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Long neurotoxin OH-56

 3L256_OPHHA             Reviewed;          91 AA.
Q53B57;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 1.
31-JUL-2019, entry version 51.
RecName: Full=Long neurotoxin OH-56;
Flags: Precursor;
Ophiophagus hannah (King cobra) (Naja hannah).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
NCBI_TaxID=8665;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
PubMed=15302536; DOI=10.1016/j.toxicon.2004.06.003;
He Y.-Y., Lee W.-H., Zhang Y.;
"Cloning and purification of alpha-neurotoxins from king cobra
(Ophiophagus hannah).";
Toxicon 44:295-303(2004).
[2]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
PubMed=24297900; DOI=10.1073/pnas.1314702110;
Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
Richardson M.K.;
"The king cobra genome reveals dynamic gene evolution and adaptation
in the snake venom system.";
Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
-!- FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1)
and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor
(nAChR) and inhibits acetylcholine from binding to the receptor,
thereby impairing neuromuscular and neuronal transmission.
{ECO:0000250|UniProtKB:P60615}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24297900}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Long-
chain subfamily. Type II alpha-neurotoxin sub-subfamily.
{ECO:0000305}.
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EMBL; AY596929; AAT97251.1; -; mRNA.
SMR; Q53B57; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Acetylcholine receptor inhibiting toxin; Disulfide bond;
Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
Secreted; Signal; Toxin.
SIGNAL 1 21 {ECO:0000250}.
CHAIN 22 91 Long neurotoxin OH-56.
/FTId=PRO_5000093322.
DISULFID 24 42 {ECO:0000250}.
DISULFID 35 63 {ECO:0000250}.
DISULFID 48 52 {ECO:0000250}.
DISULFID 67 78 {ECO:0000250}.
DISULFID 79 84 {ECO:0000250}.
SEQUENCE 91 AA; 9918 MW; DB1FA749FC8FDC45 CRC64;
MKTLLLTLVV VTIMCLDLGY TTKCYVTPDV TSQTCPDGQN ICYTETWCDA WCGSRGKRVN
LGCAATCPKV NPGVDIICCS TDNCNPFPKR S


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Pathways :
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Related Genes :
[] Neurotoxin Oh9-1 (OMEGA-neurotoxin Oh9-1)
[] Alpha-elapitoxin-Oh2b (Alpha-EPTX-Oh2b) (Alpha-neurotoxin) (LNTX3) (Long neurotoxin OH-6A/OH-6B) (OH-3)
[] Alpha-cobratoxin (Alpha-CbT) (alpha-CT) (alpha-Cbtx) (Alpha-elapitoxin-Nk2a) (Alpha-EPTX-Nk2a) (Long neurotoxin 1) (Siamensis 3)
[] Botulinum neurotoxin type C (BoNT/C) (Bontoxilysin-C1) (BoNT/C1) (Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin C heavy chain (HC)]
[botB] Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin B heavy chain (HC)]
[botD] Botulinum neurotoxin type D (BoNT/D) (Bontoxilysin-D) [Cleaved into: Botulinum neurotoxin D light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin D heavy chain (HC)]
[F bont boNT/F CLI_0851] Botulinum neurotoxin type F (BoNT/F) (Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin F heavy chain (HC)]
[] Alpha-elapitoxin-Ls2a (Alpha-EPTX-Ls2a) (Long neurotoxin Ls3) (LsIII) (Ls III) (Neurotoxin 1) (Neurotoxin alpha)
[] Alpha-bungarotoxin (Alpha-Bgtx) (Alpha-Btx) (Alpha-bungarotoxin isoform A31) (Alpha-BTX A31) (Alpha-Bgt(A31)) (BGTX A31) (Long neurotoxin 1)
[] Kappa-bungarotoxin (Kappa-bgt) (Kappa-1-bungarotoxin) (Long neurotoxin 2) (Neuronal bungarotoxin) (nBgt) (Toxin F)
[v1g113139] N.vectensis toxin 1 3 (Nv1) (Delta-edwarditoxin-Nvc1c) (Delta-EWTX-Nvc1c) (Delta-edwarditoxin-Nvc1d) (Delta-EWTX-Nvc1d) (Neurotoxin Nv1-116.28.1) (Neurotoxin Nv1-13) (Neurotoxin Nv1-15) (Neurotoxin Nv1-17) (Neurotoxin Nv1-18) (Neurotoxin Nv1-19) (Neurotoxin Nv1-2) (Neurotoxin Nv1-4) (Neurotoxin Nv1-5) (Neurotoxin Nv1-8)
[botA atx bonT] Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX) (Botulinum neurotoxin type A1) [Cleaved into: Botulinum neurotoxin A light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A heavy chain (HC)]
[] Neurotoxin BmK-M10 (Alpha-neurotoxin TX9) (BmK AngM1) (BmK-X) (BmKX) (BmK10) (BmKalphaTx9) (Bmk M10) (BmkM10) (Neurotoxin M10)
[botE] Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin E heavy chain (HC)]
[botA bna CBO0806 CLC_0862] Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A heavy chain (HC)]
[botG] Botulinum neurotoxin type G (BoNT/G) (Bontoxilysin-G) [Cleaved into: Botulinum neurotoxin G light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin G heavy chain (HC)]
[botF] Botulinum neurotoxin type F (BoNT/F) (Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin F heavy chain (HC)]
[botA atx bna bonT CLM_0897] Botulinum neurotoxin type A2 (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A2 light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A2 heavy chain (HC)]
[CBB2_0680] Botulinum neurotoxin type X (BoNT/X) (Bontoxilysin-X) [Cleaved into: Botulinum neurotoxin X light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin X heavy chain (HC)]
[] Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin E heavy chain (HC)]
[] Erabutoxin a (ETXA) (Ea) (Short neurotoxin 1a)
[] Alpha-like toxin BeM9 (Neurotoxin M9)
[v1g113210] N.vectensis toxin 1 4 (Nv1) (Neurotoxin Nv1-11) (Neurotoxin Nv1-116.37.1) (Neurotoxin Nv1-16) (Neurotoxin Nv3-1) (Neurotoxin Nv3-3)
[] Alpha-mammal toxin AaH2 (AaH II) (AaHII) (Neurotoxin II) (Toxin II)
[let-767 dhs-10 C56G2.6] Very-long-chain 3-oxooacyl-coA reductase let-767 (EC 1.1.1.330) (Lethal protein 767) (Putative steroid dehydrogenase let-767) (Short-chain dehydrogenase 10)
[] Delta-actitoxin-Avd2a (Delta-AITX-Avd2a) (ATX III) (Av3) (Neurotoxin 3) (Neurotoxin III)
[botB CLD_A0068] Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin B heavy chain (HC)]
[] Lipolysis-activating peptide 1-alpha chain (BotLVP1-alpha) (LVP1-alpha) [Cleaved into: Neurotoxin BmKBTx-like]
[] Long neurotoxin OH-55 (CM-11)
[] Alpha-elapitoxin-Nno2a (Alpha-EPTX-Nno2a) (Long neurotoxin 1) (Neurotoxin I) (NT I) (Ntx-1) (Toxin I) (NnoI)

Bibliography :
[31417406] A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.
[31415259] Botulinum Toxin A Improves Supramuscular Fat Graft Retention by Enhancing Angiogenesis and Adipogenesis.
[31413896] Treatment with Botulinum Neurotoxin Improves Activities of Daily Living and Quality of Life in Patients with Upper Limb Tremor.
[31413225] [Adverse events of botulinum toxin A in facial injection: Mechanism, prevention and treatment].
[31394847] Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice.
[31382438] Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia.
[31362422] Bottom-Up Proteomic Analysis of Polypeptide Venom Components of the Giant Ant .
[31342953] Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts.
[31254543] Investigating the Role of the Hypothalamus in Outcomes to Repetitive Mild Traumatic Brain Injury: Neonatal Monosodium Glutamate Does Not Exacerbate Deficits.
[31232563] Molecular Characterization of a Three-disulfide Bridges Beta-like Neurotoxin from Androctonus crassicauda Scorpion Venom.