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Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)

 LIRB2_HUMAN             Reviewed;         598 AA.
Q8N423; A8MU67; C9JF29; O75017; Q8NHJ7; Q8NHJ8;
03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 4.
07-APR-2021, entry version 173.
RecName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 2;
Short=LIR-2;
Short=Leukocyte immunoglobulin-like receptor 2;
AltName: Full=CD85 antigen-like family member D;
AltName: Full=Immunoglobulin-like transcript 4;
Short=ILT-4;
AltName: Full=Monocyte/macrophage immunoglobulin-like receptor 10;
Short=MIR-10;
AltName: CD_antigen=CD85d;
Flags: Precursor;
Name=LILRB2 {ECO:0000312|HGNC:HGNC:6606};
Synonyms=ILT4 {ECO:0000303|PubMed:12853576, ECO:0000303|PubMed:20448110},
LIR2, MIR10;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANTS ASP-161; TYR-300;
TRP-306 AND HIS-322.
PubMed=9382880; DOI=10.1084/jem.186.11.1809;
Colonna M., Navarro F., Bellon T., Llano M., Garcia P., Samaridis J.,
Angman L., Cella M., Lopez-Botet M.;
"A common inhibitory receptor for major histocompatibility complex class I
molecules on human lymphoid and myelomonocytic cells.";
J. Exp. Med. 186:1809-1818(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, AND
VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
TISSUE=Dendritic cell, and Peripheral blood monocyte;
PubMed=9548455;
Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.;
"A family of human lymphoid and myeloid Ig-like receptors, some of which
bind to MHC class I molecules.";
J. Immunol. 159:5192-5196(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS ASP-161;
TYR-300; TRP-306 AND HIS-322.
Canavez F.C.;
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ASP-161;
TYR-300; TRP-306 AND HIS-322.
TISSUE=Peripheral blood leukocyte;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH PTPN6 AND FCGR1A, PHOSPHORYLATION, TISSUE SPECIFICITY, AND
FUNCTION.
PubMed=9842885;
DOI=10.1002/(sici)1521-4141(199811)28:11<3423::aid-immu3423>3.0.co;2-2;
Fanger N.A., Cosman D., Peterson L., Braddy S.C., Maliszewski C.R.,
Borges L.;
"The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-
mediated signaling in monocytes.";
Eur. J. Immunol. 28:3423-3434(1998).
[7]
FUNCTION, SUBUNIT, AND INTERACTION WITH HLA-F.
PubMed=11169396;
DOI=10.1002/1521-4141(200012)30:12<3552::aid-immu3552>3.0.co;2-l;
Lepin E.J., Bastin J.M., Allan D.S., Roncador G., Braud V.M., Mason D.Y.,
van der Merwe P.A., McMichael A.J., Bell J.I., Powis S.H.,
O'Callaghan C.A.;
"Functional characterization of HLA-F and binding of HLA-F tetramers to
ILT2 and ILT4 receptors.";
Eur. J. Immunol. 30:3552-3561(2000).
[8]
FUNCTION.
PubMed=11875462; DOI=10.1038/ni760;
Chang C.C., Ciubotariu R., Manavalan J.S., Yuan J., Colovai A.I.,
Piazza F., Lederman S., Colonna M., Cortesini R., Dalla-Favera R.,
Suciu-Foca N.;
"Tolerization of dendritic cells by T(S) cells: the crucial role of
inhibitory receptors ILT3 and ILT4.";
Nat. Immunol. 3:237-243(2002).
[9]
INTERACTION WITH TYPE I MHC ALLELES, AND FUNCTION.
PubMed=12853576; DOI=10.1073/pnas.1431057100;
Shiroishi M., Tsumoto K., Amano K., Shirakihara Y., Colonna M., Braud V.M.,
Allan D.S.J., Makadzange A., Rowland-Jones S., Willcox B.E., Jones E.Y.,
van der Merwe P.A., Kumagai I., Maenaka K.;
"Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete
with CD8 for MHC class I binding and bind preferentially to HLA-G.";
Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861(2003).
[10]
FUNCTION, SUBUNIT, AND INTERACTION WITH HLA-G.
PubMed=16455647; DOI=10.1074/jbc.m512305200;
Shiroishi M., Kuroki K., Ose T., Rasubala L., Shiratori I., Arase H.,
Tsumoto K., Kumagai I., Kohda D., Maenaka K.;
"Efficient leukocyte Ig-like receptor signaling and crystal structure of
disulfide-linked HLA-G dimer.";
J. Biol. Chem. 281:10439-10447(2006).
[11]
FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed=20448110; DOI=10.1182/blood-2009-07-234872;
Gregori S., Tomasoni D., Pacciani V., Scirpoli M., Battaglia M.,
Magnani C.F., Hauben E., Roncarolo M.G.;
"Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10
requires the IL-10-dependent ILT4/HLA-G pathway.";
Blood 116:935-944(2010).
[12]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=27859042; DOI=10.1002/eji.201646564;
Koestlin N., Ostermeir A.L., Spring B., Schwarz J., Marme A., Walter C.B.,
Poets C.F., Gille C.;
"HLA-G promotes myeloid-derived suppressor cell accumulation and
suppressive activity during human pregnancy through engagement of the
receptor ILT4.";
Eur. J. Immunol. 47:374-384(2017).
[13]
X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 24-219, AND DISULFIDE BONDS.
PubMed=12390682; DOI=10.1186/1472-6807-2-6;
Willcox B.E., Thomas L.M., Chapman T.L., Heikema A.P., West A.P. Jr.,
Bjorkman P.J.;
"Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2)
in regions implicated in the binding of the human cytomegalovirus class I
MHC homolog UL18.";
BMC Struct. Biol. 2:6-6(2002).
-!- FUNCTION: Receptor for class I MHC antigens. Recognizes a broad
spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles
(PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110,
PubMed:27859042). Involved in the down-regulation of the immune
response and the development of tolerance. Recognizes HLA-G in complex
with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound
HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and
myeloid-derived suppressor cells, both of which actively maintain
maternal-fetal tolerance (PubMed:20448110, PubMed:27859042,
PubMed:16455647). Competes with CD8A for binding to class I MHC
antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins
and mobilization of intracellular calcium ions (PubMed:11875462,
PubMed:12853576, PubMed:9548455, PubMed:9842885).
{ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:11875462,
ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:16455647,
ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:27859042,
ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
-!- SUBUNIT: Binds PTPN6 when phosphorylated. Binds FCGR1A. Interacts with
peptide-bound HLA-G-B2M; this interaction is direct (PubMed:16455647).
Interacts with peptide-bound HLA-F-B2M; this interaction is direct
(PubMed:11169396). {ECO:0000269|PubMed:11169396,
ECO:0000269|PubMed:16455647}.
-!- INTERACTION:
Q8N423; Q9UKU9: ANGPTL2; NbExp=5; IntAct=EBI-2816428, EBI-15485893;
Q8N423; Q86XS5: ANGPTL5; NbExp=5; IntAct=EBI-2816428, EBI-15485927;
Q8N423; PRO_0000000092 [P05067]: APP; NbExp=7; IntAct=EBI-2816428, EBI-821758;
Q8N423; P01889: HLA-B; NbExp=2; IntAct=EBI-2816428, EBI-1046513;
Q8N423; P17693: HLA-G; NbExp=7; IntAct=EBI-2816428, EBI-1043063;
Q8N423; P17693-2: HLA-G; NbExp=4; IntAct=EBI-2816428, EBI-16586375;
Q8N423; P17693-5: HLA-G; NbExp=2; IntAct=EBI-2816428, EBI-16586455;
Q8N423; P17693-6: HLA-G; NbExp=3; IntAct=EBI-2816428, EBI-16586550;
Q8N423; P46531: NOTCH1; NbExp=8; IntAct=EBI-2816428, EBI-636374;
Q8N423; P29350: PTPN6; NbExp=3; IntAct=EBI-2816428, EBI-78260;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20448110};
Single-pass type I membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=Q8N423-1; Sequence=Displayed;
Name=2;
IsoId=Q8N423-2; Sequence=VSP_008458;
Name=3;
IsoId=Q8N423-3; Sequence=VSP_055719, VSP_055720;
Name=4;
IsoId=Q8N423-4; Sequence=VSP_055718;
-!- TISSUE SPECIFICITY: Expressed in monocytes and at lower levels in
myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic
IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid-
derived suppressor cells during pregnancy (PubMed:27859042). Detected
at low levels in natural killer (NK) cells. Expressed in B cells.
{ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:27859042,
ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
-!- DOMAIN: Contains 3 copies of a cytoplasmic motif that is referred to as
the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is
involved in modulation of cellular responses. The phosphorylated ITIM
motif can bind the SH2 domain of several SH2-containing phosphatases.
-!- PTM: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
{ECO:0000269|PubMed:9842885}.
-!- MISCELLANEOUS: [Isoform 2]: Alternative use of an acceptor site.
{ECO:0000305}.
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EMBL; AF025528; AAB87662.1; -; mRNA.
EMBL; AF283986; AAL36990.1; -; mRNA.
EMBL; AF283987; AAL36991.1; -; mRNA.
EMBL; AC010518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC036827; AAH36827.1; -; mRNA.
CCDS; CCDS12886.1; -. [Q8N423-1]
CCDS; CCDS42612.1; -. [Q8N423-2]
CCDS; CCDS62791.1; -. [Q8N423-4]
CCDS; CCDS62792.1; -. [Q8N423-3]
PDB; 2DYP; X-ray; 2.50 A; D=24-219.
PDB; 2GW5; X-ray; 1.80 A; A=24-219.
PDB; 4LLA; X-ray; 2.50 A; A/B/C=222-419.
PDB; 6AED; X-ray; 3.80 A; A=27-419.
PDB; 6BCS; X-ray; 2.10 A; A=24-220.
PDBsum; 2DYP; -.
PDBsum; 2GW5; -.
PDBsum; 4LLA; -.
PDBsum; 6AED; -.
PDBsum; 6BCS; -.
SMR; Q8N423; -.
DIP; DIP-59888N; -.
IntAct; Q8N423; 23.
STRING; 9606.ENSP00000375629; -.
GlyGen; Q8N423; 5 sites, 1 O-linked glycan (2 sites).
iPTMnet; Q8N423; -.
PhosphoSitePlus; Q8N423; -.
BioMuta; LILRB2; -.
DMDM; 311033485; -.
jPOST; Q8N423; -.
MassIVE; Q8N423; -.
PaxDb; Q8N423; -.
PeptideAtlas; Q8N423; -.
PRIDE; Q8N423; -.
ProteomicsDB; 2083; -.
ProteomicsDB; 71866; -. [Q8N423-1]
ProteomicsDB; 71867; -. [Q8N423-2]
ProteomicsDB; 9927; -.
Antibodypedia; 32869; 284 antibodies.
DNASU; 10288; -.
Ensembl; ENST00000314446; ENSP00000319960; ENSG00000131042.
Ensembl; ENST00000391746; ENSP00000375626; ENSG00000131042.
Ensembl; ENST00000391748; ENSP00000375628; ENSG00000131042.
Ensembl; ENST00000391749; ENSP00000375629; ENSG00000131042.
Ensembl; ENST00000434421; ENSP00000410117; ENSG00000131042.
Ensembl; ENST00000610886; ENSP00000482933; ENSG00000276146.
Ensembl; ENST00000614225; ENSP00000480841; ENSG00000275463. [Q8N423-4]
Ensembl; ENST00000617341; ENSP00000484373; ENSG00000276146.
Ensembl; ENST00000617886; ENSP00000483553; ENSG00000276146.
Ensembl; ENST00000618392; ENSP00000480302; ENSG00000274513.
Ensembl; ENST00000618705; ENSP00000481208; ENSG00000275463. [Q8N423-1]
Ensembl; ENST00000619122; ENSP00000483478; ENSG00000275463. [Q8N423-3]
Ensembl; ENST00000621020; ENSP00000483014; ENSG00000275463. [Q8N423-2]
UCSC; uc010eri.4; human. [Q8N423-1]
GeneCards; LILRB2; -.
HGNC; HGNC:6606; LILRB2.
HPA; ENSG00000131042; Tissue enhanced (blood, bone marrow, lymphoid tissue).
MIM; 604815; gene.
neXtProt; NX_Q8N423; -.
PharmGKB; PA30380; -.
VEuPathDB; HostDB:ENSG00000131042.13; -.
eggNOG; ENOG502RYEX; Eukaryota.
HOGENOM; CLU_021100_2_3_1; -.
InParanoid; Q8N423; -.
PhylomeDB; Q8N423; -.
TreeFam; TF336644; -.
PathwayCommons; Q8N423; -.
Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-HSA-6798695; Neutrophil degranulation.
SIGNOR; Q8N423; -.
ChiTaRS; LILRB2; human.
EvolutionaryTrace; Q8N423; -.
Pharos; Q8N423; Tbio.
PRO; PR:Q8N423; -.
Proteomes; UP000005640; Chromosome 19.
RNAct; Q8N423; protein.
Bgee; ENSG00000131042; Expressed in monocyte and 158 other tissues.
ExpressionAtlas; Q8N423; baseline and differential.
Genevisible; Q8N423; HS.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO; GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
GO; GO:0001540; F:amyloid-beta binding; IMP:ARUK-UCL.
GO; GO:0050839; F:cell adhesion molecule binding; IPI:BHF-UCL.
GO; GO:0032396; F:inhibitory MHC class I receptor activity; IDA:BHF-UCL.
GO; GO:0042288; F:MHC class I protein binding; IDA:UniProtKB.
GO; GO:0023029; F:MHC class Ib protein binding; IDA:UniProtKB.
GO; GO:0023025; F:MHC class Ib protein complex binding; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IDA:ARUK-UCL.
GO; GO:0008157; F:protein phosphatase 1 binding; IPI:UniProtKB.
GO; GO:0044877; F:protein-containing complex binding; IPI:ARUK-UCL.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IMP:BHF-UCL.
GO; GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; IDA:UniProtKB.
GO; GO:0034113; P:heterotypic cell-cell adhesion; IDA:BHF-UCL.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0140105; P:interleukin-10-mediated signaling pathway; IEP:ARUK-UCL.
GO; GO:0007611; P:learning or memory; ISS:ARUK-UCL.
GO; GO:0002578; P:negative regulation of antigen processing and presentation; IDA:BHF-UCL.
GO; GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.
GO; GO:1905875; P:negative regulation of postsynaptic density organization; IC:ARUK-UCL.
GO; GO:0051248; P:negative regulation of protein metabolic process; ISS:ARUK-UCL.
GO; GO:2000524; P:negative regulation of T cell costimulation; IMP:ARUK-UCL.
GO; GO:0042130; P:negative regulation of T cell proliferation; IDA:BHF-UCL.
GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
GO; GO:0032755; P:positive regulation of interleukin-6 production; NAS:BHF-UCL.
GO; GO:1900454; P:positive regulation of long-term synaptic depression; ISS:ARUK-UCL.
GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:ARUK-UCL.
GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IMP:BHF-UCL.
GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:BHF-UCL.
GO; GO:0002666; P:positive regulation of T cell tolerance induction; IMP:BHF-UCL.
GO; GO:0002645; P:positive regulation of tolerance induction; IMP:UniProtKB.
GO; GO:2001198; P:regulation of dendritic cell differentiation; IC:BHF-UCL.
GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
GO; GO:1900271; P:regulation of long-term synaptic potentiation; ISS:ARUK-UCL.
GO; GO:0007165; P:signal transduction; IDA:BHF-UCL.
Gene3D; 2.60.40.10; -; 4.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
Pfam; PF13895; Ig_2; 1.
SMART; SM00409; IG; 3.
SMART; SM00408; IGc2; 3.
SUPFAM; SSF48726; SSF48726; 4.
PROSITE; PS50835; IG_LIKE; 2.
1: Evidence at protein level;
3D-structure; Adaptive immunity; Alternative splicing; Cell membrane;
Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
Phosphoprotein; Receptor; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1..21
/evidence="ECO:0000255"
CHAIN 22..598
/note="Leukocyte immunoglobulin-like receptor subfamily B
member 2"
/id="PRO_0000014821"
TOPO_DOM 22..461
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 462..482
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 483..598
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 27..110
/note="Ig-like C2-type 1"
DOMAIN 111..229
/note="Ig-like C2-type 2"
DOMAIN 230..318
/note="Ig-like C2-type 3"
DOMAIN 330..419
/note="Ig-like C2-type 4"
MOTIF 531..536
/note="ITIM motif 1"
MOTIF 560..565
/note="ITIM motif 2"
MOTIF 590..595
/note="ITIM motif 3"
CARBOHYD 280
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 301
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 340
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 49..98
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:12390682, ECO:0007744|PDB:2GW5"
DISULFID 144..196
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:12390682, ECO:0007744|PDB:2GW5"
DISULFID 156..166
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:12390682, ECO:0007744|PDB:2GW5"
DISULFID 245..296
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 345..396
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
VAR_SEQ 1..116
/note="Missing (in isoform 4)"
/evidence="ECO:0000305"
/id="VSP_055718"
VAR_SEQ 437
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|Ref.3"
/id="VSP_008458"
VAR_SEQ 495..510
/note="TQRKADFQHPAGAVGP -> SPAQLPTPRKKTSMLP (in isoform 3)"
/evidence="ECO:0000303|PubMed:9382880"
/id="VSP_055719"
VAR_SEQ 511..598
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:9382880"
/id="VSP_055720"
VARIANT 20
/note="H -> R (in dbSNP:rs383369)"
/id="VAR_016997"
VARIANT 161
/note="E -> D (in dbSNP:rs373032)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:9382880, ECO:0000269|PubMed:9548455,
ECO:0000269|Ref.3"
/id="VAR_016998"
VARIANT 235
/note="V -> M (in dbSNP:rs386056)"
/id="VAR_047432"
VARIANT 300
/note="H -> Y (in dbSNP:rs7247538)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:9382880, ECO:0000269|PubMed:9548455,
ECO:0000269|Ref.3"
/id="VAR_016999"
VARIANT 306
/note="C -> W (in dbSNP:rs7247451)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:9382880, ECO:0000269|PubMed:9548455,
ECO:0000269|Ref.3"
/id="VAR_017000"
VARIANT 322
/note="R -> H (in dbSNP:rs1128646)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:9382880, ECO:0000269|PubMed:9548455,
ECO:0000269|Ref.3"
/id="VAR_061314"
VARIANT 324
/note="T -> R (in dbSNP:rs7247055)"
/id="VAR_047433"
VARIANT 326
/note="F -> S (in dbSNP:rs7246737)"
/id="VAR_047434"
VARIANT 349
/note="R -> G (in dbSNP:rs7247025)"
/id="VAR_047435"
VARIANT 403
/note="D -> N (in dbSNP:rs4993133)"
/id="VAR_061315"
CONFLICT 583
/note="R -> G (in Ref. 5; AAH36827)"
/evidence="ECO:0000305"
STRAND 30..35
/evidence="ECO:0007744|PDB:2GW5"
STRAND 37..40
/evidence="ECO:0007744|PDB:2GW5"
STRAND 45..50
/evidence="ECO:0007744|PDB:2GW5"
STRAND 57..63
/evidence="ECO:0007744|PDB:2GW5"
STRAND 68..72
/evidence="ECO:0007744|PDB:6BCS"
HELIX 75..77
/evidence="ECO:0007744|PDB:2GW5"
HELIX 78..80
/evidence="ECO:0007744|PDB:2DYP"
STRAND 82..87
/evidence="ECO:0007744|PDB:2GW5"
TURN 90..92
/evidence="ECO:0007744|PDB:2GW5"
STRAND 94..102
/evidence="ECO:0007744|PDB:2GW5"
STRAND 113..118
/evidence="ECO:0007744|PDB:2GW5"
STRAND 125..130
/evidence="ECO:0007744|PDB:2GW5"
STRAND 140..158
/evidence="ECO:0007744|PDB:2GW5"
STRAND 160..162
/evidence="ECO:0007744|PDB:6BCS"
STRAND 166..168
/evidence="ECO:0007744|PDB:2GW5"
STRAND 176..183
/evidence="ECO:0007744|PDB:2GW5"
STRAND 188..190
/evidence="ECO:0007744|PDB:6BCS"
STRAND 193..199
/evidence="ECO:0007744|PDB:2GW5"
STRAND 203..207
/evidence="ECO:0007744|PDB:6BCS"
STRAND 214..217
/evidence="ECO:0007744|PDB:6BCS"
STRAND 226..231
/evidence="ECO:0007744|PDB:4LLA"
STRAND 233..235
/evidence="ECO:0007744|PDB:4LLA"
STRAND 241..249
/evidence="ECO:0007744|PDB:4LLA"
STRAND 252..258
/evidence="ECO:0007744|PDB:4LLA"
STRAND 264..268
/evidence="ECO:0007744|PDB:4LLA"
STRAND 277..283
/evidence="ECO:0007744|PDB:4LLA"
HELIX 288..290
/evidence="ECO:0007744|PDB:4LLA"
STRAND 292..299
/evidence="ECO:0007744|PDB:4LLA"
STRAND 313..317
/evidence="ECO:0007744|PDB:4LLA"
STRAND 326..331
/evidence="ECO:0007744|PDB:4LLA"
STRAND 333..335
/evidence="ECO:0007744|PDB:4LLA"
STRAND 342..349
/evidence="ECO:0007744|PDB:4LLA"
STRAND 352..361
/evidence="ECO:0007744|PDB:4LLA"
STRAND 366..369
/evidence="ECO:0007744|PDB:4LLA"
STRAND 371..373
/evidence="ECO:0007744|PDB:4LLA"
STRAND 376..382
/evidence="ECO:0007744|PDB:4LLA"
HELIX 388..390
/evidence="ECO:0007744|PDB:4LLA"
STRAND 392..400
/evidence="ECO:0007744|PDB:4LLA"
STRAND 403..407
/evidence="ECO:0007744|PDB:4LLA"
STRAND 414..418
/evidence="ECO:0007744|PDB:4LLA"
SEQUENCE 598 AA; 65039 MW; 33E9737AFCAFCE2D CRC64;
MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ GSLEAQEYRL
YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY YSRARWSELS DPLVLVMTGA
YPKPTLSAQP SPVVTSGGRV TLQCESQVAF GGFILCKEGE EEHPQCLNSQ PHARGSSRAI
FSVGPVSPNR RWSHRCYGYD LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES
LTLQCVSDVG YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH
NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ FHTFLLTKAG
AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL NSDPYLLSHP SEPLELVVSG
PSMGSSPPPT GPISTPAGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVV LLLLLLLLLF
LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ
PEDGVEMDTR AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH


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C485 Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 LIR-2 500
C484 Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 LIR-1 lmg
C485 Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 LIR-2 lmg
C484 Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 LIR-1 500
EH2451 Leukocyte immunoglobulin-like receptor subfamily A member 2 Elisa Kit 96T
C485 Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 LIR-1 l0
CG18 Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 LIR-2 l0
CG18 Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 LIR-1 50
EH2371 Leukocyte immunoglobulin-like receptor subfamily B member 2 Elisa Kit 96T
C369 Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 LIR-2 50
CA47 Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 LILRA2 500
EH2323 Leukocyte immunoglobulin-like receptor subfamily B member 4 Elisa Kit 96T
EH2452 Leukocyte immunoglobulin-like receptor subfamily B member 1 Elisa Kit 96T
CA47 Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 LILRA2 lmg
EIAAB07943 CD300 antigen-like family member A,Cd300a,Clm8,CLM-8,CMRF35-like molecule 8,Leukocyte mono-Ig-like receptor 1,Lmir1,MAIR-1,MAIR-I,Mast cell-derived paired immunoglobulin-like receptor 1,Mcpir1,Mouse,M
E91387Hu ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3) 96T/Kit
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Pathways :
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP2292: Chemokine signaling pathway
WP2328: Allograft rejection
WP407: Kit Receptor Signaling Pathway
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP2197: Endothelin
WP783: Androgen Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1025: B Cell Receptor Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP1284: EPO Receptor Signaling
WP581: EPO Receptor Signaling
WP1341: Kit Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP88: Toll Like Receptor signaling
WP1067: Toll-like receptor signaling pathway
WP897: Androgen receptor signaling pathway
WP1130: T Cell Receptor Signaling Pathway
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP732: Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP1354: B Cell Receptor Signaling Pathway
WP26: Signal Transduction of S1P Receptor
WP75: Toll-like receptor signaling pathway
WP1384: Toll-like receptor signaling pathway

Related Genes :
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[LILRA2 ILT1 LIR7] Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)
[LILRA5 ILT11 LILRB7 LIR9] Leukocyte immunoglobulin-like receptor subfamily A member 5 (CD85 antigen-like family member F) (Immunoglobulin-like transcript 11) (ILT-11) (Leukocyte immunoglobulin-like receptor 9) (LIR-9) (CD antigen CD85f)
[LILRA3 ILT6 LIR4] Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)
[LILRA4 ILT7] Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)
[Lilrb3 Pirb] Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (Cell-surface glycoprotein p91) (Paired immunoglobulin-like receptor B) (PIR-B)
[Cd300c2 Cd300c Clm4 Igsf7 Lmir2] CMRF-35-like molecule 4 (CLM-4) (CD300C molecule 2) (Dendritic cell-derived Ig-like receptor 1) (DIgR1) (Immunoglobulin superfamily member 7) (IgSF7) (Leukocyte mono-Ig-like receptor 2) (Myeloid-associated immunoglobulin-like receptor 2) (MAIR-2) (MAIR-II)
[KIR2DS2 CD158J NKAT5] Killer cell immunoglobulin-like receptor 2DS2 (CD158 antigen-like family member J) (MHC class I NK cell receptor) (NK receptor 183 ActI) (Natural killer-associated transcript 5) (NKAT-5) (p58 natural killer cell receptor clone CL-49) (p58 NK receptor CL-49) (CD antigen CD158j)
[Cd300lf Clm1 Lmir3] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Leukocyte mono-Ig-like receptor 3) (Myeloid-associated immunoglobulin-like receptor 5) (MAIR-5) (MAIR-V) (CD antigen CD300f)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)
[Fcgr2 Fcgr2b Ly-17] Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)
[KIR2DS1 CD158H] Killer cell immunoglobulin-like receptor 2DS1 (CD158 antigen-like family member H) (MHC class I NK cell receptor Eb6 ActI) (CD antigen CD158h)
[KIR2DS5 CD158G NKAT9] Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (MHC class I NK cell receptor) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[IGLL1 IGL1] Immunoglobulin lambda-like polypeptide 1 (CD179 antigen-like family member B) (Ig lambda-5) (Immunoglobulin omega polypeptide) (Immunoglobulin-related protein 14.1) (CD antigen CD179b)
[FCGR2B CD32 FCG2 IGFR2] Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
[KIR3DS1 NKAT10] Killer cell immunoglobulin-like receptor 3DS1 (MHC class I NK cell receptor) (Natural killer-associated transcript 10) (NKAT-10)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[FCGR3B CD16B FCG3 FCGR3 IGFR3] Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)
[FCGR3A CD16A FCG3 FCGR3 IGFR3] Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
[Cd79b Igb] B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
[Fcgr4] Low affinity immunoglobulin gamma Fc region receptor IV (CD16-2) (FcgammaRIV)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[IGSF8 CD81P3 EWI2 KCT4] Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
[HAVCR2 TIM3 TIMD3] Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)

Bibliography :