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KQT-like 1 (Potassium voltage-gated channel subfamily KQT member 1) (Voltage-gated potassium channel subunit Kv7 1) (Fragment)

 A0A1C9TA97_HOMAM        Unreviewed;       503 AA.
A0A1C9TA97;
30-NOV-2016, integrated into UniProtKB/TrEMBL.
30-NOV-2016, sequence version 1.
29-SEP-2021, entry version 17.
RecName: Full=KQT-like 1 {ECO:0000256|ARBA:ARBA00013532};
AltName: Full=Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000256|ARBA:ARBA00019342};
AltName: Full=Voltage-gated potassium channel subunit Kv7.1 {ECO:0000256|ARBA:ARBA00018038};
Flags: Fragment;
Name=KCNQ2 {ECO:0000313|EMBL:AOR07220.1};
Homarus americanus (American lobster).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
Nephropoidea; Nephropidae; Homarus.
NCBI_TaxID=6706 {ECO:0000313|EMBL:AOR07220.1};
[1] {ECO:0000313|EMBL:AOR07220.1}
NUCLEOTIDE SEQUENCE.
Schulz D.J., Marder E., Northcutt A.J.;
"Ion channel discovery via a de novo neural transcriptome of the American
lobster (Homarus americanus) and Jonah crab (Cancer borealis).";
Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Basolateral cell membrane
{ECO:0000256|ARBA:ARBA00004187}. Cell membrane
{ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
{ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane
{ECO:0000256|ARBA:ARBA00004156}. Endoplasmic reticulum
{ECO:0000256|ARBA:ARBA00004240}. Lateral cell membrane
{ECO:0000256|ARBA:ARBA00004124}. Membrane
{ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
{ECO:0000256|ARBA:ARBA00004141}.
-!- SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15)
subfamily. Kv7.1/KCNQ1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009499}.
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EMBL; KU681440; AOR07220.1; -; mRNA.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
InterPro; IPR028325; VG_K_chnl.
PANTHER; PTHR11537; PTHR11537; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF03520; KCNQ_channel; 1.
PRINTS; PR01460; KCNQ1CHANNEL.
PRINTS; PR01459; KCNQCHANNEL.
2: Evidence at transcript level;
Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
Ion channel {ECO:0000256|ARBA:ARBA00022826, ECO:0000256|ARBA:ARBA00022882};
Ion transport {ECO:0000256|ARBA:ARBA00022826,
ECO:0000256|ARBA:ARBA00022882};
Membrane {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|SAM:Phobius};
Potassium {ECO:0000256|ARBA:ARBA00022826};
Potassium channel {ECO:0000256|ARBA:ARBA00022826};
Potassium transport {ECO:0000256|ARBA:ARBA00022826};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|SAM:Phobius};
Transport {ECO:0000256|ARBA:ARBA00022826, ECO:0000256|ARBA:ARBA00022882};
Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
SIGNAL 1..15
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 16..503
/note="KQT-like 1"
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5012633563"
TRANSMEM 29..49
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 70..87
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 134..155
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 200..226
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 3..227
/note="Ion_trans"
/evidence="ECO:0000259|Pfam:PF00520"
DOMAIN 359..483
/note="KCNQ_channel"
/evidence="ECO:0000259|Pfam:PF03520"
REGION 274..356
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 274..288
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 299..324
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
NON_TER 1
/evidence="ECO:0000313|EMBL:AOR07220.1"
SEQUENCE 503 AA; 56909 MW; A304F7288F5611BE CRC64;
VFMAVLICLI FSVLSTINEY EEFANETLFW MEICLVVFFG VEYAVRMWAA GCRSKYMGFL
GRIRFIRKPI CIIDLIVVVA SVVVLCVGSN GQVFATSAIR GIRFLQILRM LHVDRQGGTW
RLLGSVVFIH RQELITTLYI GFLGLIFSSY FVYLAEKKDD EDEDGEGDFS SYADALWWGV
ITVTTIGYGD TVPRTWMGKI VASCFSVFAI SFFALPAGIL GSGFALKVQQ KQRQKHFNRQ
IPAAAMLIQC LWRCYAADKH FNSTATWKIH LKDPNANNNS QSTPLSKMAK RASVLRRRKS
KSKMDVSSAP ENSSRRDSEG DMVFYVEEPR AAGTPNRTRR EGGPRGSALH SQASSVTEVA
SDEIDLDIDE PQGFTSLTEA HRNAIRAIRK IKYFVARRKF QQARKPYDVR DVIEQYSQGH
LNMMVRIKEL QRRLDQTLGK PGSYLSGIDK SGNVKPMTIG ARLYRVEQQL VLLDKKLDQM
LFVCNALAQK TQLPEIRNSD DHV


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Pathways :
WP2197: Endothelin
WP2272: Pathogenic Escherichia coli infection
WP1566: Citrate cycle (TCA cycle)
WP1634: Butanoate metabolism
WP1663: Homologous recombination
WP1680: Oxidative phosphorylation
WP1711: Trinitrotoluene degradation
WP1626: Benzoate degradation via CoA ligation
WP1655: Geraniol degradation
WP1672: Mismatch repair
WP1694: Pyrimidine metabolism
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP2292: Chemokine signaling pathway
WP1614: 1- and 2-Methylnaphthalene degradation
WP1644: DNA replication
WP1671: Methane metabolism
WP1693: Purine metabolism
WP1718: Vitamin B6 metabolism

Related Genes :
[KCNQ1 KCNA8 KCNA9 KVLQT1] Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
[KCNQ3] Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)
[KCNQ2] Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
[KCNQ5] Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5)
[KCNQ4] Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4)
[Kcnq2] Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
[Kcnq3] Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)
[Kcnq3] Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)
[KCNQ3] Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)
[KCNE1] Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)
[KCNE2] Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1)
[KCNA4 KCNA4L] Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)
[KCNA1] Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1)
[KCNA2] Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)
[KCNC1] Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
[Kcnc1] Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
[Kcnc1] Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
[KCNA5] Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
[KCNB1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[Kcnb1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[Kcna3] Potassium voltage-gated channel subfamily A member 3 (RCK3) (RGK5) (Voltage-gated potassium channel subunit Kv1.3) (Voltage-gated potassium channel subunit Kv3)
[KCNH1 EAG EAG1] Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Voltage-gated potassium channel subunit Kv10.1)
[KCNB1] Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)
[Kcnh1 Eag] Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (EAG1) (r-eag) (Voltage-gated potassium channel subunit Kv10.1)
[KCNH2 ERG ERG1 HERG] Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
[Kcne1] Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)
[Kcnh1 Eag] Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (EAG1) (m-eag) (Voltage-gated potassium channel subunit Kv10.1)
[KCNH1 EAG] Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (bEAG) (Voltage-gated potassium channel subunit Kv10.1)
[Kcnh2 Erg Merg1] Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (MERG) (Voltage-gated potassium channel subunit Kv11.1)
[KCNA3 HGK5] Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3)

Bibliography :
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