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Lipolysis-stimulated lipoprotein receptor (Lipolysis-stimulated receptor) (Liver-specific bHLH-Zip transcription factor) (Liver-specific gene on mouse chromosome 7 protein)

 LSR_MOUSE               Reviewed;         594 AA.
Q99KG5; Q3TJE7; Q3UIQ9; Q61148; Q61149; Q6U816;
11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
13-FEB-2019, entry version 136.
RecName: Full=Lipolysis-stimulated lipoprotein receptor;
AltName: Full=Lipolysis-stimulated receptor;
AltName: Full=Liver-specific bHLH-Zip transcription factor;
AltName: Full=Liver-specific gene on mouse chromosome 7 protein;
Flags: Precursor;
Name=Lsr; Synonyms=Lisch7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
[GENOMIC DNA] OF 256-594.
STRAIN=C57BL/6 X CBA;
Lin Q., Ooi K.S., Sawadogo M.;
"Lisch7, a liver-specific gene immediately upstream of the USF2 gene
on mouse chromosome 7.";
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
STRAIN=C57BL/6J; TISSUE=Amnion, and Placenta;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-576, FUNCTION, TISSUE
SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
STRAIN=129/Ola;
PubMed=15265030; DOI=10.1111/j.1432-1033.2004.04223.x;
Mesli S., Javorschi S., Berard A.M., Landry M., Priddle H.,
Kivlichan D., Smith A.J.H., Yen F.T., Bihain B.E., Darmon M.;
"Distribution of the lipolysis stimulated receptor in adult and
embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
14.5 days of gestation.";
Eur. J. Biochem. 271:3103-3114(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308 AND SER-588, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375 AND SER-379, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Probable role in the clearance of triglyceride-rich
lipoprotein from blood. Binds chylomicrons, LDL and VLDL in
presence of free fatty acids and allows their subsequent uptake in
the cells (By similarity). {ECO:0000250,
ECO:0000269|PubMed:15265030}.
-!- SUBUNIT: Homotrimer or homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
type I membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q99KG5-1; Sequence=Displayed;
Name=2;
IsoId=Q99KG5-2; Sequence=VSP_019696;
Name=3;
IsoId=Q99KG5-3; Sequence=VSP_019695;
-!- TISSUE SPECIFICITY: Specifically expressed in liver and to a lower
extent in kidney (at protein level). Also detected in brain,
testis, ovaries, adrenal gland, intestine, muscle, and lung.
{ECO:0000269|PubMed:15265030}.
-!- DEVELOPMENTAL STAGE: Expressed during embryogenesis (at protein
level). Detected from 7.5 dpc to 17 dpc.
{ECO:0000269|PubMed:15265030}.
-!- DISRUPTION PHENOTYPE: Death between 12.5 dpc and 15.5 dpc probably
due to impaired liver and embryonic development.
{ECO:0000269|PubMed:15265030}.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. LISCH7
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA92719.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; U49507; AAA92719.1; ALT_FRAME; mRNA.
EMBL; U49508; AAA92720.1; -; Genomic_DNA.
EMBL; AK146807; BAE27447.1; -; mRNA.
EMBL; AK167463; BAE39548.1; -; mRNA.
EMBL; BC004672; AAH04672.1; -; mRNA.
EMBL; AY376636; AAQ83379.1; -; Genomic_DNA.
CCDS; CCDS21119.1; -. [Q99KG5-1]
CCDS; CCDS52185.1; -. [Q99KG5-3]
CCDS; CCDS52186.1; -. [Q99KG5-2]
RefSeq; NP_001157656.1; NM_001164184.1. [Q99KG5-2]
RefSeq; NP_001157657.1; NM_001164185.1. [Q99KG5-3]
RefSeq; NP_059101.1; NM_017405.2. [Q99KG5-1]
UniGene; Mm.4067; -.
ProteinModelPortal; Q99KG5; -.
BioGrid; 207572; 1.
IntAct; Q99KG5; 2.
MINT; Q99KG5; -.
iPTMnet; Q99KG5; -.
PhosphoSitePlus; Q99KG5; -.
SwissPalm; Q99KG5; -.
jPOST; Q99KG5; -.
PaxDb; Q99KG5; -.
PeptideAtlas; Q99KG5; -.
PRIDE; Q99KG5; -.
Ensembl; ENSMUST00000001279; ENSMUSP00000001279; ENSMUSG00000001247. [Q99KG5-1]
Ensembl; ENSMUST00000098553; ENSMUSP00000096153; ENSMUSG00000001247. [Q99KG5-3]
Ensembl; ENSMUST00000108116; ENSMUSP00000103751; ENSMUSG00000001247. [Q99KG5-2]
Ensembl; ENSMUST00000205961; ENSMUSP00000146120; ENSMUSG00000001247. [Q99KG5-1]
GeneID; 54135; -.
KEGG; mmu:54135; -.
UCSC; uc009ghj.2; mouse. [Q99KG5-1]
UCSC; uc009ghk.2; mouse. [Q99KG5-2]
UCSC; uc009ghl.2; mouse. [Q99KG5-3]
CTD; 51599; -.
MGI; MGI:1927471; Lsr.
eggNOG; ENOG410IKMJ; Eukaryota.
eggNOG; ENOG411004A; LUCA.
GeneTree; ENSGT00940000153958; -.
HOGENOM; HOG000253962; -.
HOVERGEN; HBG061576; -.
InParanoid; Q99KG5; -.
OMA; YDQDDPR; -.
OrthoDB; 457764at2759; -.
PhylomeDB; Q99KG5; -.
TreeFam; TF330877; -.
PRO; PR:Q99KG5; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000001247; Expressed in 230 organ(s), highest expression level in jejunum.
ExpressionAtlas; Q99KG5; baseline and differential.
Genevisible; Q99KG5; MM.
GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:HGNC.
GO; GO:0061689; C:tricellular tight junction; IDA:MGI.
GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
GO; GO:0030228; F:lipoprotein particle receptor activity; TAS:HGNC.
GO; GO:0030169; F:low-density lipoprotein particle binding; TAS:HGNC.
GO; GO:0060856; P:establishment of blood-brain barrier; IMP:UniProtKB.
GO; GO:0042953; P:lipoprotein transport; TAS:HGNC.
GO; GO:0001889; P:liver development; IMP:HGNC.
GO; GO:0019216; P:regulation of lipid metabolic process; ISO:MGI.
GO; GO:1904274; P:tricellular tight junction assembly; IMP:UniProtKB.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR003599; Ig_sub.
InterPro; IPR008664; LISCH7.
Pfam; PF05624; LSR; 1.
SMART; SM00409; IG; 1.
SUPFAM; SSF48726; SSF48726; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Chylomicron; Complete proteome;
Disulfide bond; Immunoglobulin domain; LDL; Membrane; Phosphoprotein;
Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix; VLDL.
SIGNAL 1 35 {ECO:0000255}.
CHAIN 36 594 Lipolysis-stimulated lipoprotein
receptor.
/FTId=PRO_0000245309.
TOPO_DOM 36 206 Extracellular. {ECO:0000255}.
TRANSMEM 207 227 Helical. {ECO:0000255}.
TOPO_DOM 228 594 Cytoplasmic. {ECO:0000255}.
DOMAIN 89 181 Ig-like V-type.
COMPBIAS 227 251 Cys-rich.
MOD_RES 283 283 Phosphothreonine.
{ECO:0000250|UniProtKB:Q9WU74}.
MOD_RES 308 308 Phosphoserine.
{ECO:0000244|PubMed:17242355}.
MOD_RES 314 314 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 332 332 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 375 375 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 379 379 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 396 396 Phosphothreonine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 407 407 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 410 410 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 436 436 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 471 471 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 473 473 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 478 478 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 576 576 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
MOD_RES 588 588 Phosphoserine.
{ECO:0000244|PubMed:17242355}.
MOD_RES 591 591 Phosphoserine.
{ECO:0000250|UniProtKB:Q86X29}.
DISULFID 113 165 {ECO:0000250}.
VAR_SEQ 187 255 GRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLFFLLLGIC
WCQCCPHTCCCYVRCPCCPDKCCCPEAL -> V (in
isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_019695.
VAR_SEQ 187 205 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_019696.
CONFLICT 423 423 P -> T (in Ref. 1; AAA92720).
{ECO:0000305}.
CONFLICT 456 456 P -> H (in Ref. 2; BAE39548).
{ECO:0000305}.
CONFLICT 579 579 R -> L (in Ref. 1; AAA92720).
{ECO:0000305}.
SEQUENCE 594 AA; 66108 MW; 2ADE28BB870A001D CRC64;
MAPAASACAG APGSHPATTI FVCLFLIIYC PDRASAIQVT VPDPYHVVIL FQPVTLHCTY
QMSNTLTAPI VIWKYKSFCR DRVADAFSPA SVDNQLNAQL AAGNPGYNPY VECQDSVRTV
RVVATKQGNA VTLGDYYQGR RITITGNADL TFEQTAWGDS GVYYCSVVSA QDLDGNNEAY
AELIVLGRTS EAPELLPGFR AGPLEDWLFV VVVCLASLLF FLLLGICWCQ CCPHTCCCYV
RCPCCPDKCC CPEALYAAGK AATSGVPSIY APSIYTHLSP AKTPPPPPAM IPMRPPYGYP
GDFDRTSSVG GHSSQVPLLR EVDGSVSSEV RSGYRIQANQ QDDSMRVLYY MEKELANFDP
SRPGPPNGRV ERAMSEVTSL HEDDWRSRPS RAPALTPIRD EEWNRHSPRS PRTWEQEPLQ
EQPRGGWGSG RPRARSVDAL DDINRPGSTE SGRSSPPSSG RRGRAYAPPR SRSRDDLYDP
DDPRDLPHSR DPHYYDDLRS RDPRADPRSR QRSHDPRDAG FRSRDPQYDG RLLEEALKKK
GAGERRRVYR EEEEEEEEGH YPPAPPPYSE TDSQASRERR MKKNLALSRE SLVV


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Pathways :
WP1025: B Cell Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1144: B Cell Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1449: Regulation of toll-like receptor signaling pathway
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1963: The effect of Glucocorticoids on target gene expression
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP794: B Cell Receptor Signaling Pathway
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP908: B Cell Receptor Signaling Pathway
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1067: Toll-like receptor signaling pathway

Related Genes :
[Lsr Lisch7] Lipolysis-stimulated lipoprotein receptor (Lipolysis-stimulated receptor) (Liver-specific bHLH-Zip transcription factor) (Liver-specific gene on mouse chromosome 7 protein)
[Lsr Lisch7] Lipolysis-stimulated lipoprotein receptor (Lipolysis-stimulated remnant receptor)
[LSR LISCH] Lipolysis-stimulated lipoprotein receptor
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)
[Kdr Flk-1 Flk1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase NYK) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[Flt3 Flk-2 Flt-3] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135)
[Nr1h4 Bar Fxr Rip14] Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
[Cebpb] CCAAT/enhancer-binding protein beta (C/EBP beta) (AGP/EBP) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched transcriptional activator) (LAP)
[Akt1 Akt Rac] RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[HNF1A TCF1] Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[Arntl Bmal1] Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arnt3) (Brain and muscle ARNT-like 1)
[Egfr] Epidermal growth factor receptor (EC 2.7.10.1)
[Lrp5 Lr3 Lrp7] Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
[Rab7a Rab7] Ras-related protein Rab-7a
[CEBPB TCF5 PP9092] CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
[Stra6] Receptor for retinol uptake STRA6 (Retinoic acid-responsive protein) (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein)
[KDR FLK1 VEGFR2] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[Esr1 Esr Estr Estra Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[Ptf1a Ptf1p48] Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)
[Gbx2 Mmoxa Stra7] Homeobox protein GBX-2 (Gastrulation and brain-specific homeobox protein 2) (Stimulated by retinoic acid gene 7 protein)
[Insr] Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
[Hnf4a Hnf-4 Hnf4 Nr2a1 Tcf14] Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
[Nr2c1 Tr2 Tr2-11] Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) (mTR2)
[Tcf7l2 Tcf4] Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (mTCF-4)
[Csf1r Csfmr Fms] Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

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