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Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)

 FCG2B_HUMAN             Reviewed;         310 AA.
P31994; A6H8N3; O95649; Q53X85; Q5VXA9; Q8NIA1;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-APR-2021, entry version 224.
RecName: Full=Low affinity immunoglobulin gamma Fc region receptor II-b;
Short=IgG Fc receptor II-b;
AltName: Full=CDw32;
AltName: Full=Fc-gamma RII-b;
Short=Fc-gamma-RIIb;
Short=FcRII-b;
AltName: CD_antigen=CD32;
Flags: Precursor;
Name=FCGR2B; Synonyms=CD32, FCG2, IGFR2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1; IIB2; 4 AND 5), AND VARIANT
THR-232.
TISSUE=Lymphocyte;
Ng S., Sinclair N.R.S., Anderson C., Bell D.A., Cairns E.;
"Fc-gamma-RIIb nucleotide sequences in SLE and non-SLE humans in vivo
derived lymphocytes.";
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
TISSUE=Placenta;
PubMed=2531080; DOI=10.1002/j.1460-2075.1989.tb08540.x;
Stuart S.G., Simister N.E., Clarkson S.B., Kacinski B.M., Shapiro M.,
Mellman I.;
"Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in
macrophages, lymphocytes and IgG-transporting placental epithelium.";
EMBO J. 8:3657-3666(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1; IIB2 AND IIB3), AND VARIANT
PHE-205.
PubMed=2529342; DOI=10.1084/jem.170.4.1369;
Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V.;
"Structure and expression of human IgG FcRII(CD32). Functional
heterogeneity is encoded by the alternatively spliced products of multiple
genes.";
J. Exp. Med. 170:1369-1385(1989).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
TISSUE=Placenta;
PubMed=2142460; DOI=10.1002/eji.1830200624;
Engelhardt W., Geerds C., Frey J.;
"Distribution, inducibility and biological function of the cloned and
expressed human beta Fc receptor II.";
Eur. J. Immunol. 20:1367-1377(1990).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIB2).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IIB1 AND IIB2).
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 132-253, INVOLVEMENT IN SLE, AND VARIANT
THR-232.
PubMed=12115230; DOI=10.1002/art.10257;
Kyogoku C., Dijstelbloem H.M., Tsuchiya N., Hatta Y., Kato H.,
Yamaguchi A., Fukazawa T., Jansen M.D., Hashimoto H., van de Winkel J.G.J.,
Kallenberg C.G.M., Tokunaga K.;
"Fc gamma receptor gene polymorphisms in Japanese patients with systemic
lupus erythematosus: contribution of FCGR2B to genetic susceptibility.";
Arthritis Rheum. 46:1242-1254(2002).
[9]
INTERACTION WITH FGR.
PubMed=8327512; DOI=10.1073/pnas.90.13.6305;
Hamada F., Aoki M., Akiyama T., Toyoshima K.;
"Association of immunoglobulin G Fc receptor II with Src-like protein-
tyrosine kinase Fgr in neutrophils.";
Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993).
[10]
PHOSPHORYLATION AT TYR-292.
PubMed=8756631; DOI=10.1128/mcb.16.9.4735;
Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M.,
Frey J.;
"In vivo and in vitro specificity of protein tyrosine kinases for
immunoglobulin G receptor (FcgammaRII) phosphorylation.";
Mol. Cell. Biol. 16:4735-4743(1996).
[11]
INTERACTION WITH LYN.
PubMed=9232445; DOI=10.1016/s0165-2478(97)00055-2;
Sarmay G., Koncz G., Pecht I., Gergely J.;
"Fc gamma receptor type IIb induced recruitment of inositol and protein
phosphatases to the signal transductory complex of human B-cell.";
Immunol. Lett. 57:159-164(1997).
[12]
INTERACTION WITH MEASLES VIRUS N PROTEIN (MICROBIAL INFECTION).
PubMed=15914856; DOI=10.1099/vir.0.80791-0;
Laine D., Bourhis J.-M., Longhi S., Flacher M., Cassard L., Canard B.,
Sautes-Fridman C., Rabourdin-Combe C., Valentin H.;
"Measles virus nucleoprotein induces cell-proliferation arrest and
apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions,
respectively.";
J. Gen. Virol. 86:1771-1784(2005).
[13]
X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 46-217, AND DISULFIDE BONDS.
PubMed=10064577; DOI=10.1093/emboj/18.5.1095;
Sondermann P., Huber R., Jacob U.;
"Crystal structure of the soluble form of the human fcgamma-receptor IIb: a
new member of the immunoglobulin superfamily at 1.7 A resolution.";
EMBO J. 18:1095-1103(1999).
[14]
VARIANT ASP-258.
PubMed=8466861; DOI=10.1093/intimm/5.3.239;
Warmerdam P.A., van den Herik-Oudijk I.E., Parren P.W., Westerdaal N.A.,
van de Winkel J.G., Capel P.J.;
"Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human
IgG subclasses.";
Int. Immunol. 5:239-247(1993).
[15]
POLYMORPHISM, INVOLVEMENT IN RESISTANCE TO MALARIA, VARIANT THR-232, AND
CHARACTERIZATION OF VARIANT THR-232.
PubMed=17435165; DOI=10.1073/pnas.0608889104;
Clatworthy M.R., Willcocks L., Urban B., Langhorne J., Williams T.N.,
Peshu N., Watkins N.A., Floto R.A., Smith K.G.;
"Systemic lupus erythematosus-associated defects in the inhibitory receptor
FcgammaRIIb reduce susceptibility to malaria.";
Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007).
[16]
POLYMORPHISM, INVOLVEMENT IN SLE, VARIANT THR-232, AND INVOLVEMENT IN
RESISTANCE TO MALARIA.
PubMed=20385827; DOI=10.1073/pnas.0915133107;
Willcocks L.C., Carr E.J., Niederer H.A., Rayner T.F., Williams T.N.,
Yang W., Scott J.A., Urban B.C., Peshu N., Vyse T.J., Lau Y.L., Lyons P.A.,
Smith K.G.;
"A defunctioning polymorphism in FCGR2B is associated with protection
against malaria but susceptibility to systemic lupus erythematosus.";
Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010).
-!- FUNCTION: Receptor for the Fc region of complexed or aggregated
immunoglobulins gamma. Low affinity receptor. Involved in a variety of
effector and regulatory functions such as phagocytosis of immune
complexes and modulation of antibody production by B-cells. Binding to
this receptor results in down-modulation of previous state of cell
activation triggered via antigen receptors on B-cells (BCR), T-cells
(TCR) or via another Fc receptor. Isoform IIB1 fails to mediate
endocytosis or phagocytosis. Isoform IIB2 does not trigger
phagocytosis.
-!- SUBUNIT: Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts
with LYN. {ECO:0000269|PubMed:8327512, ECO:0000269|PubMed:9232445}.
-!- SUBUNIT: (Microbial infection) Isoform IIB1 interacts with measles
virus protein N. Protein N is released in the blood following lysis of
measles infected cells. This interaction presumably block inflammatory
immune response. {ECO:0000269|PubMed:15914856}.
-!- INTERACTION:
P31994; P01857: IGHG1; NbExp=31; IntAct=EBI-724784, EBI-356114;
P31994; Q92835: INPP5D; NbExp=3; IntAct=EBI-724784, EBI-1380477;
P31994; Q92876: KLK6; NbExp=3; IntAct=EBI-724784, EBI-2432309;
P31994; P16333: NCK1; NbExp=2; IntAct=EBI-724784, EBI-389883;
P31994; P19174: PLCG1; NbExp=2; IntAct=EBI-724784, EBI-79387;
P31994; P29350: PTPN6; NbExp=3; IntAct=EBI-724784, EBI-78260;
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=IIB1 {ECO:0000303|PubMed:2529342};
IsoId=P31994-1; Sequence=Displayed;
Name=IIB2 {ECO:0000303|PubMed:2529342};
IsoId=P31994-2; Sequence=VSP_002643;
Name=IIB3 {ECO:0000303|PubMed:2529342};
IsoId=P31994-3; Sequence=VSP_002642;
Name=4;
IsoId=P31994-4; Sequence=VSP_058635;
Name=5;
IsoId=P31994-5; Sequence=VSP_058635, VSP_002643;
-!- TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma-receptor.
Expressed in monocyte, neutrophils, macrophages, basophils,
eosinophils, Langerhans cells, B-cells, platelets cells and placenta
(endothelial cells). Not detected in natural killer cells.
-!- DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as
the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is
involved in modulation of cellular responses. The phosphorylated ITIM
motif can bind the SH2 domain of several SH2-containing phosphatases.
-!- PTM: Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
{ECO:0000269|PubMed:8756631}.
-!- POLYMORPHISM: FCGR2B polymorphisms can influence susceptibility or
resistance to malaria [MIM:611162]. {ECO:0000269|PubMed:17435165,
ECO:0000269|PubMed:20385827}.
-!- DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic,
relapsing, inflammatory, and often febrile multisystemic disorder of
connective tissue, characterized principally by involvement of the
skin, joints, kidneys and serosal membranes. It is of unknown etiology,
but is thought to represent a failure of the regulatory mechanisms of
the autoimmune system. The disease is marked by a wide range of system
dysfunctions, an elevated erythrocyte sedimentation rate, and the
formation of LE cells in the blood or bone marrow.
{ECO:0000269|PubMed:12115230, ECO:0000269|PubMed:20385827}.
Note=Disease susceptibility is associated with variants affecting the
gene represented in this entry.
-!- CAUTION: Has sometimes been attributed to correspond to FcR-IIC.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA35645.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/FCGR2BID397.html";
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EMBL; U87560; AAD00627.1; -; mRNA.
EMBL; U87561; AAD00628.1; -; mRNA.
EMBL; U87562; AAD00629.1; -; mRNA.
EMBL; U87563; AAD00630.1; -; mRNA.
EMBL; U87564; AAD00631.1; -; mRNA.
EMBL; U87565; AAD00632.1; -; mRNA.
EMBL; U87566; AAD00633.1; -; mRNA.
EMBL; U87567; AAD00634.1; -; mRNA.
EMBL; U87568; AAD00635.1; -; mRNA.
EMBL; U87569; AAD00636.1; -; mRNA.
EMBL; U87570; AAD00637.1; -; mRNA.
EMBL; U87571; AAD00638.1; -; mRNA.
EMBL; U87572; AAD00639.1; -; mRNA.
EMBL; U87573; AAD00640.1; -; mRNA.
EMBL; U87574; AAD00641.1; -; mRNA.
EMBL; U87575; AAD00642.1; -; mRNA.
EMBL; U87576; AAD00643.1; -; mRNA.
EMBL; U87577; AAD00644.1; -; mRNA.
EMBL; X17653; CAA35644.1; -; mRNA.
EMBL; X17653; CAA35645.1; ALT_INIT; mRNA.
EMBL; M31933; AAA35841.1; -; mRNA.
EMBL; M31934; AAA35842.1; -; mRNA.
EMBL; M31935; AAA35843.1; -; mRNA.
EMBL; X52473; CAA36713.1; -; mRNA.
EMBL; CR407635; CAG28563.1; -; mRNA.
EMBL; AL359541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC031992; AAH31992.1; -; mRNA.
EMBL; BC146678; AAI46679.1; -; mRNA.
EMBL; AB050934; BAB92093.1; -; mRNA.
CCDS; CCDS30924.1; -. [P31994-1]
CCDS; CCDS30925.1; -. [P31994-2]
CCDS; CCDS53414.1; -. [P31994-3]
PIR; JL0119; JL0119.
RefSeq; NP_001002273.1; NM_001002273.2. [P31994-5]
RefSeq; NP_001002274.1; NM_001002274.2. [P31994-2]
RefSeq; NP_001002275.1; NM_001002275.2. [P31994-4]
RefSeq; NP_001177757.1; NM_001190828.1. [P31994-3]
RefSeq; NP_003992.3; NM_004001.4. [P31994-1]
RefSeq; XP_016856160.1; XM_017000671.1.
RefSeq; XP_016856161.1; XM_017000672.1.
PDB; 2FCB; X-ray; 1.74 A; A=46-217.
PDB; 3WJJ; X-ray; 2.60 A; C=45-217.
PDB; 5OCC; X-ray; 2.50 A; A=43-218.
PDBsum; 2FCB; -.
PDBsum; 3WJJ; -.
PDBsum; 5OCC; -.
SMR; P31994; -.
BioGRID; 108507; 13.
DIP; DIP-36638N; -.
ELM; P31994; -.
IntAct; P31994; 19.
MINT; P31994; -.
STRING; 9606.ENSP00000351497; -.
DrugBank; DB00054; Abciximab.
DrugBank; DB00087; Alemtuzumab.
DrugBank; DB00098; Antithymocyte immunoglobulin (rabbit).
DrugBank; DB00112; Bevacizumab.
DrugBank; DB00111; Daclizumab.
DrugBank; DB00005; Etanercept.
DrugBank; DB00028; Human immunoglobulin G.
DrugBank; DB00110; Palivizumab.
DrugBank; DB11767; Sarilumab.
DrugBank; DB00081; Tositumomab.
MEROPS; I43.001; -.
GlyGen; P31994; 4 sites.
iPTMnet; P31994; -.
PhosphoSitePlus; P31994; -.
BioMuta; FCGR2B; -.
DMDM; 8039788; -.
CPTAC; CPTAC-1183; -.
jPOST; P31994; -.
MassIVE; P31994; -.
MaxQB; P31994; -.
PaxDb; P31994; -.
PeptideAtlas; P31994; -.
PRIDE; P31994; -.
ProteomicsDB; 54822; -. [P31994-1]
ProteomicsDB; 54823; -. [P31994-2]
ProteomicsDB; 54824; -. [P31994-3]
ABCD; P31994; 6 sequenced antibodies.
Antibodypedia; 3585; 859 antibodies.
Ensembl; ENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
Ensembl; ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
Ensembl; ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
GeneID; 2213; -.
KEGG; hsa:2213; -.
UCSC; uc001gaz.3; human. [P31994-1]
CTD; 2213; -.
DisGeNET; 2213; -.
GeneCards; FCGR2B; -.
HGNC; HGNC:3618; FCGR2B.
HPA; ENSG00000072694; Group enriched (blood, placenta).
MalaCards; FCGR2B; -.
MIM; 152700; phenotype.
MIM; 604590; gene.
MIM; 611162; phenotype.
neXtProt; NX_P31994; -.
OpenTargets; ENSG00000072694; -.
Orphanet; 536; Systemic lupus erythematosus.
PharmGKB; PA28064; -.
VEuPathDB; HostDB:ENSG00000072694.19; -.
eggNOG; ENOG502SVEW; Eukaryota.
GeneTree; ENSGT01020000230518; -.
HOGENOM; CLU_023383_1_2_1; -.
InParanoid; P31994; -.
OMA; DLEPPWI; -.
OrthoDB; 1246375at2759; -.
PhylomeDB; P31994; -.
TreeFam; TF335097; -.
PathwayCommons; P31994; -.
Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SignaLink; P31994; -.
SIGNOR; P31994; -.
BioGRID-ORCS; 2213; 5 hits in 978 CRISPR screens.
ChiTaRS; FCGR2B; human.
EvolutionaryTrace; P31994; -.
GeneWiki; FCGR2B; -.
GenomeRNAi; 2213; -.
Pharos; P31994; Tbio.
PRO; PR:P31994; -.
Proteomes; UP000005640; Chromosome 1.
RNAct; P31994; protein.
Bgee; ENSG00000072694; Expressed in placenta and 189 other tissues.
Genevisible; P31994; HS.
GO; GO:0044297; C:cell body; ISS:BHF-UCL.
GO; GO:0043197; C:dendritic spine; ISS:BHF-UCL.
GO; GO:0009897; C:external side of plasma membrane; ISS:ARUK-UCL.
GO; GO:0005887; C:integral component of plasma membrane; IDA:ARUK-UCL.
GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
GO; GO:0001540; F:amyloid-beta binding; IPI:ARUK-UCL.
GO; GO:0019864; F:IgG binding; IDA:ARUK-UCL.
GO; GO:0019772; F:low-affinity IgG receptor activity; IDA:ARUK-UCL.
GO; GO:0044877; F:protein-containing complex binding; IPI:ARUK-UCL.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; ISS:ARUK-UCL.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:1904646; P:cellular response to amyloid-beta; ISS:ARUK-UCL.
GO; GO:0071219; P:cellular response to molecule of bacterial origin; ISS:ARUK-UCL.
GO; GO:0021549; P:cerebellum development; ISS:BHF-UCL.
GO; GO:0006952; P:defense response; ISS:ARUK-UCL.
GO; GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; IDA:ARUK-UCL.
GO; GO:0002316; P:follicular B cell differentiation; TAS:ARUK-UCL.
GO; GO:0002266; P:follicular dendritic cell activation; TAS:ARUK-UCL.
GO; GO:0002436; P:immune complex clearance by monocytes and macrophages; TAS:ARUK-UCL.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0016064; P:immunoglobulin mediated immune response; ISS:ARUK-UCL.
GO; GO:0006954; P:inflammatory response; TAS:ARUK-UCL.
GO; GO:0002313; P:mature B cell differentiation involved in immune response; TAS:ARUK-UCL.
GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; ISS:ARUK-UCL.
GO; GO:0001814; P:negative regulation of antibody-dependent cellular cytotoxicity; TAS:ARUK-UCL.
GO; GO:0050869; P:negative regulation of B cell activation; TAS:ARUK-UCL.
GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:ARUK-UCL.
GO; GO:0050859; P:negative regulation of B cell receptor signaling pathway; IMP:ARUK-UCL.
GO; GO:0001818; P:negative regulation of cytokine production; TAS:ARUK-UCL.
GO; GO:0043318; P:negative regulation of cytotoxic T cell degranulation; TAS:ARUK-UCL.
GO; GO:0002605; P:negative regulation of dendritic cell antigen processing and presentation; TAS:ARUK-UCL.
GO; GO:2001199; P:negative regulation of dendritic cell differentiation; TAS:ARUK-UCL.
GO; GO:0002924; P:negative regulation of humoral immune response mediated by circulating immunoglobulin; ISS:ARUK-UCL.
GO; GO:0050777; P:negative regulation of immune response; ISS:ARUK-UCL.
GO; GO:0002638; P:negative regulation of immunoglobulin production; ISS:ARUK-UCL.
GO; GO:0032693; P:negative regulation of interleukin-10 production; ISS:ARUK-UCL.
GO; GO:0043031; P:negative regulation of macrophage activation; TAS:ARUK-UCL.
GO; GO:1902564; P:negative regulation of neutrophil activation; TAS:ARUK-UCL.
GO; GO:0050765; P:negative regulation of phagocytosis; TAS:ARUK-UCL.
GO; GO:0001811; P:negative regulation of type I hypersensitivity; ISS:ARUK-UCL.
GO; GO:0006911; P:phagocytosis, engulfment; ISS:ARUK-UCL.
GO; GO:0002922; P:positive regulation of humoral immune response; TAS:ARUK-UCL.
GO; GO:0046330; P:positive regulation of JNK cascade; ISS:ARUK-UCL.
GO; GO:1901216; P:positive regulation of neuron death; ISS:ARUK-UCL.
GO; GO:0050766; P:positive regulation of phagocytosis; ISS:ARUK-UCL.
GO; GO:1905898; P:positive regulation of response to endoplasmic reticulum stress; ISS:ARUK-UCL.
GO; GO:0006898; P:receptor-mediated endocytosis; IDA:ARUK-UCL.
GO; GO:0002819; P:regulation of adaptive immune response; TAS:ARUK-UCL.
GO; GO:0002622; P:regulation of B cell antigen processing and presentation; TAS:ARUK-UCL.
GO; GO:1902950; P:regulation of dendritic spine maintenance; IGI:ARUK-UCL.
GO; GO:0090264; P:regulation of immune complex clearance by monocytes and macrophages; TAS:ARUK-UCL.
GO; GO:0050776; P:regulation of immune response; IBA:GO_Central.
GO; GO:0045088; P:regulation of innate immune response; TAS:ARUK-UCL.
GO; GO:0010469; P:regulation of signaling receptor activity; TAS:ARUK-UCL.
GO; GO:0009617; P:response to bacterium; ISS:ARUK-UCL.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
Pfam; PF13895; Ig_2; 2.
SMART; SM00409; IG; 2.
SMART; SM00408; IGc2; 2.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 2.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane;
Chromosomal rearrangement; Disulfide bond; Glycoprotein;
Host-virus interaction; IgG-binding protein; Immunoglobulin domain;
Membrane; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome;
Repeat; Signal; Systemic lupus erythematosus; Transmembrane;
Transmembrane helix.
SIGNAL 1..42
/evidence="ECO:0000255"
CHAIN 43..310
/note="Low affinity immunoglobulin gamma Fc region receptor
II-b"
/id="PRO_0000015147"
TOPO_DOM 43..217
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 218..240
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 241..310
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 48..127
/note="Ig-like C2-type 1"
DOMAIN 131..213
/note="Ig-like C2-type 2"
MOTIF 290..295
/note="ITIM motif"
MOD_RES 292
/note="Phosphotyrosine; by SRC-type Tyr-kinases"
/evidence="ECO:0000269|PubMed:8756631"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 180
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 187
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 71..113
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:10064577"
DISULFID 152..196
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:10064577"
VAR_SEQ 39..45
/note="Missing (in isoform IIB3)"
/evidence="ECO:0000303|PubMed:2529342"
/id="VSP_002642"
VAR_SEQ 46
/note="Missing (in isoform 4 and isoform 5)"
/evidence="ECO:0000303|Ref.1"
/id="VSP_058635"
VAR_SEQ 254..272
/note="Missing (in isoform IIB2 and isoform 5)"
/evidence="ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:2142460, ECO:0000303|PubMed:2529342,
ECO:0000303|PubMed:2531080, ECO:0000303|Ref.1,
ECO:0000303|Ref.5"
/id="VSP_002643"
VARIANT 83
/note="Q -> P (in dbSNP:rs5017567)"
/id="VAR_059430"
VARIANT 205
/note="Y -> F (in dbSNP:rs1050499)"
/evidence="ECO:0000269|PubMed:2529342"
/id="VAR_027045"
VARIANT 232
/note="I -> T (associated with susceptibility to SLE;
associated with resistance to malaria; found at an
increased frequency in African and Asian populations from
areas where malaria is endemic; enhances phagocytosis of
Plasmodium falciparum-infected erythrocytes in vitro;
dbSNP:rs1050501)"
/evidence="ECO:0000269|PubMed:12115230,
ECO:0000269|PubMed:17435165, ECO:0000269|PubMed:20385827,
ECO:0000269|Ref.1"
/id="VAR_015515"
VARIANT 258
/note="Y -> D (in dbSNP:rs148534844)"
/evidence="ECO:0000269|PubMed:8466861"
/id="VAR_008798"
CONFLICT 178
/note="D -> I (in Ref. 2; CAA35644/CAA35645)"
/evidence="ECO:0000305"
CONFLICT 230
/note="T -> I (in Ref. 2; CAA35644/CAA35645)"
/evidence="ECO:0000305"
CONFLICT 242
/note="V -> G (in Ref. 2; CAA35644/CAA35645)"
/evidence="ECO:0000305"
CONFLICT 275
/note="P -> S (in Ref. 2; CAA35644/CAA35645)"
/evidence="ECO:0000305"
STRAND 51..56
/evidence="ECO:0007744|PDB:2FCB"
STRAND 59..62
/evidence="ECO:0007744|PDB:2FCB"
STRAND 66..72
/evidence="ECO:0007744|PDB:2FCB"
STRAND 83..86
/evidence="ECO:0007744|PDB:2FCB"
STRAND 96..102
/evidence="ECO:0007744|PDB:2FCB"
HELIX 105..107
/evidence="ECO:0007744|PDB:2FCB"
STRAND 109..114
/evidence="ECO:0007744|PDB:2FCB"
STRAND 116..118
/evidence="ECO:0007744|PDB:5OCC"
STRAND 124..129
/evidence="ECO:0007744|PDB:2FCB"
STRAND 131..136
/evidence="ECO:0007744|PDB:2FCB"
STRAND 140..142
/evidence="ECO:0007744|PDB:2FCB"
STRAND 148..154
/evidence="ECO:0007744|PDB:2FCB"
HELIX 155..157
/evidence="ECO:0007744|PDB:2FCB"
STRAND 161..167
/evidence="ECO:0007744|PDB:2FCB"
STRAND 170..177
/evidence="ECO:0007744|PDB:2FCB"
STRAND 180..183
/evidence="ECO:0007744|PDB:2FCB"
HELIX 188..190
/evidence="ECO:0007744|PDB:2FCB"
STRAND 192..200
/evidence="ECO:0007744|PDB:2FCB"
STRAND 203..206
/evidence="ECO:0007744|PDB:2FCB"
STRAND 210..214
/evidence="ECO:0007744|PDB:2FCB"
SEQUENCE 310 AA; 34044 MW; 2186F8538FF01F36 CRC64;
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN
VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL
SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN
FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA
VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA
LEEPDDQNRI


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Pathways :
WP2292: Chemokine signaling pathway
WP2006: Squamous cell TarBase
WP866: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1654: gamma-Hexachlorocyclohexane degradation
WP758: EBV LMP1 signaling
WP2199: Seed Development
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP542: Electron Transport Chain
WP262: EBV LMP1 signaling
WP1993: angiogenesis overview
WP152: FGF signaling pathway
WP537: Translation Factors
WP1225: estrogen signalling
WP868: estrogen signalling
WP1722: Th1/Th2
WP32: Translation Factors
WP2152: BDNF
WP760: estrogen signalling
WP1836: Interferon gamma signaling
WP2328: Allograft rejection
WP590: Cardiovascular Signaling
WP1004: Kit Receptor Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP274: B Cell Receptor Signaling Pathway

Related Genes :
[FCGR2B CD32 FCG2 IGFR2] Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
[Fcgr2 Fcgr2b Ly-17] Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)
[FCGR3A CD16A FCG3 FCGR3 IGFR3] Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
[FCGR3B CD16B FCG3 FCGR3 IGFR3] Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)
[Fcgr4] Low affinity immunoglobulin gamma Fc region receptor IV (CD16-2) (FcgammaRIV)
[Fcgr1 Fcg1] High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (CD antigen CD64)
[FCGR3] Low affinity immunoglobulin gamma Fc region receptor III (IgG Fc receptor III) (Cytolytic trigger molecule G7) (Fc-gamma RIII) (FcRIII) (CD antigen CD16)
[FCGR3] Low affinity immunoglobulin gamma Fc region receptor III (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII) (CD antigen CD16)
[FCGR3 FCGRIII] Low affinity immunoglobulin gamma Fc region receptor III (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII) (CD antigen CD16)
[Fcgrt Fcrn] IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
[FCGRT FCRN] IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
[Fcgr4] Low affinity immunoglobulin gamma Fc region receptor IV (FcgammaRIV)
[Fcamr] High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fc alpha/mu receptor) (mFcamR) (CD antigen CD351)
[IGHG2] Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE)
[FCGR3] Low affinity immunoglobulin gamma Fc region receptor III (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII) (CD antigen CD16)
[IGHG1] Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
[FCRL3 FCRH3 IFGP3 IRTA3 SPAP2] Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[IGHG3] Immunoglobulin heavy constant gamma 3 (HDC) (Heavy chain disease protein) (Ig gamma-3 chain C region)
[Fcgrt Fcrn] IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
[IGLV2-11] Immunoglobulin lambda variable 2-11 (Ig gamma lambda chain V-II region DOT) (Ig lambda chain V-II region BOH) (Ig lambda chain V-II region BUR) (Ig lambda chain V-II region NIG-58) (Ig lambda chain V-II region TRO) (Ig lambda chain V-II region WIN)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[FCGR3] Low affinity immunoglobulin gamma Fc region receptor III (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII) (CD antigen CD16)
[Inpp5d 7a33 Ship Ship1] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
[FCRL6 FCRH6] Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)
[FCRLA FCRL FCRL1 FCRLM1 FCRX FREB UNQ291/PRO329] Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX)
[CD3G T3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[LILRA4 ILT7] Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[IGHG4] Immunoglobulin heavy constant gamma 4 (Ig gamma-4 chain C region)

Bibliography :