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Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG); Processed kit ligand]

 SCF_CAPHI               Reviewed;         274 AA.
Q95M19;
30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
03-JUL-2019, entry version 82.
RecName: Full=Kit ligand;
AltName: Full=Mast cell growth factor;
Short=MGF;
AltName: Full=Stem cell factor;
Short=SCF;
AltName: Full=c-Kit ligand;
Contains:
RecName: Full=Soluble KIT ligand;
Short=sKITLG;
Contains:
RecName: Full=Processed kit ligand;
Flags: Precursor;
Name=KITLG; Synonyms=SCF;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Shiba; TISSUE=Brain;
Yanagisawa N., Tanaka S., Yamanouchi K., Tojo H., Tachi C.;
"Identification of splicing isoforms of caprine stem cell factor
(gSCF) transcripts and expression patterns of the two major isoforms,
gSCF825 and gSCF741, in the brain and the skin of adult and fetal
Shiba goats, Capra hircus.";
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Stimulates the proliferation of mast cells. Able to
augment the proliferation of both myeloid and lymphoid
hematopoietic progenitors in bone marrow culture. Mediates also
cell-cell adhesion. Acts synergistically with other cytokines,
probably interleukins (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer, non-covalently linked. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P21583}.
Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane
{ECO:0000250|UniProtKB:P21583}; Single-pass type I membrane
protein {ECO:0000250}. Cell projection, lamellipodium
{ECO:0000250|UniProtKB:P21583}. Cell projection, filopodium
{ECO:0000250|UniProtKB:P21583}.
-!- SUBCELLULAR LOCATION: Processed kit ligand: Secreted
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Soluble KIT ligand: Secreted {ECO:0000250}.
-!- PTM: A soluble form is produced by proteolytic processing of the
extracellular domain. {ECO:0000250}.
-!- SIMILARITY: Belongs to the SCF family. {ECO:0000305}.
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EMBL; AB002152; BAB71753.1; -; mRNA.
RefSeq; NP_001272599.1; NM_001285670.1.
SMR; Q95M19; -.
GeneID; 100860807; -.
KEGG; chx:100860807; -.
CTD; 4254; -.
KO; K05461; -.
OrthoDB; 1083457at2759; -.
Proteomes; UP000291000; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030175; C:filopodium; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:InterPro.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003452; SCF.
PANTHER; PTHR11574; PTHR11574; 1.
Pfam; PF02404; SCF; 1.
PIRSF; PIRSF015599; SCF; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Cell adhesion; Cell membrane; Cell projection; Complete proteome;
Cytoplasm; Cytoskeleton; Disulfide bond; Glycoprotein; Growth factor;
Membrane; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 274 Kit ligand.
/FTId=PRO_0000031910.
CHAIN 26 191 Soluble KIT ligand. {ECO:0000250}.
/FTId=PRO_0000403388.
CHAIN 26 ? Processed kit ligand.
/FTId=PRO_0000292274.
TOPO_DOM 26 215 Extracellular. {ECO:0000255}.
TRANSMEM 216 238 Helical. {ECO:0000255}.
TOPO_DOM 239 274 Cytoplasmic. {ECO:0000255}.
MOD_RES 26 26 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P21581}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 196 196 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 29 114 {ECO:0000250}.
DISULFID 68 164 {ECO:0000250}.
SEQUENCE 274 AA; 31053 MW; BBFE669A509EF65D CRC64;
MKKTQTWIIT CIYLQLLLFN PLVHSQGICR NRVTDDVKDV TKLVANLPKD YMITLKYVPG
MDVLPSHCWI SEMVEQLSVS LTDLLDKFSN ISEGLSNYSI IDKLVKIVDD LVECMEEHSF
ENVKKSSKSP EPRQFTPEKF FGIFNKSIDA FKDLEIVAST MSECVISSTS SPEKDSRVSV
TKPFMLPPVA ASSLRNDSSS SNRKASNSIE DSSLQWAAVA LPAFFSLVIG FAFGALYWKK
KQPNLTRTVE NRQINEEDNE ISMLQEKERE FQEV


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Related Genes :
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Bibliography :