Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)

 K2C72_RAT               Reviewed;         520 AA.
 Q6IG04;
 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
 15-JAN-2008, sequence version 2.
 26-FEB-2020, entry version 104.
 RecName: Full=Keratin, type II cytoskeletal 72;
 AltName: Full=Cytokeratin-72;
          Short=CK-72;
 AltName: Full=Keratin-72;
          Short=K72;
 AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
 AltName: Full=Type-II keratin Kb35;
 Name=Krt72; Synonyms=Kb35;
 Rattus norvegicus (Rat).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
 Murinae; Rattus.
 NCBI_TaxID=10116;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Brown Norway;
 PubMed=15057822; DOI=10.1038/nature02426;
 Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
 Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
 Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
 Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
 Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
 Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
 Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
 Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
 Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
 Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
 Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
 Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
 Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
 Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
 Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
 Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
 Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
 Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
 Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
 Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
 Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
 Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
 Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
 Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
 Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
 Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
 Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
 Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
 Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
 Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
 Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
 Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
 Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
 Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
 Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
 Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
 Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
 Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
 Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
 Mockrin S., Collins F.S.;
 "Genome sequence of the Brown Norway rat yields insights into mammalian
 evolution.";
 Nature 428:493-521(2004).
 [2]
 IDENTIFICATION.
 PubMed=15085952; DOI=10.1078/0171-9335-00354;
 Hesse M., Zimek A., Weber K., Magin T.M.;
 "Comprehensive analysis of keratin gene clusters in humans and rodents.";
 Eur. J. Cell Biol. 83:19-26(2004).
 -!- FUNCTION: Has a role in hair formation. Specific component of keratin
     intermediate filaments in the inner root sheath (IRS) of the hair
     follicle (By similarity). {ECO:0000250}.
 -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
 -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
     keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
     respectively).
 -!- SIMILARITY: Belongs to the intermediate filament family.
     {ECO:0000255|PROSITE-ProRule:PRU01188}.
 -!- SEQUENCE CAUTION:
     Sequence=DAA02226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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 EMBL; AABR03055962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; BK003981; DAA02226.1; ALT_SEQ; mRNA.
 RefSeq; NP_001008809.1; NM_001008809.1.
 RefSeq; XP_017450521.1; XM_017595032.1.
 SMR; Q6IG04; -.
 STRING; 10116.ENSRNOP00000035371; -.
 iPTMnet; Q6IG04; -.
 PhosphoSitePlus; Q6IG04; -.
 jPOST; Q6IG04; -.
 PaxDb; Q6IG04; -.
 PRIDE; Q6IG04; -.
 Ensembl; ENSRNOT00000038105; ENSRNOP00000035371; ENSRNOG00000030876.
 GeneID; 406227; -.
 KEGG; rno:406227; -.
 UCSC; RGD:1303216; rat.
 CTD; 140807; -.
 RGD; 1303216; Krt72.
 eggNOG; ENOG410IQKP; Eukaryota.
 eggNOG; ENOG4111AD7; LUCA.
 GeneTree; ENSGT00940000162105; -.
 HOGENOM; CLU_012560_6_1_1; -.
 InParanoid; Q6IG04; -.
 KO; K07605; -.
 OrthoDB; 671547at2759; -.
 PhylomeDB; Q6IG04; -.
 TreeFam; TF317854; -.
 Reactome; R-RNO-6805567; Keratinization.
 Reactome; R-RNO-6809371; Formation of the cornified envelope.
 PRO; PR:Q6IG04; -.
 Proteomes; UP000002494; Chromosome 7.
 Bgee; ENSRNOG00000030876; Expressed in heart and 2 other tissues.
 ExpressionAtlas; Q6IG04; baseline.
 GO; GO:0045095; C:keratin filament; IEA:InterPro.
 Gene3D; 1.20.5.1160; -; 1.
 InterPro; IPR018039; IF_conserved.
 InterPro; IPR039008; IF_rod_dom.
 InterPro; IPR042180; IF_rod_dom_coil1B.
 InterPro; IPR032444; Keratin_2_head.
 InterPro; IPR003054; Keratin_II.
 Pfam; PF00038; Filament; 1.
 Pfam; PF16208; Keratin_2_head; 1.
 PRINTS; PR01276; TYPE2KERATIN.
 SMART; SM01391; Filament; 1.
 PROSITE; PS00226; IF_ROD_1; 1.
 PROSITE; PS51842; IF_ROD_2; 1.
 3: Inferred from homology;
 Coiled coil; Intermediate filament; Keratin; Reference proteome.
 CHAIN           1..520
                 /note="Keratin, type II cytoskeletal 72"
                 /id="PRO_0000314879"
 DOMAIN          134..447
                 /note="IF rod"
                 /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
 REGION          1..133
                 /note="Head"
 REGION          134..169
                 /note="Coil 1A"
 REGION          170..188
                 /note="Linker 1"
 REGION          189..280
                 /note="Coil 1B"
 REGION          281..304
                 /note="Linker 12"
 REGION          305..443
                 /note="Coil 2"
 REGION          444..520
                 /note="Tail"
 COMPBIAS        10..105
                 /note="Gly-rich"
 SITE            385
                 /note="Stutter"
 SEQUENCE   520 AA;  56851 MW;  3A7B068F826DC968 CRC64;
 MSRQLTLYPG AERLGFSGCS AVISGRFSGS HASVRAGVKG AAFGSRSLFC VGGGRRLALS
 SGGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV CPPGGIPQVV VNKSLLAPLN
 VELDPEIQKV RAQEREQIKA LNNKFASFID KVRFLEQQNQ VLETKWELLQ QLDQNNSRRS
 LEPVHESYIS NLQKQLEILS GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV
 LKKDVDAAYM NKVELQAKVD SMTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
 LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKLTKS EITEINRLIQ
 RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ LEGVLQQSKE ELARMLREHQ
 ELMNVKLALD MEIATYRKLL ESEESRMAGE YPSSVSISVV SSTNAGPGGA GFSVGFGASS
 NYNYRPLALE VKTKGSCGSE LKDPPAKTSA SSCVSKKASR

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