Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)

 K2C72_BOVIN             Reviewed;         524 AA.
 Q148H8;
 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
 22-AUG-2006, sequence version 1.
 10-FEB-2021, entry version 85.
 RecName: Full=Keratin, type II cytoskeletal 72;
 AltName: Full=Cytokeratin-72;
          Short=CK-72;
 AltName: Full=Keratin-72;
          Short=K72;
 AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
 AltName: Full=Type-II keratin Kb35;
 Name=KRT72;
 Bos taurus (Bovine).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
 Bovinae; Bos.
 NCBI_TaxID=9913;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 STRAIN=Hereford; TISSUE=Fetal skin;
 NIH - Mammalian Gene Collection (MGC) project;
 Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
 -!- FUNCTION: Has a role in hair formation. Specific component of keratin
     intermediate filaments in the inner root sheath (IRS) of the hair
     follicle (By similarity). {ECO:0000250}.
 -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
 -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
     keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
     respectively).
 -!- SIMILARITY: Belongs to the intermediate filament family.
     {ECO:0000255|PROSITE-ProRule:PRU01188}.
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 EMBL; BC118311; AAI18312.1; -; mRNA.
 RefSeq; NP_001069412.1; NM_001075944.1.
 SMR; Q148H8; -.
 STRING; 9913.ENSBTAP00000010391; -.
 PaxDb; Q148H8; -.
 PRIDE; Q148H8; -.
 Ensembl; ENSBTAT00000010391; ENSBTAP00000010391; ENSBTAG00000007904.
 GeneID; 531057; -.
 KEGG; bta:531057; -.
 CTD; 140807; -.
 VGNC; VGNC:30736; KRT72.
 eggNOG; ENOG502T3SC; Eukaryota.
 GeneTree; ENSGT00940000162105; -.
 HOGENOM; CLU_012560_6_1_1; -.
 InParanoid; Q148H8; -.
 OMA; CKKRYEV; -.
 OrthoDB; 671547at2759; -.
 TreeFam; TF317854; -.
 Reactome; R-BTA-6805567; Keratinization.
 Proteomes; UP000009136; Chromosome 5.
 Bgee; ENSBTAG00000007904; Expressed in endometrium and 1 other tissue.
 GO; GO:0045095; C:keratin filament; IEA:InterPro.
 Gene3D; 1.20.5.1160; -; 1.
 InterPro; IPR018039; IF_conserved.
 InterPro; IPR039008; IF_rod_dom.
 InterPro; IPR042180; IF_rod_dom_coil1B.
 InterPro; IPR032444; Keratin_2_head.
 InterPro; IPR003054; Keratin_II.
 Pfam; PF00038; Filament; 1.
 Pfam; PF16208; Keratin_2_head; 1.
 PRINTS; PR01276; TYPE2KERATIN.
 SMART; SM01391; Filament; 1.
 PROSITE; PS00226; IF_ROD_1; 1.
 PROSITE; PS51842; IF_ROD_2; 1.
 2: Evidence at transcript level;
 Coiled coil; Intermediate filament; Keratin; Reference proteome.
 CHAIN           1..524
                 /note="Keratin, type II cytoskeletal 72"
                 /id="PRO_0000314876"
 DOMAIN          137..450
                 /note="IF rod"
                 /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
 REGION          1..136
                 /note="Head"
 REGION          137..172
                 /note="Coil 1A"
 REGION          173..191
                 /note="Linker 1"
 REGION          192..283
                 /note="Coil 1B"
 REGION          284..307
                 /note="Linker 12"
 REGION          308..446
                 /note="Coil 2"
 REGION          447..524
                 /note="Tail"
 COMPBIAS        10..108
                 /note="Gly-rich"
 SITE            388
                 /note="Stutter"
 SEQUENCE   524 AA;  56930 MW;  C65468E3518D5DAE CRC64;
 MSRQLNLYPG GERLAFSGCS AIISSRVSSS TASFRASGIK GTATFGSRSL FNCGGGRRPA
 LSSAAGRGGS ALGSCAATGG GRRGGFVGTV FGSAGLGPAC PSVCPPGGIP QVTVNKSLLS
 PLNVELDPEI QKVRAQEREQ IKALNNKFAS FIDKVRFLEQ QNQVLGTKWE LLQQLDLNNC
 KNNLEPILEG YTSNLRKQLE MLSGDRVRLD SELRSMRDVV EEYKKRYEVE INRRTAAENE
 FVMLKKDVDA AYMNKVELQA KVDSLTDEIK FLKCLYEGEI AQLQSHISDT SVILSMDNNR
 DLDLDSIIAQ VRAQYEEIAL KSKAEAEALY QTKIQELQAT AGQHGDDLKL TKAEISDLNR
 MIQRIRSEIG NVKKQCSNLE MAIADAEQRG DCALKDARAK LDELDAALLQ AKEELARMMR
 EYQELMSTKL ALDMEIATYR KLLEGEECRM SGEYPNSVSI SVISNTSTGA GGTGFSMGFG
 ALSSYSYKSS AVDVKTKGSC GGSELKDAPA KTSGSSCATK KASR

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