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Kappa-conotoxin RIIIJ (Kappa-M-RIIIJ)

 CM3J_CONRA              Reviewed;          25 AA.
P0CG45;
13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
13-JUL-2010, sequence version 1.
12-SEP-2018, entry version 20.
RecName: Full=Kappa-conotoxin RIIIJ;
Short=Kappa-M-RIIIJ;
Conus radiatus (Rayed cone).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
NCBI_TaxID=61198;
[1]
PROTEIN SEQUENCE, FUNCTION, TOXIN TARGET, ASSAY ON RAT
ISCHEMIA/REPERFUSION MODEL, MUTAGENESIS OF 6-THR--HIS-11;
6-THR--PRO-8; 9-LYS--HIS-11 AND 10-LYS-HIS-11, SITE, HYDROXYLATION AT
PRO-2; PRO-3; PRO-7; PRO-8; PRO-13; PRO-15 AND PRO-21, AND MASS
SPECTROMETRY.
TISSUE=Venom;
PubMed=20220134; DOI=10.1074/jbc.M109.068486;
Chen P., Dendorfer A., Finol-Urdaneta R.K., Terlau H., Olivera B.M.;
"Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel
blocker: evaluation of cardioprotective effects of kappaM-
conotoxins.";
J. Biol. Chem. 285:14882-14889(2010).
-!- FUNCTION: Kappa-conotoxins inhibits voltage-gated potassium
channels. This toxin dose-dependently and reversibly inhibits the
Kv1.2/KCNA2 channel in mammalia. Does not exert protective effect
on cardiac tissue when administered after an ischemic event.
{ECO:0000269|PubMed:20220134}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom duct.
-!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in
the M-4 branch, since 4 residues stand between the fourth and the
fifth cysteine residues.
-!- MASS SPECTROMETRY: Mass=2805.84; Method=Electrospray; Range=1-25;
Note=monoisotopic.; Evidence={ECO:0000269|PubMed:20220134};
-!- MISCELLANEOUS: Has no or very low potency for Kv1.1/KCNA1,
Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6, Kv7.2/KCNQ2-
Kv7.3/KCNQ3, and KCa1.1/KCNMA1. {ECO:0000305|PubMed:20220134}.
-!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0019870; F:potassium channel inhibitor activity; IDA:CACAO.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Hydroxylation;
Ion channel impairing toxin; Neurotoxin;
Potassium channel impairing toxin; Secreted; Toxin;
Voltage-gated potassium channel impairing toxin.
PEPTIDE 1 25 Kappa-conotoxin RIIIJ.
/FTId=PRO_0000395613.
SITE 9 9 Significant for high potency for
Kv1.2/KCNA2.
MOD_RES 2 2 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
MOD_RES 3 3 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
MOD_RES 7 7 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
MOD_RES 8 8 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
MOD_RES 13 13 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
MOD_RES 15 15 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
MOD_RES 21 21 4-hydroxyproline.
{ECO:0000269|PubMed:20220134}.
DISULFID 4 17 {ECO:0000250}.
DISULFID 5 22 {ECO:0000250}.
DISULFID 12 23 {ECO:0000250}.
MUTAGEN 6 11 TPPKKH->SLNLRL: 11-fold decrease in
potency for Kv1.2/KCNA2.
{ECO:0000269|PubMed:20220134}.
MUTAGEN 6 8 TPP->SLN: 2-fold decrease in potency for
Kv1.2/KCNA2.
{ECO:0000269|PubMed:20220134}.
MUTAGEN 9 11 KKH->LRL: 10-fold decrease in potency for
Kv1.2/KCNA2.
{ECO:0000269|PubMed:20220134}.
MUTAGEN 10 11 KH->RL: 1.5-fold decrease in potency for
Kv1.2/KCNA2.
{ECO:0000269|PubMed:20220134}.
SEQUENCE 25 AA; 2701 MW; DDE9E2F99524B5F3 CRC64;
LPPCCTPPKK HCPAPACKYK PCCKS


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Pathways :
WP1102: EBV LMP1 signaling
WP1209: EBV LMP1 signaling
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WP1243: EBV LMP1 signaling
WP1278: EBV LMP1 signaling
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Related Genes :
[] Kappa-conotoxin RIIIJ (Kappa-M-RIIIJ)
[] Kappa-conotoxin PVIIA (CGX-1051) (Fin-popping peptide)
[IGKV3-20] Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)
[IGKV1D-33] Immunoglobulin kappa variable 1D-33 (Ig kappa chain V-I region AG) (Ig kappa chain V-I region Bi) (Ig kappa chain V-I region Lay) (Ig kappa chain V-I region Ni) (Ig kappa chain V-I region Rei) (Ig kappa chain V-I region Roy) (Ig kappa chain V-I region Scw) (Ig kappa chain V-I region WAT)
[IGKC] Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[IKBKB IKKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[IKBKG FIP3 NEMO] NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[IGKV1-39] Immunoglobulin kappa variable 1-39 (Ig kappa chain V-I region DEE) (Ig kappa chain V-I region Hau) (Ig kappa chain V-I region Mev) (Ig kappa chain V-I region OU) (Ig kappa chain V-I region Walker)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[Ikbkb Ikkb] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Chuk Ikka] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[CHUK IKKA] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
[IGKV4-1] Immunoglobulin kappa variable 4-1 (Ig kappa chain V-IV region B17) (Ig kappa chain V-IV region JI) (Ig kappa chain V-IV region Len) (Ig kappa chain V-IV region STH)
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[IGKV1-5] Immunoglobulin kappa variable 1-5 (Ig kappa chain V-I region CAR) (Ig kappa chain V-I region EU) (Ig kappa chain V-I region HK102) (Ig kappa chain V-I region Kue)
[Ikbkg Nemo] NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[IGKV2D-28] Immunoglobulin kappa variable 2D-28 (Ig kappa chain V-II region FR) (Ig kappa chain V-II region GM607) (Ig kappa chain V-II region MIL) (Ig kappa chain V-II region TEW)
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment)
[IKBKB] Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)
[Ikbke Ikke Ikki] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[] Kappa-hexatoxin-Hv1c (Kappa-HXTX-Hv1c) (Janus-atracotoxin-Hv1c) (Janus-AcTx-Hv1c) (Kappa-atracotoxin-Hv1c) (Kappa-AcTx-Hv1c)
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[IKBKE IKKE IKKI KIAA0151] Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
[Rel CG11992] Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
[NFKBIB IKBB TRIP9] NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)

Bibliography :