Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)

 K2C72_MOUSE             Reviewed;         520 AA.
 Q6IME9;
 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
 05-JUL-2004, sequence version 1.
 17-JUN-2020, entry version 114.
 RecName: Full=Keratin, type II cytoskeletal 72;
 AltName: Full=Cytokeratin-72;
          Short=CK-72;
 AltName: Full=Keratin-72;
          Short=K72;
 AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
 AltName: Full=Type-II keratin Kb35;
 Name=Krt72; Synonyms=Kb35, Krt72-ps;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
 Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=C57BL/6J;
 PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
 Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
 Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
 Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
 Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
 Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
 Eichler E.E., Ponting C.P.;
 "Lineage-specific biology revealed by a finished genome assembly of the
 mouse.";
 PLoS Biol. 7:E1000112-E1000112(2009).
 [2]
 IDENTIFICATION.
 PubMed=15085952; DOI=10.1078/0171-9335-00354;
 Hesse M., Zimek A., Weber K., Magin T.M.;
 "Comprehensive analysis of keratin gene clusters in humans and rodents.";
 Eur. J. Cell Biol. 83:19-26(2004).
 -!- FUNCTION: Has a role in hair formation. Specific component of keratin
     intermediate filaments in the inner root sheath (IRS) of the hair
     follicle (By similarity). {ECO:0000250}.
 -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
 -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
     keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
     respectively).
 -!- SIMILARITY: Belongs to the intermediate filament family.
     {ECO:0000255|PROSITE-ProRule:PRU01188}.
 ---------------------------------------------------------------------------
 Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 ---------------------------------------------------------------------------
 EMBL; AC104862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; BK001584; DAA02059.1; -; mRNA.
 CCDS; CCDS27863.1; -.
 RefSeq; NP_998893.1; NM_213728.1.
 SMR; Q6IME9; -.
 BioGRID; 222940; 1.
 STRING; 10090.ENSMUSP00000065922; -.
 iPTMnet; Q6IME9; -.
 PhosphoSitePlus; Q6IME9; -.
 jPOST; Q6IME9; -.
 PaxDb; Q6IME9; -.
 PeptideAtlas; Q6IME9; -.
 PRIDE; Q6IME9; -.
 Antibodypedia; 55991; 116 antibodies.
 Ensembl; ENSMUST00000071104; ENSMUSP00000065922; ENSMUSG00000056605.
 GeneID; 105866; -.
 KEGG; mmu:105866; -.
 UCSC; uc007xtz.1; mouse.
 CTD; 140807; -.
 MGI; MGI:2146034; Krt72.
 eggNOG; ENOG410IQKP; Eukaryota.
 eggNOG; ENOG4111AD7; LUCA.
 GeneTree; ENSGT00940000162105; -.
 HOGENOM; CLU_012560_6_1_1; -.
 InParanoid; Q6IME9; -.
 KO; K07605; -.
 OMA; CKKRYEV; -.
 OrthoDB; 671547at2759; -.
 PhylomeDB; Q6IME9; -.
 TreeFam; TF317854; -.
 Reactome; R-MMU-6805567; Keratinization.
 Reactome; R-MMU-6809371; Formation of the cornified envelope.
 BioGRID-ORCS; 105866; 1 hit in 12 CRISPR screens.
 PRO; PR:Q6IME9; -.
 Proteomes; UP000000589; Chromosome 15.
 RNAct; Q6IME9; protein.
 Bgee; ENSMUSG00000056605; Expressed in skin of back and 35 other tissues.
 Genevisible; Q6IME9; MM.
 GO; GO:0045095; C:keratin filament; IEA:InterPro.
 Gene3D; 1.20.5.1160; -; 1.
 InterPro; IPR018039; IF_conserved.
 InterPro; IPR039008; IF_rod_dom.
 InterPro; IPR042180; IF_rod_dom_coil1B.
 InterPro; IPR032444; Keratin_2_head.
 InterPro; IPR003054; Keratin_II.
 Pfam; PF00038; Filament; 1.
 Pfam; PF16208; Keratin_2_head; 1.
 PRINTS; PR01276; TYPE2KERATIN.
 SMART; SM01391; Filament; 1.
 PROSITE; PS00226; IF_ROD_1; 1.
 PROSITE; PS51842; IF_ROD_2; 1.
 3: Inferred from homology;
 Coiled coil; Intermediate filament; Keratin; Reference proteome.
 CHAIN           1..520
                 /note="Keratin, type II cytoskeletal 72"
                 /id="PRO_0000314878"
 DOMAIN          134..447
                 /note="IF rod"
                 /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
 REGION          1..133
                 /note="Head"
 REGION          134..169
                 /note="Coil 1A"
 REGION          170..188
                 /note="Linker 1"
 REGION          189..280
                 /note="Coil 1B"
 REGION          281..304
                 /note="Linker 12"
 REGION          305..443
                 /note="Coil 2"
 REGION          444..520
                 /note="Tail"
 COMPBIAS        10..105
                 /note="Gly-rich"
 SITE            385
                 /note="Stutter"
 SEQUENCE   520 AA;  56750 MW;  BC19F6823BC58B2C CRC64;
 MSRQLTLYPG AERLGFSGCS AVISGRLSGS HASVRAGVKG AAFGSRSLFC VGGGRRLALS
 SAGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV CPPGGIPQVV VNKSLLAPLN
 VELDPEIQKV RAQEREQIKA LNNKFASFID KVRFLEQQNQ VLETKWELLQ QLDLNNSKRS
 LEPVHESYIS NLQKQLEILS GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV
 LKKDVDAAYM NKVELQAKVD SLTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
 LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKHTKS EITEINRLIQ
 RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ LEGALQQAKE ELARMLREHQ
 ELMNVKLALD MEIATYRKLL ESEESRMAGE YPNSVSISVI SSTNAGPGGA GFSVGFGASS
 SYNYRPLALE VKTKGSCGSE LKDPPAKTSG SSGTTKKTSR

Related products :