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MB2q1 protein (MB2q2 protein) (MB2q3 protein) (MB2q4 protein) (MB2q5 protein) (MB2q6 protein)

 Q95602_MOUSE            Unreviewed;       261 AA.
Q95602;
01-FEB-1997, integrated into UniProtKB/TrEMBL.
01-FEB-1997, sequence version 1.
28-FEB-2018, entry version 141.
SubName: Full=MB2q1 protein {ECO:0000313|EMBL:CAA62317.1};
SubName: Full=MB2q2 protein {ECO:0000313|EMBL:CAA62318.1};
SubName: Full=MB2q3 protein {ECO:0000313|EMBL:CAA62322.1};
SubName: Full=MB2q4 protein {ECO:0000313|EMBL:CAA62325.1};
SubName: Full=MB2q5 protein {ECO:0000313|EMBL:CAA62326.1};
SubName: Full=MB2q6 protein {ECO:0000313|EMBL:CAA62327.1};
Name=H2-DMb2 {ECO:0000313|MGI:MGI:95923};
Synonyms=MB2q1 {ECO:0000313|EMBL:CAA62317.1},
MB2q2 {ECO:0000313|EMBL:CAA62318.1},
MB2q3 {ECO:0000313|EMBL:CAA62322.1},
MB2q4 {ECO:0000313|EMBL:CAA62325.1},
MB2q5 {ECO:0000313|EMBL:CAA62326.1},
MB2q6 {ECO:0000313|EMBL:CAA62327.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:CAA62325.1};
[1] {ECO:0000313|EMBL:CAA62325.1}
NUCLEOTIDE SEQUENCE.
STRAIN=B10.G {ECO:0000313|EMBL:CAA62318.1},
B10.Q {ECO:0000313|EMBL:CAA62317.1},
DBA/1 {ECO:0000313|EMBL:CAA62327.1},
NFR/N {ECO:0000313|EMBL:CAA62325.1},
NFR/N-XID {ECO:0000313|EMBL:CAA62322.1}, and
SWR {ECO:0000313|EMBL:CAA62326.1};
TISSUE=Spleen {ECO:0000313|EMBL:CAA62325.1};
PubMed=8613139; DOI=10.1007/s002510050085;
Walter W., Loos M., Maeurer M.J.;
"H2-M polymorphism in mice susceptible to collagen-induced arthritis
involves the peptide binding groove.";
Immunogenetics 44:19-26(1996).
-!- SIMILARITY: Belongs to the MHC class II family.
{ECO:0000256|SAAS:SAAS00552561}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; X90798; CAA62317.1; -; mRNA.
EMBL; X90799; CAA62318.1; -; mRNA.
EMBL; X90803; CAA62322.1; -; mRNA.
EMBL; X90806; CAA62325.1; -; mRNA.
EMBL; X90807; CAA62326.1; -; mRNA.
EMBL; X90808; CAA62327.1; -; mRNA.
UniGene; Mm.195060; -.
MGI; MGI:95923; H2-DMb2.
eggNOG; ENOG410IFNH; Eukaryota.
eggNOG; ENOG410YU9X; LUCA.
HOVERGEN; HBG007327; -.
GO; GO:0010008; C:endosome membrane; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IDA:MGI.
GO; GO:0005770; C:late endosome; IDA:MGI.
GO; GO:0005765; C:lysosomal membrane; IDA:MGI.
GO; GO:0005764; C:lysosome; IDA:MGI.
GO; GO:0042613; C:MHC class II protein complex; ISO:MGI.
GO; GO:0005771; C:multivesicular body; IDA:MGI.
GO; GO:0023026; F:MHC class II protein complex binding; ISO:MGI.
GO; GO:0019882; P:antigen processing and presentation; IDA:MGI.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:MGI.
GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IDA:MGI.
GO; GO:0006955; P:immune response; IEA:InterPro.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.10.320.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR011162; MHC_I/II-like_Ag-recog.
InterPro; IPR014745; MHC_II_a/b_N.
InterPro; IPR000353; MHC_II_b_N.
Pfam; PF07654; C1-set; 1.
Pfam; PF00969; MHC_II_beta; 1.
SMART; SM00407; IGc1; 1.
SMART; SM00921; MHC_II_beta; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF54452; SSF54452; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00290; IG_MHC; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Disulfide bond {ECO:0000256|SAAS:SAAS00465899};
Immunity {ECO:0000256|SAAS:SAAS00437896};
Membrane {ECO:0000256|SAAS:SAAS00437953, ECO:0000256|SAM:Phobius};
MHC II {ECO:0000256|SAAS:SAAS00437896};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00437953,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00437953,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 261 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5010147612.
TRANSMEM 219 238 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 114 204 Ig-like. {ECO:0000259|PROSITE:PS50835}.
COILED 80 100 {ECO:0000256|SAM:Coils}.
SEQUENCE 261 AA; 28997 MW; 22BFD9FE83B809B6 CRC64;
MAALWLLLLV LSLDCMGAGG FVAHVESTCV LDDAGIPQDF TYCVSFNKDL LACWDPDVGK
IVPCEFGVLS RLAEIISMIL NEQESLIQRL QNRLQDCATH TQPFWDVLTH RTRPPSVRVA
QTTPFNTREP VMLACYVWGF YPADVTITWM KNGQLVPSHS NKEKTAQPNG DWTYQTVSYL
ALTPSYGDVY TCVVQHSGTS EPIRGDWTPG LSPIQTVKVS VSAATLGLGF IIFCVGFFRW
RKSHSSSYTP LPGSTYPEGR H


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair

Related Genes :
[msrP yedY b1971 JW1954] Protein-methionine-sulfoxide reductase catalytic subunit MsrP (EC 1.8.5.-)
[MICAL1 MICAL NICAL] [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)
[Mical1 Mical Nical] [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (Molecule interacting with CasL protein 1) (MICAL-1) (mMical1) (NEDD9-interacting protein with calponin homology and LIM domains)
[MICAL3 KIAA0819 KIAA1364] [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
[Mical1] [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (Molecule interacting with CasL protein 1) (MICAL-1)
[Mical3 Kiaa0819 Kiaa1364] [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
[Mical CG33208] [F-actin]-monooxygenase Mical (EC 1.14.13.225) (Molecule interacting with CasL protein homolog)
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[Mical2 Kiaa0750] [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (Molecule interacting with CasL protein 2) (MICAL-2) (mMical2)
[MSRB3 UNQ1965/PRO4487] Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14)
[MICAL1] [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (Molecule interacting with CasL protein 1) (MICAL-1)
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[OR1D2 OLFR1] Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)
[stk-1 bur1 B20D17.070 NCU01435] Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC 2.7.11.23) (Serine-threonine kinase 1)
[MICAL2 KIAA0750 MICAL2PV1 MICAL2PV2] [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (Molecule interacting with CasL protein 2) (MICAL-2)
[MSRB1 SEPX1 HSPC270] Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X) (SelX)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[Kmt2a All1 Hrx Mll Mll1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[frq B13D24.170 NCU02265] Frequency clock protein
[TY1B-OR YORWTy1-2 POL YOR142W-B O3367 YOR3367W] Transposon Ty1-OR Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)]
[TY2B-OR2 YORWTy2-2 POL YOR343W-B O6304] Transposon Ty2-OR2 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)]
[MICAL3] [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
[MLLT3 AF9 YEATS3] Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
[TY2B-OR1 YORCTy2-1 POL YOR192C-B O4785] Transposon Ty2-OR1 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)]
[RTS1 SCS1 YOR014W OR26.04] Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (Protein RTS1) (Protein SCS1)
[pep NCU02549] Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (Ubiquinol-cytochrome-c reductase complex core protein I)
[NCU03947] E3 ubiquitin-protein ligase (EC 2.3.2.26)
[RpLP0 AP3 Ape RpP0 CG7490] 60S acidic ribosomal protein P0 (Apurinic-apyrimidinic endonuclease) (DNA-(apurinic or apyrimidinic site) lyase) (EC 4.2.99.18)

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[30901725] Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.
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[30901678] Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4/MAPK pathway.
[30901675] Development of a versatile DNMT and HDAC inhibitor C02S modulating multiple cancer hallmarks for breast cancer therapy.
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