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Long neurotoxin OH-56

 3L256_OPHHA             Reviewed;          91 AA.
Q53B57;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 1.
11-DEC-2019, entry version 52.
RecName: Full=Long neurotoxin OH-56;
Flags: Precursor;
Ophiophagus hannah (King cobra) (Naja hannah).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
NCBI_TaxID=8665;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
PubMed=15302536; DOI=10.1016/j.toxicon.2004.06.003;
He Y.-Y., Lee W.-H., Zhang Y.;
"Cloning and purification of alpha-neurotoxins from king cobra (Ophiophagus
hannah).";
Toxicon 44:295-303(2004).
[2]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
PubMed=24297900; DOI=10.1073/pnas.1314702110;
Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
"The king cobra genome reveals dynamic gene evolution and adaptation in the
snake venom system.";
Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
-!- FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1) and
neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and
inhibits acetylcholine from binding to the receptor, thereby impairing
neuromuscular and neuronal transmission.
{ECO:0000250|UniProtKB:P60615}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24297900}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Long-chain
subfamily. Type II alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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EMBL; AY596929; AAT97251.1; -; mRNA.
SMR; Q53B57; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Acetylcholine receptor inhibiting toxin; Disulfide bond;
Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
Signal; Toxin.
SIGNAL 1..21
/evidence="ECO:0000250"
CHAIN 22..91
/note="Long neurotoxin OH-56"
/id="PRO_5000093322"
DISULFID 24..42
/evidence="ECO:0000250"
DISULFID 35..63
/evidence="ECO:0000250"
DISULFID 48..52
/evidence="ECO:0000250"
DISULFID 67..78
/evidence="ECO:0000250"
DISULFID 79..84
/evidence="ECO:0000250"
SEQUENCE 91 AA; 9918 MW; DB1FA749FC8FDC45 CRC64;
MKTLLLTLVV VTIMCLDLGY TTKCYVTPDV TSQTCPDGQN ICYTETWCDA WCGSRGKRVN
LGCAATCPKV NPGVDIICCS TDNCNPFPKR S


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Related Genes :
[] Neurotoxin Oh9-1 (OMEGA-neurotoxin Oh9-1) (Three-finger toxin) (3FTx)
[] Alpha-elapitoxin-Oh2b (Alpha-EPTX-Oh2b) (Alpha-neurotoxin) (LNTX3) (Long neurotoxin OH-6A/OH-6B) (OH-3)
[] Alpha-cobratoxin (Alpha-CbT) (alpha-CT) (alpha-Cbtx) (Alpha-elapitoxin-Nk2a) (Alpha-EPTX-Nk2a) (Long neurotoxin 1) (Siamensis 3)
[] Botulinum neurotoxin type C (BoNT/C) (Bontoxilysin-C1) (BoNT/C1) (Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin C heavy chain (HC)]
[botB] Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin B heavy chain (HC)]
[botD] Botulinum neurotoxin type D (BoNT/D) (Bontoxilysin-D) [Cleaved into: Botulinum neurotoxin D light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin D heavy chain (HC)]
[F bont boNT/F CLI_0851] Botulinum neurotoxin type F (BoNT/F) (Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin F heavy chain (HC)]
[] Alpha-elapitoxin-Ls2a (Alpha-EPTX-Ls2a) (Long neurotoxin Ls3) (LsIII) (Ls III) (Neurotoxin 1) (Neurotoxin alpha)
[] Alpha-bungarotoxin (Alpha-Bgtx) (Alpha-Btx) (Alpha-bungarotoxin isoform A31) (Alpha-BTX A31) (Alpha-Bgt(A31)) (BGTX A31) (Long neurotoxin 1)
[] Kappa-bungarotoxin (Kappa-bgt) (Kappa-1-bungarotoxin) (Long neurotoxin 2) (Neuronal bungarotoxin) (nBgt) (Toxin F)
[v1g113139] N.vectensis toxin 1 3 (Nv1) (Delta-edwarditoxin-Nvc1c) (Delta-EWTX-Nvc1c) (Delta-edwarditoxin-Nvc1d) (Delta-EWTX-Nvc1d) (Neurotoxin Nv1-116.28.1) (Neurotoxin Nv1-13) (Neurotoxin Nv1-15) (Neurotoxin Nv1-17) (Neurotoxin Nv1-18) (Neurotoxin Nv1-19) (Neurotoxin Nv1-2) (Neurotoxin Nv1-4) (Neurotoxin Nv1-5) (Neurotoxin Nv1-8)
[] Neurotoxin BmK-M10 (Alpha-neurotoxin TX9) (BmK AngM1) (BmK-X) (BmKX) (BmK10) (BmKalphaTx9) (Bmk M10) (BmkM10) (Neurotoxin M10)
[botA atx bonT] Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX) (Botulinum neurotoxin type A1) [Cleaved into: Botulinum neurotoxin A light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A heavy chain (HC)]
[] Alpha-like toxin BeM9 (Neurotoxin M9)
[botE] Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin E heavy chain (HC)]
[botA bna CBO0806 CLC_0862] Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A heavy chain (HC)]
[botG] Botulinum neurotoxin type G (BoNT/G) (Bontoxilysin-G) [Cleaved into: Botulinum neurotoxin G light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin G heavy chain (HC)]
[v1g113210] N.vectensis toxin 1 4 (Nv1) (Neurotoxin Nv1-11) (Neurotoxin Nv1-116.37.1) (Neurotoxin Nv1-16) (Neurotoxin Nv3-1) (Neurotoxin Nv3-3)
[botF] Botulinum neurotoxin type F (BoNT/F) (Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin F heavy chain (HC)]
[botA atx bna bonT CLM_0897] Botulinum neurotoxin type A2 (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A2 light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A2 heavy chain (HC)]
[CBB2_0680] Botulinum neurotoxin type X (BoNT/X) (Bontoxilysin-X) [Cleaved into: Botulinum neurotoxin X light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin X heavy chain (HC)]
[] Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin E heavy chain (HC)]
[] Erabutoxin a (ETXA) (Ea) (Short neurotoxin 1a)
[] Alpha-mammal toxin AaH2 (AaH II) (AaHII) (Neurotoxin II) (Toxin II)
[] Long neurotoxin OH-55 (CM-11)
[botB CLD_A0068] Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin B heavy chain (HC)]
[] Lipolysis-activating peptide 1-alpha chain (BotLVP1-alpha) (LVP1-alpha) [Cleaved into: Neurotoxin BmKBTx-like]
[] Delta-actitoxin-Avd2a (Delta-AITX-Avd2a) (ATX III) (Av3) (Neurotoxin 3) (Neurotoxin III)
[let-767 dhs-10 C56G2.6] Very-long-chain 3-oxooacyl-coA reductase let-767 (EC 1.1.1.330) (Lethal protein 767) (Putative steroid dehydrogenase let-767) (Short-chain dehydrogenase 10)
[] Alpha-elapitoxin-Nno2a (Alpha-EPTX-Nno2a) (Long neurotoxin 1) (Neurotoxin I) (NT I) (Ntx-1) (Toxin I) (NnoI)

Bibliography :
[31953609] Role of Metallothionein-1 and Metallothionein-2 in the Neuroprotective Mechanism of Sevoflurane Preconditioning in Mice.
[31939043] p-Chloroamphetamine-Enhanced Neostriatal Dopamine Exocytosis in Rats Neonatally Co-lesioned with 6-OHDA and 5,7-DHT: Relevance to Parkinson's Disease.
[31928234] 6-Formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene mitigates methamphetamine-induced photoreceptor cell toxicity through inhibiting oxidative stress.
[31905279] The Effects of Intradetrusor BoNT-A Injections on Vesicoureteral Reflux in Children With Myelodysplasia.
[31887191] Variations in neurotoxicity and proteome profile of Malayan krait (Bungarus candidus) venoms.
[31856552] Response to comments on: Ocular surface status in patients with hemifacial spasm under long-lasting treatment with botulinum A toxin: A comparative fellow eye study.
[31856551] Comments on: Ocular surface status in patients with hemifacial spasm under long-lasting treatment with botulinum A toxin: A comparative fellow eye study.
[31856406] How long does the effect of botulinum toxin in neurogenic patients last? An analysis of the subset of "good responders".
[31843645] Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
[31838305] Acute and long-term manganese exposure and subsequent accumulation in relation to idiopathic blindness in the American lobster, Homarus americanus.