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Mast/stem cell growth factor receptor (EC 2.7.10.1)

 Q63116_RAT              Unreviewed;       978 AA.
Q63116;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
13-FEB-2019, entry version 171.
RecName: Full=Mast/stem cell growth factor receptor {ECO:0000256|PIRNR:PIRNR500951};
EC=2.7.10.1 {ECO:0000256|PIRNR:PIRNR500951};
Name=Kit {ECO:0000313|EMBL:EDL89921.1,
ECO:0000313|Ensembl:ENSRNOP00000003050, ECO:0000313|RGD:620568};
Synonyms=KIT {ECO:0000313|EMBL:ABX45067.1};
ORFNames=rCG_56893 {ECO:0000313|EMBL:EDL89921.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:BAA02094.1};
[1] {ECO:0000313|EMBL:BAA02094.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley {ECO:0000313|EMBL:BAA02094.1};
PubMed=1912577;
Tsujimura T., Hirota S., Nomura S., Niwa Y., Yamazaki M., Tono T.,
Morii E., Kim H., Kondo K., Nishimune Y., Kitamura Y.;
"Characterization of Ws mutant allele of rats: a 12-base deletion in
tyrosine kinase domain of c-kit gene.";
Blood 78:1942-1946(1991).
[2] {ECO:0000313|Ensembl:ENSRNOP00000003050, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003050,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3] {ECO:0000313|EMBL:EDL89921.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL89921.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[4] {ECO:0000313|EMBL:EDL89921.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL89921.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:ABX45067.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ACI {ECO:0000313|EMBL:ABX45067.1}, and
BN {ECO:0000313|EMBL:ABX45068.1};
TISSUE=Lung {ECO:0000313|EMBL:ABX45067.1};
Lachel C.M., Fisher K.W., Shull J.D.;
"Characterization of Renag1 Candidates.";
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000213|PubMed:22673903}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
[7] {ECO:0000313|Ensembl:ENSRNOP00000003050}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003050};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|SAAS:SAAS01124082};
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000311};
Single-pass type I membrane protein
{ECO:0000256|RuleBase:RU000311}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily.
{ECO:0000256|PIRNR:PIRNR500951, ECO:0000256|RuleBase:RU000311}.
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EMBL; AABR07014877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AABR07014878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AABR07014879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EU247827; ABX45067.1; -; mRNA.
EMBL; EU247828; ABX45068.1; -; mRNA.
EMBL; D12524; BAA02094.1; -; mRNA.
EMBL; CH473981; EDL89921.1; -; Genomic_DNA.
PIR; A49814; A49814.
RefSeq; NP_071600.1; NM_022264.1.
UniGene; Rn.54004; -.
STRING; 10116.ENSRNOP00000003050; -.
Ensembl; ENSRNOT00000003050; ENSRNOP00000003050; ENSRNOG00000002227.
GeneID; 64030; -.
KEGG; rno:64030; -.
CTD; 3815; -.
RGD; 620568; Kit.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000155626; -.
HOGENOM; HOG000112008; -.
HOVERGEN; HBG004335; -.
KO; K05091; -.
OMA; YMNRTST; -.
OrthoDB; 236292at2759; -.
TreeFam; TF325768; -.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-1433557; Signaling by SCF-KIT.
Reactome; R-RNO-1433559; Regulation of KIT signaling.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000002227; Expressed in 10 organ(s), highest expression level in lung.
GO; GO:0001669; C:acrosomal vesicle; IDA:RGD.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:RGD.
GO; GO:0009897; C:external side of plasma membrane; IDA:RGD.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0019955; F:cytokine binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0004713; F:protein tyrosine kinase activity; IDA:RGD.
GO; GO:0005020; F:stem cell factor receptor activity; IEA:Ensembl.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl.
GO; GO:0002371; P:dendritic cell cytokine production; IEA:Ensembl.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
GO; GO:0050673; P:epithelial cell proliferation; IMP:RGD.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0038093; P:Fc receptor signaling pathway; IEA:UniProtKB-UniRule.
GO; GO:0008354; P:germ cell migration; IMP:RGD.
GO; GO:0006687; P:glycosphingolipid metabolic process; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
GO; GO:0035701; P:hematopoietic stem cell migration; IEA:Ensembl.
GO; GO:0002327; P:immature B cell differentiation; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0038109; P:Kit signaling pathway; IBA:GO_Central.
GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0002551; P:mast cell chemotaxis; IEA:Ensembl.
GO; GO:0032762; P:mast cell cytokine production; IEA:Ensembl.
GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
GO; GO:0060374; P:mast cell differentiation; IEA:Ensembl.
GO; GO:0035855; P:megakaryocyte development; IEA:Ensembl.
GO; GO:0097326; P:melanocyte adhesion; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0097324; P:melanocyte migration; IEA:Ensembl.
GO; GO:0002318; P:myeloid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.
GO; GO:0030335; P:positive regulation of cell migration; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
GO; GO:1904343; P:positive regulation of colon smooth muscle contraction; IMP:RGD.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IMP:RGD.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:RGD.
GO; GO:0031274; P:positive regulation of pseudopodium assembly; IMP:RGD.
GO; GO:0120072; P:positive regulation of pyloric antrum smooth muscle contraction; IMP:RGD.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
GO; GO:1904349; P:positive regulation of small intestine smooth muscle contraction; IMP:RGD.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IDA:RGD.
GO; GO:1904251; P:regulation of bile acid metabolic process; IMP:RGD.
GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
GO; GO:0048070; P:regulation of developmental pigmentation; IEA:Ensembl.
GO; GO:0046686; P:response to cadmium ion; IEP:RGD.
GO; GO:0009314; P:response to radiation; IEP:RGD.
GO; GO:0048103; P:somatic stem cell division; IMP:RGD.
GO; GO:0035019; P:somatic stem cell population maintenance; IMP:RGD.
GO; GO:0007286; P:spermatid development; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IMP:RGD.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
GO; GO:0043586; P:tongue development; IEP:RGD.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
GO; GO:0008542; P:visual learning; IMP:RGD.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF00047; ig; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 4.
SMART; SM00408; IGc2; 3.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 4.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50835; IG_LIKE; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
1: Evidence at protein level;
ATP-binding {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|PIRSR:PIRSR500951-2, ECO:0000256|SAAS:SAAS00708816};
Cell membrane {ECO:0000256|PIRNR:PIRNR500951};
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
Immunoglobulin domain {ECO:0000256|RuleBase:RU000311,
ECO:0000256|SAAS:SAAS00442402};
Kinase {ECO:0000256|PIRNR:PIRNR500951, ECO:0000256|SAAS:SAAS00582553};
Magnesium {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|PIRSR:PIRSR500951-1};
Membrane {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|SAAS:SAAS00602683};
Metal-binding {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|PIRSR:PIRSR500951-1};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|PIRSR:PIRSR500951-2, ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|RuleBase:RU000311, ECO:0000256|SAAS:SAAS00600436,
ECO:0000313|EMBL:BAA02094.1};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Repeat {ECO:0000256|SAAS:SAAS00457685};
Signal {ECO:0000256|PIRNR:PIRNR500951};
Transferase {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|SAAS:SAAS00602683};
Transmembrane helix {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|SAAS:SAAS00602683};
Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR500951,
ECO:0000256|SAAS:SAAS00582553}.
SIGNAL 1 25 {ECO:0000256|PIRNR:PIRNR500951}.
CHAIN 26 978 Mast/stem cell growth factor receptor.
{ECO:0000256|PIRNR:PIRNR500951}.
/FTId=PRO_5013989147.
TRANSMEM 523 550 Helical. {ECO:0000256|PIRNR:PIRNR500951}.
DOMAIN 37 97 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 212 310 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 591 938 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
NP_BIND 598 605 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
NP_BIND 673 679 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
METAL 570 570 Magnesium.
{ECO:0000256|PIRSR:PIRSR500951-1}.
METAL 798 798 Magnesium.
{ECO:0000256|PIRSR:PIRSR500951-1}.
METAL 811 811 Magnesium.
{ECO:0000256|PIRSR:PIRSR500951-1}.
BINDING 625 625 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
BINDING 797 797 ATP. {ECO:0000256|PIRSR:PIRSR500951-2}.
SITE 937 937 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000256|PIRSR:PIRSR500951-3}.
SEQUENCE 978 AA; 109342 MW; 0958C33F19889051 CRC64;
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA GDTIRLTCTD
PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG SGLRSSIYVF VRDPAVLFLV
GLPLFGKEDN DALVRCPLTD PQVSNYSLIE CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH
RLCIRCAAQR EGKWMRSDKF TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST
SVDSMWIKLN PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW IYMNRTPTNR
GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD VSASVTFDVY VNTKPEILTY
DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ RCTVPVPPVD VQIQNASVSP FGKLVVQSSI
DSSVFRHNGT VECKASNAVG KSSAFFNFAF KGNSKEQIQP HTLFTPLLIG FVVTAGLMGI
IVMVLAYKYL QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG NHMNIVNLLG
ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FIFSKQEEQA DAALYKNLLH SKESSCDSSN
EYMDMKPGVS YVVPTKTDKR RSARIDSYIE RDVTPAIMED DELALDLEDL LSFSYQVAKG
MAFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIRN DSNYVVKGNA RLPVKWMAPE
SIFNCVYTFE SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM LSPEHAPAAM
YEVMKTCWDA DPLKRPTFKQ VVQLIEKQIS DSSKHIYSNL ANCNPNPENP VVVDHSVRVN
SVGSSTSSTQ PLLVHEDA


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18-783-75592 GOAT ANTI HUMAN STEM CELL FACTOR - SCF; C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF Polyclonal 0.1 mg
EM248 Mast per stem cell growth factor receptor Kit Elisa Kit 96T
AE58442CH Chicken Mast per stem cell growth factor receptor (KIT) ELISA Kit 48T
CSB-EL012375BO Bovine Mast per stem cell growth factor receptor(KIT) ELISA kit 96T
10-663-45248 Stem Cell Factor - glycosylated (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.002 mg
10-663-45248 Stem Cell Factor - glycosylated (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.01 mg
10-663-45248 Stem Cell Factor - glycosylated (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 1 mg
CSB-E17423m Mouse mast per stem cell growth factor receptor (Kit per Sl per CD117) ELISA Kit 96T
E0121m ELISA Kit FOR Mast per stem cell growth factor receptor Kit; organism: Mouse; gene name: Kit 96T
10-663-45134 Stem Cell Factor (SCF) Murine - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.01 mg
10-663-45123 Stem Cell Factor (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 1 mg
10-663-45123 Stem Cell Factor (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.01 mg
10-663-45123 Stem Cell Factor (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.002 mg
10-663-45134 Stem Cell Factor (SCF) Murine - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 1 mg
10-663-45134 Stem Cell Factor (SCF) Murine - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.002 mg
X2188P Human Mast per stem cell growth factor receptor per SCRF per KIT Antigen Immunoaffinity Purified Polyclonal 50
X2189P Human Mast per stem cell growth factor receptor per SCRF per KIT Antigen Immunoaffinity Purified Polyclonal 50
10-663-45160 Stem Cell Factor (SCF) Rat - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 1 mg
10-663-45160 Stem Cell Factor (SCF) Rat - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.002 mg
10-663-45160 Stem Cell Factor (SCF) Rat - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 0.01 mg
E0120m ELISA kit c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Mouse,Mus musculus,SCF,Sl,Slf,Steel factor,Stem cell factor 96T
U0120m CLIA c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Mouse,Mus musculus,SCF,Sl,Slf,Steel factor,Stem cell factor 96T
E0120m ELISA c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Mouse,Mus musculus,SCF,Sl,Slf,Steel factor,Stem cell factor 96T
BMAhKL12 Stem Cell Factor (SCF), c_Kit Ligand, Mast Cell Growth Factor, Steel Factor, Clone hKL 12, Mab anti_Human; frozen_paraffin, IH_ELISA_WB 200 µg.

Kits Elisa; taq POLYMERASE

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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP23: B Cell Receptor Signaling Pathway
WP2328: Allograft rejection
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP352: T Cell Receptor Signaling Pathway
WP474: Endochondral Ossification

Related Genes :
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[kita kit sparse] Mast/stem cell growth factor receptor kita (SCFR) (EC 2.7.10.1) (Tyrosine-protein kinase Kit)
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[IGF1R] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[I79_024441] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[FGFR2 BEK KGFR KSAM] Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
[Fgfr1 Flg] Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Fgfr2 Bek Ect1] Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Keratinocyte growth factor receptor) (KGFR) (CD antigen CD332)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[FLT3 CD135 FLK2 STK1] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)

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