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Kinase suppressor of Ras 1 (EC 2 7 11 1)

 KSR1_HUMAN              Reviewed;         923 AA.
Q8IVT5; F8WEA9; H7BYU0; Q13476;
21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
03-SEP-2014, sequence version 3.
17-JUN-2020, entry version 168.
RecName: Full=Kinase suppressor of Ras 1;
EC=2.7.11.1 {ECO:0000250|UniProtKB:Q61097};
Name=KSR1; Synonyms=KSR;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in the
human lineage.";
Nature 440:1045-1049(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-628 (ISOFORM 3).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 243-899 (ISOFORM 2).
PubMed=8521512; DOI=10.1016/0092-8674(95)90204-x;
Therrien M., Chang H.C., Solomon N.M., Karim F.D., Wassarman D.A.,
Rubin G.M.;
"KSR, a novel protein kinase required for RAS signal transduction.";
Cell 83:879-888(1995).
[4]
INTERACTION WITH MAP2K1; MAP2K2; HSP90AA1; 14-3-3 AND CDC37, SUBCELLULAR
LOCATION, AND DOMAIN.
PubMed=10409742; DOI=10.1128/mcb.19.8.5523;
Stewart S., Sundaram M., Zhang Y., Lee J., Han M., Guan K.L.;
"Kinase suppressor of Ras forms a multiprotein signaling complex and
modulates MEK localization.";
Mol. Cell. Biol. 19:5523-5534(1999).
[5]
REVIEW.
PubMed=12007434; DOI=10.1016/s0960-9822(02)00831-x;
Roy F., Therrien M.;
"MAP kinase module: the Ksr connection.";
Curr. Biol. 12:R325-R327(2002).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling
networks.";
Cell 127:635-648(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270 AND SER-334, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18220336; DOI=10.1021/pr0705441;
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Platelet;
PubMed=18088087; DOI=10.1021/pr0704130;
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
Schuetz C., Walter U., Gambaryan S., Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270; THR-274; SER-334;
SER-406 AND SER-569, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
Mann M., Daub H.;
"Large-scale proteomics analysis of the human kinome.";
Mol. Cell. Proteomics 8:1751-1764(2009).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[12]
SUBCELLULAR LOCATION, AND INTERACTION WITH VRK2.
PubMed=20679487; DOI=10.1128/mcb.01581-09;
Fernandez I.F., Blanco S., Lozano J., Lazo P.A.;
"VRK2 inhibits mitogen-activated protein kinase signaling and inversely
correlates with ErbB2 in human breast cancer.";
Mol. Cell. Biol. 30:4687-4697(2010).
[13]
INTERACTION WITH AKAP13 AND BRAF, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=21102438; DOI=10.1038/ncb2130;
Smith F.D., Langeberg L.K., Cellurale C., Pawson T., Morrison D.K.,
Davis R.J., Scott J.D.;
"AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.";
Nat. Cell Biol. 12:1242-1249(2010).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
"System-wide temporal characterization of the proteome and phosphoproteome
of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270; THR-274; SER-311;
SER-334; SER-351; SER-406; THR-425 AND SER-569, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[17] {ECO:0000244|PDB:5VYK}
X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 27-172, FUNCTION, SUBUNIT,
INTERACTION WITH BRAF; MAP2K1; MAP2K2; HSP90AA1; 14-3-3 AND CDC37, DOMAIN,
AND MUTAGENESIS OF LEU-47; CYS-62; GLU-72; 602-TYR--GLN-604; ALA-637;
ARG-639; ARG-665 AND TRP-831.
PubMed=29433126; DOI=10.1038/nature25478;
Lavoie H., Sahmi M., Maisonneuve P., Marullo S.A., Thevakumaran N., Jin T.,
Kurinov I., Sicheri F., Therrien M.;
"MEK drives BRAF activation through allosteric control of KSR proteins.";
Nature 554:549-553(2018).
[18]
VARIANTS [LARGE SCALE ANALYSIS] PRO-227; ALA-359 AND HIS-663.
PubMed=17344846; DOI=10.1038/nature05610;
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
-!- FUNCTION: Part of a multiprotein signaling complex which promotes
phosphorylation of Raf family members and activation of downstream MAP
kinases (By similarity). Independently of its kinase activity, acts as
MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF;
upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and
promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or
MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or
MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase
activity is unsure (By similarity). Some protein kinase activity has
been detected in vitro, however the physiological relevance of this
activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097,
ECO:0000269|PubMed:29433126}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
Evidence={ECO:0000250|UniProtKB:Q61097};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q61097};
-!- SUBUNIT: Homodimer (PubMed:29433126). Heterodimerizes (via N-terminus)
with BRAF (via N-terminus) in a MAP2K1/MEK1 or MAP2K2/MEK2-dependent
manner (PubMed:29433126). Interacts with MAP2K1/MEK1 and MAP2K2/MEK2
(PubMed:10409742, PubMed:29433126). Binding to MAP2K1/MEK1 releases the
intramolecular inhibitory interaction between KSR1 N-terminus and
kinase domains which is required for the subsequent RSK1 dimerization
with BRAF (PubMed:29433126). Identified in a complex with AKAP13,
MAP2K1 and BRAF (By similarity). Interacts with AKAP13 and BRAF
(PubMed:21102438). Interacts with RAF and MAPK/ERK, in a Ras-dependent
manner (By similarity). Interacts with 14-3-3 proteins including YWHAB
(By similarity). Interacts with HSP90AA1/HSP90, YWHAE/14-3-3 and CDC37
(PubMed:10409742, PubMed:29433126). The binding of 14-3-3 proteins to
phosphorylated KSR1 prevents the membrane localization (By similarity).
Interacts with MARK3 (By similarity). Interacts with PPP2R1A and PPP2CA
(By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487).
{ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:10409742,
ECO:0000269|PubMed:20679487, ECO:0000269|PubMed:21102438,
ECO:0000269|PubMed:29433126}.
-!- INTERACTION:
Q8IVT5; P36507: MAP2K2; NbExp=8; IntAct=EBI-486984, EBI-1056930;
Q8IVT5; Q86Y07: VRK2; NbExp=4; IntAct=EBI-486984, EBI-1207615;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane
{ECO:0000269|PubMed:20679487}; Peripheral membrane protein
{ECO:0000269|PubMed:20679487}. Cell membrane
{ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane
{ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane
{ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the
phosphorylated form is bound to a 14-3-3 protein, sequestration in the
cytoplasm occurs. Following growth factor treatment, the protein is
free for membrane translocation, and it moves from the cytoplasm to the
cell periphery. {ECO:0000305|PubMed:12007434}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=Q8IVT5-1; Sequence=Displayed;
Name=2;
IsoId=Q8IVT5-2; Sequence=VSP_055656, VSP_055657;
Name=3;
IsoId=Q8IVT5-3; Sequence=VSP_055655;
Name=4;
IsoId=Q8IVT5-4; Sequence=VSP_055655, VSP_055657;
-!- DOMAIN: The protein kinase domain is predicted to be catalytically
inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1
and MAP2K2 membrane localization. The domain is required but not
sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation
(PubMed:10409742). {ECO:0000255, ECO:0000269|PubMed:10409742}.
-!- DOMAIN: The N-terminal region mediates interaction with BRAF
(PubMed:29433126). Also mediates membrane localization (By similarity).
{ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.
-!- PTM: Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by
MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells,
phosphorylated KSR1 is cytoplasmic and in stimulated cells,
dephosphorylated KSR1 is membrane-associated. Phosphorylated by PKA at
Ser-888. Phosphorylation at Ser-888 is required for cAMP-dependent
activation of MAPK1 and/or MAPK3 (By similarity).
{ECO:0000250|UniProtKB:Q61097}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. {ECO:0000305}.
-!- CAUTION: Although it belongs to the protein kinase superfamily, the
ATP-binding motif VAIK has an arginine instead of a lysine residue
suggesting that KSR1 can not bind ATP and therefore lacks protein
kinase activity. However, KSR1 is capable of binding ATP
(PubMed:29433126). Has protein kinase activity towards MAP2K1 in the
presence of RAF1/c-RAF in vitro (By similarity).
{ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126,
ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/KSR1ID41107ch17q11.html";
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EMBL; AC069366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC015688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC042106; AAH42106.1; -; mRNA.
EMBL; U43586; AAC50354.1; -; mRNA.
CCDS; CCDS58532.1; -. [Q8IVT5-4]
RefSeq; NP_055053.1; NM_014238.1. [Q8IVT5-4]
RefSeq; XP_011523731.1; XM_011525429.2. [Q8IVT5-1]
RefSeq; XP_016880760.1; XM_017025271.1. [Q8IVT5-3]
RefSeq; XP_016880761.1; XM_017025272.1. [Q8IVT5-3]
RefSeq; XP_016880762.1; XM_017025273.1. [Q8IVT5-3]
RefSeq; XP_016880763.1; XM_017025274.1. [Q8IVT5-3]
RefSeq; XP_016880764.1; XM_017025275.1. [Q8IVT5-3]
RefSeq; XP_016880765.1; XM_017025276.1. [Q8IVT5-3]
PDB; 5VYK; X-ray; 1.75 A; A/C=27-172.
PDBsum; 5VYK; -.
SMR; Q8IVT5; -.
BioGRID; 114371; 108.
CORUM; Q8IVT5; -.
DIP; DIP-32619N; -.
IntAct; Q8IVT5; 358.
MINT; Q8IVT5; -.
STRING; 9606.ENSP00000381958; -.
ChEMBL; CHEMBL1938215; -.
iPTMnet; Q8IVT5; -.
PhosphoSitePlus; Q8IVT5; -.
BioMuta; KSR1; -.
DMDM; 56749095; -.
EPD; Q8IVT5; -.
jPOST; Q8IVT5; -.
MassIVE; Q8IVT5; -.
MaxQB; Q8IVT5; -.
PaxDb; Q8IVT5; -.
PeptideAtlas; Q8IVT5; -.
PRIDE; Q8IVT5; -.
ProteomicsDB; 31779; -.
ProteomicsDB; 43732; -.
ProteomicsDB; 70766; -. [Q8IVT5-1]
ProteomicsDB; 70767; -. [Q8IVT5-2]
ProteomicsDB; 70768; -. [Q8IVT5-3]
Antibodypedia; 2110; 408 antibodies.
DNASU; 8844; -.
Ensembl; ENST00000398988; ENSP00000381958; ENSG00000141068. [Q8IVT5-4]
Ensembl; ENST00000509603; ENSP00000438795; ENSG00000141068. [Q8IVT5-4]
GeneID; 8844; -.
KEGG; hsa:8844; -.
UCSC; uc002gzo.2; human. [Q8IVT5-1]
CTD; 8844; -.
DisGeNET; 8844; -.
EuPathDB; HostDB:ENSG00000141068.13; -.
GeneCards; KSR1; -.
HGNC; HGNC:6465; KSR1.
HPA; ENSG00000141068; Tissue enhanced (pancreas).
MIM; 601132; gene.
neXtProt; NX_Q8IVT5; -.
OpenTargets; ENSG00000141068; -.
PharmGKB; PA30254; -.
eggNOG; KOG0193; Eukaryota.
eggNOG; ENOG410Y4UP; LUCA.
GeneTree; ENSGT00940000156066; -.
InParanoid; Q8IVT5; -.
KO; K14958; -.
OrthoDB; 281487at2759; -.
PhylomeDB; Q8IVT5; -.
TreeFam; TF317006; -.
Reactome; R-HSA-5673000; RAF activation.
Reactome; R-HSA-5674135; MAP2K and MAPK activation.
Reactome; R-HSA-5675221; Negative regulation of MAPK pathway.
Reactome; R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants.
Reactome; R-HSA-6802948; Signaling by high-kinase activity BRAF mutants.
Reactome; R-HSA-6802952; Signaling by BRAF and RAF fusions.
Reactome; R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF.
Reactome; R-HSA-9649948; Signaling downstream of RAS mutants.
SignaLink; Q8IVT5; -.
SIGNOR; Q8IVT5; -.
BioGRID-ORCS; 8844; 4 hits in 817 CRISPR screens.
ChiTaRS; KSR1; human.
GeneWiki; KSR1; -.
GenomeRNAi; 8844; -.
Pharos; Q8IVT5; Tbio.
PRO; PR:Q8IVT5; -.
Proteomes; UP000005640; Chromosome 17.
RNAct; Q8IVT5; protein.
Bgee; ENSG00000141068; Expressed in body of pancreas and 195 other tissues.
ExpressionAtlas; Q8IVT5; baseline and differential.
Genevisible; Q8IVT5; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0032991; C:protein-containing complex; IDA:MGI.
GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO; GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
GO; GO:0051087; F:chaperone binding; IEA:Ensembl.
GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
GO; GO:0005078; F:MAP-kinase scaffold activity; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; IDA:MGI.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0000185; P:activation of MAPKKK activity; IDA:UniProtKB.
GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
GO; GO:0000165; P:MAPK cascade; TAS:Reactome.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
GO; GO:0007265; P:Ras protein signal transduction; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0043405; P:regulation of MAP kinase activity; ISS:UniProtKB.
CDD; cd00029; C1; 1.
Gene3D; 1.10.150.50; -; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR025561; KSR_SAM-like_dom.
InterPro; IPR002219; PE/DAG-bd.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR013761; SAM/pointed_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF13543; SAM_KSR1; 1.
SMART; SM00109; C1; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PROSITE; PS00479; ZF_DAG_PE_1; 1.
PROSITE; PS50081; ZF_DAG_PE_2; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; ATP-binding; Cell membrane;
Cell projection; Cytoplasm; Endoplasmic reticulum; Kinase; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism;
Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc;
Zinc-finger.
CHAIN 1..923
/note="Kinase suppressor of Ras 1"
/id="PRO_0000086229"
DOMAIN 613..883
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
ZN_FING 347..391
/note="Phorbol-ester/DAG-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
NP_BIND 619..627
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 1..172
/note="Mediates association with membranes"
/evidence="ECO:0000250|UniProtKB:Q61097"
COMPBIAS 17..21
/note="Poly-Gly"
COMPBIAS 289..292
/note="Poly-Pro"
ACT_SITE 733
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU10027"
METAL 348
/note="Zinc 1"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 360
/note="Zinc 2"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 363
/note="Zinc 2"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 373
/note="Zinc 1"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 376
/note="Zinc 1"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 381
/note="Zinc 2"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 384
/note="Zinc 2"
/evidence="ECO:0000250|UniProtKB:Q61097"
METAL 391
/note="Zinc 1"
/evidence="ECO:0000250|UniProtKB:Q61097"
BINDING 735
/note="ATP"
/evidence="ECO:0000250|UniProtKB:Q6VAB6"
BINDING 750
/note="ATP"
/evidence="ECO:0000250|UniProtKB:Q6VAB6"
MOD_RES 270
/note="Phosphothreonine"
/evidence="ECO:0000244|PubMed:18088087,
ECO:0000244|PubMed:18220336, ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163"
MOD_RES 274
/note="Phosphothreonine"
/evidence="ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163"
MOD_RES 311
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163"
MOD_RES 334
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:18220336,
ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:23186163"
MOD_RES 351
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:23186163"
MOD_RES 406
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:23186163"
MOD_RES 425
/note="Phosphothreonine"
/evidence="ECO:0000244|PubMed:23186163"
MOD_RES 569
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163"
MOD_RES 888
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q61097"
VAR_SEQ 1..137
/note="Missing (in isoform 3 and isoform 4)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_055655"
VAR_SEQ 504..526
/note="VPSAGHCWKCLLIAESLKENAFN -> D (in isoform 2)"
/evidence="ECO:0000303|PubMed:8521512"
/id="VSP_055656"
VAR_SEQ 898..923
/note="DINSSKVVPRFERFGLGVLESSNPKM -> EL (in isoform 2 and
isoform 4)"
/evidence="ECO:0000303|PubMed:8521512"
/id="VSP_055657"
VARIANT 227
/note="S -> P"
/evidence="ECO:0000269|PubMed:17344846"
/id="VAR_040658"
VARIANT 359
/note="V -> A"
/evidence="ECO:0000269|PubMed:17344846"
/id="VAR_046048"
VARIANT 663
/note="Q -> H"
/evidence="ECO:0000269|PubMed:17344846"
/id="VAR_046049"
MUTAGEN 47
/note="L->D: Reduces interaction with BRAF and MAP2K1 and
thus phosphorylation of MAP2K1."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 62
/note="C->D: Reduces interaction with BRAF and MAP2K1 and
thus phosphorylation of MAP2K1."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 72
/note="E->K: Loss of interaction with BRAF and MAP2K1 and
severe decrease in MAP2K1 phosphorylation levels."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 602..604
/note="YLQ->DDE: No effect on MAP2K1- or MAP2K2-mediated-
BRAF-KSR1 dimerization and BRAF activation."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 637
/note="A->F: No effect on MAP2K1 or MAP2K2 mediated-BRAF-
KSR1 dimerization and BRAF activation."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 639
/note="R->M: No effect on MAP2K1 mediated-BRAF-KSR1
dimerization and BRAF activation."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 665
/note="R->H: Loss of MAP2K1 mediated-BRAF-KSR1
dimerization."
/evidence="ECO:0000269|PubMed:29433126"
MUTAGEN 831
/note="W->R: Loss of the interaction with MAP2K1 resulting
in loss of BRAF-KSR1 dimerization and BRAF activation. No
effect on ATP binding or interaction with HSP90AA1, 14-3-3
and CDC37."
/evidence="ECO:0000269|PubMed:29433126"
CONFLICT 243..265
/note="FSEGLSDTCIPLHASGRLTPRAL -> EFRHTSALTQHTAHTQHTSAHTQ
(in Ref. 3; AAH42106)"
/evidence="ECO:0000305"
HELIX 34..61
/evidence="ECO:0000244|PDB:5VYK"
HELIX 67..93
/evidence="ECO:0000244|PDB:5VYK"
HELIX 101..104
/evidence="ECO:0000244|PDB:5VYK"
HELIX 109..115
/evidence="ECO:0000244|PDB:5VYK"
HELIX 120..124
/evidence="ECO:0000244|PDB:5VYK"
HELIX 132..137
/evidence="ECO:0000244|PDB:5VYK"
HELIX 140..149
/evidence="ECO:0000244|PDB:5VYK"
HELIX 154..170
/evidence="ECO:0000244|PDB:5VYK"
SEQUENCE 923 AA; 102160 MW; 61BF0F1598349540 CRC64;
MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
SSKVVPRFER FGLGVLESSN PKM


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WP1701: Starch and sucrose metabolism
WP1946: Cori Cycle
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WP1844: MAP kinase cascade
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway

Related Genes :
[ksr-1 F13B9.5] Kinase suppressor of Ras A (EC 2.7.11.1)
[KSR1 KSR] Kinase suppressor of Ras 1 (EC 2.7.11.1)
[Ksr1 Ksr] Kinase suppressor of Ras 1 (mKSR1) (EC 2.7.11.1) (Protein Hb)
[KSR2] Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 CIG45_02340 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G29_20785 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQE83_22775 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K55_17625 E4K61_03800 E5P22_21380 E5S46_06650 EA213_19000 EA225_13320 EAX79_27320 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC019_03873 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F18_11615 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FQZ46_21375 FWK02_18105 FZ043_14730 GIY13_02485 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQL64_10635 GQM17_02800 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[hchA AM465_15370 AWF59_019055 AZZ83_004235 B9N33_26475 BFD68_20845 C7B02_06890 C9Z28_17130 CCZ14_26645 CCZ17_22700 CRJUMX01_1140054 CRT43_11430 CUB99_23505 D3C88_02905 D3P02_16265 D9D33_15385 D9D94_15735 D9E49_19020 D9I20_10460 D9J46_03345 DJ487_18960 DJ492_13470 DL251_00505 DL979_00380 DMC44_18755 DMZ50_24495 DNR41_00375 DS966_16070 DU333_03260 DW236_02290 E0L04_20335 EA159_21345 EA167_21075 EA189_00370 EA191_21560 EA198_02280 EA200_00370 EA203_21510 EA222_02305 EA232_20265 EA233_11705 EA242_17410 EA245_13290 EA429_05770 EA435_21775 EA834_21700 ECTO124_02024 EGT48_04930 ELT23_21030 ELT33_08025 ELT34_19745 ELU82_24705 ELU96_05025 ELV13_26065 ELX79_15035 ELX83_25640 ELY23_20490 ELY24_19085 ELY50_24510 EPS76_06485 EPS91_17475 EPS94_00505 ERS085406_02591 EWK56_00075 ExPECSC065_02714 EYX99_25670 FNJ67_10775 FV295_16190 GFU40_00360 GFU45_09680 GFU47_04835 GJ638_18410 GKE92_23545 GKF28_00040 GKF34_00055 GKF47_00040 GKG08_13460 GKG09_11990 GKG11_12245 GKG22_12830 GKG29_13740 GQE47_24120 GQN33_12435 GQS26_09145 NCTC10766_03778 NCTC7928_05955 NCTC8450_02317 NCTC9007_02951 NCTC9075_02834 SY51_11150 U12A_02105 U14A_02105] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[ark-1 C01C7.1] Ack-related non-receptor tyrosine kinase (EC 2.7.10.2) (EC 2.7.11.1) (Ras-regulating kinase ark-1)
[KSS1 YGR040W] Mitogen-activated protein kinase KSS1 (MAP kinase KSS1) (EC 2.7.11.24) (Kinase suppressor of SST2)
[nnrD nnrE BHS81_24940 BMA87_06210 BON75_25135 BUE81_24185 BW690_00535 C5P01_11605 C9114_00800 C9141_20385 C9160_20005 C9201_17640 C9Z03_11025 C9Z39_09990 CF006_04810 CG692_00180 CI641_014360 CI693_12780 COD46_22200 CWS33_03515 D2185_07770 D3821_07085 D3O91_01535 D3Y67_00680 D4011_02210 D4638_06395 D6W00_07670 D6X63_00505 D7W70_13040 D8Y65_09515 D9D20_08295 D9D44_05795 D9G29_02235 D9H68_15720 D9H94_06330 D9I18_04405 D9J11_13510 D9J52_05810 D9J63_13405 DAH30_09295 DAH34_17710 DAH37_06235 DEN89_23315 DEO04_15015 DK132_00975 DL292_04305 DL326_12595 DLU82_19955 DM973_03315 DMC44_08050 DMY83_06260 DNW42_15620 DOY22_05310 DOY61_22135 DQE91_09055 DT034_15395 E0I42_01095 E2119_06500 E5P22_06605 E5S42_20000 EA213_12050 EAI42_08035 EAI42_19730 EAI46_08330 ED307_02425 EEP23_07485 EH186_16255 EI021_09655 EI041_04975 EIZ86_02830 EL75_3998 EL79_4176 EL80_4091 ELT20_09170 EPT01_09990 EXX24_09350 EXX78_19455 F1E13_09470 F1E19_03510 FQ022_21765 FQR64_20885 FRV13_14670 FV293_00830 GHR40_02625 GKF89_03420 GNZ03_04915 GP654_08840 GP689_08305 GQE30_17865 GQE34_01730 GQE51_12505 GQE64_09140 GQL64_02225 GRW80_01300 RK56_012375] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[CNKSR1 CNK1] Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
[LATS2 KPM] Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
[stk-1 bur1 B20D17.070 NCU01435] Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC 2.7.11.23) (Serine-threonine kinase 1)
[Lats2] Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm)
[ksr-2 F58D5.4] Kinase suppressor of Ras B
[CNKSR2 CNK2 KIAA0902 KSR2] Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)
[TK UL23] Thymidine kinase (EC 2.7.1.21)
[Cnksr2] Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMA87_25350 BMT91_24760 BON76_21885 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 C9Z39_20510 CR538_10415 D3Y67_22910 D4023_08350 D9G42_11130 D9I97_22010 D9J11_25195 D9J52_16665 DJ503_24045 DLX40_18195 DM267_05215 DN627_18690 DP258_02540 DQE91_25240 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 FORC82_1921 FV293_07100 GHR40_13690 GKE15_01795 GKE22_01795 GKE24_01795 GKE26_01795 GKE29_19015 GKE31_01795 GKE39_01795 GKE46_01795 GKE58_00235 GKE60_01795 GKE64_01795 GKE77_01800 GKE87_19180 GKE93_04790 GKF00_12775 GKF03_06100 GKF74_23075 GKF86_23585 GKF89_24720 GKG12_21690 GP700_02420 GP720_02430 GP727_01495 GP912_03195 NCTC12650_02300 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[UL97] Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[RPS6KA1 MAPKAPK1A RSK1] Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
[aro-1 aro-2 aro-4 aro-5 aro-9 B14H13.20 NCU016321] Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]
[lrk-1 T27C10.6] Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)
[SCL1 PRC2 PRS2 YGL011C] Proteasome subunit alpha type-1 (EC 3.4.25.1) (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
[TOR2 DRR2 TSC14 YKL203C] Serine/threonine-protein kinase TOR2 (EC 2.7.1.67) (EC 2.7.11.1) (Dominant rapamycin resistance protein 2) (Phosphatidylinositol 4-kinase TOR2) (PI4-kinase TOR2) (PI4K TOR2) (PtdIns-4-kinase TOR2) (Target of rapamycin kinase 2) (Temperature-sensitive CSG2 suppressor protein 14)
[RPS6KA3 ISPK1 MAPKAPK1B RSK2] Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
[STK4 KRS2 MST1] Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
[RPS6KA2 MAPKAPK1C RSK3] Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)
[Rps6ka2 Mapkapk1c Rsk3] Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Protein-tyrosine kinase Mpk-9) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)

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