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Mast/stem cell growth factor receptor kita (SCFR) (EC 2.7.10.1) (Tyrosine-protein kinase Kit)

 KITA_DANRE              Reviewed;         976 AA.
Q8JFR5; Q5RID5; Q9W755;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
03-OCT-2006, sequence version 2.
13-FEB-2019, entry version 129.
RecName: Full=Mast/stem cell growth factor receptor kita;
Short=SCFR;
EC=2.7.10.1;
AltName: Full=Tyrosine-protein kinase Kit;
Flags: Precursor;
Name=kita; Synonyms=kit, sparse;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
DISRUPTION PHENOTYPE.
PubMed=10393121;
Parichy D.M., Rawls J.F., Pratt S.J., Whitfield T.T., Johnson S.L.;
"Zebrafish sparse corresponds to an orthologue of c-kit and is
required for the morphogenesis of a subpopulation of melanocytes, but
is not essential for hematopoiesis or primordial germ cell
development.";
Development 126:3425-3436(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-!- FUNCTION: Tyrosine-protein kinase that acts as cell-surface
receptor for the cytokine kitlg/scf and plays a role in the
regulation of cell survival and proliferation, hematopoiesis, stem
cell maintenance, gametogenesis, and in mast cell development,
migration and function. Required for the migration of cells in the
melanocyte lineage and the survival of embryonic melanocytes.
Required for the differentiation of some, but not all,
melanocytes. Not essential for hematopoiesis or primordial germ
cell development. {ECO:0000269|PubMed:10393121}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in cells of the neural crest-
melanocyte lineage. In the embryo, also expressed in mesodermal
cells that give rise to hematopoietic precursors, notochord,
neural crest-derived cells of the branchial arches, pineal gland,
retina and mechanoreceptive sensory cells of lateral line
neuromasts. Not detected in primordial germ cells or larval gut.
{ECO:0000269|PubMed:10393121}.
-!- PTM: Ubiquitinated. Rapidly ubiquitinated after
autophosphorylation induced by kitlg/scf binding, leading to
internalization and degradation. {ECO:0000250}.
-!- PTM: Autophosphorylated on tyrosine residues. Phosphorylated
tyrosine residues are important for interaction with specific
binding partners (By similarity). {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Defects in the number and distribution of
melanocytes. {ECO:0000269|PubMed:10393121}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. CSF-1/PDGF receptor subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF153446; AAD41890.1; -; mRNA.
EMBL; AL691516; CAD43458.1; -; Genomic_DNA.
EMBL; BX248242; CAD43458.1; JOINED; Genomic_DNA.
EMBL; BX248242; CAI11525.1; -; Genomic_DNA.
EMBL; AL691516; CAI11525.1; JOINED; Genomic_DNA.
EMBL; BX276114; CAI11666.1; -; Genomic_DNA.
RefSeq; NP_571128.1; NM_131053.1.
UniGene; Dr.81312; -.
ProteinModelPortal; Q8JFR5; -.
SMR; Q8JFR5; -.
STRING; 7955.ENSDARP00000099069; -.
PaxDb; Q8JFR5; -.
PRIDE; Q8JFR5; -.
Ensembl; ENSDART00000011135; ENSDARP00000024170; ENSDARG00000043317.
GeneID; 30256; -.
KEGG; dre:30256; -.
CTD; 30256; -.
ZFIN; ZDB-GENE-980526-464; kita.
eggNOG; KOG0200; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000155626; -.
HOGENOM; HOG000112008; -.
HOVERGEN; HBG004335; -.
InParanoid; Q8JFR5; -.
KO; K05091; -.
OMA; YMNRTST; -.
OrthoDB; 236292at2759; -.
Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
Reactome; R-DRE-1433557; Signaling by SCF-KIT.
Reactome; R-DRE-1433559; Regulation of KIT signaling.
Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
PRO; PR:Q8JFR5; -.
Proteomes; UP000000437; Chromosome 20.
Bgee; ENSDARG00000043317; Expressed in 41 organ(s), highest expression level in pigment cell.
ExpressionAtlas; Q8JFR5; baseline.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019955; F:cytokine binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
GO; GO:0048066; P:developmental pigmentation; IMP:ZFIN.
GO; GO:0038093; P:Fc receptor signaling pathway; IEA:InterPro.
GO; GO:0014831; P:gastro-intestinal system smooth muscle contraction; IMP:ZFIN.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
GO; GO:0038109; P:Kit signaling pathway; IBA:GO_Central.
GO; GO:1902362; P:melanocyte apoptotic process; IMP:ZFIN.
GO; GO:0030318; P:melanocyte differentiation; IMP:ZFIN.
GO; GO:0097324; P:melanocyte migration; IMP:ZFIN.
GO; GO:0043473; P:pigmentation; IMP:ZFIN.
GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
GO; GO:0048865; P:stem cell fate commitment; IMP:ZFIN.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR027263; SCGF_receptor.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF500951; SCGF_recepter; 1.
SMART; SM00409; IG; 4.
SMART; SM00408; IGc2; 3.
SMART; SM00220; S_TKc; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 4.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50835; IG_LIKE; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
2: Evidence at transcript level;
ATP-binding; Cell membrane; Complete proteome; Differentiation;
Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase;
Magnesium; Membrane; Metal-binding; Nucleotide-binding;
Phosphoprotein; Receptor; Reference proteome; Repeat; Signal;
Transferase; Transmembrane; Transmembrane helix;
Tyrosine-protein kinase; Ubl conjugation.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 976 Mast/stem cell growth factor receptor
kita.
/FTId=PRO_0000248880.
TOPO_DOM 22 515 Extracellular. {ECO:0000255}.
TRANSMEM 516 536 Helical. {ECO:0000255}.
TOPO_DOM 537 976 Cytoplasmic. {ECO:0000255}.
DOMAIN 23 105 Ig-like C2-type 1.
DOMAIN 100 199 Ig-like C2-type 2.
DOMAIN 206 301 Ig-like C2-type 3.
DOMAIN 308 402 Ig-like C2-type 4.
DOMAIN 399 504 Ig-like C2-type 5.
DOMAIN 580 922 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 587 594 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 662 668 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 777 777 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
METAL 559 559 Magnesium. {ECO:0000250}.
METAL 782 782 Magnesium. {ECO:0000250}.
METAL 795 795 Magnesium. {ECO:0000250}.
BINDING 614 614 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 781 781 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 559 559 Phosphotyrosine; by autocatalysis.
{ECO:0000250}.
MOD_RES 561 561 Phosphotyrosine; by autocatalysis.
{ECO:0000250}.
MOD_RES 691 691 Phosphotyrosine; by autocatalysis.
{ECO:0000250}.
MOD_RES 707 707 Phosphotyrosine; by autocatalysis.
{ECO:0000250}.
MOD_RES 808 808 Phosphotyrosine; by autocatalysis.
{ECO:0000250}.
MOD_RES 921 921 Phosphotyrosine; by autocatalysis.
{ECO:0000250}.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 47 47 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 282 282 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 309 309 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 315 315 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 352 352 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 449 449 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 477 477 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 44 89 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 131 180 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 146 177 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 228 285 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 422 488 {ECO:0000255|PROSITE-ProRule:PRU00114}.
CONFLICT 168 168 E -> Q (in Ref. 1; AAD41890).
{ECO:0000305}.
CONFLICT 460 460 V -> L (in Ref. 2; CAD43458/CAI11525).
{ECO:0000305}.
SEQUENCE 976 AA; 109280 MW; A56921FA4ED2A90D CRC64;
MEYHCVLFTV LLQLIIQPGR SRPTITPEGP RLTVPLYSNF SLHCQSNSTV RWQHENRPMR
TLKEEQRQGQ QTILKVNRAG PQHLGKYSCR EEKTGEKSSI YVYVKDPENP FRRTIVFDIV
AAEGDTTVIP CLATDPDMKN LNLQKCDGQP LPNSLRYSAS LETGVSVEKV RKEFEGCYVC
VGTLDAATVK SGRYQLTVRL VPDAPPPITL GQPQRVLLTQ GEKLSLSCST SNVNSDIAVK
WKAPNGVNPS VHQNSHLLTE PITHVRTAIL SLSSVTMQDA GNYSCEAINE KGTTAKPVWV
NIYEKGFINI TSVDNSTRRV RAGESLSLRV VMNAYPKPHT FSWSYSGVKL TNTTDHVITS
RTHGNSYTSE LKLVRLKVSE SGIYTFSCLN RDATIRQTFE VHVISKPQIV SYEGPIDGQV
RCVAEGYPTP QIKWYYCDLP HSRCSNLLNA TQEEEDVVTV TMTNPPFGKG AVESRLNITK
NNYATLECVA SANGEIVYTL FSISENTVPH ELFTPLLIGF VAAAVILVLI LIVLTYKYMQ
KPKYQIQWKV IEGIHGNNYV YIDPTQLPYD HQWEFPRDKL RFGKTLGSGA FGKVVEATAY
GMSKADTVMT VAVKMLKPSA HATEKEALMS ELKVLSYLGN HINIVNLLGA CTVGGPTLVI
TEYCCFGDLL NFLRRRRVYF YYTTLGEDAY YRNVMMQSEP NDSRNGYMTM KPSVLGILSS
ENRRSLNKGD SYSDSDAVSE ILQEDGLTLD TEDLLSFSYQ VAKGMDFLAS KNCIHRDLAA
RNILLTQGRV AKICDFGLAR DITTDSNYVV KGNARLPVKW MSPESIFECV YTFESDVWSY
GILLWEIFSL GSSPYPGMPV DSKFYKMIKE GYRMESPEFS PSEMYDIMHS CWDADPVKRP
SFSKIVEKIE QQISDSTKHI YLNFSSRLPA APGPREESSS HVHRLNSVGS HSTATQPLLS
SNDVFLDRSS PSHPVV


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP1714: Tyrosine metabolism
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP23: B Cell Receptor Signaling Pathway
WP2328: Allograft rejection

Related Genes :
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[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
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[kit krk1] Mast/stem cell growth factor receptor-related protein Kit (EC 2.7.10.1) (Kit-related kinase 1) (xKrk1) (Tyrosine-protein kinase kit)
[KITLG MGF SCF] Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[Kitlg Kitl Mgf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[FLT3 CD135 FLK2 STK1] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[FLT1 FLT FRT VEGFR1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
[NTRK1 MTC TRK TRKA] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
[Kdr Flk-1 Flk1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase NYK) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[Flt1 Emrk2 Flt Vegfr1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
[kdr flk1b kdrb si:busm1-205d10.1 si:ch211-254j6.1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1b) (FLK-1b) (Kinase insert domain receptor) (Kinase insert domain receptor-B) (Protein-tyrosine kinase receptor flk-1b) (Vascular endothelial growth factor receptor 2 homolog B) (VEGFR-2 homolog B)
[KDR FLK1 VEGFR2] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[kdrl flk flk-1 flk1 flka kdr kdra vegfr2 vegfr4 vegr2 si:ch211-276g21.4] Vascular endothelial growth factor receptor kdr-like (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor-A) (Kinase insert domain receptor-like) (Protein-tyrosine kinase receptor flk-1) (Vascular endothelial growth factor receptor 4) (VEGFR-4)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[Ntrk1 Trk Trka] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Slow nerve growth factor receptor) (p140-TrkA) (Trk-A)

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