surface
expression. {ECO:0000250|UniProtKB:P40189}.
-!- PTM: Heavily N-glycosylated. Glycosylation is required for protein
stability and localization in plasma membrane but not for ligand
binding. {ECO:0000250|UniProtKB:P40189}.
-!- DISRUPTION PHENOTYPE: Progressively lethal between 12.5 dpc and
birth (PubMed:8552649). Embryos show hypoplastic ventricular
myocardium without septal and trabecular defect, reduced numbers
of pluripotential and committed hematopoietic progenitors in liver
and reduced differentiated lineages in thymus (PubMed:8552649).
Impaired differentiation of astrocytes and decreased number of
dorsal root ganglion and motor neurons at 18.5 dpc
(PubMed:10377352). Decreased volume of mineralized trabecular
bones, while number of osteoclasts is increased (PubMed:9348227,
PubMed:26255596). Conditional knockout from the entire osteoblast
lineage or specifically in osteocytes causes no significant
skeletal or morphological defects but mice show 30% lower
trabecular bone formation rate and larger cortical diameter
compared to wild type (PubMed:24339143, PubMed:26255596).
Conditional knockout in primary nociceptive afferents causes
reduced sensitivity to mechanical stimulation due to reduced
sensitivity of nociceptive neurons and reduces TRPA1 mRNA
expression in dorsal root ganglion neurons (PubMed:25057188).
{ECO:0000269|PubMed:10377352, ECO:0000269|PubMed:24339143,
ECO:0000269|PubMed:25057188, ECO:0000269|PubMed:26255596,
ECO:0000269|PubMed:8552649, ECO:0000269|PubMed:9348227}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
subfamily. {ECO:0000305}.
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EMBL; X62646; CAA44515.1; -; mRNA.
EMBL; M83336; AAA37723.1; -; mRNA.
EMBL; AC159196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466568; EDL18412.1; -; Genomic_DNA.
CCDS; CCDS26773.1; -.
PIR; I49699; I49699.
RefSeq; NP_034690.3; NM_010560.3.
PDB; 2BBU; NMR; -; B=750-764.
PDB; 2HMH; X-ray; 2.00 A; B=753-763.
PDB; 4GL9; X-ray; 3.90 A; I/J/K/L=750-764.
PDB; 6C5X; X-ray; 3.10 A; G=754-763.
PDBsum; 2BBU; -.
PDBsum; 2HMH; -.
PDBsum; 4GL9; -.
PDBsum; 6C5X; -.
SMR; Q00560; -.
BioGrid; 200643; 12.
CORUM; Q00560; -.
DIP; DIP-5782N; -.
IntAct; Q00560; 8.
MINT; Q00560; -.
STRING; 10090.ENSMUSP00000138836; -.
GlyConnect; 2412; -.
iPTMnet; Q00560; -.
PhosphoSitePlus; Q00560; -.
SwissPalm; Q00560; -.
jPOST; Q00560; -.
MaxQB; Q00560; -.
PaxDb; Q00560; -.
PRIDE; Q00560; -.
Ensembl; ENSMUST00000070731; ENSMUSP00000064205; ENSMUSG00000021756.
Ensembl; ENSMUST00000183663; ENSMUSP00000138836; ENSMUSG00000021756.
Ensembl; ENSMUST00000184311; ENSMUSP00000139227; ENSMUSG00000021756.
GeneID; 16195; -.
KEGG; mmu:16195; -.
UCSC; uc007rwg.2; mouse.
CTD; 3572; -.
MGI; MGI:96560; Il6st.
eggNOG; ENOG410IF1N; Eukaryota.
eggNOG; ENOG410YNQ4; LUCA.
GeneTree; ENSGT00940000159608; -.
HOGENOM; HOG000015771; -.
InParanoid; Q00560; -.
KO; K05060; -.
OMA; NVLWVEW; -.
OrthoDB; 144839at2759; -.
TreeFam; TF338122; -.
Reactome; R-MMU-1059683; Interleukin-6 signaling.
Reactome; R-MMU-110056; MAPK3 (ERK1) activation.
Reactome; R-MMU-112411; MAPK1 (ERK2) activation.
Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
Reactome; R-MMU-8984722; Interleukin-35 Signalling.
Reactome; R-MMU-9020956; Interleukin-27 signaling.
ChiTaRS; Il6st; mouse.
EvolutionaryTrace; Q00560; -.
PRO; PR:Q00560; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021756; Expressed in 284 organ(s), highest expression level in fibroblast.
ExpressionAtlas; Q00560; baseline and differential.
Genevisible; Q00560; MM.
GO; GO:0044297; C:cell body; IDA:MGI.
GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; ISO:MGI.
GO; GO:0030425; C:dendrite; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0005896; C:interleukin-6 receptor complex; ISO:MGI.
GO; GO:0043025; C:neuronal cell body; IDA:MGI.
GO; GO:0032809; C:neuronal cell body membrane; ISO:MGI.
GO; GO:0005900; C:oncostatin-M receptor complex; ISO:MGI.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0004897; F:ciliary neurotrophic factor receptor activity; ISO:MGI.
GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; ISO:MGI.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0019838; F:growth factor binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0019981; F:interleukin-6 binding; IEA:Ensembl.
GO; GO:0004915; F:interleukin-6 receptor activity; IEA:Ensembl.
GO; GO:0005138; F:interleukin-6 receptor binding; IEA:Ensembl.
GO; GO:0004923; F:leukemia inhibitory factor receptor activity; IEA:Ensembl.
GO; GO:0004924; F:oncostatin-M receptor activity; IEA:Ensembl.
GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; ISO:MGI.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.
GO; GO:0005977; P:glycogen metabolic process; IMP:MGI.
GO; GO:0038154; P:interleukin-11-mediated signaling pathway; IEA:GOC.
GO; GO:0070106; P:interleukin-27-mediated signaling pathway; ISO:MGI.
GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISO:MGI.
GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; ISO:MGI.
GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; ISO:MGI.
GO; GO:0070104; P:negative regulation of interleukin-6-mediated signaling pathway; ISO:MGI.
GO; GO:0038165; P:oncostatin-M-mediated signaling pathway; ISO:MGI.
GO; GO:0048711; P:positive regulation of astrocyte differentiation; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; IGI:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:MGI.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISO:MGI.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:MGI.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
GO; GO:0008593; P:regulation of Notch signaling pathway; IDA:MGI.
GO; GO:0034097; P:response to cytokine; ISO:MGI.
GO; GO:0007165; P:signal transduction; IDA:MGI.
GO; GO:0006642; P:triglyceride mobilization; ISO:MGI.
CDD; cd00063; FN3; 3.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR010457; IgC2-like_lig-bd.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF00041; fn3; 2.
Pfam; PF09240; IL6Ra-bind; 1.
Pfam; PF06328; Lep_receptor_Ig; 1.
SMART; SM00060; FN3; 5.
SUPFAM; SSF49265; SSF49265; 4.
PROSITE; PS50853; FN3; 5.
PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein;
Receptor; Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 917 Interleukin-6 receptor subunit beta.
/FTId=PRO_0000010900.
TOPO_DOM 23 617 Extracellular. {ECO:0000255}.
TRANSMEM 618 639 Helical. {ECO:0000255}.
TOPO_DOM 640 917 Cytoplasmic. {ECO:0000255}.
DOMAIN 26 120 Ig-like C2-type.
DOMAIN 128 221 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 222 322 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 327 417 Fibronectin type-III 3.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 422 515 Fibronectin type-III 4.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 517 611 Fibronectin type-III 5.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 308 312 WSXWS motif.
MOTIF 649 657 Box 1 motif.
COMPBIAS 723 741 Ser-rich.
MOD_RES 659 659 Phosphoserine.
{ECO:0000250|UniProtKB:P40189}.
MOD_RES 665 665 Phosphoserine.
{ECO:0000250|UniProtKB:P40189}.
MOD_RES 780 780 Phosphoserine.
{ECO:0000250|UniProtKB:P40189}.
MOD_RES 787 787 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 827 827 Phosphoserine.
{ECO:0000250|UniProtKB:P40189}.
MOD_RES 837 837 Phosphoserine.
{ECO:0000250|UniProtKB:P40189}.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 61 61 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 83 83 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 131 131 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 157 157 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 225 225 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19349973}.
CARBOHYD 388 388 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 476 476 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 551 551 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 28 54 {ECO:0000250|UniProtKB:P40189}.
DISULFID 48 103 {ECO:0000250|UniProtKB:P40189}.
DISULFID 134 144 {ECO:0000250|UniProtKB:P40189}.
DISULFID 172 180 {ECO:0000250|UniProtKB:P40189}.
DISULFID 456 464 {ECO:0000250|UniProtKB:P40189}.
CONFLICT 756 756 Q -> E (in Ref. 1; CAA44515/AAA37723).
{ECO:0000305}.
SEQUENCE 917 AA; 102451 MW; EDA69AB865E5A6E8 CRC64;
MSAPRIWLAQ ALLFFLTTES IGQLLEPCGY IYPEFPVVQR GSNFTAICVL KEACLQHYYV
NASYIVWKTN HAAVPREQVT VINRTTSSVT FTDVVLPSVQ LTCNILSFGQ IEQNVYGVTM
LSGFPPDKPT NLTCIVNEGK NMLCQWDPGR ETYLETNYTL KSEWATEKFP DCQSKHGTSC
MVSYMPTYYV NIEVWVEAEN ALGKVSSESI NFDPVDKVKP TPPYNLSVTN SEELSSILKL
SWVSSGLGGL LDLKSDIQYR TKDASTWIQV PLEDTMSPRT SFTVQDLKPF TEYVFRIRSI
KDSGKGYWSD WSEEASGTTY EDRPSRPPSF WYKTNPSHGQ EYRSVRLIWK ALPLSEANGK
ILDYEVILTQ SKSVSQTYTV TGTELTVNLT NDRYVASLAA RNKVGKSAAA VLTIPSPHVT
AAYSVVNLKA FPKDNLLWVE WTPPPKPVSK YILEWCVLSE NAPCVEDWQQ EDATVNRTHL
RGRLLESKCY QITVTPVFAT GPGGSESLKA YLKQAAPARG PTVRTKKVGK NEAVLAWDQI
PVDDQNGFIR NYSISYRTSV GKEMVVHVDS SHTEYTLSSL SSDTLYMVRM AAYTDEGGKD
GPEFTFTTPK FAQGEIEAIV VPVCLAFLLT TLLGVLFCFN KRDLIKKHIW PNVPDPSKSH
IAQWSPHTPP RHNFNSKDQM YSDGNFTDVS VVEIEANNKK PCPDDLKSVD LFKKEKVSTE
GHSSGIGGSS CMSSSRPSIS SNEENESAQS TASTVQYSTV VHSGYRHQVP SVQVFSRSES
TQPLLDSEER PEDLQLVDSV DGGDEILPRQ PYFKQNCSQP EACPEISHFE RSNQVLSGNE
EDFVRLKQQQ VSDHISQPYG SEQRRLFQEG STADALGTGA DGQMERFESV GMETTIDEEI
PKSYLPQTVR QGGYMPQ


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U0046r CLIA gp130,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,Il6st,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Oncostatin-M receptor sub 96T
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E0046h ELISA CDw130,gp130,Homo sapiens,Human,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,IL6ST,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 13 96T
U0046h CLIA CDw130,gp130,Homo sapiens,Human,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,IL6ST,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130 96T
U0046m CLIA gp130,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,Il6st,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Mouse,Mus musculus,Oncost 96T
E0046m ELISA gp130,IL-6 receptor subunit beta,IL-6R subunit beta,IL-6RB,IL-6R-beta,Il6st,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Mouse,Mus musculus,Oncos 96T
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U1761h CLIA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
E1761h ELISA kit Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
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Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1566: Citrate cycle (TCA cycle)
WP566: canonical wnt - zebrafish
WP2292: Chemokine signaling pathway
WP258: TGF-beta Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP809: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP244: Alpha 6 Beta 4 signaling pathway
WP215: noncanonical wnt pathway
WP210: Cytoplasmic Ribosomal Proteins
WP537: Translation Factors
WP1434: Osteopontin Signaling
WP433: tRNA Synthetases
WP1225: estrogen signalling
WP1835: Interferon alpha/beta signaling
WP1571: EBV LMP1 signaling
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1224: EBV LMP1 signaling
WP219: Cytoplasmic tRNA Synthetases

Related Genes :
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL6ST] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[IL6R] Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[OSMR OSMRB] Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
[Osmr Osmrb] Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
[Il12rb2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[IL12RB1 IL12R IL12RB] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)
[Il12rb1 Il12rb] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12 receptor beta component) (CD antigen CD212)
[IL2RB IL15RB] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
[IL12RB2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1)
[Il3ra Sut-1] Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[Il7r] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[Il2rg] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il1rap] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-33 receptot beta chain)
[IL10RA IL10R] Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
[IL15RA] Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[IL7R] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)

Bibliography :