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Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)

 KIT_CANLF               Reviewed;         979 AA.
O97799; Q7YRV7; Q8WN23;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
05-SEP-2006, sequence version 2.
17-JUN-2020, entry version 172.
RecName: Full=Mast/stem cell growth factor receptor Kit;
Short=SCFR;
EC=2.7.10.1;
AltName: Full=Proto-oncogene c-Kit;
AltName: Full=Tyrosine-protein kinase Kit;
AltName: CD_antigen=CD117;
Flags: Precursor;
Name=KIT;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=9989791; DOI=10.1046/j.1523-1747.1999.00488.x;
Ma Y., Longley B.J., Wang X., Blount J.L., Langley K., Caughey G.H.;
"Clustering of activating mutations in c-KIT's juxtamembrane coding region
in canine mast cell neoplasms.";
J. Invest. Dermatol. 112:165-170(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Zemke D., Yuzbasiyan-Gurkan V.;
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tsai K.L., Guyon R., Murphy K.E.;
"Characterization of an isoform and RH mapping of canine c-kit.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor
for the cytokine KITLG/SCF and plays an essential role in the
regulation of cell survival and proliferation, hematopoiesis, stem cell
maintenance, gametogenesis, mast cell development, migration and
function, and in melanogenesis. In response to KITLG/SCF binding, KIT
can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1,
SH2B2/APS and CBL. Activates the AKT1 signaling pathway by
phosphorylation of PIK3R1, the regulatory subunit of
phosphatidylinositol 3-kinase. Activated KIT also transmits signals via
GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or
MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3,
STAT5A and STAT5B. Activation of PLCG1 leads to the production of the
cellular signaling molecules diacylglycerol and inositol 1,4,5-
trisphosphate. KIT signaling is modulated by protein phosphatases, and
by rapid internalization and degradation of the receptor. Activated KIT
promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and
PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and
STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II),
LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- ACTIVITY REGULATION: Present in an inactive conformation in the absence
of bound ligand. KITLG/SCF binding leads to dimerization and activation
by autophosphorylation on tyrosine residues. Activity is down-regulated
by PRKCA-mediated phosphorylation on serine residues (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Monomer in the absence of bound KITLG/SCF. Homodimer in the
presence of bound KITLG/SCF, forming a heterotetramer with two
KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues)
with the adapter proteins GRB2 and GRB7 (via SH2 domain), and
SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ
domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1
and PIK3 catalytic subunit. Interacts (via phosphorylated tyrosine)
with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain).
Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine
residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain),
PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1.
Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of
stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced
interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88
(By similarity). {ECO:0000250|UniProtKB:P05532,
ECO:0000250|UniProtKB:P10721}.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O97799-1; Sequence=Displayed;
Name=2;
IsoId=O97799-2; Sequence=VSP_020224;
-!- PTM: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after
autophosphorylation induced by KITLG/SCF binding, leading to
internalization and degradation. {ECO:0000250}.
-!- PTM: Autophosphorylated on tyrosine residues. KITLG/SCF binding
promotes autophosphorylation. Phosphorylated tyrosine residues are
important for interaction with specific binding partners (By
similarity). {ECO:0000250}.
-!- MISCELLANEOUS: Numerous proteins are phosphorylated in response to KIT
signaling, but it is not evident to determine which are directly
phosphorylated by KIT under in vivo conditions. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
---------------------------------------------------------------------------
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EMBL; AF044249; AAD02327.1; -; mRNA.
EMBL; AF448148; AAL40833.1; -; mRNA.
EMBL; AY296484; AAP51178.1; -; mRNA.
EMBL; AY313776; AAP76390.1; -; mRNA.
RefSeq; NP_001003181.1; NM_001003181.1.
RefSeq; XP_005628025.1; XM_005627968.2. [O97799-1]
SMR; O97799; -.
STRING; 9612.ENSCAFP00000039467; -.
PaxDb; O97799; -.
PRIDE; O97799; -.
Ensembl; ENSCAFT00000003274; ENSCAFP00000003042; ENSCAFG00000002065. [O97799-2]
GeneID; 403811; -.
KEGG; cfa:403811; -.
CTD; 3815; -.
VGNC; VGNC:42422; KIT.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000155626; -.
InParanoid; O97799; -.
KO; K05091; -.
OMA; PSEMYQI; -.
OrthoDB; 236292at2759; -.
TreeFam; TF325768; -.
BRENDA; 2.7.10.1; 1153.
Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
Reactome; R-CFA-1433557; Signaling by SCF-KIT.
Reactome; R-CFA-1433559; Regulation of KIT signaling.
Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Proteomes; UP000002254; Chromosome 13.
Bgee; ENSCAFG00000002065; Expressed in prefrontal cortex and 2 other tissues.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019955; F:cytokine binding; ISS:UniProtKB.
GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
GO; GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
GO; GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0002371; P:dendritic cell cytokine production; ISS:UniProtKB.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; ISS:UniProtKB.
GO; GO:0048565; P:digestive tract development; ISS:UniProtKB.
GO; GO:0035162; P:embryonic hemopoiesis; ISS:UniProtKB.
GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0038093; P:Fc receptor signaling pathway; ISS:UniProtKB.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
GO; GO:0002327; P:immature B cell differentiation; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0038109; P:Kit signaling pathway; ISS:UniProtKB.
GO; GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.
GO; GO:0032762; P:mast cell cytokine production; ISS:UniProtKB.
GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
GO; GO:0060374; P:mast cell differentiation; ISS:UniProtKB.
GO; GO:0035855; P:megakaryocyte development; ISS:UniProtKB.
GO; GO:0097326; P:melanocyte adhesion; ISS:UniProtKB.
GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
GO; GO:0097324; P:melanocyte migration; ISS:UniProtKB.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0043473; P:pigmentation; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
GO; GO:0033674; P:positive regulation of kinase activity; IBA:GO_Central.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF00047; ig; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 4.
SMART; SM00408; IGc2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 3.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50835; IG_LIKE; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Cell membrane; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Kinase; Magnesium; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein; Proto-oncogene;
Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane;
Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.
SIGNAL 1..27
/evidence="ECO:0000255"
CHAIN 28..979
/note="Mast/stem cell growth factor receptor Kit"
/id="PRO_0000016751"
TOPO_DOM 28..527
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 528..548
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 549..979
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 29..114
/note="Ig-like C2-type 1"
DOMAIN 123..207
/note="Ig-like C2-type 2"
DOMAIN 214..311
/note="Ig-like C2-type 3"
DOMAIN 320..413
/note="Ig-like C2-type 4"
DOMAIN 416..510
/note="Ig-like C2-type 5"
DOMAIN 592..940
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 599..606
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 674..680
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 571..573
/note="Important for interaction with phosphotyrosine-
binding proteins"
/evidence="ECO:0000250"
ACT_SITE 795
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10028"
METAL 571
/note="Magnesium"
/evidence="ECO:0000250"
METAL 800
/note="Magnesium"
/evidence="ECO:0000250"
METAL 813
/note="Magnesium"
/evidence="ECO:0000250"
BINDING 626
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 799
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SITE 571
/note="Interaction with SH2B2/APS"
/evidence="ECO:0000250"
SITE 939
/note="Important for interaction with phosphotyrosine-
binding proteins"
/evidence="ECO:0000250"
SITE 939
/note="Interaction with SH2B2/APS"
/evidence="ECO:0000250"
MOD_RES 550
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 556
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 571
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 573
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 706
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 724
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 733
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 744
/note="Phosphoserine; by PKC/PRKCA"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 749
/note="Phosphoserine; by PKC/PRKCA"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 824
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 826
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 894
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 903
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 939
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P10721"
MOD_RES 962
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P10721"
CARBOHYD 96
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 132
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 147
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 286
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 296
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 303
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 355
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 370
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 403
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 466
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 489
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 60..99
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 138..188
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 153..185
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 235..293
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 431..494
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
VAR_SEQ 512..515
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:9989791, ECO:0000303|Ref.3"
/id="VSP_020224"
CONFLICT 23
/note="Q -> R (in Ref. 1; AAD02327)"
/evidence="ECO:0000305"
CONFLICT 332
/note="E -> Q (in Ref. 1; AAD02327)"
/evidence="ECO:0000305"
CONFLICT 442
/note="D -> G (in Ref. 1; AAD02327)"
/evidence="ECO:0000305"
SEQUENCE 979 AA; 109753 MW; 46C30D5DEB8E33D3 CRC64;
MRGARGAWDF LCVLLLLLLL GVQTGSSQPS VSPGEPSLPS IHPAKSELIV SVGDELRLSC
TDPGFVKWTF ETLGQLNENT HNEWITEKAE AGHTGNYTCT NRDGLSRSIY VFVRDPAKLF
LVDLPLYGKE GNDTLVRCPL TDPEVTNYSL RGCEGKPLPK DLTFVADPKA GITIRNVKRE
YHRLCLHCSA DQKGRTVLSK KFTLKVRAAI RAVPVVSVSK TSSLLKEGEA FSVMCFIKDV
SSFVDSMWIK ENSQQTNAQT QSNSWHHGDF NFERQEKLII SSARVNDSGV FMCYANNTFG
SANVTTTLEV VDKGFINIFP MMSTTIFVND GENVDLIVEY EAYPKPEHQQ WIYMNRTFTD
KWEDYPKSDN ESNIRYVSEL HLTRLKGNEG GTYTFQVSNS DVNSSVTFNV YVNTKPEILT
HESLTNGMLQ CVVAGFPEPA VDWYFCPGAE QRCSVPIGPM DVQMQNSSLS PSGKLVVQSS
IDYSAFKHNG TVECRAYNNV GRSSAFFNFA FKGNSKEQIH PHTLFTPLLI GFVIAAGMMC
IIVMILTYKY LQKPMYEVQW KVVEEINGNN YVYIDPTQLP YDHKWEFPRN RLSFGKTLGA
GAFGKVVEAT AYGLIKSDAA MTVAVKMLKP SAHLTEREAL MSELKVLSYL GNHMNIVNLL
GACTVGGPTL VITEYCCYGD LLNFLRRKRD SFICSKQEDH GEVALYKNLL HSKESSCSDS
TNEYMDMKPG VSYVVPTKAD KRRSARIGSY IERDVTPAIM EDDELALDLE DLLSFSYQVA
KGMAFLASKN CIHRDLAARN ILLTHGRITK ICDFGLARDI KNDSNYVVKG NARLPVKWMA
PESIFNCVYT FESDVWSYGI FLWELFSLGS SPYPGMPVDS KFYKMIKEGF RMLSPEHAPA
EMYDIMKTCW DADPLKRPTF KQIVQLIEKQ ISDSTNHIYS NLANCSPNPE RPVVDHSVRI
NSVGSSASST QPLLVHEDV


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18-785-210252 c-Kit (Phospho-Tyr721) - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Polyclonal 0.05 mg
18-785-210252 c-Kit (Phospho-Tyr721) - EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Polyclonal 0.1 mg
32-138 C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c 0.1 mL
U0121c CLIA Canis familiaris,Canis lupus familiaris,Dog,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
E0121c ELISA Canis familiaris,Canis lupus familiaris,Dog,KIT,Mast_stem cell growth factor receptor Kit,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit 96T
20-272-190432 c - Kit - Mouse monoclonal [104D2] to c - Kit; EC 2.7.10.1; SCFR; Proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 antigen Monoclonal 0.05 mg
Pathways :
WP2328: Allograft rejection
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP2272: Pathogenic Escherichia coli infection
WP352: T Cell Receptor Signaling Pathway
WP23: B Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP794: B Cell Receptor Signaling Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1130: T Cell Receptor Signaling Pathway
WP2292: Chemokine signaling pathway
WP274: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway

Related Genes :
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
[kita kit sparse] Mast/stem cell growth factor receptor kita (SCFR) (EC 2.7.10.1) (Tyrosine-protein kinase Kit)
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[KITLG MGF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[FES FPS] Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
[Erbb2 Neu] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Epidermal growth factor receptor-related protein) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (p185neu) (CD antigen CD340)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[Fyn] Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
[ERBB2 HER2 MLN19 NEU NGL] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
[LCK] Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Ros1 Ros Ros-1] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)

Bibliography :