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Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]

 SCF_MOUSE               Reviewed;         273 AA.
P20826; P97332; Q3TNJ7; Q62524; Q64222; Q921N5;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 1.
13-FEB-2019, entry version 176.
RecName: Full=Kit ligand;
AltName: Full=Hematopoietic growth factor KL;
AltName: Full=Mast cell growth factor;
Short=MGF;
AltName: Full=Steel factor;
AltName: Full=Stem cell factor;
Short=SCF;
AltName: Full=c-Kit ligand;
Contains:
RecName: Full=Soluble KIT ligand;
Short=sKITLG;
Flags: Precursor;
Name=Kitlg; Synonyms=Kitl, Mgf, Sl, Slf;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=WCB6F1;
PubMed=1698558; DOI=10.1016/0092-8674(90)90304-W;
Anderson D.M., Lyman S.D., Baird A., Wignall J.M., Eisenman J.,
Rauch C., March C.J., Boswell H.S., Gimpel S.D., Cosman D.,
Williams D.E.;
"Molecular cloning of mast cell growth factor, a hematopoietin that is
active in both membrane bound and soluble forms.";
Cell 63:235-243(1990).
[2]
NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
PubMed=1378327; DOI=10.1091/mbc.3.3.349;
Huang E.J., Nocka K.H., Buck J., Besmer P.;
"Differential expression and processing of two cell associated forms
of the kit-ligand: KL-1 and KL-2.";
Mol. Biol. Cell 3:349-362(1992).
[3]
NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
STRAIN=WCB6F1;
PubMed=1705866; DOI=10.1016/0092-8674(91)90326-T;
Flanagan J.G., Chan D.C., Leder P.;
"Transmembrane form of the kit ligand growth factor is determined by
alternative splicing and is missing in the Sld mutant.";
Cell 64:1025-1035(1991).
[4]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
PubMed=1383087; DOI=10.1101/gad.6.10.1832;
Brannan C.I., Bedell M.A., Resnick J.L., Eppig J.J., Handel M.A.,
Williams D.E., Lyman S.D., Donovan P.J., Jenkins N.A., Copeland N.G.;
"Developmental abnormalities in Steel17H mice result from a splicing
defect in the steel factor cytoplasmic tail.";
Genes Dev. 6:1832-1842(1992).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
PubMed=8849898;
Bedell M.A., Copeland N.G., Jenkins N.A.;
"Multiple pathways for Steel regulation suggested by genomic and
sequence analysis of the murine Steel gene.";
Genetics 142:927-934(1996).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS PRO-193 AND
SER-207.
STRAIN=C3H/E1; TISSUE=Brain;
PubMed=8875893; DOI=10.1007/s003359900247;
Graw J., Loester J., Neuhaeuser-Klaus A., Pretsch W., Schmitt-John T.;
"Molecular analysis of two new Steel mutations in mice shows a
transversion or an insertion.";
Mamm. Genome 7:843-846(1996).
[7]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS SER-122; PRO-193
AND SER-207.
STRAIN=102/E1 X C3H/E1;
PubMed=9360640; DOI=10.1016/S1383-5726(97)00005-8;
Graw J., Neuhauser-Klaus A., Pretsch W.;
"Detection of a point mutation (A to G) in exon 5 of the murine Mgf
gene defines a novel allele at the Steel locus with a weak
phenotype.";
Mutat. Res. 382:75-78(1997).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Cerebellum, and Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
SER-207.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
NUCLEOTIDE SEQUENCE OF 1-270 (ISOFORM 1), AND PROTEIN SEQUENCE OF
26-65.
PubMed=1698557; DOI=10.1016/0092-8674(90)90303-V;
Huang E., Nocka K., Beier D.R., Chu T.Y., Buck J., Lahm H.W.,
Wellner D., Leder P., Besmer P.;
"The hematopoietic growth factor KL is encoded by the Sl locus and is
the ligand of the c-kit receptor, the gene product of the W locus.";
Cell 63:225-233(1990).
[11]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-201.
PubMed=1698556; DOI=10.1016/0092-8674(90)90302-U;
Zsebo K.M., Williams D.A., Geissler E.N., Broudy V.C., Martin F.H.,
Atkins H.L., Hsu R.-Y., Birkett N.C., Okino K.H., Murdock D.C.,
Jacobsen F.W., Langley K.E., Smith K.A., Takeishi T., Cattanach B.M.,
Galli S.J., Suggs S.V.;
"Stem cell factor is encoded at the Sl locus of the mouse and is the
ligand for the c-kit tyrosine kinase receptor.";
Cell 63:213-224(1990).
[12]
PROTEIN SEQUENCE OF 26-53.
PubMed=1698554; DOI=10.1016/0092-8674(90)90298-S;
Copeland N.G., Gilbert D.J., Cho B.C., Donovan P.J., Jenkins N.A.,
Cosman D., Anderson D., Lyman S.D., Williams D.E.;
"Mast cell growth factor maps near the steel locus on mouse chromosome
10 and is deleted in a number of steel alleles.";
Cell 63:175-183(1990).
[13]
PROTEIN SEQUENCE OF 26-78.
PubMed=1698553; DOI=10.1016/0092-8674(90)90297-R;
Williams D.E., Eisenman J., Baird A., Rauch C., van Ness K.,
March C.J., Park L.S., Martin U., Mochizuki D.Y., Boswell H.S.,
Burgess G.S., Cosman D., Lyman S.D.;
"Identification of a ligand for the c-kit proto-oncogene.";
Cell 63:167-174(1990).
[14]
TISSUE SPECIFICITY.
PubMed=26522471; DOI=10.1016/j.ajhg.2015.09.011;
Baylor-Hopkins Center for Mendelian Genomics;
Zazo Seco C., Serrao de Castro L., van Nierop J.W., Morin M.,
Jhangiani S., Verver E.J., Schraders M., Maiwald N., Wesdorp M.,
Venselaar H., Spruijt L., Oostrik J., Schoots J., van Reeuwijk J.,
Lelieveld S.H., Huygen P.L., Insenser M., Admiraal R.J.,
Pennings R.J., Hoefsloot L.H., Arias-Vasquez A., de Ligt J.,
Yntema H.G., Jansen J.H., Muzny D.M., Huls G., van Rossum M.M.,
Lupski J.R., Moreno-Pelayo M.A., Kunst H.P., Kremer H.;
"Allelic Mutations of KITLG, Encoding KIT Ligand, Cause Asymmetric and
Unilateral Hearing Loss and Waardenburg Syndrome Type 2.";
Am. J. Hum. Genet. 97:647-660(2015).
[15]
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 28-166 ALONE AND IN COMPLEX
WITH KIT, SUBUNIT, AND DISULFIDE BONDS.
PubMed=17255936; DOI=10.1038/sj.emboj.7601545;
Liu H., Chen X., Focia P.J., He X.;
"Structural basis for stem cell factor-KIT signaling and activation of
class III receptor tyrosine kinases.";
EMBO J. 26:891-901(2007).
-!- FUNCTION: Ligand for the receptor-type protein-tyrosine kinase
KIT. Plays an essential role in the regulation of cell survival
and proliferation, hematopoiesis, stem cell maintenance,
gametogenesis, mast cell development, migration and function, and
in melanogenesis. KITLG/SCF binding can activate several signaling
pathways. Promotes phosphorylation of PIK3R1, the regulatory
subunit of phosphatidylinositol 3-kinase, and subsequent
activation of the kinase AKT1. KITLG/SCF and KIT also transmit
signals via GRB2 and activation of RAS, RAF1 and the MAP kinases
MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation
of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT
promote activation of PLCG1, leading to the production of the
cellular signaling molecules diacylglycerol and inositol 1,4,5-
trisphosphate. KITLG/SCF acts synergistically with other
cytokines, probably interleukins.
-!- SUBUNIT: Homodimer, non-covalently linked (Probable).
Heterotetramer with KIT, binding two KIT molecules; thereby
mediates KIT dimerization and subsequent activation by
autophosphorylation. {ECO:0000269|PubMed:17255936, ECO:0000305}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
{ECO:0000250|UniProtKB:P21583}. Cytoplasm, cytoskeleton
{ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P21583};
Single-pass type I membrane protein {ECO:0000250}. Cytoplasm,
cytoskeleton {ECO:0000250|UniProtKB:P21583}. Cell projection,
lamellipodium {ECO:0000250|UniProtKB:P21583}. Cell projection,
filopodium {ECO:0000250|UniProtKB:P21583}.
-!- SUBCELLULAR LOCATION: Soluble KIT ligand: Secreted {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=KL-1;
IsoId=P20826-1; Sequence=Displayed;
Name=2; Synonyms=KL-2;
IsoId=P20826-2; Sequence=VSP_006023;
-!- TISSUE SPECIFICITY: Expressed in the cochlea.
{ECO:0000269|PubMed:26522471}.
-!- DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.
-!- PTM: A soluble form is produced by proteolytic processing of
isoform 1 in the extracellular domain.
-!- SIMILARITY: Belongs to the SCF family. {ECO:0000305}.
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EMBL; M59915; AAA40095.1; -; mRNA.
EMBL; M57647; AAA39538.1; -; mRNA.
EMBL; S40534; AAB22555.2; -; mRNA.
EMBL; X68989; CAA48778.1; -; mRNA.
EMBL; U44724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; U44725; AAC52447.1; -; mRNA.
EMBL; X95381; CAA64667.1; -; mRNA.
EMBL; X99322; CAA67698.1; -; mRNA.
EMBL; Y10287; CAA71329.1; -; mRNA.
EMBL; AK018777; BAB31402.1; -; mRNA.
EMBL; AK134301; BAE22091.1; -; mRNA.
EMBL; AK165233; BAE38091.1; -; mRNA.
EMBL; BC011322; AAH11322.1; -; mRNA.
EMBL; S40364; AAB22554.2; -; mRNA.
EMBL; M59912; AAA39539.1; -; mRNA.
CCDS; CCDS36046.1; -. [P20826-1]
CCDS; CCDS83751.1; -. [P20826-2]
PIR; A35971; A35971.
PIR; A37934; A37934.
PIR; B35971; B35971.
PIR; S65801; S65801.
RefSeq; NP_001334085.1; NM_001347156.1. [P20826-2]
RefSeq; NP_038626.1; NM_013598.3. [P20826-1]
UniGene; Mm.45124; -.
PDB; 2O26; X-ray; 2.50 A; A/B/E/F=28-166.
PDB; 2O27; X-ray; 2.20 A; A/B=28-166.
PDBsum; 2O26; -.
PDBsum; 2O27; -.
ProteinModelPortal; P20826; -.
SMR; P20826; -.
BioGrid; 201412; 1.
STRING; 10090.ENSMUSP00000100920; -.
PhosphoSitePlus; P20826; -.
MaxQB; P20826; -.
PaxDb; P20826; -.
PeptideAtlas; P20826; -.
PRIDE; P20826; -.
Ensembl; ENSMUST00000020129; ENSMUSP00000020129; ENSMUSG00000019966. [P20826-2]
Ensembl; ENSMUST00000105283; ENSMUSP00000100920; ENSMUSG00000019966. [P20826-1]
GeneID; 17311; -.
KEGG; mmu:17311; -.
UCSC; uc007gxp.1; mouse. [P20826-1]
UCSC; uc007gxq.1; mouse. [P20826-2]
CTD; 17311; -.
MGI; MGI:96974; Kitl.
eggNOG; ENOG410IF3Y; Eukaryota.
eggNOG; ENOG410XYQR; LUCA.
GeneTree; ENSGT00390000018272; -.
HOGENOM; HOG000082493; -.
HOVERGEN; HBG036146; -.
InParanoid; P20826; -.
KO; K05461; -.
OMA; VKTKGIC; -.
OrthoDB; 1083457at2759; -.
PhylomeDB; P20826; -.
TreeFam; TF330811; -.
Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
Reactome; R-MMU-1433557; Signaling by SCF-KIT.
Reactome; R-MMU-1433559; Regulation of KIT signaling.
Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
EvolutionaryTrace; P20826; -.
PMAP-CutDB; P20826; -.
PRO; PR:P20826; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000019966; Expressed in 372 organ(s), highest expression level in brain blood vessel.
ExpressionAtlas; P20826; baseline and differential.
Genevisible; P20826; MM.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0030175; C:filopodium; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IDA:MGI.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005173; F:stem cell factor receptor binding; IDA:MGI.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IMP:MGI.
GO; GO:0035162; P:embryonic hemopoiesis; ISO:MGI.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
GO; GO:0007281; P:germ cell development; TAS:MGI.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IDA:MGI.
GO; GO:0001755; P:neural crest cell migration; IDA:MGI.
GO; GO:0001541; P:ovarian follicle development; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IDA:MGI.
GO; GO:0002687; P:positive regulation of leukocyte migration; IDA:MGI.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IGI:MGI.
GO; GO:0070668; P:positive regulation of mast cell proliferation; IDA:MGI.
GO; GO:0045636; P:positive regulation of melanocyte differentiation; IDA:MGI.
GO; GO:0002763; P:positive regulation of myeloid leukocyte differentiation; IGI:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:MGI.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003452; SCF.
PANTHER; PTHR11574; PTHR11574; 1.
Pfam; PF02404; SCF; 1.
PIRSF; PIRSF015599; SCF; 1.
SUPFAM; SSF47266; SSF47266; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell adhesion; Cell membrane;
Cell projection; Complete proteome; Cytoplasm; Cytoskeleton;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Growth factor; Membrane; Polymorphism; Reference proteome; Secreted;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 25 {ECO:0000269|PubMed:1698553,
ECO:0000269|PubMed:1698554,
ECO:0000269|PubMed:1698557}.
CHAIN 26 273 Kit ligand.
/FTId=PRO_0000031914.
CHAIN 26 190 Soluble KIT ligand. {ECO:0000250}.
/FTId=PRO_0000403392.
TOPO_DOM 26 214 Extracellular. {ECO:0000255}.
TRANSMEM 215 237 Helical. {ECO:0000255}.
TOPO_DOM 238 273 Cytoplasmic. {ECO:0000255}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 195 195 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 29 114 {ECO:0000269|PubMed:17255936}.
DISULFID 68 163 {ECO:0000269|PubMed:17255936}.
VAR_SEQ 174 202 DSRVSVTKPFMLPPVAASSLRNDSSSSNR -> G (in
isoform 2). {ECO:0000305}.
/FTId=VSP_006023.
VARIANT 122 122 N -> S (in MGFSL-3NEU).
{ECO:0000269|PubMed:9360640}.
VARIANT 193 193 L -> P. {ECO:0000269|PubMed:8875893,
ECO:0000269|PubMed:9360640}.
VARIANT 207 207 A -> S. {ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:8875893,
ECO:0000269|PubMed:9360640}.
CONFLICT 215 215 W -> L (in Ref. 2; AAB22555/AAB22554).
{ECO:0000305}.
HELIX 35 39 {ECO:0000244|PDB:2O26}.
HELIX 40 45 {ECO:0000244|PDB:2O27}.
STRAND 53 57 {ECO:0000244|PDB:2O27}.
TURN 59 63 {ECO:0000244|PDB:2O27}.
HELIX 66 68 {ECO:0000244|PDB:2O27}.
HELIX 70 85 {ECO:0000244|PDB:2O27}.
HELIX 97 118 {ECO:0000244|PDB:2O27}.
STRAND 131 135 {ECO:0000244|PDB:2O27}.
HELIX 137 151 {ECO:0000244|PDB:2O27}.
TURN 153 156 {ECO:0000244|PDB:2O26}.
SEQUENCE 273 AA; 30645 MW; A7FC899B592A7967 CRC64;
MKKTQTWIIT CIYLQLLLFN PLVKTKEICG NPVTDNVKDI TKLVANLPND YMITLNYVAG
MDVLPSHCWL RDMVIQLSLS LTTLLDKFSN ISEGLSNYSI IDKLGKIVDD LVLCMEENAP
KNIKESPKRP ETRSFTPEEF FSIFNRSIDA FKDFMVASDT SDCVLSSTLG PEKDSRVSVT
KPFMLPPVAA SSLRNDSSSS NRKAAKAPED SGLQWTAMAL PALISLVIGF AFGALYWKKK
QSSLTRAVEN IQINEEDNEI SMLQQKEREF QEV


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BMAhKL12 Stem Cell Factor (SCF), c_Kit Ligand, Mast Cell Growth Factor, Steel Factor, Clone hKL 12, Mab anti_Human; frozen_paraffin, IH_ELISA_WB 200 µg.
100-097-SC SCF Human Host: E. coli KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; stem cell factor; Mast cell growth factor; c-Kit ligand 50
100-097 SCF Human Host: E. coli KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; stem cell factor; Mast cell growth factor; c-Kit ligand 10
100-097S SCF Human Host: E. coli KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; stem cell factor; Mast cell growth factor; c-Kit ligand 2
E0120h ELISA kit c-Kit ligand,Homo sapiens,Human,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,SCF,SCF,Stem cell factor 96T
E0120h ELISA c-Kit ligand,Homo sapiens,Human,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,SCF,SCF,Stem cell factor 96T
U0120h CLIA c-Kit ligand,Homo sapiens,Human,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,SCF,SCF,Stem cell factor 96T
E0120b ELISA kit Bos taurus,Bovine,c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
U0120b CLIA Bos taurus,Bovine,c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
E0120b ELISA Bos taurus,Bovine,c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
U0120p CLIA c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,Pig,SCF,Stem cell factor,Sus scrofa 96T
E0120p ELISA kit c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,Pig,SCF,Stem cell factor,Sus scrofa 96T
E0120p ELISA c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,Pig,SCF,Stem cell factor,Sus scrofa 96T
18-783-78902 GOAT ANTI HUMAN STEM CELL FACTOR Biotin - SCF; C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF Polyclonal 0.05 mg
18-783-75592 GOAT ANTI HUMAN STEM CELL FACTOR - SCF; C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF Polyclonal 0.1 mg
E0120c ELISA kit Chicken,c-Kit ligand,Gallus gallus,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
U0120c CLIA Chicken,c-Kit ligand,Gallus gallus,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
E0120c ELISA Chicken,c-Kit ligand,Gallus gallus,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
10-663-45248 Stem Cell Factor - glycosylated (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.002 mg

Kits Elisa; taq POLYMERASE

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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP1089: Small Ligand GPCRs
WP1317: Small Ligand GPCRs
WP161: Small Ligand GPCRs
WP1825: GPCR ligand binding
WP2355: Corticotropin-releasing hormone
WP247: Small Ligand GPCRs
WP353: Small Ligand GPCRs
WP746: Small Ligand GPCRs
WP853: Small Ligand GPCRs
WP971: Small Ligand GPCRs

Related Genes :
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[KITLG MGF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[KITLG SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[KITLG SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] (Fragment)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[kita kit sparse] Mast/stem cell growth factor receptor kita (SCFR) (EC 2.7.10.1) (Tyrosine-protein kinase Kit)
[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[Faslg Apt1Lg1 Cd95l Fasl Tnfsf6] Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
[Tnfsf11 Opgl Rankl Trance] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[TNFSF11 OPGL RANKL TRANCE] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[TNFSF14 HVEML LIGHT UNQ391/PRO726] Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
[CD40LG CD40L TNFSF5 TRAP] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form]
[VEGFC] Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)
[GRB7] Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
[Gas6] Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) (Growth-potentiating factor) (GPF)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[NRG1 GGF HGL HRGA NDF SMDF] Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]

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