Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (MHC class I NK cell receptor) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)

 KI2L3_HUMAN             Reviewed;         341 AA.
 P43628; O43472; P78402; Q14944; Q14945; Q9UM51; Q9UQ70;
 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
 01-NOV-1995, sequence version 1.
 10-FEB-2021, entry version 195.
 RecName: Full=Killer cell immunoglobulin-like receptor 2DL3;
 AltName: Full=CD158 antigen-like family member B2;
 AltName: Full=KIR-023GB;
 AltName: Full=Killer inhibitory receptor cl 2-3;
 AltName: Full=MHC class I NK cell receptor;
 AltName: Full=NKAT2a;
 AltName: Full=NKAT2b;
 AltName: Full=Natural killer-associated transcript 2;
          Short=NKAT-2;
 AltName: Full=p58 natural killer cell receptor clone CL-6;
          Short=p58 NK receptor CL-6;
 AltName: Full=p58.2 MHC class-I-specific NK receptor;
 AltName: CD_antigen=CD158b2;
 Flags: Precursor;
 Name=KIR2DL3; Synonyms=CD158B2, KIRCL23, NKAT2;
 Homo sapiens (Human).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
 Homo.
 NCBI_TaxID=9606;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
 TISSUE=Natural killer cell;
 PubMed=7716543; DOI=10.1126/science.7716543;
 Colonna M., Samaridis J.;
 "Cloning of immunoglobulin-superfamily members associated with HLA-C and
 HLA-B recognition by human natural killer cells.";
 Science 268:405-408(1995).
 [2]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
 TISSUE=Natural killer cell;
 PubMed=7749980; DOI=10.1016/1074-7613(95)90025-x;
 Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M.,
 Bottino C., Moretta L., Moretta A., Long E.O.;
 "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related
 molecules with diversity in both the extra- and intracellular domains.";
 Immunity 2:439-449(1995).
 [3]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS LEU-229;
 THR-304 AND HIS-318.
 PubMed=8662091; DOI=10.1007/bf02602590;
 Doehring C., Samaridis J., Colonna M.;
 "Alternatively spliced forms of human killer inhibitory receptors.";
 Immunogenetics 44:227-230(1996).
 [4]
 NUCLEOTIDE SEQUENCE (ISOFORM 1), AND VARIANTS ALA-9; ARG-32; GLU-56; ARG-71
 AND HIS-318.
 PubMed=9430221; DOI=10.1016/s1074-7613(00)80394-5;
 Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K.,
 Corliss B., Tyan D., Lanier L.L., Parham P.;
 "Human diversity in killer cell inhibitory receptor genes.";
 Immunity 7:753-763(1997).
 [5]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ALA-9; ARG-32; GLU-56;
 ARG-71; ILE-242 AND HIS-318.
 PubMed=9059894; DOI=10.1111/j.1600-065x.1997.tb00951.x;
 Selvakumar A., Steffens U., Dupont B.;
 "Polymorphism and domain variability of human killer cell inhibitory
 receptors.";
 Immunol. Rev. 155:183-196(1997).
 [6]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-229
 AND HIS-318.
 TISSUE=Blood;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA project:
 the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 [7]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298 (ISOFORM 1), AND VARIANT
 LEU-229.
 PubMed=9234478; DOI=10.1111/j.1399-0039.1997.tb02804.x;
 Wilson M.J., Torkar M., Trowsdale J.;
 "Genomic organization of a human killer cell inhibitory receptor gene.";
 Tissue Antigens 49:574-579(1997).
 [8]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341, AND VARIANT GLN-34.
 TISSUE=Placenta;
 Chae J.H., Kim Y.M., Ahn J.M., Kim C.G., Kim J., Kim S.J., Park J.H.;
 "Genomic organization of novel genes encoding human killer inhibitory
 receptors.";
 Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
 [9]
 INTERACTION WITH ARRB2.
 PubMed=18604210; DOI=10.1038/ni.1635;
 Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L.,
 Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.;
 "An essential function for beta-arrestin 2 in the inhibitory signaling of
 natural killer cells.";
 Nat. Immunol. 9:898-907(2008).
 [10]
 X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-245.
 PubMed=10196125; DOI=10.1016/s0969-2126(99)80052-5;
 Maenaka K., Juji T., Stuart D.I., Jones E.Y.;
 "Crystal structure of the human p58 killer cell inhibitory receptor
 (KIR2DL3) specific for HLA-Cw3-related MHC class I.";
 Structure 7:391-398(1999).
 -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-
     Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus
     preventing cell lysis.
 -!- SUBUNIT: Interacts with ARRB2. {ECO:0000269|PubMed:18604210}.
 -!- INTERACTION:
     P43628; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-8632435, EBI-11277970;
     P43628; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-8632435, EBI-11522760;
     P43628; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-8632435, EBI-11957045;
     P43628; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-8632435, EBI-12109402;
     P43628; P02652: APOA2; NbExp=3; IntAct=EBI-8632435, EBI-1171525;
     P43628; P05090: APOD; NbExp=3; IntAct=EBI-8632435, EBI-715495;
     P43628; Q96PS8: AQP10; NbExp=3; IntAct=EBI-8632435, EBI-12820279;
     P43628; P07306: ASGR1; NbExp=3; IntAct=EBI-8632435, EBI-1172335;
     P43628; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-8632435, EBI-12935759;
     P43628; O95393: BMP10; NbExp=3; IntAct=EBI-8632435, EBI-3922513;
     P43628; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-8632435, EBI-12244618;
     P43628; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-8632435, EBI-8648738;
     P43628; O14735: CDIPT; NbExp=3; IntAct=EBI-8632435, EBI-358858;
     P43628; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8632435, EBI-1045797;
     P43628; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-8632435, EBI-12256978;
     P43628; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-8632435, EBI-6165897;
     P43628; O75208: COQ9; NbExp=3; IntAct=EBI-8632435, EBI-724524;
     P43628; A0A6I8PIU0: CXCL16; NbExp=3; IntAct=EBI-8632435, EBI-10176529;
     P43628; Q07325: CXCL9; NbExp=3; IntAct=EBI-8632435, EBI-3911467;
     P43628; O43169: CYB5B; NbExp=3; IntAct=EBI-8632435, EBI-1058710;
     P43628; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-8632435, EBI-2680384;
     P43628; P50402: EMD; NbExp=3; IntAct=EBI-8632435, EBI-489887;
     P43628; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8632435, EBI-18304435;
     P43628; Q92520: FAM3C; NbExp=3; IntAct=EBI-8632435, EBI-2876774;
     P43628; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-8632435, EBI-714482;
     P43628; P01350: GAST; NbExp=3; IntAct=EBI-8632435, EBI-3436637;
     P43628; P48165: GJA8; NbExp=3; IntAct=EBI-8632435, EBI-17458373;
     P43628; Q9NPR9: GPR108; NbExp=3; IntAct=EBI-8632435, EBI-11343451;
     P43628; Q8TED1: GPX8; NbExp=3; IntAct=EBI-8632435, EBI-11721746;
     P43628; P01889: HLA-B; NbExp=2; IntAct=EBI-8632435, EBI-1046513;
     P43628; P10321: HLA-C; NbExp=9; IntAct=EBI-8632435, EBI-1051396;
     P43628; Q53YP1: HLA-C; NbExp=2; IntAct=EBI-8632435, EBI-13917186;
     P43628; Q01628: IFITM3; NbExp=3; IntAct=EBI-8632435, EBI-7932862;
     P43628; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-8632435, EBI-8503746;
     P43628; P11215: ITGAM; NbExp=3; IntAct=EBI-8632435, EBI-2568251;
     P43628; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-8632435, EBI-10266796;
     P43628; P43628: KIR2DL3; NbExp=3; IntAct=EBI-8632435, EBI-8632435;
     P43628; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-8632435, EBI-12007212;
     P43628; O43561-2: LAT; NbExp=3; IntAct=EBI-8632435, EBI-8070286;
     P43628; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-8632435, EBI-17490413;
     P43628; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8632435, EBI-2820517;
     P43628; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-8632435, EBI-10317425;
     P43628; Q8IXM6: NRM; NbExp=3; IntAct=EBI-8632435, EBI-10262547;
     P43628; P42857: NSG1; NbExp=3; IntAct=EBI-8632435, EBI-6380741;
     P43628; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-8632435, EBI-2804156;
     P43628; P26678: PLN; NbExp=3; IntAct=EBI-8632435, EBI-692836;
     P43628; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-8632435, EBI-12955265;
     P43628; Q06124: PTPN11; NbExp=4; IntAct=EBI-8632435, EBI-297779;
     P43628; P29350: PTPN6; NbExp=13; IntAct=EBI-8632435, EBI-78260;
     P43628; Q8N8N0: RNF152; NbExp=3; IntAct=EBI-8632435, EBI-2129725;
     P43628; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-8632435, EBI-10244780;
     P43628; O75396: SEC22B; NbExp=3; IntAct=EBI-8632435, EBI-1058865;
     P43628; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-8632435, EBI-10314552;
     P43628; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-8632435, EBI-12188413;
     P43628; Q6UX34: SNORC; NbExp=3; IntAct=EBI-8632435, EBI-11957067;
     P43628; P07204: THBD; NbExp=3; IntAct=EBI-8632435, EBI-941422;
     P43628; A2RU14: TMEM218; NbExp=3; IntAct=EBI-8632435, EBI-10173151;
     P43628; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-8632435, EBI-347385;
     P43628; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-8632435, EBI-12887458;
     P43628; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-8632435, EBI-2548832;
     P43628; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-8632435, EBI-12111910;
     P43628; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-8632435, EBI-765817;
     P43628; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-8632435, EBI-10243654;
     P43628; O75841: UPK1B; NbExp=3; IntAct=EBI-8632435, EBI-12237619;
     P43628; O00526: UPK2; NbExp=3; IntAct=EBI-8632435, EBI-10179682;
     P43628; O95183: VAMP5; NbExp=3; IntAct=EBI-8632435, EBI-10191195;
 -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
     protein.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=2;
     Name=1;
       IsoId=P43628-1; Sequence=Displayed;
     Name=2; Synonyms=NKAT2a-delta-Ig2;
       IsoId=P43628-2; Sequence=VSP_007814;
 -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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 EMBL; L41268; AAA69869.1; -; mRNA.
 EMBL; U24074; AAC50333.1; -; mRNA.
 EMBL; L76662; AAB36590.1; -; mRNA.
 EMBL; L76663; AAB36591.1; -; mRNA.
 EMBL; AF022048; AAB95321.1; -; mRNA.
 EMBL; U73395; AAC51147.1; -; mRNA.
 EMBL; BC032422; AAH32422.1; -; mRNA.
 EMBL; BC050730; AAH50730.1; -; mRNA.
 EMBL; AH006692; AAC51651.1; -; Genomic_DNA.
 EMBL; AH007572; AAD24477.1; -; Genomic_DNA.
 CCDS; CCDS33107.1; -. [P43628-1]
 PIR; I61725; I61725.
 RefSeq; NP_056952.2; NM_015868.2. [P43628-1]
 PDB; 1B6U; X-ray; 3.00 A; A=22-245.
 PDBsum; 1B6U; -.
 SMR; P43628; -.
 BioGRID; 110005; 63.
 IntAct; P43628; 77.
 MINT; P43628; -.
 STRING; 9606.ENSP00000342215; -.
 ChEMBL; CHEMBL3713026; -.
 GlyGen; P43628; 3 sites.
 iPTMnet; P43628; -.
 PhosphoSitePlus; P43628; -.
 BioMuta; KIR2DL3; -.
 DMDM; 1171727; -.
 jPOST; P43628; -.
 MassIVE; P43628; -.
 PaxDb; P43628; -.
 PeptideAtlas; P43628; -.
 PRIDE; P43628; -.
 ProteomicsDB; 55641; -. [P43628-1]
 ProteomicsDB; 55642; -. [P43628-2]
 TopDownProteomics; P43628-1; -. [P43628-1]
 ABCD; P43628; 1 sequenced antibody.
 Antibodypedia; 35081; 525 antibodies.
 DNASU; 3804; -.
 Ensembl; ENST00000342376; ENSP00000342215; ENSG00000243772. [P43628-1]
 Ensembl; ENST00000610407; ENSP00000478848; ENSG00000274830.
 Ensembl; ENST00000611207; ENSP00000478657; ENSG00000276218. [P43628-1]
 Ensembl; ENST00000611369; ENSP00000483975; ENSG00000277484. [P43628-1]
 Ensembl; ENST00000611821; ENSP00000484459; ENSG00000276590. [P43628-1]
 Ensembl; ENST00000611990; ENSP00000479121; ENSG00000278327. [P43628-1]
 Ensembl; ENST00000614792; ENSP00000481237; ENSG00000277554. [P43628-1]
 Ensembl; ENST00000615091; ENSP00000483551; ENSG00000275658. [P43628-1]
 Ensembl; ENST00000615739; ENSP00000478136; ENSG00000273887.
 Ensembl; ENST00000617150; ENSP00000481159; ENSG00000274952.
 Ensembl; ENST00000617242; ENSP00000483883; ENSG00000274410. [P43628-1]
 Ensembl; ENST00000617404; ENSP00000481478; ENSG00000275008. [P43628-1]
 Ensembl; ENST00000617593; ENSP00000483192; ENSG00000274108. [P43628-1]
 Ensembl; ENST00000617790; ENSP00000481355; ENSG00000275623. [P43628-1]
 Ensembl; ENST00000619702; ENSP00000480464; ENSG00000274402. [P43628-1]
 Ensembl; ENST00000619995; ENSP00000480087; ENSG00000277317. [P43628-1]
 Ensembl; ENST00000620549; ENSP00000483419; ENSG00000277924. [P43628-1]
 Ensembl; ENST00000622644; ENSP00000482830; ENSG00000276459. [P43628-1]
 Ensembl; ENST00000638813; ENSP00000492856; ENSG00000284333. [P43628-1]
 Ensembl; ENST00000638851; ENSP00000491452; ENSG00000283708. [P43628-1]
 Ensembl; ENST00000639089; ENSP00000491264; ENSG00000283702. [P43628-1]
 Ensembl; ENST00000639101; ENSP00000492356; ENSG00000283790. [P43628-1]
 Ensembl; ENST00000639176; ENSP00000491273; ENSG00000284504. [P43628-1]
 Ensembl; ENST00000640485; ENSP00000491955; ENSG00000284510. [P43628-1]
 GeneID; 3804; -.
 KEGG; hsa:3804; -.
 UCSC; uc002qgx.4; human. [P43628-1]
 CTD; 3804; -.
 DisGeNET; 3804; -.
 GeneCards; KIR2DL3; -.
 HGNC; HGNC:6331; KIR2DL3.
 HPA; ENSG00000243772; Tissue enhanced (lung, lymphoid tissue).
 MIM; 604938; gene.
 neXtProt; NX_P43628; -.
 OpenTargets; ENSG00000243772; -.
 PharmGKB; PA30116; -.
 VEuPathDB; HostDB:ENSG00000243772.7; -.
 eggNOG; ENOG502RU21; Eukaryota.
 GeneTree; ENSGT01000000214458; -.
 InParanoid; P43628; -.
 OMA; VACVGEC; -.
 PhylomeDB; P43628; -.
 TreeFam; TF352669; -.
 PathwayCommons; P43628; -.
 Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
 BioGRID-ORCS; 3804; 7 hits in 831 CRISPR screens.
 ChiTaRS; KIR2DL3; human.
 EvolutionaryTrace; P43628; -.
 GenomeRNAi; 3804; -.
 Pharos; P43628; Tbio.
 PRO; PR:P43628; -.
 Proteomes; UP000005640; Chromosome 19.
 RNAct; P43628; protein.
 Bgee; ENSG00000243772; Expressed in blood and 40 other tissues.
 ExpressionAtlas; P43628; baseline and differential.
 Genevisible; P43628; HS.
 GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
 GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
 GO; GO:0005886; C:plasma membrane; TAS:Reactome.
 GO; GO:0003823; F:antigen binding; TAS:ProtInc.
 GO; GO:0042802; F:identical protein binding; IPI:IntAct.
 GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
 GO; GO:0006955; P:immune response; TAS:ProtInc.
 GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
 Gene3D; 2.60.40.10; -; 2.
 InterPro; IPR036179; Ig-like_dom_sf.
 InterPro; IPR013783; Ig-like_fold.
 InterPro; IPR003599; Ig_sub.
 InterPro; IPR013151; Immunoglobulin.
 Pfam; PF00047; ig; 2.
 SMART; SM00409; IG; 2.
 SUPFAM; SSF48726; SSF48726; 2.
 1: Evidence at protein level;
 3D-structure; Alternative splicing; Cell membrane; Disulfide bond;
 Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
 Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
 SIGNAL          1..21
                 /evidence="ECO:0000250"
 CHAIN           22..341
                 /note="Killer cell immunoglobulin-like receptor 2DL3"
                 /id="PRO_0000015080"
 TOPO_DOM        22..245
                 /note="Extracellular"
                 /evidence="ECO:0000255"
 TRANSMEM        246..265
                 /note="Helical"
                 /evidence="ECO:0000255"
 TOPO_DOM        266..341
                 /note="Cytoplasmic"
                 /evidence="ECO:0000255"
 DOMAIN          42..107
                 /note="Ig-like C2-type 1"
 DOMAIN          142..205
                 /note="Ig-like C2-type 2"
 CARBOHYD        84
                 /note="N-linked (GlcNAc...) asparagine"
                 /evidence="ECO:0000255"
 CARBOHYD        178
                 /note="N-linked (GlcNAc...) asparagine"
                 /evidence="ECO:0000255"
 CARBOHYD        211
                 /note="N-linked (GlcNAc...) asparagine"
                 /evidence="ECO:0000255"
 DISULFID        49..100
                 /evidence="ECO:0000250|UniProtKB:P43626"
 DISULFID        149..198
                 /evidence="ECO:0000250|UniProtKB:P43626"
 VAR_SEQ         117..214
                 /note="Missing (in isoform 2)"
                 /evidence="ECO:0000303|PubMed:8662091"
                 /id="VSP_007814"
 VARIANT         9
                 /note="V -> A (in dbSNP:rs3810343)"
                 /evidence="ECO:0000269|PubMed:9059894,
                 ECO:0000269|PubMed:9430221"
                 /id="VAR_010313"
 VARIANT         32
                 /note="L -> R (in dbSNP:rs202032116)"
                 /evidence="ECO:0000269|PubMed:9059894,
                 ECO:0000269|PubMed:9430221"
                 /id="VAR_010314"
 VARIANT         34
                 /note="H -> Q (in dbSNP:rs683003)"
                 /evidence="ECO:0000269|Ref.8"
                 /id="VAR_015967"
 VARIANT         37
                 /note="P -> R (in dbSNP:rs613240)"
                 /id="VAR_049978"
 VARIANT         56
                 /note="Q -> E (in dbSNP:rs35719984)"
                 /evidence="ECO:0000269|PubMed:9059894,
                 ECO:0000269|PubMed:9430221"
                 /id="VAR_010315"
 VARIANT         66
                 /note="F -> Y (in dbSNP:rs78713511)"
                 /id="VAR_049979"
 VARIANT         71
                 /note="H -> R (in dbSNP:rs138897134)"
                 /evidence="ECO:0000269|PubMed:9059894,
                 ECO:0000269|PubMed:9430221"
                 /id="VAR_010316"
 VARIANT         229
                 /note="P -> L (in dbSNP:rs35861855)"
                 /evidence="ECO:0000269|PubMed:15489334,
                 ECO:0000269|PubMed:8662091, ECO:0000269|PubMed:9234478"
                 /id="VAR_015968"
 VARIANT         242
                 /note="R -> I"
                 /evidence="ECO:0000269|PubMed:9059894"
                 /id="VAR_015969"
 VARIANT         304
                 /note="A -> T (in dbSNP:rs4020187)"
                 /evidence="ECO:0000269|PubMed:8662091"
                 /id="VAR_015970"
 VARIANT         318
                 /note="R -> H (in dbSNP:rs1049267)"
                 /evidence="ECO:0000269|PubMed:15489334,
                 ECO:0000269|PubMed:8662091, ECO:0000269|PubMed:9059894,
                 ECO:0000269|PubMed:9430221"
                 /id="VAR_010317"
 STRAND          37..42
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          45..53
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          56..64
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          68..73
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          81..87
                 /evidence="ECO:0000244|PDB:1B6U"
 TURN            92..94
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          96..103
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          118..123
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          130..132
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          144..150
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          156..162
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          177..179
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          182..189
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          194..201
                 /evidence="ECO:0000244|PDB:1B6U"
 STRAND          216..218
                 /evidence="ECO:0000244|PDB:1B6U"
 SEQUENCE   341 AA;  37886 MW;  C21EAFF80EA9AAB2 CRC64;
 MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFQHFLL
 HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
 VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT
 FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN
 PRHLHVLIGT SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
 VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P

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