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MARVEL domain-containing protein

 Q3TA49_MOUSE            Unreviewed;       184 AA.
Q3TA49;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
11-DEC-2019, entry version 66.
RecName: Full=MARVEL domain-containing protein {ECO:0000259|PROSITE:PS51225};
Name=Cmtm3 {ECO:0000313|MGI:MGI:2447162};
Synonyms=Cklfsf3 {ECO:0000313|MGI:MGI:2447162};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE42821.1};
[1] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to prepare
full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format sequencing
pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[6] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[8] {ECO:0000313|EMBL:BAE42821.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE42821.1};
TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42821.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
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EMBL; AK172091; BAE42821.1; -; mRNA.
PeptideAtlas; Q3TA49; -.
MGI; MGI:2447162; Cmtm3.
eggNOG; KOG4788; Eukaryota.
eggNOG; ENOG4111IAF; LUCA.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
InterPro; IPR008253; Marvel.
Pfam; PF01284; MARVEL; 1.
PROSITE; PS51225; MARVEL; 1.
2: Evidence at transcript level;
Membrane {ECO:0000256|SAAS:SAAS00070488, ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAAS:SAAS00070488, ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00070488,
ECO:0000256|SAM:Phobius}.
TRANSMEM 53..83
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 103..122
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 128..151
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 36..155
/note="MARVEL"
/evidence="ECO:0000259|PROSITE:PS51225"
REGION 1..22
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 163..184
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 184 AA; 20265 MW; 6AAF8A4531151EB3 CRC64;
MWPPDAEPEP DPESAHGPRS GRTVPGLRAL LPARAFLCSL KGRLLLAESG LSFMTFICYV
VSSASAFLTV PLLEFLLAVY FLFADAMQLN DKWQGLCWPM MDFLRCVTAA LIYFVISITA
VAKYSDGAYK AAGVFGFFAT IVFAIDFYLI FNEVAKFLKQ GDSGNETTAH RTEEENSNSD
SDSD


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Catalog number Product name Quantity
MALD3_MOUSE Mouse ELISA Kit FOR MARVEL domain-containing protein 3 96T
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MALD3_HUMAN Human ELISA Kit FOR MARVEL domain-containing protein 3 96T
CSB-EL013504HU Human MARVEL domain-containing protein 3(MARVELD3) ELISA kit 96T
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Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP163: Cytoplasmic Ribosomal Proteins
WP1659: Glycine, serine and threonine metabolism
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection

Related Genes :

Bibliography :
[32568178] CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
[32305130] Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.
[32219331] PD-L1 is induced on the hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 up-regulation by the anti-HBV drug Entecavir.
[32185721] Checkpoints Under Traffic Control: From and to Organelles.
[32022930] CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
[31990600] Downregulated CMTM2 Poses Potential Clinical Significance in Hepatocellular Carcinoma.
[31897604] In focus in HCB.
[31754330] Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer.
[31739405] Tricellulin Effect on Paracellular Water Transport.
[31605795] Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non-Small Cell Lung Cancer.