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Inward rectifier potassium channel 2 (Inward rectifier K( ) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)

 KCNJ2_RABIT             Reviewed;         427 AA.
P49656;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
16-JAN-2019, entry version 130.
RecName: Full=Inward rectifier potassium channel 2;
AltName: Full=Inward rectifier K(+) channel Kir2.1;
Short=IRK-1;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 2;
Name=KCNJ2; Synonyms=IRK1;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Heart;
PubMed=8307148; DOI=10.1016/0014-5793(94)80126-6;
Ishii K., Yamagishi T., Taira N.;
"Cloning and functional expression of a cardiac inward rectifier K+
channel.";
FEBS Lett. 338:107-111(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Lens epithelium;
PubMed=9533862; DOI=10.1006/exer.1997.0432;
Rae J.L., Shepard A.R.;
"Inwardly rectifying potassium channels in lens epithelium are from
the IRK1 (Kir 2.1) family.";
Exp. Eye Res. 66:347-359(1998).
-!- FUNCTION: Probably participates in establishing action potential
waveform and excitability of neuronal and muscle tissues. Inward
rectifier potassium channels are characterized by a greater
tendency to allow potassium to flow into the cell rather than out
of it. Their voltage dependence is regulated by the concentration
of extracellular potassium; as external potassium is raised, the
voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage
of outward current by internal magnesium. Can be blocked by
extracellular barium and cesium.
-!- SUBUNIT: Homomultimeric and heteromultimeric association with
KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with
LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its
localization and trafficking (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P63252}.
-!- TISSUE SPECIFICITY: Highly expressed in the ventricle and skeletal
muscle, moderately in cerebrum and cerebellum. Only low levels are
detected in kidney or lung.
-!- PTM: S-nitrosylation increases the open probability and inward
rectifying currents. {ECO:0000250}.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ2 subfamily. {ECO:0000305}.
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EMBL; D21057; BAA04636.1; -; mRNA.
EMBL; AF021138; AAB88796.1; -; mRNA.
PIR; S41087; S41087.
RefSeq; NP_001075667.1; NM_001082198.1.
RefSeq; XP_017204295.1; XM_017348806.1.
RefSeq; XP_017204296.1; XM_017348807.1.
UniGene; Ocu.2469; -.
ProteinModelPortal; P49656; -.
SMR; P49656; -.
STRING; 9986.ENSOCUP00000008971; -.
PRIDE; P49656; -.
Ensembl; ENSOCUT00000010415; ENSOCUP00000008971; ENSOCUG00000010416.
GeneID; 100008987; -.
KEGG; ocu:100008987; -.
CTD; 3759; -.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
GeneTree; ENSGT00940000154011; -.
HOGENOM; HOG000237325; -.
HOVERGEN; HBG006178; -.
InParanoid; P49656; -.
KO; K04996; -.
OMA; VFSHNAT; -.
OrthoDB; 956263at2759; -.
TreeFam; TF313676; -.
Proteomes; UP000001811; Chromosome 19.
Bgee; ENSOCUG00000010416; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
GO; GO:0031224; C:intrinsic component of membrane; ISS:UniProtKB.
GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0005242; F:inward rectifier potassium channel activity; ISS:UniProtKB.
GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
GO; GO:0086008; F:voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; IEA:Ensembl.
GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
GO; GO:0015693; P:magnesium ion transport; IEA:Ensembl.
GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
GO; GO:0006813; P:potassium ion transport; ISS:UniProtKB.
GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
GO; GO:0060306; P:regulation of membrane repolarization; IEA:Ensembl.
GO; GO:0014861; P:regulation of skeletal muscle contraction via regulation of action potential; IEA:Ensembl.
GO; GO:0055119; P:relaxation of cardiac muscle; IEA:Ensembl.
GO; GO:0090076; P:relaxation of skeletal muscle; IEA:Ensembl.
Gene3D; 2.60.40.1400; -; 1.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003271; K_chnl_inward-rec_Kir2.1.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
InterPro; IPR040445; Kir_TM.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF43; PTHR11767:SF43; 1.
Pfam; PF01007; IRK; 1.
Pfam; PF08466; IRK_N; 1.
PIRSF; PIRSF005465; GIRK_kir; 1.
PRINTS; PR01324; KIR21CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
2: Evidence at transcript level;
Complete proteome; Ion channel; Ion transport; Lipoprotein; Membrane;
Myristate; Potassium; Potassium transport; Reference proteome;
S-nitrosylation; Transmembrane; Transmembrane helix; Transport;
Voltage-gated channel.
INIT_MET 1 1 Removed.
CHAIN 2 427 Inward rectifier potassium channel 2.
/FTId=PRO_0000154927.
TOPO_DOM 2 81 Cytoplasmic. {ECO:0000250}.
TRANSMEM 82 106 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 107 128 Extracellular. {ECO:0000250}.
INTRAMEM 129 140 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 141 147 Pore-forming. {ECO:0000250}.
TOPO_DOM 148 156 Extracellular. {ECO:0000250}.
TRANSMEM 157 178 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 179 427 Cytoplasmic. {ECO:0000250}.
MOTIF 142 147 Selectivity filter. {ECO:0000250}.
MOTIF 425 427 PDZ-binding. {ECO:0000255}.
SITE 172 172 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
MOD_RES 76 76 S-nitrosocysteine.
{ECO:0000250|UniProtKB:P63252}.
LIPID 2 2 N-myristoyl glycine.
{ECO:0000250|UniProtKB:P63252}.
SEQUENCE 427 AA; 48350 MW; 1A57A8BB19B8A4A3 CRC64;
MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN
VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASRESK
ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPVAVFM VVFQSIVGCI IDAFIIGAVM
AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG
EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDMDNA DFEIVVILEG
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD
LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP
LRRESEI


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Kits Elisa; taq POLYMERASE

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Pathways :
WP2197: Endothelin
WP1485: Interactions between CFTR and other ion channels
WP1800: Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins

Related Genes :
[KCNJ2 IRK1] Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
[KCNJ2 IRK1] Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)
[KCNJ2 IRK1] Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)
[KCNJ4 IRK3] Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)
[KCNJ2 IRK1] Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)
[KCNJ2 IRK1] Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)
[KCNJ18] Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18)
[KCNJ12] ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (Potassium channel, inwardly rectifying subfamily J member 12)
[KCNJ5 GIRK4] G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
[KCNJ6 GIRK2 KATP2 KCNJ7] G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)
[KCNJ11] ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
[KCNJ13] Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13)
[KCNJ3 GIRK1] G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
[Kcnj6 Girk2 Kcnj7 W] G protein-activated inward rectifier potassium channel 2 (GIRK-2) (Inward rectifier K(+) channel Kir3.2) (Potassium channel, inwardly rectifying subfamily J member 6)
[Kcnj6 Girk2 Kcnj7] G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)
[Kcnj5 Girk4] G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
[Kcnj3 Girk1 Kga] G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (KGA) (KGB1) (Potassium channel, inwardly rectifying subfamily J member 3)
[KCNJ8] ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)
[KCNJ4 IRK3] Inward rectifier potassium channel 4 (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)
[Kcnj3 Girk1] G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
[KCNK1 HOHO1 KCNO1 TWIK1] Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)
[Kcnk1] Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (rTWIK) (Potassium channel K2P1)
[Kcnk1] Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1)
[KCNK6 TOSS TWIK2] Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
[KCNB1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[KCNJ3 GIRK1] G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
[KCNH2 ERG ERG1 HERG] Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
[Kcnh2 Erg Merg1] Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (MERG) (Voltage-gated potassium channel subunit Kv11.1)
[KCNK2 TREK TREK1] Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1)
[Kcnb1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

Bibliography :
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