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Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (MHC class I NK cell receptor) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)

 KI2L3_HUMAN             Reviewed;         341 AA.
P43628; O43472; P78402; Q14944; Q14945; Q9UM51; Q9UQ70;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
10-FEB-2021, entry version 195.
RecName: Full=Killer cell immunoglobulin-like receptor 2DL3;
AltName: Full=CD158 antigen-like family member B2;
AltName: Full=KIR-023GB;
AltName: Full=Killer inhibitory receptor cl 2-3;
AltName: Full=MHC class I NK cell receptor;
AltName: Full=NKAT2a;
AltName: Full=NKAT2b;
AltName: Full=Natural killer-associated transcript 2;
Short=NKAT-2;
AltName: Full=p58 natural killer cell receptor clone CL-6;
Short=p58 NK receptor CL-6;
AltName: Full=p58.2 MHC class-I-specific NK receptor;
AltName: CD_antigen=CD158b2;
Flags: Precursor;
Name=KIR2DL3; Synonyms=CD158B2, KIRCL23, NKAT2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Natural killer cell;
PubMed=7716543; DOI=10.1126/science.7716543;
Colonna M., Samaridis J.;
"Cloning of immunoglobulin-superfamily members associated with HLA-C and
HLA-B recognition by human natural killer cells.";
Science 268:405-408(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Natural killer cell;
PubMed=7749980; DOI=10.1016/1074-7613(95)90025-x;
Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M.,
Bottino C., Moretta L., Moretta A., Long E.O.;
"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related
molecules with diversity in both the extra- and intracellular domains.";
Immunity 2:439-449(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS LEU-229;
THR-304 AND HIS-318.
PubMed=8662091; DOI=10.1007/bf02602590;
Doehring C., Samaridis J., Colonna M.;
"Alternatively spliced forms of human killer inhibitory receptors.";
Immunogenetics 44:227-230(1996).
[4]
NUCLEOTIDE SEQUENCE (ISOFORM 1), AND VARIANTS ALA-9; ARG-32; GLU-56; ARG-71
AND HIS-318.
PubMed=9430221; DOI=10.1016/s1074-7613(00)80394-5;
Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K.,
Corliss B., Tyan D., Lanier L.L., Parham P.;
"Human diversity in killer cell inhibitory receptor genes.";
Immunity 7:753-763(1997).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ALA-9; ARG-32; GLU-56;
ARG-71; ILE-242 AND HIS-318.
PubMed=9059894; DOI=10.1111/j.1600-065x.1997.tb00951.x;
Selvakumar A., Steffens U., Dupont B.;
"Polymorphism and domain variability of human killer cell inhibitory
receptors.";
Immunol. Rev. 155:183-196(1997).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-229
AND HIS-318.
TISSUE=Blood;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298 (ISOFORM 1), AND VARIANT
LEU-229.
PubMed=9234478; DOI=10.1111/j.1399-0039.1997.tb02804.x;
Wilson M.J., Torkar M., Trowsdale J.;
"Genomic organization of a human killer cell inhibitory receptor gene.";
Tissue Antigens 49:574-579(1997).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341, AND VARIANT GLN-34.
TISSUE=Placenta;
Chae J.H., Kim Y.M., Ahn J.M., Kim C.G., Kim J., Kim S.J., Park J.H.;
"Genomic organization of novel genes encoding human killer inhibitory
receptors.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[9]
INTERACTION WITH ARRB2.
PubMed=18604210; DOI=10.1038/ni.1635;
Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L.,
Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.;
"An essential function for beta-arrestin 2 in the inhibitory signaling of
natural killer cells.";
Nat. Immunol. 9:898-907(2008).
[10]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-245.
PubMed=10196125; DOI=10.1016/s0969-2126(99)80052-5;
Maenaka K., Juji T., Stuart D.I., Jones E.Y.;
"Crystal structure of the human p58 killer cell inhibitory receptor
(KIR2DL3) specific for HLA-Cw3-related MHC class I.";
Structure 7:391-398(1999).
-!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-
Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus
preventing cell lysis.
-!- SUBUNIT: Interacts with ARRB2. {ECO:0000269|PubMed:18604210}.
-!- INTERACTION:
P43628; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-8632435, EBI-11277970;
P43628; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-8632435, EBI-11522760;
P43628; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-8632435, EBI-11957045;
P43628; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-8632435, EBI-12109402;
P43628; P02652: APOA2; NbExp=3; IntAct=EBI-8632435, EBI-1171525;
P43628; P05090: APOD; NbExp=3; IntAct=EBI-8632435, EBI-715495;
P43628; Q96PS8: AQP10; NbExp=3; IntAct=EBI-8632435, EBI-12820279;
P43628; P07306: ASGR1; NbExp=3; IntAct=EBI-8632435, EBI-1172335;
P43628; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-8632435, EBI-12935759;
P43628; O95393: BMP10; NbExp=3; IntAct=EBI-8632435, EBI-3922513;
P43628; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-8632435, EBI-12244618;
P43628; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-8632435, EBI-8648738;
P43628; O14735: CDIPT; NbExp=3; IntAct=EBI-8632435, EBI-358858;
P43628; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8632435, EBI-1045797;
P43628; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-8632435, EBI-12256978;
P43628; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-8632435, EBI-6165897;
P43628; O75208: COQ9; NbExp=3; IntAct=EBI-8632435, EBI-724524;
P43628; A0A6I8PIU0: CXCL16; NbExp=3; IntAct=EBI-8632435, EBI-10176529;
P43628; Q07325: CXCL9; NbExp=3; IntAct=EBI-8632435, EBI-3911467;
P43628; O43169: CYB5B; NbExp=3; IntAct=EBI-8632435, EBI-1058710;
P43628; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-8632435, EBI-2680384;
P43628; P50402: EMD; NbExp=3; IntAct=EBI-8632435, EBI-489887;
P43628; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8632435, EBI-18304435;
P43628; Q92520: FAM3C; NbExp=3; IntAct=EBI-8632435, EBI-2876774;
P43628; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-8632435, EBI-714482;
P43628; P01350: GAST; NbExp=3; IntAct=EBI-8632435, EBI-3436637;
P43628; P48165: GJA8; NbExp=3; IntAct=EBI-8632435, EBI-17458373;
P43628; Q9NPR9: GPR108; NbExp=3; IntAct=EBI-8632435, EBI-11343451;
P43628; Q8TED1: GPX8; NbExp=3; IntAct=EBI-8632435, EBI-11721746;
P43628; P01889: HLA-B; NbExp=2; IntAct=EBI-8632435, EBI-1046513;
P43628; P10321: HLA-C; NbExp=9; IntAct=EBI-8632435, EBI-1051396;
P43628; Q53YP1: HLA-C; NbExp=2; IntAct=EBI-8632435, EBI-13917186;
P43628; Q01628: IFITM3; NbExp=3; IntAct=EBI-8632435, EBI-7932862;
P43628; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-8632435, EBI-8503746;
P43628; P11215: ITGAM; NbExp=3; IntAct=EBI-8632435, EBI-2568251;
P43628; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-8632435, EBI-10266796;
P43628; P43628: KIR2DL3; NbExp=3; IntAct=EBI-8632435, EBI-8632435;
P43628; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-8632435, EBI-12007212;
P43628; O43561-2: LAT; NbExp=3; IntAct=EBI-8632435, EBI-8070286;
P43628; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-8632435, EBI-17490413;
P43628; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8632435, EBI-2820517;
P43628; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-8632435, EBI-10317425;
P43628; Q8IXM6: NRM; NbExp=3; IntAct=EBI-8632435, EBI-10262547;
P43628; P42857: NSG1; NbExp=3; IntAct=EBI-8632435, EBI-6380741;
P43628; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-8632435, EBI-2804156;
P43628; P26678: PLN; NbExp=3; IntAct=EBI-8632435, EBI-692836;
P43628; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-8632435, EBI-12955265;
P43628; Q06124: PTPN11; NbExp=4; IntAct=EBI-8632435, EBI-297779;
P43628; P29350: PTPN6; NbExp=13; IntAct=EBI-8632435, EBI-78260;
P43628; Q8N8N0: RNF152; NbExp=3; IntAct=EBI-8632435, EBI-2129725;
P43628; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-8632435, EBI-10244780;
P43628; O75396: SEC22B; NbExp=3; IntAct=EBI-8632435, EBI-1058865;
P43628; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-8632435, EBI-10314552;
P43628; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-8632435, EBI-12188413;
P43628; Q6UX34: SNORC; NbExp=3; IntAct=EBI-8632435, EBI-11957067;
P43628; P07204: THBD; NbExp=3; IntAct=EBI-8632435, EBI-941422;
P43628; A2RU14: TMEM218; NbExp=3; IntAct=EBI-8632435, EBI-10173151;
P43628; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-8632435, EBI-347385;
P43628; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-8632435, EBI-12887458;
P43628; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-8632435, EBI-2548832;
P43628; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-8632435, EBI-12111910;
P43628; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-8632435, EBI-765817;
P43628; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-8632435, EBI-10243654;
P43628; O75841: UPK1B; NbExp=3; IntAct=EBI-8632435, EBI-12237619;
P43628; O00526: UPK2; NbExp=3; IntAct=EBI-8632435, EBI-10179682;
P43628; O95183: VAMP5; NbExp=3; IntAct=EBI-8632435, EBI-10191195;
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P43628-1; Sequence=Displayed;
Name=2; Synonyms=NKAT2a-delta-Ig2;
IsoId=P43628-2; Sequence=VSP_007814;
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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EMBL; L41268; AAA69869.1; -; mRNA.
EMBL; U24074; AAC50333.1; -; mRNA.
EMBL; L76662; AAB36590.1; -; mRNA.
EMBL; L76663; AAB36591.1; -; mRNA.
EMBL; AF022048; AAB95321.1; -; mRNA.
EMBL; U73395; AAC51147.1; -; mRNA.
EMBL; BC032422; AAH32422.1; -; mRNA.
EMBL; BC050730; AAH50730.1; -; mRNA.
EMBL; AH006692; AAC51651.1; -; Genomic_DNA.
EMBL; AH007572; AAD24477.1; -; Genomic_DNA.
CCDS; CCDS33107.1; -. [P43628-1]
PIR; I61725; I61725.
RefSeq; NP_056952.2; NM_015868.2. [P43628-1]
PDB; 1B6U; X-ray; 3.00 A; A=22-245.
PDBsum; 1B6U; -.
SMR; P43628; -.
BioGRID; 110005; 63.
IntAct; P43628; 77.
MINT; P43628; -.
STRING; 9606.ENSP00000342215; -.
ChEMBL; CHEMBL3713026; -.
GlyGen; P43628; 3 sites.
iPTMnet; P43628; -.
PhosphoSitePlus; P43628; -.
BioMuta; KIR2DL3; -.
DMDM; 1171727; -.
jPOST; P43628; -.
MassIVE; P43628; -.
PaxDb; P43628; -.
PeptideAtlas; P43628; -.
PRIDE; P43628; -.
ProteomicsDB; 55641; -. [P43628-1]
ProteomicsDB; 55642; -. [P43628-2]
TopDownProteomics; P43628-1; -. [P43628-1]
ABCD; P43628; 1 sequenced antibody.
Antibodypedia; 35081; 525 antibodies.
DNASU; 3804; -.
Ensembl; ENST00000342376; ENSP00000342215; ENSG00000243772. [P43628-1]
Ensembl; ENST00000610407; ENSP00000478848; ENSG00000274830.
Ensembl; ENST00000611207; ENSP00000478657; ENSG00000276218. [P43628-1]
Ensembl; ENST00000611369; ENSP00000483975; ENSG00000277484. [P43628-1]
Ensembl; ENST00000611821; ENSP00000484459; ENSG00000276590. [P43628-1]
Ensembl; ENST00000611990; ENSP00000479121; ENSG00000278327. [P43628-1]
Ensembl; ENST00000614792; ENSP00000481237; ENSG00000277554. [P43628-1]
Ensembl; ENST00000615091; ENSP00000483551; ENSG00000275658. [P43628-1]
Ensembl; ENST00000615739; ENSP00000478136; ENSG00000273887.
Ensembl; ENST00000617150; ENSP00000481159; ENSG00000274952.
Ensembl; ENST00000617242; ENSP00000483883; ENSG00000274410. [P43628-1]
Ensembl; ENST00000617404; ENSP00000481478; ENSG00000275008. [P43628-1]
Ensembl; ENST00000617593; ENSP00000483192; ENSG00000274108. [P43628-1]
Ensembl; ENST00000617790; ENSP00000481355; ENSG00000275623. [P43628-1]
Ensembl; ENST00000619702; ENSP00000480464; ENSG00000274402. [P43628-1]
Ensembl; ENST00000619995; ENSP00000480087; ENSG00000277317. [P43628-1]
Ensembl; ENST00000620549; ENSP00000483419; ENSG00000277924. [P43628-1]
Ensembl; ENST00000622644; ENSP00000482830; ENSG00000276459. [P43628-1]
Ensembl; ENST00000638813; ENSP00000492856; ENSG00000284333. [P43628-1]
Ensembl; ENST00000638851; ENSP00000491452; ENSG00000283708. [P43628-1]
Ensembl; ENST00000639089; ENSP00000491264; ENSG00000283702. [P43628-1]
Ensembl; ENST00000639101; ENSP00000492356; ENSG00000283790. [P43628-1]
Ensembl; ENST00000639176; ENSP00000491273; ENSG00000284504. [P43628-1]
Ensembl; ENST00000640485; ENSP00000491955; ENSG00000284510. [P43628-1]
GeneID; 3804; -.
KEGG; hsa:3804; -.
UCSC; uc002qgx.4; human. [P43628-1]
CTD; 3804; -.
DisGeNET; 3804; -.
GeneCards; KIR2DL3; -.
HGNC; HGNC:6331; KIR2DL3.
HPA; ENSG00000243772; Tissue enhanced (lung, lymphoid tissue).
MIM; 604938; gene.
neXtProt; NX_P43628; -.
OpenTargets; ENSG00000243772; -.
PharmGKB; PA30116; -.
VEuPathDB; HostDB:ENSG00000243772.7; -.
eggNOG; ENOG502RU21; Eukaryota.
GeneTree; ENSGT01000000214458; -.
InParanoid; P43628; -.
OMA; VACVGEC; -.
PhylomeDB; P43628; -.
TreeFam; TF352669; -.
PathwayCommons; P43628; -.
Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
BioGRID-ORCS; 3804; 7 hits in 831 CRISPR screens.
ChiTaRS; KIR2DL3; human.
EvolutionaryTrace; P43628; -.
GenomeRNAi; 3804; -.
Pharos; P43628; Tbio.
PRO; PR:P43628; -.
Proteomes; UP000005640; Chromosome 19.
RNAct; P43628; protein.
Bgee; ENSG00000243772; Expressed in blood and 40 other tissues.
ExpressionAtlas; P43628; baseline and differential.
Genevisible; P43628; HS.
GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0003823; F:antigen binding; TAS:ProtInc.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013151; Immunoglobulin.
Pfam; PF00047; ig; 2.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 2.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..21
/evidence="ECO:0000250"
CHAIN 22..341
/note="Killer cell immunoglobulin-like receptor 2DL3"
/id="PRO_0000015080"
TOPO_DOM 22..245
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 246..265
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 266..341
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 42..107
/note="Ig-like C2-type 1"
DOMAIN 142..205
/note="Ig-like C2-type 2"
CARBOHYD 84
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 178
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 211
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 49..100
/evidence="ECO:0000250|UniProtKB:P43626"
DISULFID 149..198
/evidence="ECO:0000250|UniProtKB:P43626"
VAR_SEQ 117..214
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:8662091"
/id="VSP_007814"
VARIANT 9
/note="V -> A (in dbSNP:rs3810343)"
/evidence="ECO:0000269|PubMed:9059894,
ECO:0000269|PubMed:9430221"
/id="VAR_010313"
VARIANT 32
/note="L -> R (in dbSNP:rs202032116)"
/evidence="ECO:0000269|PubMed:9059894,
ECO:0000269|PubMed:9430221"
/id="VAR_010314"
VARIANT 34
/note="H -> Q (in dbSNP:rs683003)"
/evidence="ECO:0000269|Ref.8"
/id="VAR_015967"
VARIANT 37
/note="P -> R (in dbSNP:rs613240)"
/id="VAR_049978"
VARIANT 56
/note="Q -> E (in dbSNP:rs35719984)"
/evidence="ECO:0000269|PubMed:9059894,
ECO:0000269|PubMed:9430221"
/id="VAR_010315"
VARIANT 66
/note="F -> Y (in dbSNP:rs78713511)"
/id="VAR_049979"
VARIANT 71
/note="H -> R (in dbSNP:rs138897134)"
/evidence="ECO:0000269|PubMed:9059894,
ECO:0000269|PubMed:9430221"
/id="VAR_010316"
VARIANT 229
/note="P -> L (in dbSNP:rs35861855)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:8662091, ECO:0000269|PubMed:9234478"
/id="VAR_015968"
VARIANT 242
/note="R -> I"
/evidence="ECO:0000269|PubMed:9059894"
/id="VAR_015969"
VARIANT 304
/note="A -> T (in dbSNP:rs4020187)"
/evidence="ECO:0000269|PubMed:8662091"
/id="VAR_015970"
VARIANT 318
/note="R -> H (in dbSNP:rs1049267)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:8662091, ECO:0000269|PubMed:9059894,
ECO:0000269|PubMed:9430221"
/id="VAR_010317"
STRAND 37..42
/evidence="ECO:0000244|PDB:1B6U"
STRAND 45..53
/evidence="ECO:0000244|PDB:1B6U"
STRAND 56..64
/evidence="ECO:0000244|PDB:1B6U"
STRAND 68..73
/evidence="ECO:0000244|PDB:1B6U"
STRAND 81..87
/evidence="ECO:0000244|PDB:1B6U"
TURN 92..94
/evidence="ECO:0000244|PDB:1B6U"
STRAND 96..103
/evidence="ECO:0000244|PDB:1B6U"
STRAND 118..123
/evidence="ECO:0000244|PDB:1B6U"
STRAND 130..132
/evidence="ECO:0000244|PDB:1B6U"
STRAND 144..150
/evidence="ECO:0000244|PDB:1B6U"
STRAND 156..162
/evidence="ECO:0000244|PDB:1B6U"
STRAND 177..179
/evidence="ECO:0000244|PDB:1B6U"
STRAND 182..189
/evidence="ECO:0000244|PDB:1B6U"
STRAND 194..201
/evidence="ECO:0000244|PDB:1B6U"
STRAND 216..218
/evidence="ECO:0000244|PDB:1B6U"
SEQUENCE 341 AA; 37886 MW; C21EAFF80EA9AAB2 CRC64;
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFQHFLL
HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN
PRHLHVLIGT SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P


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Related Genes :
[KIR2DS2 CD158J NKAT5] Killer cell immunoglobulin-like receptor 2DS2 (CD158 antigen-like family member J) (MHC class I NK cell receptor) (NK receptor 183 ActI) (Natural killer-associated transcript 5) (NKAT-5) (p58 natural killer cell receptor clone CL-49) (p58 NK receptor CL-49) (CD antigen CD158j)
[KIR2DS5 CD158G NKAT9] Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (MHC class I NK cell receptor) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g)
[KIR3DS1 NKAT10] Killer cell immunoglobulin-like receptor 3DS1 (MHC class I NK cell receptor) (Natural killer-associated transcript 10) (NKAT-10)
[KIR2DS1 CD158H] Killer cell immunoglobulin-like receptor 2DS1 (CD158 antigen-like family member H) (MHC class I NK cell receptor Eb6 ActI) (CD antigen CD158h)
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[KLRD1 CD94] Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[Cd160 By55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[Klrk1 Nkg2d Nkrp2] NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NK lectin-like receptor) (NKLLR) (NKG2-D-activating NK receptor) (NKR-P2) (CD antigen CD314)
[CD160 BY55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[KLRD1 CD94] Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[Klrg1 Mafa] Killer cell lectin-like receptor subfamily G member 1 (Mast cell function-associated antigen 2F1)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[Klrd1 Cd94] Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (CD antigen CD94)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[LILRA3 ILT6 LIR4] Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)
[KLRD1 CD94] Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
[LILRA2 ILT1 LIR7] Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)
[Klre1 NKG2I] Killer cell lectin-like receptor subfamily E member 1
[Clec9a Dngr-1] C-type lectin domain family 9 member A (Dendritic cell natural killer lectin group receptor 1) (CD antigen CD370)
[SLAMF6 KALI UNQ6123/PRO20080] SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[KLRD1 CD94] Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (Popy-CD94) (CD antigen CD94)
[HAVCR2 TIM3 TIMD3] Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.22.-) (Papain-like proteinase) (PL-PRO) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Non-structural protein 9 (nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p39); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16) (p35)]
[FGR SRC2] Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)

Bibliography :
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