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K2C72_RAT Reviewed; 520 AA.
Q6IG04;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
15-JAN-2008, sequence version 2.
02-DEC-2020, entry version 106.
RecName: Full=Keratin, type II cytoskeletal 72;
AltName: Full=Cytokeratin-72;
Short=CK-72;
AltName: Full=Keratin-72;
Short=K72;
AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
AltName: Full=Type-II keratin Kb35;
Name=Krt72; Synonyms=Kb35;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
Mockrin S., Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into mammalian
evolution.";
Nature 428:493-521(2004).
[2]
IDENTIFICATION.
PubMed=15085952; DOI=10.1078/0171-9335-00354;
Hesse M., Zimek A., Weber K., Magin T.M.;
"Comprehensive analysis of keratin gene clusters in humans and rodents.";
Eur. J. Cell Biol. 83:19-26(2004).
-!- FUNCTION: Has a role in hair formation. Specific component of keratin
intermediate filaments in the inner root sheath (IRS) of the hair
follicle (By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
-!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
respectively).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
-!- SEQUENCE CAUTION:
Sequence=DAA02226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AABR03055962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BK003981; DAA02226.1; ALT_SEQ; mRNA.
RefSeq; NP_001008809.1; NM_001008809.1.
RefSeq; XP_017450521.1; XM_017595032.1.
SMR; Q6IG04; -.
STRING; 10116.ENSRNOP00000035371; -.
iPTMnet; Q6IG04; -.
PhosphoSitePlus; Q6IG04; -.
jPOST; Q6IG04; -.
PaxDb; Q6IG04; -.
PRIDE; Q6IG04; -.
Ensembl; ENSRNOT00000038105; ENSRNOP00000035371; ENSRNOG00000030876.
GeneID; 406227; -.
KEGG; rno:406227; -.
UCSC; RGD:1303216; rat.
CTD; 140807; -.
RGD; 1303216; Krt72.
eggNOG; ENOG502T3SC; Eukaryota.
GeneTree; ENSGT00940000162105; -.
HOGENOM; CLU_012560_6_1_1; -.
InParanoid; Q6IG04; -.
OrthoDB; 671547at2759; -.
PhylomeDB; Q6IG04; -.
TreeFam; TF317854; -.
Reactome; R-RNO-6805567; Keratinization.
Reactome; R-RNO-6809371; Formation of the cornified envelope.
PRO; PR:Q6IG04; -.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000030876; Expressed in heart and 12 other tissues.
ExpressionAtlas; Q6IG04; baseline.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
Gene3D; 1.20.5.1160; -; 1.
InterPro; IPR018039; IF_conserved.
InterPro; IPR039008; IF_rod_dom.
InterPro; IPR042180; IF_rod_dom_coil1B.
InterPro; IPR032444; Keratin_2_head.
InterPro; IPR003054; Keratin_II.
Pfam; PF00038; Filament; 1.
Pfam; PF16208; Keratin_2_head; 1.
PRINTS; PR01276; TYPE2KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
3: Inferred from homology;
Coiled coil; Intermediate filament; Keratin; Reference proteome.
CHAIN 1..520
/note="Keratin, type II cytoskeletal 72"
/id="PRO_0000314879"
DOMAIN 134..447
/note="IF rod"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
REGION 1..133
/note="Head"
REGION 134..169
/note="Coil 1A"
REGION 170..188
/note="Linker 1"
REGION 189..280
/note="Coil 1B"
REGION 281..304
/note="Linker 12"
REGION 305..443
/note="Coil 2"
REGION 444..520
/note="Tail"
COMPBIAS 10..105
/note="Gly-rich"
SITE 385
/note="Stutter"
SEQUENCE 520 AA; 56851 MW; 3A7B068F826DC968 CRC64;
MSRQLTLYPG AERLGFSGCS AVISGRFSGS HASVRAGVKG AAFGSRSLFC VGGGRRLALS
SGGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV CPPGGIPQVV VNKSLLAPLN
VELDPEIQKV RAQEREQIKA LNNKFASFID KVRFLEQQNQ VLETKWELLQ QLDQNNSRRS
LEPVHESYIS NLQKQLEILS GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV
LKKDVDAAYM NKVELQAKVD SMTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKLTKS EITEINRLIQ
RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ LEGVLQQSKE ELARMLREHQ
ELMNVKLALD MEIATYRKLL ESEESRMAGE YPSSVSISVV SSTNAGPGGA GFSVGFGASS
NYNYRPLALE VKTKGSCGSE LKDPPAKTSA SSCVSKKASR