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Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)

 MED17_HUMAN             Reviewed;         651 AA.
Q9NVC6; B3KN07; Q9HA81; Q9UNP7; Q9Y2W0; Q9Y660;
28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 2.
13-FEB-2019, entry version 154.
RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
AltName: Full=Activator-recruited cofactor 77 kDa component;
Short=ARC77;
AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 6;
Short=CRSP complex subunit 6;
AltName: Full=Mediator complex subunit 17;
AltName: Full=Thyroid hormone receptor-associated protein complex 80 kDa component;
Short=Trap80;
AltName: Full=Transcriptional coactivator CRSP77;
AltName: Full=Vitamin D3 receptor-interacting protein complex 80 kDa component;
Short=DRIP80;
Name=MED17; Synonyms=ARC77, CRSP6, DRIP77, DRIP80, TRAP80;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 306-319;
405-415 AND 592-602, TISSUE SPECIFICITY, IDENTIFICATION IN TRAP
COMPLEX, AND VARIANT ASP-69.
TISSUE=Cervix carcinoma;
PubMed=10198638; DOI=10.1016/S1097-2765(00)80463-3;
Ito M., Yuan C.-X., Malik S., Gu W., Fondell J.D., Yamamura S.,
Fu Z.-Y., Zhang X., Qin J., Roeder R.G.;
"Identity between TRAP and SMCC complexes indicates novel pathways for
the function of nuclear receptors and diverse mammalian activators.";
Mol. Cell 3:361-370(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 88-99 AND
607-619, IDENTIFICATION IN ARC COMPLEX, AND VARIANT ASP-69.
TISSUE=Cervix carcinoma;
PubMed=10235266; DOI=10.1038/19783;
Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M.,
Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P.;
"Ligand-dependent transcription activation by nuclear receptors
requires the DRIP complex.";
Nature 398:824-828(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
ASP-69.
TISSUE=Embryo;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
ASP-69.
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 269-651 (ISOFORM 1).
PubMed=9989412; DOI=10.1038/17141;
Ryu S., Zhou S., Ladurner A.G., Tjian R.;
"The transcriptional cofactor complex CRSP is required for activity of
the enhancer-binding protein Sp1.";
Nature 397:446-450(1999).
[7]
IDENTIFICATION IN ARC COMPLEX, AND PROTEIN SEQUENCE OF 168-179 AND
355-361.
PubMed=10235267; DOI=10.1038/19789;
Naeaer A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W.B.,
Tjian R.;
"Composite co-activator ARC mediates chromatin-directed
transcriptional activation.";
Nature 398:828-832(1999).
[8]
INTERACTION WITH MED10.
PubMed=12584197; DOI=10.1074/jbc.C300054200;
Sato S., Tomomori-Sato C., Banks C.A.S., Sorokina I., Parmely T.J.,
Kong S.E., Jin J., Cai Y., Lane W.S., Brower C.S., Conaway R.C.,
Conaway J.W.;
"Identification of mammalian Mediator subunits with similarities to
yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.";
J. Biol. Chem. 278:15123-15127(2003).
[9]
INTERACTION WITH STAT2.
PubMed=12509459; DOI=10.1128/MCB.23.2.620-628.2003;
Lau J.F., Nusinzon I., Burakov D., Freedman L.P., Horvath C.M.;
"Role of metazoan mediator proteins in interferon-responsive
transcription.";
Mol. Cell. Biol. 23:620-628(2003).
[10]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
MEDIATOR COMPLEX.
PubMed=15175163; DOI=10.1016/j.molcel.2004.05.006;
Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B.,
Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P.,
Conaway J.W., Conaway R.C.;
"A set of consensus mammalian mediator subunits identified by
multidimensional protein identification technology.";
Mol. Cell 14:685-691(2004).
[11]
INTERACTION WITH MED1; MED10; MED18; MED21; MED28 AND MED30,
IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR
COMPLEX, AND ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE
II.
PubMed=15989967; DOI=10.1016/j.molcel.2005.05.015;
Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T.,
Roeder R.G.;
"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation
enriched in RNA polymerase II and is required for ER-mediated
transcription.";
Mol. Cell 19:89-100(2005).
[12]
FUNCTION, AND INTERACTION WITH MED1 AND MED10.
PubMed=16595664; DOI=10.1074/jbc.M601983200;
Baek H.J., Kang Y.K., Roeder R.G.;
"Human Mediator enhances basal transcription by facilitating
recruitment of transcription factor IIB during preinitiation complex
assembly.";
J. Biol. Chem. 281:15172-15181(2006).
[13]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic kidney;
PubMed=17525332; DOI=10.1126/science.1140321;
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks
responsive to DNA damage.";
Science 316:1160-1166(2007).
[14]
VARIANT [LARGE SCALE ANALYSIS] ASP-69, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of
the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[15]
VARIANT [LARGE SCALE ANALYSIS] ASP-69, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
Mann M., Daub H.;
"Large-scale proteomics analysis of the human kinome.";
Mol. Cell. Proteomics 8:1751-1764(2009).
[16]
VARIANT MCPHSBA PRO-371.
PubMed=20950787; DOI=10.1016/j.ajhg.2010.09.016;
Kaufmann R., Straussberg R., Mandel H., Fattal-Valevski A.,
Ben-Zeev B., Naamati A., Shaag A., Zenvirt S., Konen O.,
Mimouni-Bloch A., Dobyns W.B., Edvardson S., Pines O., Elpeleg O.;
"Infantile cerebral and cerebellar atrophy is associated with a
mutation in the MED17 subunit of the transcription preinitiation
mediator complex.";
Am. J. Hum. Genet. 87:667-670(2010).
-!- FUNCTION: Component of the Mediator complex, a coactivator
involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to
convey information from gene-specific regulatory proteins to the
basal RNA polymerase II transcription machinery. Mediator is
recruited to promoters by direct interactions with regulatory
proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general
transcription factors. {ECO:0000269|PubMed:16595664}.
-!- SUBUNIT: Interacts with GATA1 and PPARG (By similarity). Component
of the Mediator complex, which is composed of MED1, MED4, MED6,
MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14,
MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a
distinct module termed the CDK8 module. Mediator containing the
CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of
the Mediator complex lacking one or more distinct subunits have
been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Interacts with STAT2. {ECO:0000250, ECO:0000269|PubMed:10198638,
ECO:0000269|PubMed:10235266, ECO:0000269|PubMed:10235267,
ECO:0000269|PubMed:12509459, ECO:0000269|PubMed:12584197,
ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15989967,
ECO:0000269|PubMed:16595664}.
-!- INTERACTION:
Q9D8C6:Med11 (xeno); NbExp=2; IntAct=EBI-394562, EBI-6260909;
Q15528:MED22; NbExp=3; IntAct=EBI-394562, EBI-394687;
Q6P2C8:MED27; NbExp=2; IntAct=EBI-394562, EBI-394603;
Q9CQI9:Med30 (xeno); NbExp=2; IntAct=EBI-394562, EBI-309220;
O75586:MED6; NbExp=2; IntAct=EBI-394562, EBI-394624;
Q9D7W5:Med8 (xeno); NbExp=2; IntAct=EBI-394562, EBI-7990252;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9NVC6-1; Sequence=Displayed;
Name=2;
IsoId=Q9NVC6-2; Sequence=VSP_028115, VSP_028116;
Note=May be due to intron retention.;
-!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10198638}.
-!- DISEASE: Microcephaly, postnatal progressive, with seizures and
brain atrophy (MCPHSBA) [MIM:613668]: A disorder characterized by
postnatal progressive microcephaly and severe developmental
retardation associated with cerebral and cerebellar atrophy.
Infants manifest swallowing difficulties leading to failure to
thrive, jitteriness, poor visual fixation, truncal arching,
seizures. There is no acquisition of developmental milestones and
patients suffer from marked spasticity and profound retardation.
Progressive microcephaly becomes evident few months after birth.
{ECO:0000269|PubMed:20950787}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD30856.1; Type=Frameshift; Positions=333, 335, 341, 346; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF117657; AAD22031.2; -; mRNA.
EMBL; AF105421; AAD30856.1; ALT_FRAME; mRNA.
EMBL; AK001674; BAA91827.1; -; mRNA.
EMBL; AK022156; BAB13973.1; -; mRNA.
EMBL; AK023209; BAG51169.1; -; mRNA.
EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC021101; AAH21101.1; -; mRNA.
EMBL; AF104254; AAD12723.1; -; mRNA.
CCDS; CCDS8295.1; -. [Q9NVC6-1]
RefSeq; NP_004259.3; NM_004268.4. [Q9NVC6-1]
UniGene; Hs.444931; -.
ProteinModelPortal; Q9NVC6; -.
SMR; Q9NVC6; -.
BioGrid; 114830; 94.
ComplexPortal; CPX-3227; Core mediator complex.
CORUM; Q9NVC6; -.
DIP; DIP-31451N; -.
IntAct; Q9NVC6; 44.
MINT; Q9NVC6; -.
STRING; 9606.ENSP00000251871; -.
iPTMnet; Q9NVC6; -.
PhosphoSitePlus; Q9NVC6; -.
BioMuta; MED17; -.
DMDM; 296437366; -.
EPD; Q9NVC6; -.
jPOST; Q9NVC6; -.
MaxQB; Q9NVC6; -.
PaxDb; Q9NVC6; -.
PeptideAtlas; Q9NVC6; -.
PRIDE; Q9NVC6; -.
ProteomicsDB; 82777; -.
ProteomicsDB; 82778; -. [Q9NVC6-2]
Ensembl; ENST00000251871; ENSP00000251871; ENSG00000042429. [Q9NVC6-1]
GeneID; 9440; -.
KEGG; hsa:9440; -.
UCSC; uc001pel.3; human. [Q9NVC6-1]
CTD; 9440; -.
DisGeNET; 9440; -.
EuPathDB; HostDB:ENSG00000042429.10; -.
GeneCards; MED17; -.
H-InvDB; HIX0010027; -.
HGNC; HGNC:2375; MED17.
HPA; HPA064236; -.
MalaCards; MED17; -.
MIM; 603810; gene.
MIM; 613668; phenotype.
neXtProt; NX_Q9NVC6; -.
OpenTargets; ENSG00000042429; -.
Orphanet; 402364; Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly.
PharmGKB; PA162395443; -.
eggNOG; KOG4512; Eukaryota.
eggNOG; ENOG410XRQ8; LUCA.
GeneTree; ENSGT00390000011810; -.
HOGENOM; HOG000008073; -.
HOVERGEN; HBG103247; -.
InParanoid; Q9NVC6; -.
KO; K15133; -.
OMA; CQIYQHQ; -.
OrthoDB; 976669at2759; -.
PhylomeDB; Q9NVC6; -.
TreeFam; TF323615; -.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-212436; Generic Transcription Pathway.
Reactome; R-HSA-381340; Transcriptional regulation of white adipocyte differentiation.
ChiTaRS; MED17; human.
GeneWiki; MED17; -.
GenomeRNAi; 9440; -.
PRO; PR:Q9NVC6; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000042429; Expressed in 217 organ(s), highest expression level in kidney.
ExpressionAtlas; Q9NVC6; baseline and differential.
Genevisible; Q9NVC6; HS.
GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; IDA:UniProtKB.
GO; GO:0046966; F:thyroid hormone receptor binding; IDA:UniProtKB.
GO; GO:0003713; F:transcription coactivator activity; IDA:MGI.
GO; GO:0003712; F:transcription coregulator activity; IDA:UniProtKB.
GO; GO:0042809; F:vitamin D receptor binding; NAS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
InterPro; IPR019313; Mediator_Med17.
PANTHER; PTHR13114; PTHR13114; 1.
Pfam; PF10156; Med17; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Complete proteome;
Direct protein sequencing; Disease mutation; Nucleus; Polymorphism;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 651 Mediator of RNA polymerase II
transcription subunit 17.
/FTId=PRO_0000079359.
VAR_SEQ 140 145 NPQTLQ -> VFVDFN (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_028115.
VAR_SEQ 146 651 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_028116.
VARIANT 69 69 E -> D (in dbSNP:rs2848477).
{ECO:0000244|PubMed:18691976,
ECO:0000244|PubMed:19369195,
ECO:0000269|PubMed:10198638,
ECO:0000269|PubMed:10235266,
ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_063126.
VARIANT 357 357 F -> L (in dbSNP:rs35313315).
/FTId=VAR_057781.
VARIANT 371 371 L -> P (in MCPHSBA; dbSNP:rs267607232).
{ECO:0000269|PubMed:20950787}.
/FTId=VAR_065066.
CONFLICT 21 21 E -> G (in Ref. 3; BAB13973).
{ECO:0000305}.
CONFLICT 58 58 E -> G (in Ref. 3; BAB13973).
{ECO:0000305}.
CONFLICT 356 356 K -> N (in Ref. 2; AAD30856).
{ECO:0000305}.
CONFLICT 409 409 G -> Q (in Ref. 1; AA sequence).
{ECO:0000305}.
CONFLICT 531 531 Q -> H (in Ref. 6; AAD12723).
{ECO:0000305}.
SEQUENCE 651 AA; 72890 MW; 47011210952D287B CRC64;
MSGVRAVRIS IESACEKQVH EVGLDGTETY LPPLSMSQNL ARLAQRIDFS QGSGSEEEEA
AGTEGDAQEW PGAGSSADQD DEEGVVKFQP SLWPWDSVRN NLRSALTEMC VLYDVLSIVR
DKKFMTLDPV SQDALPPKQN PQTLQLISKK KSLAGAAQIL LKGAERLTKS VTENQENKLQ
RDFNSELLRL RQHWKLRKVG DKILGDLSYR SAGSLFPHHG TFEVIKNTDL DLDKKIPEDY
CPLDVQIPSD LEGSAYIKVS IQKQAPDIGD LGTVNLFKRP LPKSKPGSPH WQTKLEAAQN
VLLCKEIFAQ LSREAVQIKS QVPHIVVKNQ IISQPFPSLQ LSISLCHSSN DKKSQKFATE
KQCPEDHLYV LEHNLHLLIR EFHKQTLSSI MMPHPASAPF GHKRMRLSGP QAFDKNEINS
LQSSEGLLEK IIKQAKHIFL RSRAAATIDS LASRIEDPQI QAHWSNINDV YESSVKVLIT
SQGYEQICKS IQLQLNIGVE QIRVVHRDGR VITLSYQEQE LQDFLLSQMS QHQVHAVQQL
AKVMGWQVLS FSNHVGLGPI ESIGNASAIT VASPSGDYAI SVRNGPESGS KIMVQFPRNQ
CKDLPKSDVL QDNKWSHLRG PFKEVQWNKM EGRNFVYKME LLMSALSPCL L


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18-003-42176 Thyroid hormone receptor-associated protein complex 95 kDa component - Trap95; Thyroid hormone receptor-associated protein 5; Vitamin D3 receptor-interacting protein complex component DRIP92 Polyclona 0.1 mg Protein A
EIAAB08492 COG complex subunit 1,Cog1,Component of oligomeric Golgi complex 1,Conserved oligomeric Golgi complex subunit 1,Ldlb,Low density lipoprotein receptor defect B-complementing protein,Mouse,Mus musculus
EIAAB08495 COG complex subunit 2,Cog2,Component of oligomeric Golgi complex 2,Conserved oligomeric Golgi complex subunit 2,Ldlc,Low density lipoprotein receptor defect C-complementing protein,Mouse,Mus musculus
EIAAB08494 COG complex subunit 2,COG2,Component of oligomeric Golgi complex 2,Conserved oligomeric Golgi complex subunit 2,Homo sapiens,Human,LDLC,Low density lipoprotein receptor defect C-complementing protein
20-372-60194 cofactor required for Sp1 transcriptional activation. subunit 2. 150kDa (CRSP2) - Mouse monoclonal anti-human CRSP2 antibody; Cofactor required for Sp1 transcriptional activation subunit 2; Transcript 0.1 mg
20-372-60196 cofactor required for Sp1 transcriptional activation. subunit 7. 70kDa (CRSP7) - Mouse monoclonal anti-human CRSP7 antibody; Cofactor required for Sp1 transcriptional activation subunit 7; Transcripti 0.1 mg
25-191 MED6 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information 0.05 mg
EIAAB08503 13S Golgi transport complex 90 kDa subunit,Bos taurus,Bovine,COG complex subunit 5,COG5,Component of oligomeric Golgi complex 5,Conserved oligomeric Golgi complex subunit 5,GTC-90
EIAAB08496 COG complex subunit 3,COG3,Component of oligomeric Golgi complex 3,Conserved oligomeric Golgi complex subunit 3,Homo sapiens,Human,p94,SEC34,Vesicle-docking protein SEC34 homolog
EIAAB08501 13S Golgi transport complex 90 kDa subunit,COG complex subunit 5,COG5,Component of oligomeric Golgi complex 5,Conserved oligomeric Golgi complex subunit 5,Golgi transport complex 1,GOLTC1,GTC90,GTC-90
EIAAB06531 Cdk8,Cell division protein kinase 8,Cyclin-dependent kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Mouse,Mus musculus
EIAAB33312 Complex III subunit 8,Complex III subunit VIII,Cytochrome b-c1 complex subunit 8,Low molecular mass ubiquinone-binding protein,Qpc,Rat,Rattus norvegicus,Ubiquinol-cytochrome c reductase complex 9.5 kD
EIAAB08493 COG complex subunit 1,COG1,Component of oligomeric Golgi complex 1,Conserved oligomeric Golgi complex subunit 1,Homo sapiens,Human,KIAA1381,LDLB
27-157 USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B and is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression. I 0.05 mg
EIAAB08512 COG complex subunit 8,Cog8,Component of oligomeric Golgi complex 8,Conserved oligomeric Golgi complex subunit 8,MNCb-5704,Mouse,Mus musculus
EIAAB08505 COG complex subunit 6,COG6,Component of oligomeric Golgi complex 6,Conserved oligomeric Golgi complex subunit 6,Homo sapiens,Human,KIAA1134
EIAAB08509 COG complex subunit 7,COG7,Component of oligomeric Golgi complex 7,Conserved oligomeric Golgi complex subunit 7,Homo sapiens,Human,UNQ3082_PRO10013

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1566: Citrate cycle (TCA cycle)
WP1624: Bacterial secretion system
WP1692: Protein export
WP1713: Two-component system
WP1718: Vitamin B6 metabolism
WP1102: EBV LMP1 signaling
WP1122: Blood Clotting Cascade
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1243: EBV LMP1 signaling
WP1278: EBV LMP1 signaling
WP1328: EBV LMP1 signaling
WP1531: Vitamin D synthesis
WP1571: EBV LMP1 signaling
WP1602: Nicotine Activity on Dopaminergic Neurons
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism

Related Genes :
[MED17 ARC77 CRSP6 DRIP77 DRIP80 TRAP80] Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
[MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170] Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
[MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100] Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
[MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2] Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
[Med17 Crsp6 Trap80] Mediator of RNA polymerase II transcription subunit 17 (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component)
[MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2] Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
[MED7 ARC34 CRSP9] Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
[MED26 ARC70 CRSP7] Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)
[MED13 ARC250 KIAA0593 THRAP1 TRAP240] Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
[Med14 Crsp2 Gm641 Trap170] Mediator of RNA polymerase II transcription subunit 14 (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170)
[MED4 ARC36 DRIP36 VDRIP HSPC126] Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
[MED16 DRIP92 THRAP5] Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)
[MED27 CRSP34 CRSP8] Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230] Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
[MED30 THRAP6 TRAP25] Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
[Med24 D11Ertd307e Thrap4 Trap100] Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (mTRAP100)
[Med30 Thrap6 Trap25] Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
[Med23 Crsp3 Kiaa1216 Sur2] Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (mSur-2)
[MED6 ARC33] Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)
[Med12 Kiaa0192 Mopa Tnrc11 Trap230] Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
[MED25 ACID1 ARC92 PTOV2 TCBAP0758] Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)
[MED13L KIAA1025 PROSIT240 THRAP2 TRAP240L] Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
[MED15 ARC105 CTG7A PCQAP TIG1 TNRC7] Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
[MED8] Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
[Med16 Thrap5] Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)
[med12 kto mot trap230] Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Protein kohtalo) (Protein motionless) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230)
[Med27 Crsp8] Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27)
[NCOA6 AIB3 KIAA0181 RAP250 TRBP] Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
[Med13 Kiaa0593 Thrap1 Trap240] Mediator of RNA polymerase II transcription subunit 13 (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240)

Bibliography :
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