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Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)

 KIT_CAPHI               Reviewed;         978 AA.
Q28317;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
03-JUL-2019, entry version 144.
RecName: Full=Mast/stem cell growth factor receptor Kit;
Short=SCFR;
EC=2.7.10.1;
AltName: Full=Proto-oncogene c-Kit;
AltName: Full=Tyrosine-protein kinase Kit;
AltName: CD_antigen=CD117;
Flags: Precursor;
Name=KIT;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Shiba; TISSUE=Cerebellum;
PubMed=9199245; DOI=10.1016/S0167-4781(97)00055-9;
Tanaka S., Yanagisawa N., Tojo H., Kim Y.-J., Tsujimura T.,
Kitamura Y., Sawasaki T., Tachi C.;
"Molecular cloning of cDNA encoding the c-kit receptor of Shiba goats
and a novel alanine insertion specific to goats and sheep in the
kinase insert region.";
Biochim. Biophys. Acta 1352:151-155(1997).
-!- FUNCTION: Tyrosine-protein kinase that acts as cell-surface
receptor for the cytokine KITLG/SCF and plays an essential role in
the regulation of cell survival and proliferation, hematopoiesis,
stem cell maintenance, gametogenesis, mast cell development,
migration and function, and in melanogenesis. In response to
KITLG/SCF binding, KIT can activate several signaling pathways.
Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the
AKT1 signaling pathway by phosphorylation of PIK3R1, the
regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT
also transmits signals via GRB2 and activation of RAS, RAF1 and
the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation
of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation
of PLCG1 leads to the production of the cellular signaling
molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT
signaling is modulated by protein phosphatases, and by rapid
internalization and degradation of the receptor. Activated KIT
promotes phosphorylation of the protein phosphatases PTPN6/SHP-1
and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A
and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform
Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1
(By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- ACTIVITY REGULATION: Present in an inactive conformation in the
absence of bound ligand. KITLG/SCF binding leads to dimerization
and activation by autophosphorylation on tyrosine residues.
Activity is down-regulated by PRKCA-mediated phosphorylation on
serine residues (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer in the absence of bound KITLG/SCF. Homodimer in
the presence of bound KITLG/SCF, forming a heterotetramer with two
KITLG/SCF molecules. Interacts (via phosphorylated tyrosine
residues) with the adapter proteins GRB2 and GRB7 (via SH2
domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via
the tenth PDZ domain). Interacts (via phosphorylated tyrosine
residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated
tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via
SH2 domain). Interacts with LYN and FES/FPS. Interacts (via
phosphorylated tyrosine residues) with the protein phosphatases
PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and
PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC.
Interacts with IL1RAP (independent of stimulation with KITLG/SCF).
A mast cell-specific KITLG/SCF-induced interleukin-33 signaling
complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
{ECO:0000250|UniProtKB:P05532, ECO:0000250|UniProtKB:P10721}.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- PTM: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after
autophosphorylation induced by KITLG/SCF binding, leading to
internalization and degradation. {ECO:0000250}.
-!- PTM: Autophosphorylated on tyrosine residues. KITLG/SCF binding
promotes autophosphorylation. Phosphorylated tyrosine residues are
important for interaction with specific binding partners (By
similarity). {ECO:0000250}.
-!- MISCELLANEOUS: Numerous proteins are phosphorylated in response to
KIT signaling, but it is not evident to determine which are
directly phosphorylated by KIT under in vivo conditions.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
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EMBL; D45168; BAA08116.1; -; mRNA.
RefSeq; NP_001272653.1; NM_001285724.1.
SMR; Q28317; -.
PRIDE; Q28317; -.
GeneID; 100861386; -.
KEGG; chx:100861386; -.
CTD; 3815; -.
KO; K05091; -.
OrthoDB; 236292at2759; -.
BRENDA; 2.7.10.1; 1166.
Proteomes; UP000291000; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019955; F:cytokine binding; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
GO; GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0002371; P:dendritic cell cytokine production; ISS:UniProtKB.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; ISS:UniProtKB.
GO; GO:0048565; P:digestive tract development; ISS:UniProtKB.
GO; GO:0035162; P:embryonic hemopoiesis; ISS:UniProtKB.
GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0038093; P:Fc receptor signaling pathway; ISS:UniProtKB.
GO; GO:0002327; P:immature B cell differentiation; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0038109; P:Kit signaling pathway; ISS:UniProtKB.
GO; GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.
GO; GO:0032762; P:mast cell cytokine production; ISS:UniProtKB.
GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
GO; GO:0060374; P:mast cell differentiation; ISS:UniProtKB.
GO; GO:0035855; P:megakaryocyte development; ISS:UniProtKB.
GO; GO:0097326; P:melanocyte adhesion; ISS:UniProtKB.
GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
GO; GO:0097324; P:melanocyte migration; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0043473; P:pigmentation; ISS:UniProtKB.
GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF00047; ig; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 4.
SMART; SM00408; IGc2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 3.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50835; IG_LIKE; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
2: Evidence at transcript level;
ATP-binding; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Kinase; Magnesium; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein; Proto-oncogene;
Receptor; Reference proteome; Repeat; Signal; Transferase;
Transmembrane; Transmembrane helix; Tyrosine-protein kinase;
Ubl conjugation.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 978 Mast/stem cell growth factor receptor
Kit.
/FTId=PRO_0000016752.
TOPO_DOM 26 525 Extracellular. {ECO:0000255}.
TRANSMEM 526 546 Helical. {ECO:0000255}.
TOPO_DOM 547 978 Cytoplasmic. {ECO:0000255}.
DOMAIN 27 112 Ig-like C2-type 1.
DOMAIN 121 205 Ig-like C2-type 2.
DOMAIN 212 309 Ig-like C2-type 3.
DOMAIN 318 411 Ig-like C2-type 4.
DOMAIN 414 508 Ig-like C2-type 5.
DOMAIN 590 939 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 597 604 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 672 678 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 569 571 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000250}.
ACT_SITE 794 794 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
METAL 569 569 Magnesium. {ECO:0000250}.
METAL 799 799 Magnesium. {ECO:0000250}.
METAL 812 812 Magnesium. {ECO:0000250}.
BINDING 624 624 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 798 798 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SITE 569 569 Interaction with SH2B2/APS.
{ECO:0000250}.
SITE 938 938 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000250}.
SITE 938 938 Interaction with SH2B2/APS.
{ECO:0000250}.
MOD_RES 548 548 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 554 554 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 569 569 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 571 571 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 704 704 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 722 722 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 731 731 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 743 743 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 748 748 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 823 823 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 825 825 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 893 893 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 902 902 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 938 938 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 961 961 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
CARBOHYD 94 94 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 130 130 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 284 284 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 294 294 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 321 321 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 353 353 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 368 368 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 401 401 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 464 464 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 487 487 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 58 97 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 136 186 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 151 183 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 233 291 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 429 492 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 978 AA; 109722 MW; CA4D663F98205CA9 CRC64;
MRGARGAWDF LFVLLLLLLV QTGSSQPSVS PGELSLPSIH PAKSELIVSV GDEIRLLCTD
PGFVKWTFEI LGQLSEKTNP EWITEKAEAT NTGNYTCTNK GGLSSSIYVF VRDPEKLFLI
DLPLYGKEEN DTLVRCPLTD PEVTNYSLTG CEGKPLPKDL TFVADPKAGI TIRNVKREYH
RLCLHCSANQ KGKSMLSKKF TLKVRAAIKA VPVVSVSKTS YLLREGEEFA VTCLIKDVSS
SVDSMWIKEN SQQSKAQTKK NSWHQGDFSY LRQERLTISS ARVNDSGVFM CYANNTFGSA
NVTTTLEVVD KGFINIFPMM NTTVFVNDGE NVDLVVEYEA YPKPEHRQWI YMNRTSTDKW
DDYPKSENES NIRYVNELHL TRLKGTEGGT YTFHVSNSDV NSSVTFNVNV NTKPEILTHD
RLVNGMLQCV AAGFPEPTID WYFCPGTEQR CSVPVGPVDV QIQNSSVSPF GKLVVYSTID
DSTFKHNGTV ECRAYNDVGK SSASFNFAFK GNNKEQIHAH TLFTPLLIGF VIAAGLMCIF
VMILTYKYLQ KPMYEVQWKV VEEINGNNYV YIDPTQLPYD HKWEFPRNRL SFGKTLGAGA
FGKVVEATAY GLIKSDAAMT VAVKMLKPSA HLTEREALMS ELKVLSYLGN HMNIVNLLGA
CTIGGPTLVI TEYCCYGDLL NFLRRKRDSF ICSKQEDHAE VALYKNLLHS KESSCNDSTN
EYMDMKPGVS YVVPTKAADK RRSARIGSYI ERDVTPAIME DDELALDLED LLSFSYQVAK
GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN ARLPVKWMAP
ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR MLSPEHAPAE
MYDIMKTCWD ADPLKRPTFK QIVQLIEKQI SESTNHIYSN LANCSPHREN PAVDHSVRIN
SVGSSASSTQ PLLVHEDV


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[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[KITLG MGF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Erbb2 Neu] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Epidermal growth factor receptor-related protein) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (p185neu) (CD antigen CD340)
[FES FPS] Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[ERBB2 HER2 MLN19 NEU NGL] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
[LCK] Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[Ros1 Ros Ros-1] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
[FER TYK3] Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)

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