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Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)

 KIT_CALJA               Reviewed;         972 AA.
Q76II0;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
16-JAN-2019, entry version 101.
RecName: Full=Mast/stem cell growth factor receptor Kit;
Short=SCFR;
EC=2.7.10.1;
AltName: Full=Proto-oncogene c-Kit;
AltName: Full=Tyrosine-protein kinase Kit;
AltName: CD_antigen=CD117;
Flags: Precursor;
Name=KIT;
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Izawa K.;
"Cloning of c-kit cDNA of common marmoset.";
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Tyrosine-protein kinase that acts as cell-surface
receptor for the cytokine KITLG/SCF and plays an essential role in
the regulation of cell survival and proliferation, hematopoiesis,
stem cell maintenance, gametogenesis, mast cell development,
migration and function, and in melanogenesis. In response to
KITLG/SCF binding, KIT can activate several signaling pathways.
Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the
AKT1 signaling pathway by phosphorylation of PIK3R1, the
regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT
also transmits signals via GRB2 and activation of RAS, RAF1 and
the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation
of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation
of PLCG1 leads to the production of the cellular signaling
molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT
signaling is modulated by protein phosphatases, and by rapid
internalization and degradation of the receptor. Activated KIT
promotes phosphorylation of the protein phosphatases PTPN6/SHP-1
and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A
and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform
Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1
(By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- ACTIVITY REGULATION: Present in an inactive conformation in the
absence of bound ligand. KITLG/SCF binding leads to dimerization
and activation by autophosphorylation on tyrosine residues.
Activity is down-regulated by PRKCA-mediated phosphorylation on
serine residues (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer in the absence of bound KITLG/SCF. Homodimer in
the presence of bound KITLG/SCF, forming a heterotetramer with two
KITLG/SCF molecules. Interacts (via phosphorylated tyrosine
residues) with the adapter proteins GRB2 and GRB7 (via SH2
domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via
the tenth PDZ domain). Interacts (via phosphorylated tyrosine
residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated
tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via
SH2 domain). Interacts with LYN and FES/FPS. Interacts (via
phosphorylated tyrosine residues) with the protein phosphatases
PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and
PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC.
Interacts with IL1RAP (independent of stimulation with KITLG/SCF).
A mast cell-specific KITLG/SCF-induced interleukin-33 signaling
complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
{ECO:0000250|UniProtKB:P05532, ECO:0000250|UniProtKB:P10721}.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- PTM: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after
autophosphorylation induced by KITLG/SCF binding, leading to
internalization and degradation. {ECO:0000250}.
-!- PTM: Autophosphorylated on tyrosine residues. KITLG/SCF binding
promotes autophosphorylation. Phosphorylated tyrosine residues are
important for interaction with specific binding partners (By
similarity). {ECO:0000250}.
-!- MISCELLANEOUS: Numerous proteins are phosphorylated in response to
KIT signaling, but it is not evident to determine which are
directly phosphorylated by KIT under in vivo conditions.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
-----------------------------------------------------------------------
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EMBL; AB097502; BAD04018.1; -; mRNA.
RefSeq; NP_001171967.1; NM_001185038.1.
ProteinModelPortal; Q76II0; -.
SMR; Q76II0; -.
STRING; 9483.ENSCJAP00000034112; -.
GeneID; 100411615; -.
KEGG; cjc:100411615; -.
CTD; 3815; -.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
HOGENOM; HOG000112008; -.
HOVERGEN; HBG004335; -.
InParanoid; Q76II0; -.
KO; K05091; -.
OrthoDB; 236292at2759; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019955; F:cytokine binding; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
GO; GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0002371; P:dendritic cell cytokine production; ISS:UniProtKB.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; ISS:UniProtKB.
GO; GO:0048565; P:digestive tract development; ISS:UniProtKB.
GO; GO:0035162; P:embryonic hemopoiesis; ISS:UniProtKB.
GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0038093; P:Fc receptor signaling pathway; ISS:UniProtKB.
GO; GO:0002327; P:immature B cell differentiation; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0038109; P:Kit signaling pathway; ISS:UniProtKB.
GO; GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.
GO; GO:0032762; P:mast cell cytokine production; ISS:UniProtKB.
GO; GO:0043303; P:mast cell degranulation; ISS:UniProtKB.
GO; GO:0060374; P:mast cell differentiation; ISS:UniProtKB.
GO; GO:0035855; P:megakaryocyte development; ISS:UniProtKB.
GO; GO:0097326; P:melanocyte adhesion; ISS:UniProtKB.
GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
GO; GO:0097324; P:melanocyte migration; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0043473; P:pigmentation; ISS:UniProtKB.
GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF00047; ig; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 3.
SMART; SM00408; IGc2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 3.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
2: Evidence at transcript level;
ATP-binding; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Kinase; Magnesium; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein; Proto-oncogene;
Receptor; Reference proteome; Repeat; Signal; Transferase;
Transmembrane; Transmembrane helix; Tyrosine-protein kinase;
Ubl conjugation.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 972 Mast/stem cell growth factor receptor
Kit.
/FTId=PRO_0000248275.
TOPO_DOM 26 520 Extracellular. {ECO:0000255}.
TRANSMEM 521 541 Helical. {ECO:0000255}.
TOPO_DOM 542 972 Cytoplasmic. {ECO:0000255}.
DOMAIN 27 112 Ig-like C2-type 1.
DOMAIN 121 205 Ig-like C2-type 2.
DOMAIN 212 308 Ig-like C2-type 3.
DOMAIN 317 410 Ig-like C2-type 4.
DOMAIN 413 507 Ig-like C2-type 5.
DOMAIN 585 933 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 592 599 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 667 673 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 564 566 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000250}.
ACT_SITE 788 788 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
METAL 564 564 Magnesium. {ECO:0000250}.
METAL 793 793 Magnesium. {ECO:0000250}.
METAL 806 806 Magnesium. {ECO:0000250}.
BINDING 619 619 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 792 792 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SITE 564 564 Interaction with SH2B2/APS.
{ECO:0000250}.
SITE 932 932 Important for interaction with
phosphotyrosine-binding proteins.
{ECO:0000250}.
SITE 932 932 Interaction with SH2B2/APS.
{ECO:0000250}.
MOD_RES 543 543 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 549 549 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 564 564 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 566 566 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 699 699 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 717 717 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 726 726 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 737 737 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 742 742 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 817 817 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 819 819 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 887 887 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 896 896 Phosphotyrosine.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 932 932 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P10721}.
MOD_RES 955 955 Phosphoserine.
{ECO:0000250|UniProtKB:P10721}.
CARBOHYD 130 130 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 283 283 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 300 300 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 320 320 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 352 352 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 367 367 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 463 463 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 486 486 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 58 97 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 136 186 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 151 183 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 233 290 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 428 491 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 972 AA; 109680 MW; 5BC959312C3BB1FA CRC64;
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PEEASPPFID PAKSELIVSV GDEIRLFCND
PGFVKWTFEV LDQMNENKQK EWIMQKAEAT NTGKYTCTNK HGLSSSIYVF VRDPDKLFLV
DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPIPKDL RFVPDPKAGI TIKNVKRAYH
RLCLHCSADR KGQSKLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS
SVYSSWKKEN SPTKLQEKYN SWHQGDFNYE RQATLTISSV RVNDSGVFMC YASNTFGSAN
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PRPEHQQWIY MNRTFTDKWE
DYPKSENESN IRYVSELHLT RLKDTEGGTY TFLVSNSDVS SSIAFTVYVN TKPEILTYDR
LMNGMLQCVA AGFPEPTIDW YFCPGTEQRC SAPVLPVDVQ IQNTSGPPFG KLVVQSSIDS
SAFKHNGTVE CKAYNDVGKT SAYFNFAFKE QIQPHTLFTP LLIGFVVVAG MMCIIVMILT
YKYLQKPMYE VQWKVVEEIN GNNYVYIDPT QLPYDHKWEF PRNRLSFGKT LGAGAFGKVV
EATAYGLIKS DTAMTVAVKM LKPSAHLTER EALMSELKVL SYLGNHMNIV NLLGACTIGG
PTLVITEYCC YGDLLNFLRR KRDSFICSKQ EDHAEAALYK NLLHSKESSC SDSTNEYMDM
KPGVSYVVPT KAEKRRSARV GSYIERDVTP AIMEDDELAL DLEDLLSFSY QVAKGMAFLA
SKNCIHRDLA ARNILLTHGR ITKICDFGLA RDIKNDSNYV VKGNARLPVK WMAPESIFNC
VYTFESDVWS YGIFLWELFS LGSSPYPGMP VDSKFYKMIK EGFRMLSPEH APAEMYDIMK
TCWDADPLKR PTFKQIVQLI EKQISESTNH IYSNLTNCSP SQQKPVVDHS VRINSVGSTA
SSSQPLLVRD DV


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2328: Allograft rejection
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP1714: Tyrosine metabolism
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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WP23: B Cell Receptor Signaling Pathway

Related Genes :
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
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[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
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[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[FES FPS] Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[ERBB2 HER2 MLN19 NEU NGL] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
[Ros1 Ros Ros-1] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[KITLG MGF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Erbb2 Neu] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Epidermal growth factor receptor-related protein) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (p185neu) (CD antigen CD340)
[LCK] Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[CBL CBL2 RNF55] E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[FER TYK3] Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)

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