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MARVEL domain-containing protein

 G1PPZ7_MYOLU            Unreviewed;       180 AA.
G1PPZ7;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
11-DEC-2019, entry version 42.
SubName: Full=CKLF like MARVEL transmembrane domain containing 3 {ECO:0000313|Ensembl:ENSMLUP00000013114};
Name=CMTM3 {ECO:0000313|Ensembl:ENSMLUP00000013114};
Myotis lucifugus (Little brown bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
Myotis.
NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013114, ECO:0000313|Proteomes:UP000001074};
[1] {ECO:0000313|Ensembl:ENSMLUP00000013114, ECO:0000313|Proteomes:UP000001074}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29 mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSMLUP00000013114}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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EMBL; AAPE02038676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAPE02038677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_014320370.1; XM_014464884.1.
STRING; 59463.ENSMLUP00000013114; -.
Ensembl; ENSMLUT00000014422; ENSMLUP00000013114; ENSMLUG00000014424.
eggNOG; KOG4788; Eukaryota.
eggNOG; ENOG4111IAF; LUCA.
GeneTree; ENSGT00940000160432; -.
InParanoid; G1PPZ7; -.
OMA; VFALDFY; -.
TreeFam; TF317387; -.
Proteomes; UP000001074; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
GO; GO:0050861; P:positive regulation of B cell receptor signaling pathway; IEA:Ensembl.
InterPro; IPR008253; Marvel.
Pfam; PF01284; MARVEL; 1.
PROSITE; PS51225; MARVEL; 1.
4: Predicted;
Membrane {ECO:0000256|SAAS:SAAS00070488, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000001074};
Transmembrane {ECO:0000256|SAAS:SAAS00070488, ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00070488,
ECO:0000256|SAM:Phobius}.
TRANSMEM 66..88
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 100..120
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 126..149
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 34..153
/note="MARVEL"
/evidence="ECO:0000259|PROSITE:PS51225"
REGION 1..21
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 161..180
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1..17
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 166..180
/note="Acidic"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 180 AA; 19610 MW; CE1A7E3D85612BE4 CRC64;
MWPPDPDPEP DPSPPAAKLR TPARGCAPSW LPFLAARAKG RLLLAAPGLS FIIFVCYVAS
TASAFLTAPL LEFLLALFFL FADAMQLNDK WQGLCWPMMD FLRCVTAALI YFAISITAVA
KYSDGAAKAA GVFGFFATIV FAIDFYLIFN DVAKFLKQEG SADETTANKE EEEDSDSDSD


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