GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)

 MKNK2_HUMAN             Reviewed;         465 AA.
Q9HBH9; Q6GPI3; Q9HBH8; Q9UHR0; Q9Y2N6;
30-APR-2003, integrated into UniProtKB/Swiss-Prot.
07-MAR-2006, sequence version 3.
07-APR-2021, entry version 192.
RecName: Full=MAP kinase-interacting serine/threonine-protein kinase 2;
EC=2.7.11.1;
AltName: Full=MAP kinase signal-integrating kinase 2;
Short=MAPK signal-integrating kinase 2;
Short=Mnk2;
Name=MKNK2; Synonyms=GPRK7, MNK2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606 {ECO:0000312|EMBL:AAG26336.1};
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), TISSUE SPECIFICITY,
AND INTERACTION WITH ESR2.
TISSUE=Fetal brain;
PubMed=11013076; DOI=10.1006/geno.2000.6299;
Slentz-Kesler K., Moore J.T., Lombard M., Zhang J., Hollingsworth R.,
Weiner M.P.;
"Identification of the human Mnk2 gene (MKNK2) through protein interaction
with estrogen receptor beta.";
Genomics 69:63-71(2000).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Adrenal gland;
Li Y., Shi J., Huang C., Ren S., Fu S., Zhou J., Yu Y., Xu S., Wang Y.,
Fu G., Chen Z., Han Z.;
"A novel gene expressed in human adrenal gland.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION AS EIF4E KINASE, ACTIVITY REGULATION, ALTERNATIVE SPLICING,
PHOSPHORYLATION BY MAPK1/ERK2; MAPK11 AND MAPK14, AND INTERACTION WITH
EIF4G PROTEINS.
PubMed=11154262; DOI=10.1128/mcb.21.3.743-754.2001;
Scheper G.C., Morrice N.A., Kleijn M., Proud C.G.;
"The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a
eukaryotic initiation factor 4E kinase with high levels of basal activity
in mammalian cells.";
Mol. Cell. Biol. 21:743-754(2001).
[6] {ECO:0000305}
FUNCTION, PHOSPHORYLATION AT THR-244; THR-249 AND THR-379, AND MUTAGENESIS
OF THR-244; THR-249 AND THR-379.
TISSUE=Leukocyte;
PubMed=11463832; DOI=10.1128/mcb.21.16.5500-5511.2001;
Knauf U., Tschopp C., Gram H.;
"Negative regulation of protein translation by mitogen-activated protein
kinase-interacting kinases 1 and 2.";
Mol. Cell. Biol. 21:5500-5511(2001).
[7]
FUNCTION AS EIF4E KINASE, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION,
PHOSPHORYLATION, AND INTERACTION WITH EIF4E; EIF4G1 AND EIF4G2.
PubMed=12897141; DOI=10.1128/mcb.23.16.5692-5705.2003;
Scheper G.C., Parra J.L., Wilson M., Van Kollenburg B., Vertegaal A.C.O.,
Han Z.-G., Proud C.G.;
"The N and C termini of the splice variants of the human mitogen-activated
protein kinase-interacting kinase Mnk2 determine activity and
localization.";
Mol. Cell. Biol. 23:5692-5705(2003).
[8]
FUNCTION AS HNRNPA1 KINASE, AND ACTIVITY REGULATION.
PubMed=16111636; DOI=10.1016/j.immuni.2005.06.009;
Buxade M., Parra J.L., Rousseau S., Shpiro N., Marquez R., Morrice N.,
Bain J., Espel E., Proud C.G.;
"The Mnks are novel components in the control of TNF alpha biosynthesis and
phosphorylate and regulate hnRNP A1.";
Immunity 23:177-189(2005).
[9]
FUNCTION AS SFPQ/PSF KINASE.
PubMed=17965020; DOI=10.1074/jbc.m705286200;
Buxade M., Morrice N., Krebs D.L., Proud C.G.;
"The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for
tumor necrosis factor alpha.";
J. Biol. Chem. 283:57-65(2008).
[10]
FUNCTION IN ARSENIC TRIOXIDE SIGNALING, AND PHOSPHORYLATION IN RESPONSE TO
ARSENIC TRIOXIDE.
PubMed=18299328; DOI=10.1074/jbc.m708816200;
Dolniak B., Katsoulidis E., Carayol N., Altman J.K., Redig A.J.,
Tallman M.S., Ueda T., Watanabe-Fukunaga R., Fukunaga R., Platanias L.C.;
"Regulation of arsenic trioxide-induced cellular responses by Mnk1 and
Mnk2.";
J. Biol. Chem. 283:12034-12042(2008).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the
kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[13]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[14]
ACTIVITY REGULATION.
PubMed=20722422; DOI=10.1021/jm1005513;
Oyarzabal J., Zarich N., Albarran M.I., Palacios I., Urbano-Cuadrado M.,
Mateos G., Reymundo I., Rabal O., Salgado A., Corrionero A., Fominaya J.,
Pastor J., Bischoff J.R.;
"Discovery of mitogen-activated protein kinase-interacting kinase 1
inhibitors by a comprehensive fragment-oriented virtual screening
approach.";
J. Med. Chem. 53:6618-6628(2010).
[15]
FUNCTION AS EIF4E KINASE, AND INTERACTION WITH EIF4G1.
PubMed=20823271; DOI=10.1128/mcb.00448-10;
Shveygert M., Kaiser C., Bradrick S.S., Gromeier M.;
"Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by
mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G
interaction.";
Mol. Cell. Biol. 30:5160-5167(2010).
[16]
ACTIVITY REGULATION.
PubMed=20664001; DOI=10.1124/mol.110.064642;
Altman J.K., Glaser H., Sassano A., Joshi S., Ueda T.,
Watanabe-Fukunaga R., Fukunaga R., Tallman M.S., Platanias L.C.;
"Negative regulatory effects of Mnk kinases in the generation of
chemotherapy-induced antileukemic responses.";
Mol. Pharmacol. 78:778-784(2010).
[17]
FUNCTION IN EIF4E PHOSPHORYLATION REGULATION, DEPHOSPHORYLATION BY PP2A,
AND ACTIVITY REGULATION.
PubMed=20927323; DOI=10.1593/neo.10704;
Li Y., Yue P., Deng X., Ueda T., Fukunaga R., Khuri F.R., Sun S.-Y.;
"Protein phosphatase 2A negatively regulates eukaryotic initiation factor
4E phosphorylation and eIF4F assembly through direct dephosphorylation of
Mnk and eIF4E.";
Neoplasia 12:848-855(2010).
[18]
FUNCTION IN IFNGAMMA SIGNALING.
PubMed=21149447; DOI=10.1074/jbc.m110.197921;
Joshi S., Sharma B., Kaur S., Majchrzak B., Ueda T., Fukunaga R.,
Verma A.K., Fish E.N., Platanias L.C.;
"Essential role for Mnk kinases in type II interferon (IFNgamma) signaling
and its suppressive effects on normal hematopoiesis.";
J. Biol. Chem. 286:6017-6026(2011).
[19]
REVIEW.
PubMed=18508592; DOI=10.2741/3086;
Buxade M., Parra-Palau J.L., Proud C.G.;
"The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating
kinases).";
Front. Biosci. 13:5359-5373(2008).
[20]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[21]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 72-385 IN COMPLEX WITH ZINC, AND
SUBUNIT.
PubMed=16216586; DOI=10.1016/j.str.2005.07.013;
Jauch R., Jaekel S., Netter C., Schreiter K., Aicher B., Jaeckle H.,
Wahl M.C.;
"Crystal structures of the Mnk2 kinase domain reveal an inhibitory
conformation and a zinc binding site.";
Structure 13:1559-1568(2005).
[22]
X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 72-385 IN COMPLEX WITH ZINC AND
STAUROSPORINE, ACTIVITY REGULATION, AND MUTAGENESIS OF ASP-228.
PubMed=16917500; DOI=10.1038/sj.emboj.7601285;
Jauch R., Cho M.-K., Jaekel S., Netter C., Schreiter K., Aicher B.,
Zweckstetter M., Jaeckle H., Wahl M.C.;
"Mitogen-activated protein kinases interacting kinases are autoinhibited by
a reprogrammed activation segment.";
EMBO J. 25:4020-4032(2006).
[23]
VARIANT [LARGE SCALE ANALYSIS] ASN-73.
PubMed=17344846; DOI=10.1038/nature05610;
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
-!- FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF,
HNRNPA1 and EIF4E. May play a role in the response to environmental
stress and cytokines. Appears to regulate translation by
phosphorylating EIF4E, thus increasing the affinity of this protein for
the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-
inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from
cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity,
but isoform 2 exhibits a very low kinase activity. Acts as a mediator
of the suppressive effects of IFNgamma on hematopoiesis. Negative
regulator for signals that control generation of arsenic trioxide
As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in
anti-apoptotic signaling in response to serum withdrawal.
{ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832,
ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636,
ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328,
ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323,
ECO:0000269|PubMed:21149447}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
Evidence={ECO:0000269|PubMed:11463832};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11463832};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:11463832};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Note=Binds 1 zinc ion per subunit.;
-!- ACTIVITY REGULATION: Inhibited by CGP57380 and staurosporine. Activated
by phosphorylation in a negative-feedback regulatory manner in response
to chemotherapy (e.g. cytarabine) and thus impairs the generation of
antileukemic responses. {ECO:0000269|PubMed:11154262,
ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:16917500,
ECO:0000269|PubMed:20664001, ECO:0000269|PubMed:20722422,
ECO:0000269|PubMed:20927323}.
-!- SUBUNIT: Monomer. Interacts with the C-terminal regions of EIF4G1 and
EIF4G2; this interaction is promoted when MAPK pathways are repressed
but repressed upon ERK proteins activation. Also binds to
dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with
phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from
dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and
EIF4E in the nucleus. {ECO:0000269|PubMed:11013076,
ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12897141,
ECO:0000269|PubMed:16216586, ECO:0000269|PubMed:16917500,
ECO:0000269|PubMed:20823271}.
-!- INTERACTION:
Q9HBH9; Q16539: MAPK14; NbExp=3; IntAct=EBI-2864341, EBI-73946;
Q9HBH9-2; P46379-2: BAG6; NbExp=3; IntAct=EBI-14141314, EBI-10988864;
Q9HBH9-2; O14901: KLF11; NbExp=3; IntAct=EBI-14141314, EBI-948266;
Q9HBH9-2; Q14696: MESD; NbExp=3; IntAct=EBI-14141314, EBI-6165891;
Q9HBH9-2; P25786: PSMA1; NbExp=3; IntAct=EBI-14141314, EBI-359352;
-!- SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, PML body.
-!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=1 {ECO:0000269|PubMed:11013076}; Synonyms=2a
{ECO:0000303|PubMed:11013076};
IsoId=Q9HBH9-1; Sequence=Displayed;
Name=2 {ECO:0000269|PubMed:11013076}; Synonyms=2b
{ECO:0000303|PubMed:11013076};
IsoId=Q9HBH9-2; Sequence=VSP_007353, VSP_007354;
Name=3 {ECO:0000303|PubMed:11013076};
IsoId=Q9HBH9-3; Sequence=Not described;
Name=4 {ECO:0000303|PubMed:11013076};
IsoId=Q9HBH9-4; Sequence=Not described;
Name=5 {ECO:0000303|PubMed:11013076};
IsoId=Q9HBH9-5; Sequence=Not described;
-!- TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined.
Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
{ECO:0000269|PubMed:11013076}.
-!- PTM: Dual phosphorylation of Thr-244 and Thr-249 activates the kinase.
Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon
arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2,
MAPK11 and MAPK14. Dephosphorylated by PP2A.
{ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832,
ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:18299328}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
protein kinase family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AF237775; AAG26336.1; -; mRNA.
EMBL; AF237776; AAG26337.1; -; mRNA.
EMBL; AF125532; AAF17226.1; -; mRNA.
EMBL; BC073140; AAH73140.1; -; mRNA.
CCDS; CCDS12079.1; -. [Q9HBH9-2]
CCDS; CCDS12080.1; -. [Q9HBH9-1]
RefSeq; NP_060042.2; NM_017572.3. [Q9HBH9-2]
RefSeq; NP_951009.1; NM_199054.2. [Q9HBH9-1]
PDB; 2AC3; X-ray; 2.10 A; A=72-385.
PDB; 2AC5; X-ray; 3.20 A; A=72-385.
PDB; 2HW7; X-ray; 2.71 A; A=72-385.
PDB; 6CJ5; X-ray; 2.80 A; A=72-385.
PDB; 6CJE; X-ray; 3.36 A; A=72-385.
PDB; 6CJH; X-ray; 3.60 A; A=72-385.
PDB; 6CJW; X-ray; 3.38 A; A=72-385.
PDB; 6CJY; X-ray; 3.05 A; A=72-385.
PDB; 6CK3; X-ray; 2.90 A; A=72-385.
PDB; 6CK6; X-ray; 3.32 A; A=72-385.
PDB; 6CKI; X-ray; 2.95 A; A=72-385.
PDB; 6JLR; X-ray; 2.90 A; A=72-385.
PDBsum; 2AC3; -.
PDBsum; 2AC5; -.
PDBsum; 2HW7; -.
PDBsum; 6CJ5; -.
PDBsum; 6CJE; -.
PDBsum; 6CJH; -.
PDBsum; 6CJW; -.
PDBsum; 6CJY; -.
PDBsum; 6CK3; -.
PDBsum; 6CK6; -.
PDBsum; 6CKI; -.
PDBsum; 6JLR; -.
SMR; Q9HBH9; -.
BioGRID; 109130; 42.
IntAct; Q9HBH9; 36.
STRING; 9606.ENSP00000250896; -.
BindingDB; Q9HBH9; -.
ChEMBL; CHEMBL4204; -.
DrugBank; DB12010; Fostamatinib.
DrugCentral; Q9HBH9; -.
GuidetoPHARMACOLOGY; 2105; -.
iPTMnet; Q9HBH9; -.
PhosphoSitePlus; Q9HBH9; -.
BioMuta; MKNK2; -.
DMDM; 90102033; -.
EPD; Q9HBH9; -.
jPOST; Q9HBH9; -.
MassIVE; Q9HBH9; -.
PaxDb; Q9HBH9; -.
PeptideAtlas; Q9HBH9; -.
PRIDE; Q9HBH9; -.
ProteomicsDB; 81554; -. [Q9HBH9-1]
ProteomicsDB; 81555; -. [Q9HBH9-2]
Antibodypedia; 10678; 304 antibodies.
DNASU; 2872; -.
Ensembl; ENST00000250896; ENSP00000250896; ENSG00000099875. [Q9HBH9-1]
Ensembl; ENST00000309340; ENSP00000309485; ENSG00000099875. [Q9HBH9-2]
GeneID; 2872; -.
KEGG; hsa:2872; -.
UCSC; uc002lus.3; human. [Q9HBH9-1]
CTD; 2872; -.
DisGeNET; 2872; -.
GeneCards; MKNK2; -.
HGNC; HGNC:7111; MKNK2.
HPA; ENSG00000099875; Tissue enhanced (skeletal).
MIM; 605069; gene.
neXtProt; NX_Q9HBH9; -.
OpenTargets; ENSG00000099875; -.
PharmGKB; PA30830; -.
VEuPathDB; HostDB:ENSG00000099875.14; -.
eggNOG; KOG0607; Eukaryota.
GeneTree; ENSGT00940000154587; -.
InParanoid; Q9HBH9; -.
OMA; YARVQAC; -.
PhylomeDB; Q9HBH9; -.
PathwayCommons; Q9HBH9; -.
SignaLink; Q9HBH9; -.
SIGNOR; Q9HBH9; -.
BioGRID-ORCS; 2872; 6 hits in 1028 CRISPR screens.
ChiTaRS; MKNK2; human.
EvolutionaryTrace; Q9HBH9; -.
GeneWiki; MKNK2; -.
GenomeRNAi; 2872; -.
Pharos; Q9HBH9; Tchem.
PRO; PR:Q9HBH9; -.
Proteomes; UP000005640; Chromosome 19.
RNAct; Q9HBH9; protein.
Bgee; ENSG00000099875; Expressed in vagina and 244 other tissues.
ExpressionAtlas; Q9HBH9; baseline and differential.
Genevisible; Q9HBH9; HS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0016604; C:nuclear body; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
GO; GO:0009931; F:calcium-dependent protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0106310; F:protein serine kinase activity; IEA:UniProtKB-EC.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO; GO:0106311; F:protein threonine kinase activity; IEA:UniProtKB-EC.
GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
GO; GO:0071243; P:cellular response to arsenic-containing substance; IDA:UniProtKB.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0030097; P:hemopoiesis; IDA:UniProtKB.
GO; GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0046777; P:protein autophosphorylation; IBA:GO_Central.
GO; GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
IDEAL; IID00680; -.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Apoptosis; ATP-binding; Cytoplasm;
Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus;
Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
Transferase; Translation regulation; Zinc.
CHAIN 1..465
/note="MAP kinase-interacting serine/threonine-protein
kinase 2"
/id="PRO_0000086336"
DOMAIN 84..388
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 90..98
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 160..162
/note="Staurosporine binding"
MOTIF 60..66
/note="Nuclear localization signal"
MOTIF 444..448
/note="MAP kinase binding"
/evidence="ECO:0000250"
ACT_SITE 205
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
METAL 299
/note="Zinc"
/evidence="ECO:0000269|PubMed:16216586,
ECO:0000269|PubMed:16917500"
METAL 311
/note="Zinc"
/evidence="ECO:0000269|PubMed:16216586,
ECO:0000269|PubMed:16917500"
METAL 314
/note="Zinc"
/evidence="ECO:0000269|PubMed:16216586,
ECO:0000269|PubMed:16917500"
BINDING 113
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 209
/note="Staurosporine"
/evidence="ECO:0000269|PubMed:16917500"
MOD_RES 74
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8CDB0"
MOD_RES 244
/note="Phosphothreonine"
/evidence="ECO:0000269|PubMed:11463832"
MOD_RES 249
/note="Phosphothreonine"
/evidence="ECO:0000269|PubMed:11463832"
MOD_RES 379
/note="Phosphothreonine"
/evidence="ECO:0000269|PubMed:11463832"
MOD_RES 437
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8CDB0"
MOD_RES 440
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8CDB0"
MOD_RES 452
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:23186163"
VAR_SEQ 386..414
/note="NSCAKDLTSFAAEAIAMNRQLAQHDEDLA -> WDSHFLLPPHPCRIHVRPG
GLVRTVTVNE (in isoform 2)"
/evidence="ECO:0000303|PubMed:11013076,
ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
/id="VSP_007353"
VAR_SEQ 415..465
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:11013076,
ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
/id="VSP_007354"
VARIANT 10
/note="Q -> K (in dbSNP:rs3746101)"
/id="VAR_051648"
VARIANT 73
/note="D -> N (in dbSNP:rs56158214)"
/evidence="ECO:0000269|PubMed:17344846"
/id="VAR_040805"
VARIANT 428
/note="R -> Q (in dbSNP:rs34475638)"
/id="VAR_051649"
MUTAGEN 228
/note="D->G: Reduced phosphorylation."
/evidence="ECO:0000269|PubMed:16917500"
MUTAGEN 244
/note="T->A: Loss of kinase activity; when associated with
T-249."
/evidence="ECO:0000269|PubMed:11463832"
MUTAGEN 249
/note="T->A: Loss of kinase activity; when associated with
T-244."
/evidence="ECO:0000269|PubMed:11463832"
MUTAGEN 379
/note="T->D: Constitutively active."
/evidence="ECO:0000269|PubMed:11463832"
CONFLICT 261
/note="V -> L (in Ref. 2; AAF17226)"
/evidence="ECO:0000305"
STRAND 74..76
/evidence="ECO:0007744|PDB:6CK3"
TURN 79..81
/evidence="ECO:0007744|PDB:2AC3"
STRAND 83..85
/evidence="ECO:0007744|PDB:2HW7"
STRAND 90..92
/evidence="ECO:0007744|PDB:6CK3"
STRAND 94..102
/evidence="ECO:0007744|PDB:2AC3"
STRAND 104..106
/evidence="ECO:0007744|PDB:2AC3"
STRAND 109..116
/evidence="ECO:0007744|PDB:2AC3"
STRAND 119..121
/evidence="ECO:0007744|PDB:6CJ5"
HELIX 123..135
/evidence="ECO:0007744|PDB:2AC3"
STRAND 145..151
/evidence="ECO:0007744|PDB:2AC3"
STRAND 154..160
/evidence="ECO:0007744|PDB:2AC3"
HELIX 167..174
/evidence="ECO:0007744|PDB:2AC3"
HELIX 179..198
/evidence="ECO:0007744|PDB:2AC3"
HELIX 208..210
/evidence="ECO:0007744|PDB:2AC3"
STRAND 211..214
/evidence="ECO:0007744|PDB:2AC3"
STRAND 216..219
/evidence="ECO:0007744|PDB:2AC3"
STRAND 221..224
/evidence="ECO:0007744|PDB:2AC3"
HELIX 254..256
/evidence="ECO:0007744|PDB:2AC3"
HELIX 259..264
/evidence="ECO:0007744|PDB:2AC3"
HELIX 267..272
/evidence="ECO:0007744|PDB:2AC3"
HELIX 273..275
/evidence="ECO:0007744|PDB:2AC3"
HELIX 276..290
/evidence="ECO:0007744|PDB:2AC3"
HELIX 312..324
/evidence="ECO:0007744|PDB:2AC3"
HELIX 331..334
/evidence="ECO:0007744|PDB:2AC3"
HELIX 339..348
/evidence="ECO:0007744|PDB:2AC3"
TURN 353..355
/evidence="ECO:0007744|PDB:2AC3"
HELIX 359..364
/evidence="ECO:0007744|PDB:2AC3"
TURN 366..368
/evidence="ECO:0007744|PDB:2HW7"
SEQUENCE 465 AA; 51875 MW; D6D4BE6C541012B1 CRC64;
MVQKKPAELQ GFHRSFKGQN PFELAFSLDQ PDHGDSDFGL QCSARPDMPA SQPIDIPDAK
KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITSQEY AVKIIEKQPG
HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL
EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS
PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGRCG
SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWAHISCA AKDLISKLLV RDAKQRLSAA
QVLQHPWVQG CAPENTLPTP MVLQRNSCAK DLTSFAAEAI AMNRQLAQHD EDLAEEEAAG
QGQPVLVRAT SRCLQLSPPS QSKLAQRRQR ASLSSAPVVL VGDHA


Related products :

Catalog number Product name Quantity
EIAAB24897 GPRK7,Homo sapiens,Human,MAP kinase signal-integrating kinase 2,MAP kinase-interacting serine_threonine-protein kinase 2,MKNK2,Mnk2,MNK2
EIAAB24899 MAP kinase signal-integrating kinase 2,MAP kinase-interacting serine_threonine-protein kinase 2,Mknk2,Mnk2,Mnk2,Mouse,Mus musculus
EIAAB24898 MAP kinase signal-integrating kinase 2,MAP kinase-interacting serine_threonine-protein kinase 2,Mknk2,Mnk2,Rat,Rattus norvegicus
EIAAB24894 Bos taurus,Bovine,MAP kinase signal-integrating kinase 1,MAP kinase-interacting serine_threonine-protein kinase 1,MKNK1,Mnk1
EIAAB24893 Homo sapiens,Human,MAP kinase signal-integrating kinase 1,MAP kinase-interacting serine_threonine-protein kinase 1,MKNK1,Mnk1,MNK1
EIAAB24895 MAP kinase signal-integrating kinase 1,MAP kinase-interacting serine_threonine-protein kinase 1,Mknk1,Mnk1,Mnk1,Mouse,Mus musculus
EIAAB24896 MAP kinase signal-integrating kinase 1,MAP kinase-interacting serine_threonine-protein kinase 1,Mknk1,Mnk1,Mnk1,Rat,Rattus norvegicus
EIAAB24845 ERK-4,Extracellular signal-regulated kinase 4,MAP kinase 4,MAP kinase isoform p63,MAPK 4,Mapk4,Mitogen-activated protein kinase 4,MNK2,p63-MAPK,Prkm4,Rat,Rattus norvegicus
U1357m CLIA Erk1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,Mapk3,Microtubule-associated protein 2 kinase 96T
U1357r CLIA Erk1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,Mapk3,Microtubule-associated protein 2 kinase 96T
E1357m ELISA kit Erk1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,Mapk3,Microtubule-associated protein 2 96T
E1357r ELISA kit Erk1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,Mapk3,Microtubule-associated protein 2 96T
E1357r ELISA Erk1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,Mapk3,Microtubule-associated protein 2 kinas 96T
E1357m ELISA Erk1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,Mapk3,Microtubule-associated protein 2 kinas 96T
E1357h ELISA kit ERK1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Homo sapiens,Human,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,MAPK3,Microtubule-as 96T
U1357h CLIA ERK1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Homo sapiens,Human,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,MAPK3,Microtubule-associat 96T
E1357h ELISA ERK1,ERK-1,ERT2,Extracellular signal-regulated kinase 1,Homo sapiens,Human,Insulin-stimulated MAP2 kinase,MAP kinase 1,MAP kinase 3,MAP kinase isoform p44,MAPK 1,MAPK 3,MAPK3,Microtubule-associa 96T
E1206h ELISA kit ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,Homo sapiens,Human,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-ac 96T
E1206h ELISA ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,Homo sapiens,Human,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-activat 96T
U1206h CLIA ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,Homo sapiens,Human,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-activate 96T
10-663-45536 ERK2_MAPK1 (p42 MAP Kinase) - Active Enzyme Human - EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1 N_A 0.001 mg
10-663-45536 ERK2_MAPK1 (p42 MAP Kinase) - Active Enzyme Human - EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1 N_A 0.005 mg
10-663-45537 ERK2_MAPK1 (p42 MAP Kinase) - Inactive Enzyme Human - EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1 N_A 0.01 mg
10-663-45537 ERK2_MAPK1 (p42 MAP Kinase) - Inactive Enzyme Human - EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1 N_A 0.003 mg
10-663-45537 ERK2_MAPK1 (p42 MAP Kinase) - Inactive Enzyme Human - EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1 N_A 0.02 mg
Pathways :
WP1493: Carbon assimilation C4 pathway
WP1703: Streptomycin biosynthesis
WP253: Glycolysis
WP1567: Glycolysis and Gluconeogenesis
WP1844: MAP kinase cascade
WP1619: Amino sugar and nucleotide sugar metabolism
WP1701: Starch and sucrose metabolism
WP1653: Galactose metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP32: Translation Factors
WP1681: Pantothenate and CoA biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1946: Cori Cycle
WP1909: Signal regulatory protein (SIRP) family interactions
WP1965: VEGF-receptor Signal Transduction
WP1659: Glycine, serine and threonine metabolism
WP842: Signal Transduction of S1P
WP2199: Seed Development
WP1081: Signal Transduction of S1P
WP1391: Signal Transduction of S1P
WP1312: Signal Transduction of S1P
WP2185: Purine metabolism
WP656: p53 signal pathway
WP962: Signal Transduction of S1P
WP402: ERK1 - ERK2 MAPK cascade

Related Genes :
[Mknk2 Mnk2] MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[mnk-1 R166.5] MAP kinase-interacting serine/threonine-protein kinase mnk-1 (EC 2.7.11.1) (MAP kinase integrating kinase-1)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[MAPK14 CSBP1 CSBP2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk11 Prkm11] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK7 BMK1 ERK5 PRKM7] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[Mapk7 Bmk1 Erk5] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[MAP3K5 ASK1 MAPKKK5 MEKK5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[Mapk7 Bmk1 Erk5] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK14 CSBP1] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a)
[Map3k5 Ask1 Mekk5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[mak-2 C44C8.6] MAP kinase-activated protein kinase mak-2 (MAPK-activated protein kinase mak-2) (EC 2.7.11.1)
[MAPK10 JNK3 JNK3A PRKM10 SAPK1B] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[MPK4 At4g01370 F2N1.1 F2N1_2-t] Mitogen-activated protein kinase 4 (AtMPK4) (MAP kinase 4) (EC 2.7.11.24)
[Map4k2 Rab8ip] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (Germinal center kinase) (GCK) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)

Bibliography :