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Mediator of RNA polymerase II transcription subunit 15 (Autonomous replication regulatory protein 3) (Basal expression activator protein 1) (Defective silencing suppressor protein 4) (Mediator complex subunit 15) (Transcription regulatory protein GAL11) (Ty insertion suppressor protein 13)

 MED15_YEAST             Reviewed;        1081 AA.
P19659; D6W217; Q08221;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 3.
07-APR-2021, entry version 191.
RecName: Full=Mediator of RNA polymerase II transcription subunit 15;
AltName: Full=Autonomous replication regulatory protein 3;
AltName: Full=Basal expression activator protein 1;
AltName: Full=Defective silencing suppressor protein 4;
AltName: Full=Mediator complex subunit 15;
AltName: Full=Transcription regulatory protein GAL11;
AltName: Full=Ty insertion suppressor protein 13;
Name=GAL11 {ECO:0000303|PubMed:3062377, ECO:0000312|SGD:S000005411};
Synonyms=ABE1 {ECO:0000312|SGD:S000005411},
MED15 {ECO:0000303|PubMed:19940160}, RAR3 {ECO:0000312|SGD:S000005411},
SDS4 {ECO:0000312|SGD:S000005411}, SPT13 {ECO:0000312|SGD:S000005411};
OrderedLocusNames=YOL051W;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=3062377; DOI=10.1128/mcb.8.11.4991;
Suzuki Y., Nogi Y., Abe A., Fukasawa T.;
"GAL11 protein, an auxiliary transcription activator for genes encoding
galactose-metabolizing enzymes in Saccharomyces cerevisiae.";
Mol. Cell. Biol. 8:4991-4999(1988).
[2]
ERRATUM OF PUBMED:3062377, AND SEQUENCE REVISION.
PubMed=1406662; DOI=10.1128/mcb.12.10.4806;
Suzuki Y., Nogi Y., Abe A., Fukasawa T.;
Mol. Cell. Biol. 12:4806-4806(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169874;
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
Nature 387:98-102(1997).
[4]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
G3 (Bethesda) 4:389-398(2014).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-352.
STRAIN=ATCC 90843 / S288c / FY73;
PubMed=8789261;
DOI=10.1002/(sici)1097-0061(199601)12:1<67::aid-yea884>3.0.co;2-f;
Mannhaupt G., Vetter I., Schwarzlose C., Mitzel S., Feldmann H.;
"Analysis of a 26 kb region on the left arm of yeast chromosome XV.";
Yeast 12:67-76(1996).
[6]
CHARACTERIZATION.
PubMed=2005915; DOI=10.1128/mcb.11.4.2311;
Long R.M., Mylin L.M., Hopper J.E.;
"GAL11 (SPT13), a transcriptional regulator of diverse yeast genes, affects
the phosphorylation state of GAL4, a highly specific transcriptional
activator.";
Mol. Cell. Biol. 11:2311-2314(1991).
[7]
COMPONENT OF MEDIATOR COMPLEX.
PubMed=8187178; DOI=10.1016/0092-8674(94)90221-6;
Kim Y.-J., Bjoerklund S., Li Y., Sayre M.H., Kornberg R.D.;
"A multiprotein mediator of transcriptional activation and its interaction
with the C-terminal repeat domain of RNA polymerase II.";
Cell 77:599-608(1994).
[8]
INTERACTION WITH GAL4.
PubMed=11478912; DOI=10.1021/bi010011k;
Jeong C.-J., Yang S.-H., Xie Y., Zhang L., Johnston S.A., Kodadek T.;
"Evidence that Gal11 protein is a target of the Gal4 activation domain in
the mediator.";
Biochemistry 40:9421-9427(2001).
[9]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[10]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[11]
NOMENCLATURE.
PubMed=15175151; DOI=10.1016/j.molcel.2004.05.011;
Bourbon H.-M., Aguilera A., Ansari A.Z., Asturias F.J., Berk A.J.,
Bjoerklund S., Blackwell T.K., Borggrefe T., Carey M., Carlson M.,
Conaway J.W., Conaway R.C., Emmons S.W., Fondell J.D., Freedman L.P.,
Fukasawa T., Gustafsson C.M., Han M., He X., Herman P.K., Hinnebusch A.G.,
Holmberg S., Holstege F.C.P., Jaehning J.A., Kim Y.-J., Kuras L., Leutz A.,
Lis J.T., Meisterernest M., Naeaer A.M., Nasmyth K., Parvin J.D.,
Ptashne M., Reinberg D., Ronne H., Sadowski I., Sakurai H., Sipiczki M.,
Sternberg P.W., Stillman D.J., Strich R., Struhl K., Svejstrup J.Q.,
Tuck S., Winston F., Roeder R.G., Kornberg R.D.;
"A unified nomenclature for protein subunits of mediator complexes linking
transcriptional regulators to RNA polymerase II.";
Mol. Cell 14:553-557(2004).
[12]
TOPOLOGY OF THE MEDIATOR COMPLEX.
PubMed=15477388; DOI=10.1093/nar/gkh878;
Guglielmi B., van Berkum N.L., Klapholz B., Bijma T., Boube M.,
Boschiero C., Bourbon H.-M., Holstege F.C.P., Werner M.;
"A high resolution protein interaction map of the yeast Mediator complex.";
Nucleic Acids Res. 32:5379-5391(2004).
[13]
FUNCTION OF THE MEDIATOR COMPLEX.
PubMed=16076843; DOI=10.1074/jbc.m506067200;
Nair D., Kim Y., Myers L.C.;
"Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription
in yeast extracts.";
J. Biol. Chem. 280:33739-33748(2005).
[14]
FUNCTION.
PubMed=16109375; DOI=10.1016/j.molcel.2005.06.033;
van de Peppel J., Kettelarij N., van Bakel H., Kockelkorn T.T.J.P.,
van Leenen D., Holstege F.C.P.;
"Mediator expression profiling epistasis reveals a signal transduction
pathway with antagonistic submodules and highly specific downstream
targets.";
Mol. Cell 19:511-522(2005).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=YAL6B;
PubMed=15665377; DOI=10.1074/mcp.m400219-mcp200;
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M.,
Jensen O.N.;
"Quantitative phosphoproteomics applied to the yeast pheromone signaling
pathway.";
Mol. Cell. Proteomics 4:310-327(2005).
[16]
FUNCTION OF THE MEDIATOR COMPLEX.
PubMed=16263706; DOI=10.1074/jbc.m508253200;
Takagi Y., Kornberg R.D.;
"Mediator as a general transcription factor.";
J. Biol. Chem. 281:80-89(2006).
[17]
SUBCELLULAR LOCATION.
PubMed=16630888; DOI=10.1016/j.molcel.2006.03.023;
Andrau J.-C., van de Pasch L., Lijnzaad P., Bijma T., Koerkamp M.G.,
van de Peppel J., Werner M., Holstege F.C.P.;
"Genome-wide location of the coactivator mediator: binding without
activation and transient Cdk8 interaction on DNA.";
Mol. Cell 22:179-192(2006).
[18]
ASSOCIATION WITH PROMOTER REGIONS.
PubMed=16429153; DOI=10.1038/nsmb1049;
Fan X., Chou D.M., Struhl K.;
"Activator-specific recruitment of Mediator in vivo.";
Nat. Struct. Mol. Biol. 13:117-120(2006).
[19]
CHARACTERIZATION OF THE MEDIATOR COMPLEX, AND INTERACTION OF THE MEDIATOR
COMPLEX WITH RNA POLYMERASE II.
PubMed=17192271; DOI=10.1074/jbc.m609484200;
Baidoobonso S.M., Guidi B.W., Myers L.C.;
"Med19(Rox3) regulates intermodule interactions in the Saccharomyces
cerevisiae mediator complex.";
J. Biol. Chem. 282:5551-5559(2007).
[20]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1034, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ADR376;
PubMed=17330950; DOI=10.1021/pr060559j;
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
Elias J.E., Gygi S.P.;
"Large-scale phosphorylation analysis of alpha-factor-arrested
Saccharomyces cerevisiae.";
J. Proteome Res. 6:1190-1197(2007).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1034, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=17287358; DOI=10.1073/pnas.0607084104;
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
"Analysis of phosphorylation sites on proteins from Saccharomyces
cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
[22]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; SER-736; SER-752;
THR-793; SER-1003; SER-1018 AND SER-1034, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome
analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
[23]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783; SER-785; SER-789;
THR-793; SER-831; SER-1003; SER-1008; SER-1018 AND SER-1034, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides insights
into evolution.";
Science 325:1682-1686(2009).
[24]
INTERACTION WITH GCN4, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
29-MET--ASP-43; 29-MET--SER-39 AND 196-TRP--VAL-199.
PubMed=19940160; DOI=10.1074/jbc.m109.071589;
Jedidi I., Zhang F., Qiu H., Stahl S.J., Palmer I., Kaufman J.D.,
Nadaud P.S., Mukherjee S., Wingfield P.T., Jaroniec C.P., Hinnebusch A.G.;
"Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX
domain, to recruit mediator to target genes in vivo.";
J. Biol. Chem. 285:2438-2455(2010).
[25]
ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-terminal
acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[26]
ELECTRON MICROSCOPY OF MEDIATOR COMPLEX IN COMPLEX WITH RNA POLYMERASE II.
PubMed=12191485; DOI=10.1016/s1097-2765(02)00598-1;
Davis J.A., Takagi Y., Kornberg R.D., Asturias F.J.;
"Structure of the yeast RNA polymerase II holoenzyme: mediator conformation
and polymerase interaction.";
Mol. Cell 10:409-415(2002).
-!- FUNCTION: Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. The Mediator complex, having a compact
conformation in its free form, is recruited to promoters by direct
interactions with regulatory proteins and serves for the assembly of a
functional pre-initiation complex with RNA polymerase II and the
general transcription factors. The Mediator complex unfolds to an
extended conformation and partially surrounds RNA polymerase II,
specifically interacting with the unphosphorylated form of the C-
terminal domain (CTD) of RNA polymerase II. The Mediator complex
dissociates from the RNA polymerase II holoenzyme and stays at the
promoter when transcriptional elongation begins. It has an important
role in the negative regulation of Ty transcription.
{ECO:0000269|PubMed:16076843, ECO:0000269|PubMed:16109375,
ECO:0000269|PubMed:16263706}.
-!- SUBUNIT: Component of the Mediator complex, which is composed of at
least 21 subunits that form three structurally distinct submodules
(PubMed:17192271). The Mediator head module contains MED6, MED8, MED11,
SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22, the
middle module contains MED1, MED4, NUT1/MED5, MED7, CSE2/MED9,
NUT2/MED10, SRB7/MED21 and SOH1/MED31, and the tail module contains
MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16
(PubMed:17192271). The head and the middle modules interact directly
with RNA polymerase II, whereas the elongated tail module interacts
with gene-specific regulatory proteins (PubMed:17192271). GAL11/MED15
interacts with the activator GAL4; the interaction is direct
(PubMed:11478912). GAL11/MED15 interacts (via multiple regions) with
the activator GCN4; the interaction is direct (PubMed:19940160).
{ECO:0000269|PubMed:11478912, ECO:0000269|PubMed:17192271,
ECO:0000269|PubMed:19940160}.
-!- INTERACTION:
P19659; P12383: PDR1; NbExp=5; IntAct=EBI-7305, EBI-13019;
P19659; P36956-1: SREBF1; Xeno; NbExp=3; IntAct=EBI-7305, EBI-948328;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095,
ECO:0000269|PubMed:16630888}.
-!- DISRUPTION PHENOTYPE: Sensitive to amino acid starvation
(PubMed:19940160). Normal GCN4 protein level during amino acid
starvation (PubMed:19940160). {ECO:0000269|PubMed:19940160}.
-!- MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
{ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
{ECO:0000305}.
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EMBL; M22481; AAA34622.1; -; Genomic_DNA.
EMBL; Z74793; CAA99056.1; -; Genomic_DNA.
EMBL; X91067; CAA62537.1; -; Genomic_DNA.
EMBL; BK006948; DAA10733.1; -; Genomic_DNA.
PIR; S66736; S66736.
RefSeq; NP_014591.1; NM_001183305.1.
PDB; 2K0N; NMR; -; A=6-90.
PDB; 2LPB; NMR; -; A=158-238.
PDB; 6ALY; NMR; -; A=277-368.
PDBsum; 2K0N; -.
PDBsum; 2LPB; -.
PDBsum; 6ALY; -.
BMRB; P19659; -.
SMR; P19659; -.
BioGRID; 34353; 168.
ComplexPortal; CPX-3226; Core mediator complex.
DIP; DIP-2334N; -.
IntAct; P19659; 20.
MINT; P19659; -.
STRING; 4932.YOL051W; -.
iPTMnet; P19659; -.
MaxQB; P19659; -.
PaxDb; P19659; -.
PRIDE; P19659; -.
EnsemblFungi; YOL051W_mRNA; YOL051W; YOL051W.
GeneID; 854106; -.
KEGG; sce:YOL051W; -.
SGD; S000005411; GAL11.
VEuPathDB; FungiDB:YOL051W; -.
eggNOG; ENOG502QVXD; Eukaryota.
HOGENOM; CLU_009962_0_0_1; -.
InParanoid; P19659; -.
OMA; KYWESMK; -.
EvolutionaryTrace; P19659; -.
PRO; PR:P19659; -.
Proteomes; UP000002311; Chromosome XV.
RNAct; P19659; protein.
GO; GO:0070847; C:core mediator complex; IDA:SGD.
GO; GO:0016592; C:mediator complex; IEA:InterPro.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IDA:SGD.
GO; GO:0001095; F:TFIIE-class transcription factor complex binding; IDA:SGD.
GO; GO:0001097; F:TFIIH-class transcription factor complex binding; IDA:SGD.
GO; GO:0003713; F:transcription coactivator activity; IDA:SGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
GO; GO:2000219; P:positive regulation of invasive growth in response to glucose limitation; IMP:SGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
GO; GO:0070202; P:regulation of establishment of protein localization to chromosome; IMP:SGD.
GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IDA:SGD.
CDD; cd12191; gal11_coact; 1.
Gene3D; 1.10.246.20; -; 1.
InterPro; IPR033789; Gal11_coact.
InterPro; IPR036529; KIX_dom_sf.
InterPro; IPR036546; MED15_KIX.
InterPro; IPR008626; Mediator_Med15_fun.
Pfam; PF18535; Gal11_ABD1; 1.
Pfam; PF16987; KIX_2; 1.
Pfam; PF05397; Med15_fungi; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Activator; Nucleus; Phosphoprotein;
Reference proteome; Repeat; Transcription; Transcription regulation.
INIT_MET 1
/note="Removed"
/evidence="ECO:0007744|PubMed:22814378"
CHAIN 2..1081
/note="Mediator of RNA polymerase II transcription subunit
15"
/id="PRO_0000096363"
REPEAT 422..423
/note="1"
REPEAT 424..425
/note="2"
REPEAT 426..427
/note="3"
REPEAT 428..429
/note="4"
REPEAT 430..431
/note="5"
REPEAT 432..433
/note="6"
REPEAT 434..435
/note="7"
REPEAT 436..437
/note="8"
REPEAT 438..439
/note="9"
REPEAT 440..441
/note="10"
REPEAT 442..443
/note="11"
REPEAT 444..445
/note="12; approximate"
REPEAT 446..447
/note="13; approximate"
REPEAT 448..449
/note="14"
REPEAT 450..451
/note="15"
REPEAT 452..453
/note="16"
REPEAT 454..455
/note="17"
REPEAT 456..457
/note="18"
REPEAT 458..459
/note="19"
REPEAT 460..461
/note="20"
REPEAT 462..463
/note="21"
REPEAT 464..465
/note="22"
REPEAT 466..467
/note="23"
REPEAT 468..469
/note="24"
REPEAT 470..471
/note="25"
REPEAT 472..473
/note="26"
REPEAT 474..475
/note="27"
REPEAT 476..477
/note="28"
REPEAT 478..479
/note="29"
REPEAT 480..481
/note="30"
REGION 25..49
/note="Interaction with GCN4"
/evidence="ECO:0000269|PubMed:19940160"
REGION 422..481
/note="30 X 2 AA approximate tandem repeats of Q-A"
COMPBIAS 147..158
/note="Poly-Gln"
COMPBIAS 674..696
/note="Poly-Gln"
MOD_RES 2
/note="N-acetylserine"
/evidence="ECO:0007744|PubMed:22814378"
MOD_RES 335
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:18407956"
MOD_RES 736
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:18407956"
MOD_RES 752
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:18407956"
MOD_RES 783
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:15665377,
ECO:0007744|PubMed:19779198"
MOD_RES 785
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:19779198"
MOD_RES 789
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:19779198"
MOD_RES 793
/note="Phosphothreonine"
/evidence="ECO:0007744|PubMed:18407956,
ECO:0007744|PubMed:19779198"
MOD_RES 831
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:19779198"
MOD_RES 1003
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:18407956,
ECO:0007744|PubMed:19779198"
MOD_RES 1008
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:19779198"
MOD_RES 1018
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:18407956,
ECO:0007744|PubMed:19779198"
MOD_RES 1034
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:17287358,
ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956,
ECO:0007744|PubMed:19779198"
MUTAGEN 29..43
/note="MDINTLNGGSSDTAD->ADIATANGGAADAAA: Decreases the
interaction between the mediator complex and GCN4.
Decreases transcription of GCN4-dependent targets.
Sensitive to amino acid starvation."
/evidence="ECO:0000269|PubMed:19940160"
MUTAGEN 29..39
/note="MDINTLNGGSS->ADIATLNGGAA: Decreases the interaction
between the mediator complex and GCN4. Decreases
transcription of GCN4-dependent targets. Sensitive to amino
acid starvation."
/evidence="ECO:0000269|PubMed:19940160"
MUTAGEN 196..199
/note="WQQV->AQAA: Decreases transcription of GCN4-
dependent targets. Decreases recruitment of the mediator
complex to the upstream activating sequence (UAS) of amino-
acid starvation responsive genes. Sensitive to amino acid
starvation."
/evidence="ECO:0000269|PubMed:19940160"
CONFLICT 171
/note="N -> T (in Ref. 1; AAA34622)"
/evidence="ECO:0000305"
CONFLICT 302
/note="P -> Q (in Ref. 1; AAA34622)"
/evidence="ECO:0000305"
CONFLICT 499
/note="N -> T (in Ref. 1; AAA34622)"
/evidence="ECO:0000305"
CONFLICT 751
/note="P -> Q (in Ref. 1; AAA34622)"
/evidence="ECO:0000305"
STRAND 8..11
/evidence="ECO:0007744|PDB:2K0N"
HELIX 14..35
/evidence="ECO:0007744|PDB:2K0N"
HELIX 41..58
/evidence="ECO:0007744|PDB:2K0N"
HELIX 63..89
/evidence="ECO:0007744|PDB:2K0N"
HELIX 164..170
/evidence="ECO:0007744|PDB:2LPB"
HELIX 172..174
/evidence="ECO:0007744|PDB:2LPB"
HELIX 180..183
/evidence="ECO:0007744|PDB:2LPB"
HELIX 196..199
/evidence="ECO:0007744|PDB:2LPB"
HELIX 201..204
/evidence="ECO:0007744|PDB:2LPB"
HELIX 210..232
/evidence="ECO:0007744|PDB:2LPB"
HELIX 296..299
/evidence="ECO:0007744|PDB:6ALY"
HELIX 302..322
/evidence="ECO:0007744|PDB:6ALY"
HELIX 330..353
/evidence="ECO:0007744|PDB:6ALY"
SEQUENCE 1081 AA; 120309 MW; 275C78721B5415C7 CRC64;
MSAAPVQDKD TLSNAERAKN VNGLLQVLMD INTLNGGSSD TADKIRIHAK NFEAALFAKS
SSKKEYMDSM NEKVAVMRNT YNTRKNAVTA AAANNNIKPV EQHHINNLKN SGNSANNMNV
NMNLNPQMFL NQQAQARQQV AQQLRNQQQQ QQQQQQQQRR QLTPQQQQLV NQMKVAPIPK
QLLQRIPNIP PNINTWQQVT ALAQQKLLTP QDMEAAKEVY KIHQQLLFKA RLQQQQAQAQ
AQANNNNNGL PQNGNINNNI NIPQQQQMQP PNSSANNNPL QQQSSQNTVP NVLNQINQIF
SPEEQRSLLQ EAIETCKNFE KTQLGSTMTE PVKQSFIRKY INQKALRKIQ ALRDVKNNNN
ANNNGSNLQR AQNVPMNIIQ QQQQQNTNNN DTIATSATPN AAAFSQQQNA SSKLYQMQQQ
QQAQAQAQAQ AQAQAQAQAQ AQAAQAAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ
AHAQHQPSQQ PQQAQQQPNP LHGLTPTAKD VEVIKQLSLD ASKTNLRLTD VTNSLSNEEK
EKIKMKLKQG QKLFVQVSNF APQVYIITKN ENFLKEVFQL RIFVKEILEK CAEGIFVVKL
DTVDRLIIKY QKYWESMRIQ ILRRQAILRQ QQQMANNNGN PGTTSTGNNN NIATQQNMQQ
SLQQMQHLQQ LKMQQQQQQQ QQQQQQQQQQ QQQQQQHIYP SSTPGVANYS AMANAPGNNI
PYMNHKNTSS MDFLNSMENT PKVPVSAAAT PSLNKTINGK VNGRTKSNTI PVTSIPSTNK
KLSISNAASQ QPTPRSASNT AKSTPNTNPS PLKTQTKNGT PNPNNMKTVQ SPMGAQPSYN
SAIIENAFRK EELLLKDLEI RKLEISSRFK HRQEIFKDSP MDLFMSTLGD CLGIKDEEML
TSCTIPKAVV DHINGSGKRK PTKAAQRARD QDSIDISIKD NKLVMKSKFN KSNRSYSIAL
SNVAAIFKGI GGNFKDLSTL VHSSSPSTSS NMDVGNPRKR KASVLEISPQ DSIASVLSPD
SNIMSDSKKI KVDSPDDPFM TKSGATTSEK QEVTNEAPFL TSGTSSEQFN VWDWNNWTSA
T


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Related Genes :
[MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2] Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
[MED15 ARC105 CTG7A PCQAP TIG1 TNRC7] Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[MED13 ARC250 KIAA0593 THRAP1 TRAP240] Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
[MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170] Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
[MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100] Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2] Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
[MED4 ARC36 DRIP36 VDRIP HSPC126] Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
[MED17 ARC77 CRSP6 DRIP77 DRIP80 TRAP80] Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
[MED7 ARC34 CRSP9] Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
[MED28 EG1 FKSG20] Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
[MED25 ACID1 ARC92 PTOV2 TCBAP0758] Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)
[MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230] Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
[mdt-15 R12B2.5] Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[MED29 IXL] Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Med24 D11Ertd307e Thrap4 Trap100] Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (mTRAP100)
[MED26 ARC70 CRSP7] Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[MED13L KIAA1025 PROSIT240 THRAP2 TRAP240L] Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[pol] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]

Bibliography :
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