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MARVEL domain-containing protein 1

 MALD1_HUMAN             Reviewed;         173 AA.
Q9BSK0;
09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
13-FEB-2019, entry version 119.
RecName: Full=MARVEL domain-containing protein 1;
Name=MARVELD1; Synonyms=MRVLDC1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=19364627; DOI=10.1016/j.canlet.2009.03.008;
Wang S., Li Y., Han F., Hu J., Yue L., Yu Y., Zhang Y., He J.,
Zheng H., Shi S., Fu X., Wu H.;
"Identification and characterization of MARVELD1, a novel nuclear
protein that is down-regulated in multiple cancers and silenced by DNA
methylation.";
Cancer Lett. 282:77-86(2009).
[4]
ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
-!- FUNCTION: Microtubule-associated protein that exhibits cell cycle-
dependent localization and can inhibit cell proliferation and
migration. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
{ECO:0000250}. Nucleus {ECO:0000269|PubMed:19364627}.
Note=Observed in the nucleus and at the perinuclear region during
interphase, but localizes at the mitotic spindle and midbody at
metaphase. A significant fraction of MARVELD1 translocates to the
plasma membrane during anaphase or upon microtubule
depolymerization (By similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Widely expressed in normal tissues. Down-
regulated in multiple primary tumors.
{ECO:0000269|PubMed:19364627}.
-!- MISCELLANEOUS: Down-regulated in primary multiple tumors derived
from ovary, vulva, uterus, cervix, breast, testis, kidney bladder
and liver. The reduced expression is owing to DNA methylation and
could be reversed by pharmacologic demethylation
(PubMed:19364627). {ECO:0000305|PubMed:19364627}.
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EMBL; AL355315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC004995; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; BC062544; -; NOT_ANNOTATED_CDS; mRNA.
RefSeq; NP_113672.1; NM_031484.3.
UniGene; Hs.744073; -.
ProteinModelPortal; Q9BSK0; -.
BioGrid; 123750; 1.
STRING; 9606.ENSP00000441365; -.
iPTMnet; Q9BSK0; -.
PhosphoSitePlus; Q9BSK0; -.
SwissPalm; Q9BSK0; -.
BioMuta; MARVELD1; -.
DMDM; 74752303; -.
jPOST; Q9BSK0; -.
PaxDb; Q9BSK0; -.
PeptideAtlas; Q9BSK0; -.
PRIDE; Q9BSK0; -.
ProteomicsDB; 78908; -.
Ensembl; ENST00000285605; ENSP00000441365; ENSG00000155254.
GeneID; 83742; -.
KEGG; hsa:83742; -.
UCSC; uc001koj.5; human.
CTD; 83742; -.
DisGeNET; 83742; -.
EuPathDB; HostDB:ENSG00000155254.12; -.
GeneCards; MARVELD1; -.
HGNC; HGNC:28674; MARVELD1.
neXtProt; NX_Q9BSK0; -.
OpenTargets; ENSG00000155254; -.
PharmGKB; PA134937190; -.
eggNOG; KOG4788; Eukaryota.
eggNOG; ENOG4111IAF; LUCA.
GeneTree; ENSGT00510000049375; -.
HOVERGEN; HBG081949; -.
InParanoid; Q9BSK0; -.
OMA; KYEGSIH; -.
OrthoDB; 1449334at2759; -.
PhylomeDB; Q9BSK0; -.
TreeFam; TF316174; -.
GenomeRNAi; 83742; -.
PRO; PR:Q9BSK0; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000155254; Expressed in 206 organ(s), highest expression level in metanephros.
Genevisible; Q9BSK0; HS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0042552; P:myelination; IBA:GO_Central.
InterPro; IPR008253; Marvel.
Pfam; PF01284; MARVEL; 1.
PROSITE; PS51225; MARVEL; 1.
1: Evidence at protein level;
Acetylation; Cell cycle; Cell membrane; Complete proteome; Cytoplasm;
Cytoskeleton; Membrane; Nucleus; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN 1 173 MARVEL domain-containing protein 1.
/FTId=PRO_0000271522.
TOPO_DOM 1 29 Cytoplasmic. {ECO:0000255}.
TRANSMEM 30 50 Helical. {ECO:0000255}.
TOPO_DOM 51 59 Extracellular. {ECO:0000255}.
TRANSMEM 60 80 Helical. {ECO:0000255}.
TOPO_DOM 81 94 Cytoplasmic. {ECO:0000255}.
TRANSMEM 95 115 Helical. {ECO:0000255}.
TOPO_DOM 116 138 Extracellular. {ECO:0000255}.
TRANSMEM 139 159 Helical. {ECO:0000255}.
TOPO_DOM 160 173 Cytoplasmic. {ECO:0000255}.
DOMAIN 26 166 MARVEL. {ECO:0000255|PROSITE-
ProRule:PRU00581}.
COMPBIAS 3 6 Poly-Pro.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000244|PubMed:22223895}.
SEQUENCE 173 AA; 18914 MW; D39B3DBF06EB32EA CRC64;
MLPPPPRQPP PQARAARGAV RLQRPFLRSP LGVLRLLQLL AGAAFWITIA TSKYQGPVHF
ALFVSVLFWL LTLGLYFLTL LGKHELVPVL GSRWLMVNVA HDVLAAALYG AATGIMSDQM
QRHSYCNLKD YPLPCAYHAF LAAAVCGGVC HGLYLLSALY GCGRRCQGKQ EVA


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