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K2C72_MOUSE Reviewed; 520 AA.
Q6IME9;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
10-FEB-2021, entry version 117.
RecName: Full=Keratin, type II cytoskeletal 72;
AltName: Full=Cytokeratin-72;
Short=CK-72;
AltName: Full=Keratin-72;
Short=K72;
AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
AltName: Full=Type-II keratin Kb35;
Name=Krt72; Synonyms=Kb35, Krt72-ps;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
IDENTIFICATION.
PubMed=15085952; DOI=10.1078/0171-9335-00354;
Hesse M., Zimek A., Weber K., Magin T.M.;
"Comprehensive analysis of keratin gene clusters in humans and rodents.";
Eur. J. Cell Biol. 83:19-26(2004).
-!- FUNCTION: Has a role in hair formation. Specific component of keratin
intermediate filaments in the inner root sheath (IRS) of the hair
follicle (By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
-!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
respectively).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
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EMBL; AC104862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BK001584; DAA02059.1; -; mRNA.
CCDS; CCDS27863.1; -.
RefSeq; NP_998893.1; NM_213728.1.
SMR; Q6IME9; -.
BioGRID; 222940; 4.
STRING; 10090.ENSMUSP00000065922; -.
iPTMnet; Q6IME9; -.
PhosphoSitePlus; Q6IME9; -.
jPOST; Q6IME9; -.
PaxDb; Q6IME9; -.
PeptideAtlas; Q6IME9; -.
PRIDE; Q6IME9; -.
Antibodypedia; 55991; 116 antibodies.
Ensembl; ENSMUST00000071104; ENSMUSP00000065922; ENSMUSG00000056605.
GeneID; 105866; -.
KEGG; mmu:105866; -.
UCSC; uc007xtz.1; mouse.
CTD; 140807; -.
MGI; MGI:2146034; Krt72.
eggNOG; ENOG502T3SC; Eukaryota.
GeneTree; ENSGT00940000162105; -.
HOGENOM; CLU_012560_6_1_1; -.
InParanoid; Q6IME9; -.
OMA; CKKRYEV; -.
OrthoDB; 671547at2759; -.
PhylomeDB; Q6IME9; -.
TreeFam; TF317854; -.
Reactome; R-MMU-6805567; Keratinization.
Reactome; R-MMU-6809371; Formation of the cornified envelope.
BioGRID-ORCS; 105866; 1 hit in 17 CRISPR screens.
PRO; PR:Q6IME9; -.
Proteomes; UP000000589; Chromosome 15.
RNAct; Q6IME9; protein.
Bgee; ENSMUSG00000056605; Expressed in skin of back and 51 other tissues.
Genevisible; Q6IME9; MM.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
Gene3D; 1.20.5.1160; -; 1.
InterPro; IPR018039; IF_conserved.
InterPro; IPR039008; IF_rod_dom.
InterPro; IPR042180; IF_rod_dom_coil1B.
InterPro; IPR032444; Keratin_2_head.
InterPro; IPR003054; Keratin_II.
Pfam; PF00038; Filament; 1.
Pfam; PF16208; Keratin_2_head; 1.
PRINTS; PR01276; TYPE2KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
3: Inferred from homology;
Coiled coil; Intermediate filament; Keratin; Reference proteome.
CHAIN 1..520
/note="Keratin, type II cytoskeletal 72"
/id="PRO_0000314878"
DOMAIN 134..447
/note="IF rod"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
REGION 1..133
/note="Head"
REGION 134..169
/note="Coil 1A"
REGION 170..188
/note="Linker 1"
REGION 189..280
/note="Coil 1B"
REGION 281..304
/note="Linker 12"
REGION 305..443
/note="Coil 2"
REGION 444..520
/note="Tail"
COMPBIAS 10..105
/note="Gly-rich"
SITE 385
/note="Stutter"
SEQUENCE 520 AA; 56750 MW; BC19F6823BC58B2C CRC64;
MSRQLTLYPG AERLGFSGCS AVISGRLSGS HASVRAGVKG AAFGSRSLFC VGGGRRLALS
SAGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV CPPGGIPQVV VNKSLLAPLN
VELDPEIQKV RAQEREQIKA LNNKFASFID KVRFLEQQNQ VLETKWELLQ QLDLNNSKRS
LEPVHESYIS NLQKQLEILS GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV
LKKDVDAAYM NKVELQAKVD SLTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKHTKS EITEINRLIQ
RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ LEGALQQAKE ELARMLREHQ
ELMNVKLALD MEIATYRKLL ESEESRMAGE YPNSVSISVI SSTNAGPGGA GFSVGFGASS
SYNYRPLALE VKTKGSCGSE LKDPPAKTSG SSGTTKKTSR