GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)

 KIT_CANLF               Reviewed;         979 AA.
O97799; Q7YRV7; Q8WN23;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
05-SEP-2006, sequence version 2.
03-JUL-2019, entry version 168.
RecName: Full=Mast/stem cell growth factor receptor Kit;
Short=SCFR;
EC=2.7.10.1;
AltName: Full=Proto-oncogene c-Kit;
AltName: Full=Tyrosine-protein kinase Kit;
AltName: CD_antigen=CD117;
Flags: Precursor;
Name=KIT;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=9989791; DOI=10.1046/j.1523-1747.1999.00488.x;
Ma Y., Longley B.J., Wang X., Blount J.L., Langley K., Caughey G.H.;
"Clustering of activating mutations in c-KIT's juxtamembrane coding
region in canine mast cell neoplasms.";
J. Invest. Dermatol. 112:165-170(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Zemke D., Yuzbasiyan-Gurkan V.;
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tsai K.L., Guyon R., Murphy K.E.;
"Characterization of an isoform and RH mapping of canine c-kit.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Tyrosine-protein kinase that acts as cell-surface
receptor for the cytokine KITLG/SCF and plays an essential role in
the regulation of cell survival and proliferation, hematopoiesis,
stem cell maintenance, gametogenesis, mast cell development,
migration and function, and in melanogenesis. In response to
KITLG/SCF binding, KIT can activate several signaling pathways.
Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the
AKT1 signaling pathway by phosphorylation of PIK3R1, the
regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT
also transmits signals via GRB2 and activation of RAS, RAF1 and
the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation
of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation
of PLCG1 leads to the production of the cellular signaling
molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT
signaling is modulated by protein phosphatases, and by rapid
internalization and degradation of the receptor. Activated KIT
promotes phosphorylation of the protein phosphatases PTPN6/SHP-1
and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A
and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform
Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1
(By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- ACTIVITY REGULATION: Present in an inactive conformation in the
absence of bound ligand. KITLG/SCF binding leads to dimerization
and activation by autophosphorylation on tyrosine residues.
Activity is down-regulated by PRKCA-mediated phosphorylation on
serine residues (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer in the absence of bound KITLG/SCF. Homodimer in
the presence of bound KITLG/SCF, forming a heterotetramer with two
KITLG/SCF molecules. Interacts (via phosphorylated tyrosine
residues) with the adapter proteins GRB2 and GRB7 (via SH2
domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via
the tenth PDZ domain). Interacts (via phosphorylated tyrosine
residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via
phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and
MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS.
Interacts (via phosphorylated tyrosine residues) with the protein
phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2
domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and
TEC. Interacts with IL1RAP (independent of stimulation with
KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33
signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By
similarity). {ECO:0000250|UniProtKB:P05532,
ECO:0000250|UniProtKB:P10721}.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O97799-1; Sequence=Displayed;
Name=2;
IsoId=O97799-2; Sequence=VSP_020224;
-!- PTM: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after
autophosphorylation induced by KITLG/SCF binding, leading to
internalization and degradation. {ECO:0000250}.
-!- PTM: Autophosphorylated on tyrosine residues. KITLG/SCF binding
promotes autophosphorylation. Phosphorylated tyrosine residues are
important for interaction with specific binding partners (By
similarity). {ECO:0000250}.
-!- MISCELLANEOUS: Numerous proteins are phosphorylated in response to
KIT signaling, but it is not evident to determine which are
directly phosphorylated by KIT under in vivo conditions.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF044249; AAD02327.1; -; mRNA.
EMBL; AF448148; AAL40833.1; -; mRNA.
EMBL; AY296484; AAP51178.1; -; mRNA.
EMBL; AY313776; AAP76390.1; -; mRNA.
RefSeq; NP_001003181.1; NM_001003181.1.
RefSeq; XP_005628025.1; XM_005627968.2. [O97799-1]
SMR; O97799; -.
STRING; 9612.ENSCAFP00000039467; -.
PaxDb; O97799; -.
PRIDE; O97799; -.
Ensembl; ENSCAFT00000049830; ENSCAFP00000039467; ENSCAFG00000002065. [O97799-2]
GeneID; 403811; -.
KEGG; cfa:403811; -.
CTD; 3815; -.
VGNC; VGNC:42422; KIT.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000155626; -.
HOGENOM; HOG000112008; -.
InParanoid; O97799; -.
KO; K05091; -.
OMA; YMNRTST; -.
OrthoDB; 236292at2759; -.
TreeFam; TF325768; -.
BRENDA; 2.7.10.1; 1153.
Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
Reactome; R-CFA-1433557; Signaling by SCF-KIT.
Reactome; R-CFA-1433559; Regulation of KIT signaling.
Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Proteomes; UP000002254; Chromosome 13.
Bgee; ENSCAFG00000002065; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019955; F:cytokine binding; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
GO; GO:0005020; F:stem cell factor receptor activity; IEA:Ensembl.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
GO; GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
GO; GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0002371; P:dendritic cell cytokine production; ISS:UniProtKB.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; ISS:UniProtKB.
GO; GO:0048565; P:digestive tract development; ISS:UniProtKB.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; ISS:UniProtKB.
GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0038093; P:Fc receptor signaling pathway; ISS:UniProtKB.
GO; GO:0006687; P:glycosphingolipid metabolic process; IEA:Ensembl.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
GO; GO:0035701; P:hematopoietic stem cell migration; IEA:Ensembl.
GO; GO:0002327; P:immature B cell differentiation; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0038109; P:Kit signaling pathway; ISS:UniProtKB.
GO; GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0002551; P:mast cell chemotaxis; IEA:Ensembl.
GO; GO:0032762; P:mast cell cytokine production; ISS:UniProtKB.
GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
GO; GO:0060374; P:mast cell differentiation; ISS:UniProtKB.
GO; GO:0035855; P:megakaryocyte development; ISS:UniProtKB.
GO; GO:0097326; P:melanocyte adhesion; ISS:UniProtKB.
GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
GO; GO:0097324; P:melanocyte migration; ISS:UniProtKB.
GO; GO:0002318; P:myeloid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0043473; P:pigmentation; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
GO; GO:0009314; P:response to radiation; IEA:Ensembl.
GO; GO:0007286; P:spermatid development; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF00047; ig; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 4.
SMART; SM00408; IGc2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 3.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50835; IG_LIKE; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase;
Magnesium; Membrane; Metal-binding; Nucleotide-binding;
Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat;
Signal; Transferase; Transmembrane; Transmembrane helix;
Tyrosine-protein kinase; Ubl conjugation.
SIGNAL 1 27 {ECO:0000255}.
CHAIN 28 979 Mast/stem cell growth factor receptor
Kit.
/FTId=PRO_0000016751.
TOPO_DOM 28 527 Extracellular. {ECO:0000255}.
TRANSMEM 528 548 Helical. {ECO:0000255}.
TOPO_DOM 549 979 Cytoplasmic. {ECO:0000255}.
DOMAIN 29 114 Ig-like C2-type 1.
DOMAIN 123 207 Ig-like C2-type 2.
DOMAIN 214 311 Ig-like C2-type 3.
DOMAIN 320 413 Ig-like C2-type 4.
DOMAIN 416 510 Ig-like C2-type 5.
DOMAIN 592 940 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 599 606 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 674 680 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 571 573 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000250}.
ACT_SITE 795 795 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
METAL 571 571 Magnesium. {ECO:0000250}.
METAL 800 800 Magnesium. {ECO:0000250}.
METAL 813 813 Magnesium. {ECO:0000250}.
BINDING 626 626 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 799 799 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SITE 571 571 Interaction with SH2B2/APS.
{ECO:0000250}.
SITE 939 939 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000250}.
SITE 939 939 Interaction with SH2B2/APS.
{ECO:0000250}.
MOD_RES 550 550 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 556 556 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 571 571 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 573 573 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 706 706 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 724 724 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 733 733 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 744 744 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 749 749 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 824 824 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 826 826 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 894 894 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 903 903 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 939 939 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 962 962 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
CARBOHYD 96 96 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 132 132 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 147 147 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 286 286 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 296 296 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 303 303 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 355 355 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 370 370 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 403 403 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 466 466 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 489 489 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 60 99 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 138 188 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 153 185 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 235 293 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 431 494 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VAR_SEQ 512 515 Missing (in isoform 2).
{ECO:0000303|PubMed:9989791,
ECO:0000303|Ref.3}.
/FTId=VSP_020224.
CONFLICT 23 23 Q -> R (in Ref. 1; AAD02327).
{ECO:0000305}.
CONFLICT 332 332 E -> Q (in Ref. 1; AAD02327).
{ECO:0000305}.
CONFLICT 442 442 D -> G (in Ref. 1; AAD02327).
{ECO:0000305}.
SEQUENCE 979 AA; 109753 MW; 46C30D5DEB8E33D3 CRC64;
MRGARGAWDF LCVLLLLLLL GVQTGSSQPS VSPGEPSLPS IHPAKSELIV SVGDELRLSC
TDPGFVKWTF ETLGQLNENT HNEWITEKAE AGHTGNYTCT NRDGLSRSIY VFVRDPAKLF
LVDLPLYGKE GNDTLVRCPL TDPEVTNYSL RGCEGKPLPK DLTFVADPKA GITIRNVKRE
YHRLCLHCSA DQKGRTVLSK KFTLKVRAAI RAVPVVSVSK TSSLLKEGEA FSVMCFIKDV
SSFVDSMWIK ENSQQTNAQT QSNSWHHGDF NFERQEKLII SSARVNDSGV FMCYANNTFG
SANVTTTLEV VDKGFINIFP MMSTTIFVND GENVDLIVEY EAYPKPEHQQ WIYMNRTFTD
KWEDYPKSDN ESNIRYVSEL HLTRLKGNEG GTYTFQVSNS DVNSSVTFNV YVNTKPEILT
HESLTNGMLQ CVVAGFPEPA VDWYFCPGAE QRCSVPIGPM DVQMQNSSLS PSGKLVVQSS
IDYSAFKHNG TVECRAYNNV GRSSAFFNFA FKGNSKEQIH PHTLFTPLLI GFVIAAGMMC
IIVMILTYKY LQKPMYEVQW KVVEEINGNN YVYIDPTQLP YDHKWEFPRN RLSFGKTLGA
GAFGKVVEAT AYGLIKSDAA MTVAVKMLKP SAHLTEREAL MSELKVLSYL GNHMNIVNLL
GACTVGGPTL VITEYCCYGD LLNFLRRKRD SFICSKQEDH GEVALYKNLL HSKESSCSDS
TNEYMDMKPG VSYVVPTKAD KRRSARIGSY IERDVTPAIM EDDELALDLE DLLSFSYQVA
KGMAFLASKN CIHRDLAARN ILLTHGRITK ICDFGLARDI KNDSNYVVKG NARLPVKWMA
PESIFNCVYT FESDVWSYGI FLWELFSLGS SPYPGMPVDS KFYKMIKEGF RMLSPEHAPA
EMYDIMKTCW DADPLKRPTF KQIVQLIEKQ ISDSTNHIYS NLANCSPNPE RPVVDHSVRI
NSVGSSASST QPLLVHEDV


Related products :

Catalog number Product name Quantity
15-288-21114 Mast_stem cell growth factor receptor - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Polyclonal 0.05 mg
15-288-21114 Mast_stem cell growth factor receptor - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Polyclonal 0.1 mg
U0121h CLIA Homo sapiens,Human,KIT,Mast_stem cell growth factor receptor Kit,p145 c-kit,PBT,Piebald trait protein,Proto-oncogene c-Kit,SCFR,SCFR,Tyrosine-protein kinase Kit,v-kit Hardy-Zuckerman 4 feline sar 96T
E0121h ELISA kit Homo sapiens,Human,KIT,Mast_stem cell growth factor receptor Kit,p145 c-kit,PBT,Piebald trait protein,Proto-oncogene c-Kit,SCFR,SCFR,Tyrosine-protein kinase Kit,v-kit Hardy-Zuckerman 4 feli 96T
E0121h ELISA Homo sapiens,Human,KIT,Mast_stem cell growth factor receptor Kit,p145 c-kit,PBT,Piebald trait protein,Proto-oncogene c-Kit,SCFR,SCFR,Tyrosine-protein kinase Kit,v-kit Hardy-Zuckerman 4 feline sa 96T
U0121p CLIA KIT,Mast_stem cell growth factor receptor Kit,Pig,Proto-oncogene c-Kit,SCFR,Sus scrofa,Tyrosine-protein kinase Kit 96T
E0121p ELISA kit KIT,Mast_stem cell growth factor receptor Kit,Pig,Proto-oncogene c-Kit,SCFR,Sus scrofa,Tyrosine-protein kinase Kit 96T
E0121p ELISA KIT,Mast_stem cell growth factor receptor Kit,Pig,Proto-oncogene c-Kit,SCFR,Sus scrofa,Tyrosine-protein kinase Kit 96T
E0121b ELISA Bos taurus,Bovine,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
U0121b CLIA Bos taurus,Bovine,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
U0121m CLIA Kit,Mast_stem cell growth factor receptor Kit,Mouse,Mus musculus,Proto-oncogene c-Kit,SCFR,Sl,Tyrosine-protein kinase Kit 96T
E0121m ELISA kit Kit,Mast_stem cell growth factor receptor Kit,Mouse,Mus musculus,Proto-oncogene c-Kit,SCFR,Sl,Tyrosine-protein kinase Kit 96T
E0121b ELISA kit Bos taurus,Bovine,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121m ELISA Kit,Mast_stem cell growth factor receptor Kit,Mouse,Mus musculus,Proto-oncogene c-Kit,SCFR,Sl,Tyrosine-protein kinase Kit 96T
10-054-165009 cKit HUMAN - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen 0.01 mg
U0121c CLIA Chicken,Gallus gallus,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121c ELISA kit Chicken,Gallus gallus,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121c ELISA Chicken,Gallus gallus,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
18-785-210252 c-Kit (Phospho-Tyr721) - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Polyclonal 0.05 mg
18-785-210252 c-Kit (Phospho-Tyr721) - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Polyclonal 0.1 mg
32-138 C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c 0.1 mL
U0121c CLIA Canis familiaris,Canis lupus familiaris,Dog,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121c ELISA Canis familiaris,Canis lupus familiaris,Dog,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
20-272-190432 c - Kit - Mouse monoclonal [104D2] to c - Kit; EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Monoclonal 0.05 mg
Pathways :
WP2328: Allograft rejection
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP23: B Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP780: T Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1130: T Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP2292: Chemokine signaling pathway
WP794: B Cell Receptor Signaling Pathway
WP274: B Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

Related Genes :
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
[kita kit sparse] Mast/stem cell growth factor receptor kita (SCFR) (EC 2.7.10.1) (Tyrosine-protein kinase Kit)
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[KITLG MGF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Erbb2 Neu] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Epidermal growth factor receptor-related protein) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (p185neu) (CD antigen CD340)
[FES FPS] Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[ERBB2 HER2 MLN19 NEU NGL] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
[LCK] Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[Ros1 Ros Ros-1] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
[FER TYK3] Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)

Bibliography :
No related Items