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Limulus clotting factor C (FC) (EC 3.4.21.84) [Cleaved into: Limulus clotting factor C heavy chain; Limulus clotting factor C light chain; Limulus clotting factor C chain A; Limulus clotting factor C chain B]

 LFC_CARRO               Reviewed;        1019 AA.
Q26422;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
29-SEP-2021, entry version 114.
RecName: Full=Limulus clotting factor C;
Short=FC;
EC=3.4.21.84;
Contains:
RecName: Full=Limulus clotting factor C heavy chain;
Contains:
RecName: Full=Limulus clotting factor C light chain;
Contains:
RecName: Full=Limulus clotting factor C chain A;
Contains:
RecName: Full=Limulus clotting factor C chain B;
Flags: Precursor;
Carcinoscorpius rotundicauda (Mangrove horseshoe crab) (Limulus
rotundicauda).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
Xiphosura; Limulidae; Carcinoscorpius.
NCBI_TaxID=6848;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Blood;
PubMed=7538401;
Ding J.L., Navas M.A. III, Ho B.;
"Molecular cloning and sequence analysis of factor C cDNA from the
Singapore horseshoe crab, Carcinoscorpius rotundicauda.";
Mol. Mar. Biol. Biotechnol. 4:90-103(1995).
-!- FUNCTION: This enzyme is closely associated with an endotoxin-sensitive
hemolymph coagulation system which may play important roles in both
hemostasis and host defense mechanisms. Its active form catalyzes the
activation of factor B.
-!- CATALYTIC ACTIVITY:
Reaction=Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125
bonds in Limulus clotting factor B to form activated factor B.
Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.;
EC=3.4.21.84;
-!- ACTIVITY REGULATION: Activated by Gram-negative bacterial
lipopolysaccharides and chymotrypsin. {ECO:0000250}.
-!- SUBUNIT: Heterodimer of a light chain and a heavy chain linked by a
disulfide bond. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted. Note=Secreted in hemolymph.
-!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
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EMBL; S77063; AAB34361.1; -; mRNA.
MEROPS; S01.219; -.
BRENDA; 3.4.21.84; 6973.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0042381; P:hemolymph coagulation; IEA:UniProtKB-KW.
CDD; cd00033; CCP; 5.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.170.130.20; -; 1.
Gene3D; 2.40.10.10; -; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR004043; LCCL.
InterPro; IPR036609; LCCL_sf.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR035976; Sushi/SCR/CCP_sf.
InterPro; IPR000436; Sushi_SCR_CCP_dom.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF03815; LCCL; 1.
Pfam; PF00059; Lectin_C; 1.
Pfam; PF00084; Sushi; 5.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00032; CCP; 5.
SMART; SM00034; CLECT; 1.
SMART; SM00603; LCCL; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF56436; SSF56436; 1.
SUPFAM; SSF57535; SSF57535; 5.
SUPFAM; SSF69848; SSF69848; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS50820; LCCL; 1.
PROSITE; PS50923; SUSHI; 5.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
2: Evidence at transcript level;
Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein;
Hemolymph clotting; Hydrolase; Lectin; Protease; Repeat; Secreted;
Serine protease; Signal; Sushi.
SIGNAL 1..25
/evidence="ECO:0000250"
CHAIN 26..1019
/note="Limulus clotting factor C"
/id="PRO_0000028430"
CHAIN 26..690
/note="Limulus clotting factor C heavy chain"
/id="PRO_0000028431"
CHAIN 691..1019
/note="Limulus clotting factor C light chain"
/id="PRO_0000028432"
CHAIN 691..762
/note="Limulus clotting factor C chain A"
/id="PRO_0000028433"
CHAIN 763..1019
/note="Limulus clotting factor C chain B"
/id="PRO_0000028434"
DOMAIN 102..137
/note="EGF-like"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
DOMAIN 140..197
/note="Sushi 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
DOMAIN 198..256
/note="Sushi 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
DOMAIN 258..323
/note="Sushi 3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
DOMAIN 325..421
/note="LCCL"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
DOMAIN 436..568
/note="C-type lectin"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
DOMAIN 574..636
/note="Sushi 4"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
DOMAIN 689..750
/note="Sushi 5"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
DOMAIN 763..1019
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
ACT_SITE 809
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 865
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 966
/note="Charge relay system"
/evidence="ECO:0000250"
BINDING 960
/note="Substrate"
/evidence="ECO:0000250"
CARBOHYD 523
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 534
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 624
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 740
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 767
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 912
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 106..118
/evidence="ECO:0000250"
DISULFID 112..125
/evidence="ECO:0000250"
DISULFID 127..136
/evidence="ECO:0000250"
DISULFID 142..182
/evidence="ECO:0000250"
DISULFID 168..195
/evidence="ECO:0000250"
DISULFID 199..241
/evidence="ECO:0000250"
DISULFID 227..254
/evidence="ECO:0000250"
DISULFID 260..308
/evidence="ECO:0000250"
DISULFID 294..321
/evidence="ECO:0000250"
DISULFID 331..350
/evidence="ECO:0000250"
DISULFID 354..374
/evidence="ECO:0000250"
DISULFID 436..447
/evidence="ECO:0000250"
DISULFID 464..564
/evidence="ECO:0000250"
DISULFID 538..556
/evidence="ECO:0000250"
DISULFID 576..621
/evidence="ECO:0000250"
DISULFID 607..634
/evidence="ECO:0000250"
DISULFID 720..748
/evidence="ECO:0000250"
DISULFID 794..810
/evidence="ECO:0000250"
DISULFID 932..951
/evidence="ECO:0000250"
DISULFID 962..996
/evidence="ECO:0000250"
SEQUENCE 1019 AA; 112430 MW; 918A1ED8B817B6C3 CRC64;
MVLASFLVSG LVLGLLAQKM RPVQSKGVDL GLCDETRFEC KCGDPGYVFN IPVKQCTYFY
RWRPYCKPCD DLEAKDICPK YKRCQECKAG LDSCVTCPPN KYGTWCSGEC QCKNGGICDQ
RTGACACRDR YEGVHCEILK GCPLLPSDSQ VQEVRNPPDN PQTIDYSCSP GFKLKGMARI
SCLPNGQWSN FPPKCIRECA MVSSPEHGKV NALSGDMIEG ATLRFSCDSP YYLIGQETLT
CQGNGQWNGQ IPQCKNLVFC PDLDPVNHAE HKVKIGVEQK YGQFPQGTEV TYTCSGNYFL
MGFDTLKCNP DGSWSGSQPS CVKVADREVD CDSKAVDFLD DVGEPVRIHC PAGCSLTAGT
VWGTAIYHEL SSVCRAAIHA GKLPNSGGAV HVVNNGPYSD FLGSDLNGIK SEELKSLARS
FRFDYVRSST AGKSGCPDGW FEVDENCVYV TSKQRAWERA QGVCTNMAAR LAVLDKDVIP
NSLTETLRGK GLTTTWIGLH RLDAEKPFIW ELMDRSNVVL NDNLTFWASG EPGNETNCVY
MDIQDQLQSV WKTKSCFQPS SFACMMDLSD RNKAKCDDPG SLENGHATLH GQSIDGFYAG
SSIRYSCEVL HYLSGTETVT CTTNGTWSAP KPRCIKVITC QNPPVPSYGS VEIKPPSRTN
SISRVGSPFL RLPRLPLPLA RAAKPPPKPR SSQPSTVDLA SKVKLPEGHY RVGSRAIYTC
ESRYYELLGS QGRRCDSNGN WSGRPASCIP VCGRSDSPRS PFIWNGNSTE IGQWPWQAGI
SRWLADHNMW FLQCGGSLLN EKWIVTAAHC VTYSATAEII DPNQFKMYLG KYYRDDSRDD
DYVQVREALE IHVNPNYDPG NLNFDIALIQ LKTPVTLTTR VQPICLPTDI TTREHLKEGT
LAVVTGWGLN ENNTYSETIQ QAVLPVVAAS TCEEGYKEAD LPLTVTENMF CAGYKKGRYD
ACSGDSGGPL VFADDSRTER RWVLEGIVSW GSPSGCGKAN QYGGFTKVNV FLSWIRQFI


Related products :

Catalog number Product name Quantity
orb81192 Limulus Antilipopolysaccharide Factor protein Recombinant LALF, entire coding region for limulus antilipopolysaccharide factor derived from Pichia pastoris. LALF is 12,000 dalton protein. The LALF is 20
RP-819 Recombinant Limulus Antilipopolysaccharide Factor 20 ug
PRO-361 Recombinant Limulus Antilipopolysaccharide Factor 20µg
PRO-361 Recombinant Limulus Antilipopolysaccharide Factor 100µg
PRO-361 Recombinant Limulus Antilipopolysaccharide Factor 500µg
BA1091 Limulus Antilipopolysaccharide Factor (LALF) 0.1 mg
ACLPRO361B Antilipopolysaccharide Factor, Limulus, recombinant 100 µg.
ACLPRO361 Antilipopolysaccharide Factor, Limulus, recombinant 20 µg.
OETPRO361 Limulus Antilipopolysaccharide Factor Recombinant 20
228-11006-1 Recombinant Limulus Antilipopolysaccharide Factor 20
OETPRO361 Limulus Antilipopolysaccharide Factor Recombinant 100
PA1299XC Limulus Antilipopolysaccharide Factor (LALF) 0.5 mg
228-11006-2 Recombinant Limulus Antilipopolysaccharide Factor 100
228-11006-3 Recombinant Limulus Antilipopolysaccharide Factor 500
BA1091 Limulus Antilipopolysaccharide Factor (LALF) 0.1 mg
Z5010496 Recombinant Limulus Antilipopolysaccharide Factor 100 µg
Z5010496 Recombinant Limulus Antilipopolysaccharide Factor 100 µg
BA1091 Limulus Antilipopolysaccharide Factor (LALF) 0.1 mg
PA1299 Limulus Antilipopolysaccharide Factor (LALF) 20 µg
PA1299X Limulus Antilipopolysaccharide Factor (LALF) 0.1 mg
RPRO-361B Recombinant Limulus Antilipopolysaccharide Factor 100µg
RPRO-361A Recombinant Limulus Antilipopolysaccharide Factor 20µg
RPRO-361C Recombinant Limulus Antilipopolysaccharide Factor 500µg
orb81192 Limulus Antilipopolysaccharide Factor protein Proteins 20
RPRO-361C Recombinant Limulus Antilipopolysaccharide Factor 500 µg
Pathways :
WP272: Blood Clotting Cascade
WP460: Blood Clotting Cascade
WP1818: Formation of Fibrin Clot (Clotting Cascade)
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2148: Brain derived neurotrophic factor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP255: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1122: Blood Clotting Cascade
WP775: Blood Clotting Cascade
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP887: Blood Clotting Cascade
WP1002: Electron Transport Chain
WP1673: Naphthalene and anthracene degradation
WP1119: Electron Transport Chain
WP772: Electron Transport Chain

Related Genes :
[] Clotting factor B (EC 3.4.21.85) (Coagulation factor B) [Cleaved into: Clotting factor B light chain; Clotting factor B heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F9] Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[F10 FX] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Virus-activating protease) (VAP) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[Cfi If] Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[yaiE ppnP yaiE_1 yaiE_2 A5U30_004171 A6519_004168 A6583_19230 A6592_08565 A8499_002689 A8C65_08910 A8W81_002402 A8X68_002957 A9819_01890 A9X72_19070 AAG43_001684 AAS29_000851 ABE90_005680 ABT96_001030 ACN002_0406 ACN68_10320 ACN81_25005 ACU57_12035 ACW72_000537 AM270_02350 AM340_00170 AM464_18935 AMK64_000048 AML23_18615 AO169_001228 APX88_10995 AT845_004245 AUQ29_12220 AW059_14025 AW086_04940 AW118_21925 AZZ83_000156 B2D52_001288 B5N24_001418 B6L15_000900 B6R12_004630 B6R15_004744 B6R17_001763 B6R27_001430 B6R48_001853 B6R87_002119 B7C15_002412 B9T59_05995 BANRA_00925 BANRA_01371 BANRA_02015 BANRA_03594 BB545_15535 BE963_16095 BER14_23410 BF271_000352 BFL24_02350 BG821_003456 BG944_000956 BH692_02565 BHF52_11910 BHS81_02405 BHS87_02130 BIQ87_02175 BIZ41_26355 BJI68_13875 BJJ90_20310 BK272_17750 BK292_14635 BK373_01320 BK375_26975 BKD45_000677 BMC34_003941 BMC79_001982 BMR21_14190 BMT50_02930 BMT91_05310 BN17_01951 BO068_001728 BOB65_000444 BOH76_16090 BON63_11530 BON65_18745 BON66_09075 BON70_06170 BON72_15085 BON73_05975 BON76_23825 BON83_20655 BON86_03800 BON87_15370 BON91_23895 BON92_15465 BON93_19270 BON94_14845 BON95_06500 BON96_22295 BON98_18895 BR158_003623 BR331_05500 BRV34_002179 BRV41_001603 BTQ06_17790 BUE81_15520 BUE82_18690 BvCms2454_01767 BvCmsC61A_02990 BvCmsHHP019_02594 BvCmsHHP019_02735 BvCmsHHP056_01410 BvCmsKKP005_02375 BvCmsKKP036_04281 BvCmsKKP057_03186 BvCmsKKP061_04019 BvCmsKSNP073_05624 BvCmsKSP011_04945 BvCmsKSP067_05191 BvCmsKSP076_04759 BvCmsNSNP036_04163 BvCmsSIP024_01003 BvCmsSIP082_02880 BVL39_00880 BWI89_12535 BXT93_00165 BZL69_16805 C2M16_02670 C2U48_08110 C3F40_10585 C4952_000933 C4M78_16865 C5542_003745 C5715_13595 C5F72_20070 C5N07_12740 C5Y87_03235 C6B22_00620 C6L19_003123 C6N50_002569 C7B02_04545 C9114_16640 C9160_00550 C9E67_23765 C9Z62_15540 C9Z68_20485 CA593_01185 CBT22_001283 CCS08_21635 CCZ91_001256 CD42_000819 CDC27_00860 CDL36_14165 CDL37_09465 CF32_001327 CG692_05055 CG831_000443 CIG67_05475 CLG78_001395 CN875_002288 CO706_24355 COD50_07875 CQP61_20925 CR539_06140 CS116_000640 CT143_00140 CV83915_01183 CWS33_22875 CXJ73_003963 CY655_02075 D0X26_07420 D1912_23295 D3822_22465 D3C88_28950 D3G36_08025 D3O91_15305 D3Y67_14350 D4U49_03050 D4V09_04715 D5H22_03840 D6T60_09300 D9D31_21970 D9D43_14830 D9D77_05600 D9E34_09525 D9E49_06955 D9H13_03415 D9H94_24405 D9J03_17400 D9J11_02150 D9J61_02635 D9K17_07345 DAH18_14975 DAH23_10455 DAH34_21345 DAH37_05240 DAH50_14800 DB282_04950 DD762_07680 DEN86_05080 DEN89_14495 DEN95_09255 DEO15_17360 DIV22_26285 DL654_17660 DLX40_16565 DM968_04210 DN627_04525 DNQ45_00335 DP258_05110 DRW19_06400 DS732_06920 DS966_18475 DTL43_07415 DTL90_10740 DTM10_06080 DTM45_10960 DU321_19460 DXB10_13805 DXT69_08115 DXT71_02970 DXT73_01860 E0I42_07410 E0N24_10860 E0P28_09655 E2119_01725 E2123_04610 E2127_09375 E2128_04435 E2129_13975 E2135_01410 E3N34_04125 E4K51_12070 E4K54_07340 E5P52_05895 E5S34_07545 E5S35_14895 E5S38_06765 E5S43_12135 E5S47_09895 E5S52_06115 E5S61_09810 E5S62_19990 EA239_15730 EA435_05820 EAI46_25725 EAI46_25840 EAN77_07940 EAX79_06830 EBP16_12520 EC1094V2_3464 EC3234A_4c00610 EC95NR1_04612 ECs0441 ED648_16775 EGC08_04505 EH88_002240 EHD79_03470 EHH55_15815 EI021_16245 EI041_08145 EIA13_09645 EIZ93_00830 EKI52_09170 EL79_3454 EL80_3408 ELT17_22260 ELT29_22585 ELT31_00280 ELT33_03015 ELT48_00735 ELT49_21480 ELT58_21305 ELT72_05540 ELU83_10395 ELU85_08960 ELU95_12465 ELV08_00785 ELV13_00555 ELV15_22680 ELV22_01630 ELV24_16525 ELV28_08410 ELX56_03900 ELX68_02065 ELX69_19550 ELX70_07125 ELX76_05850 ELX79_24270 ELX83_01445 ELX96_14305 ELY05_09885 ELY23_04665 ELY24_07180 ELY32_22740 ELY41_15435 ELY48_07355 ELY50_04295 EO241_13835 EPS76_10515 EQO00_19840 ERS085366_04179 ERS085386_01096 ERS085406_02227 ERS139208_01812 Esc0902E_04100 ETECE1373_03601 ETECE36_04584 ETECE925_03600 EVY14_00050 EWK56_10245 ExPECSC038_04895 EXX13_09665 EXX79_08270 EYX47_16280 EYX55_13650 EYY34_27625 F2N27_03375 F2N28_02020 F2N31_18495 F3N40_11580 F6U69_13610 F7F11_06850 F9386_04870 F9400_03995 F9407_08955 F9571_08760 F9B07_11235 F9S76_00660 F9S83_01525 F9V07_00950 F9V24_00540 F9X20_010625 F9X20_10705 FA849_16230 FA868_02660 FC554_02980 FDM60_01545 FEL34_02665 FFF58_18140 FGG80_03620 FGY90_08925 FHD44_10100 FHR00_04660 FJQ51_13145 FKO60_24460 FMP09_15400 FNJ67_20330 FOI11_011505 FOI11_08540 FPI65_02250 FPS82_09410 FQ021_04720 FQE77_10330 FQF29_11270 FTV90_10360 FTV92_11870 FTV93_12360 FV293_06120 FWK02_29295 FZC17_02065 FZN26_02330 FZN30_08825 FZN31_18905 G3565_02860 G3813_001670 G4A38_05410 G5696_10795 G6P89_19245 G6Z99_23355 G7635_000369 G9448_08700 GAJ26_09340 GBE29_07095 GF147_12390 GF646_06625 GF699_04160 GFY34_04590 GFY48_03475 GFZ60_05015 GIB53_01735 GJ11_02375 GKE84_19495 GKF52_17565 GKF86_04910 GKF89_04055 GKG12_02940 GKZ24_03305 GNO40_22710 GNZ05_01665 GOP20_09010 GP650_16700 GP662_13045 GP711_02810 GP946_18990 GP954_12950 GP979_17585 GQE42_04900 GQE64_07505 GQE87_15550 GQF58_00730 GQF59_00790 GQM04_16295 GQM06_17115 GQM09_10135 GQM10_05275 GQM13_16755 GQR15_01785 GQW07_10130 GQW68_15010 GQW76_11855 GQW80_20255 GRC73_12510 GRO95_09290 GRQ19_02985 GRW05_15575 GRW57_16360 GRW80_21245 GRW81_04110 GSY44_11760 GTP88_03425 GUB08_22335 GUB92_14995 GUC01_07480 GUI33_03675 GW978_01435 GXV26_001683 H0O53_01395 H0O72_08355 H4P47_18630 H4P50_19265 H4P51_19115 H5C78_05615 HCF72_000699 HH795_003019 HHH44_001374 HI055_001796 HIE44_000773 HIF90_002068 HIN64_001318 HIR12_001426 HIT56_001577 HJ942_001977 HJM92_003231 HJN04_001825 HJO75_000225 HJQ60_002362 HJS37_002167 HJS41_003943 HJU54_001570 HKA49_002910 HL563_20960 HLU10_04740 HLU56_09785 HLV18_07370 HLZ50_17655 HmCms169_03669 HmCms184_01874 HmCmsJML074_04353 HMS79_05370 HMT08_08320 HMT08_28135 HMU06_13895 HMU48_14510 HMV41_12865 HMV95_11570 HNC30_09785 HNC36_06780 HNC38_21355 HNC52_05780 HNC59_10160 HNC66_06600 HNC75_03340 HNC99_09055 HND24_23650 HNO08_21040 HNV65_12835 HNY50_21730 HNY54_14805 HPE39_05435 HV109_18115 HVV39_18775 HVV53_22620 HVW11_04845 HVW22_00965 HVW43_10265 HVX16_19490 HVY77_19945 HVZ33_18480 HVZ71_18990 HX136_19525 HZ71_000860 HZ72_001928 I6H02_19720 IA00_002609 JE86ST02C_04160 JE86ST05C_04220 MJ49_04490 MS7163_00387 NCTC10082_01078 NCTC10089_03910 NCTC10418_05682 NCTC10429_03762 NCTC10764_05371 NCTC10767_04209 NCTC10865_04787 NCTC11022_05137 NCTC11126_00022 NCTC11181_01145 NCTC11341_03896 NCTC12950_04180 NCTC13127_05156 NCTC13216_02895 NCTC7922_06246 NCTC7927_04270 NCTC8008_03382 NCTC8009_07014 NCTC8179_01642 NCTC8450_01367 NCTC8500_04283 NCTC8621_03984 NCTC8622_02997 NCTC8959_05017 NCTC8960_01314 NCTC8985_02798 NCTC9001_00537 NCTC9036_03840 NCTC9044_03501 NCTC9045_04434 NCTC9048_04159 NCTC9050_01764 NCTC9075_05103 NCTC9077_04792 NCTC9081_02496 NCTC9111_03977 NCTC9117_04804 NCTC9434_02812 NCTC9702_04480 NCTC9703_03222 NCTC9706_01114 NCTC9775_02088 NCTC9777_00174 NCTC9969_04032 ND22_001447 PGD_02920 PU06_02955 RG28_02910 SAMEA3472043_02682 SAMEA3472044_00466 SAMEA3472056_03633 SAMEA3472064_01205 SAMEA3472080_01810 SAMEA3472112_02965 SAMEA3472117_02973 SAMEA3472120_01236 SAMEA3472147_04902 SAMEA3484427_03543 SAMEA3484429_01888 SAMEA3485101_03989 SAMEA3485110_03675 SAMEA3751407_02141 SAMEA3752312_01369 SAMEA3752386_01995 SAMEA3752557_00215 SAMEA3753064_01236 SAMEA3753290_01725 SAMEA3753300_00458 SM09_01165 THOESC010_34040 TUM18780_32860 UN91_18725 WP2S18E08_35360 WP4S18E07_34480 WP4S18E08_34230 WQ89_01420 WR15_04360] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[CFI IF] Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]
[KNG1 BDK KNG] Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]
[Masp1 Crarf Masp3] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[PROC] Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
[] Thrombin-like enzyme cerastocytin (SVTLE) (EC 3.4.21.-) (C.cerastes platelet proaggregant protein) (CC-PPP) (Factor VIII activator) (Fibrinogen-clotting enzyme) (Proaggregant serine proteinase) (Snake venom serine protease) (SVSP)
[F8 F8C] Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[] Venom prothrombin activator pseutarin-C catalytic subunit (PCCS) (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Pseutarin-C catalytic subunit light chain; Pseutarin-C catalytic subunit heavy chain]
[Hcfc1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[Klkb1 Klk3 Pk] Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
[F5] Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
[] Thrombin-like enzyme stejnobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[F12] Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
[] Intracellular coagulation inhibitor 1 (Limulus intracellular coagulation inhibitor 1) (LICI-1)
[HABP2 HGFAL PHBP] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[F10 TrFX] Coagulation factor X (EC 3.4.21.6) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[ORF1ab ORF1a orf1ab] 3C-like proteinase (EC 3.4.19.12) (EC 3.4.22.69) (Growth factor-like peptide) (Leader protein) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (Papain-like proteinase) (p65 homolog)

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