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Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)

 MED24_HUMAN             Reviewed;         989 AA.
O75448; A8K4S5; B3KMR9; Q14143; Q9NNY5;
24-JUN-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
13-FEB-2019, entry version 172.
RecName: Full=Mediator of RNA polymerase II transcription subunit 24;
AltName: Full=Activator-recruited cofactor 100 kDa component;
Short=ARC100;
AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 4;
Short=CRSP complex subunit 4;
AltName: Full=Mediator complex subunit 24;
AltName: Full=Thyroid hormone receptor-associated protein 4;
AltName: Full=Thyroid hormone receptor-associated protein complex 100 kDa component;
Short=Trap100;
Short=hTRAP100;
AltName: Full=Vitamin D3 receptor-interacting protein complex 100 kDa component;
Short=DRIP100;
Name=MED24;
Synonyms=ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-15, AND
TISSUE SPECIFICITY.
PubMed=9653119; DOI=10.1073/pnas.95.14.7939;
Yuan C.-X., Ito M., Fondell J.D., Fu Z.-Y., Roeder R.G.;
"The TRAP220 component of a thyroid hormone receptor-associated
protein (TRAP) coactivator complex interacts directly with nuclear
receptors in a ligand-dependent fashion.";
Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND IDENTIFICATION IN DRIP
COMPLEX.
PubMed=9637681; DOI=10.1101/gad.12.12.1787;
Rachez C., Suldan Z., Ward J., Chang C.-P.B., Burakov D.,
Erdjument-Bromage H., Tempst P., Freedman L.P.;
"A novel protein complex that interacts with the vitamin D3 receptor
in a ligand-dependent manner and enhances VDR transactivation in a
cell-free system.";
Genes Dev. 12:1787-1800(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
THR-204.
TISSUE=Bone marrow;
PubMed=8590280; DOI=10.1093/dnares/2.4.167;
Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.;
"Prediction of the coding sequences of unidentified human genes. IV.
The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by
analysis of cDNA clones from human cell line KG-1.";
DNA Res. 2:167-174(1995).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Teratocarcinoma;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 1-11 AND 957-965, AND IDENTIFICATION IN ARC
COMPLEX.
PubMed=10235267; DOI=10.1038/19789;
Naeaer A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W.B.,
Tjian R.;
"Composite co-activator ARC mediates chromatin-directed
transcriptional activation.";
Nature 398:828-832(1999).
[8]
PROTEIN SEQUENCE OF 467-489, AND IDENTIFICATION IN ARC COMPLEX.
TISSUE=Cervix carcinoma;
PubMed=10235266; DOI=10.1038/19783;
Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M.,
Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P.;
"Ligand-dependent transcription activation by nuclear receptors
requires the DRIP complex.";
Nature 398:824-828(1999).
[9]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE SMCC
COMPLEX.
PubMed=10024883; DOI=10.1016/S1097-2765(00)80178-1;
Gu W., Malik S., Ito M., Yuan C.-X., Fondell J.D., Zhang X.,
Martinez E., Qin J., Roeder R.G.;
"A novel human SRB/MED-containing cofactor complex, SMCC, involved in
transcription regulation.";
Mol. Cell 3:97-108(1999).
[10]
ERRATUM.
Gu W., Malik S., Ito M., Yuan C.-X., Fondell J.D., Zhang X.,
Martinez E., Qin J., Roeder R.G.;
Mol. Cell 3:541-541(1999).
[11]
FUNCTION, AND INTERACTION WITH AR.
PubMed=12218053; DOI=10.1074/jbc.M206061200;
Wang Q., Sharma D., Ren Y., Fondell J.D.;
"A coregulatory role for the TRAP-mediator complex in androgen
receptor-mediated gene expression.";
J. Biol. Chem. 277:42852-42858(2002).
[12]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
MEDIATOR COMPLEX.
PubMed=15175163; DOI=10.1016/j.molcel.2004.05.006;
Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B.,
Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P.,
Conaway J.W., Conaway R.C.;
"A set of consensus mammalian mediator subunits identified by
multidimensional protein identification technology.";
Mol. Cell 14:685-691(2004).
[13]
INTERACTION WITH MED1; MED10; MED21 AND MED30, IDENTIFICATION BY MASS
SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, AND ASSOCIATION
OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
PubMed=15989967; DOI=10.1016/j.molcel.2005.05.015;
Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T.,
Roeder R.G.;
"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation
enriched in RNA polymerase II and is required for ER-mediated
transcription.";
Mol. Cell 19:89-100(2005).
[14]
FUNCTION, AND INTERACTION WITH MED1 AND MED10.
PubMed=16595664; DOI=10.1074/jbc.M601983200;
Baek H.J., Kang Y.K., Roeder R.G.;
"Human Mediator enhances basal transcription by facilitating
recruitment of transcription factor IIB during preinitiation complex
assembly.";
J. Biol. Chem. 281:15172-15181(2006).
[15]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of
the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-862 AND SER-873, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[17]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19413330; DOI=10.1021/ac9004309;
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
Mohammed S.;
"Lys-N and trypsin cover complementary parts of the phosphoproteome in
a refined SCX-based approach.";
Anal. Chem. 81:4493-4501(2009).
[18]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
Mann M., Daub H.;
"Large-scale proteomics analysis of the human kinome.";
Mol. Cell. Proteomics 8:1751-1764(2009).
[19]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-862 AND SER-873, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[20]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-862 AND SER-873, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-862, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[22]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-862 AND SER-873, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
-!- FUNCTION: Component of the Mediator complex, a coactivator
involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to
convey information from gene-specific regulatory proteins to the
basal RNA polymerase II transcription machinery. Mediator is
recruited to promoters by direct interactions with regulatory
proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general
transcription factors. {ECO:0000269|PubMed:12218053,
ECO:0000269|PubMed:16595664}.
-!- SUBUNIT: Component of the Mediator complex, which is composed of
MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13,
MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31,
CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8
subunits form a distinct module termed the CDK8 module. Mediator
containing the CDK8 module is less active than Mediator lacking
this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and
TRAP. Interacts with AR. {ECO:0000269|PubMed:10024883,
ECO:0000269|PubMed:10235266, ECO:0000269|PubMed:10235267,
ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:15175163,
ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16595664,
ECO:0000269|PubMed:9637681}.
-!- INTERACTION:
Q9Y2X0:MED16; NbExp=2; IntAct=EBI-394523, EBI-394541;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O75448-1; Sequence=Displayed;
Name=2;
IsoId=O75448-2; Sequence=VSP_041125;
-!- TISSUE SPECIFICITY: Ubiquitous. Abundant in skeletal muscle, heart
and placenta. {ECO:0000269|PubMed:9653119}.
-!- SIMILARITY: Belongs to the Mediator complex subunit 24 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAA09479.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF055995; AAC39855.1; -; mRNA.
EMBL; AF277379; AAF78764.1; -; mRNA.
EMBL; D50920; BAA09479.2; ALT_INIT; mRNA.
EMBL; AK022508; BAG51081.1; -; mRNA.
EMBL; AK291040; BAF83729.1; -; mRNA.
EMBL; AC090844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC102799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC011375; AAH11375.1; -; mRNA.
CCDS; CCDS11359.1; -. [O75448-1]
CCDS; CCDS42315.1; -. [O75448-2]
RefSeq; NP_001072986.1; NM_001079518.1. [O75448-2]
RefSeq; NP_001254726.1; NM_001267797.1. [O75448-2]
RefSeq; NP_055630.2; NM_014815.3. [O75448-1]
RefSeq; XP_016880955.1; XM_017025466.1.
UniGene; Hs.462983; -.
ProteinModelPortal; O75448; -.
BioGrid; 115196; 93.
ComplexPortal; CPX-3227; Core mediator complex.
CORUM; O75448; -.
DIP; DIP-31462N; -.
IntAct; O75448; 38.
MINT; O75448; -.
STRING; 9606.ENSP00000377686; -.
iPTMnet; O75448; -.
PhosphoSitePlus; O75448; -.
BioMuta; MED24; -.
EPD; O75448; -.
jPOST; O75448; -.
MaxQB; O75448; -.
PaxDb; O75448; -.
PeptideAtlas; O75448; -.
PRIDE; O75448; -.
ProteomicsDB; 50015; -.
ProteomicsDB; 50016; -. [O75448-2]
DNASU; 9862; -.
Ensembl; ENST00000356271; ENSP00000348610; ENSG00000008838. [O75448-2]
Ensembl; ENST00000394127; ENSP00000377685; ENSG00000008838. [O75448-2]
Ensembl; ENST00000394128; ENSP00000377686; ENSG00000008838. [O75448-1]
GeneID; 9862; -.
KEGG; hsa:9862; -.
UCSC; uc002htt.4; human. [O75448-1]
CTD; 9862; -.
DisGeNET; 9862; -.
EuPathDB; HostDB:ENSG00000008838.17; -.
GeneCards; MED24; -.
H-InvDB; HIX0174136; -.
HGNC; HGNC:22963; MED24.
MIM; 607000; gene.
neXtProt; NX_O75448; -.
OpenTargets; ENSG00000008838; -.
PharmGKB; PA162395566; -.
eggNOG; ENOG410IF72; Eukaryota.
eggNOG; ENOG410YPDT; LUCA.
GeneTree; ENSGT00390000016438; -.
HOGENOM; HOG000293419; -.
HOVERGEN; HBG055588; -.
InParanoid; O75448; -.
KO; K15167; -.
OrthoDB; 739187at2759; -.
PhylomeDB; O75448; -.
TreeFam; TF323565; -.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-212436; Generic Transcription Pathway.
Reactome; R-HSA-381340; Transcriptional regulation of white adipocyte differentiation.
ChiTaRS; MED24; human.
GeneWiki; MED24; -.
GenomeRNAi; 9862; -.
PRO; PR:O75448; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000008838; Expressed in 201 organ(s), highest expression level in pituitary gland.
ExpressionAtlas; O75448; baseline and differential.
Genevisible; O75448; HS.
GO; GO:0016592; C:mediator complex; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; NAS:UniProtKB.
GO; GO:0046966; F:thyroid hormone receptor binding; IDA:UniProtKB.
GO; GO:0003712; F:transcription coregulator activity; IDA:UniProtKB.
GO; GO:0042809; F:vitamin D receptor binding; NAS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
InterPro; IPR021429; Mediator_Med24.
PANTHER; PTHR12898; PTHR12898; 1.
Pfam; PF11277; Med24_N; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Complete proteome;
Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism;
Reference proteome; Repeat; Transcription; Transcription regulation.
CHAIN 1 989 Mediator of RNA polymerase II
transcription subunit 24.
/FTId=PRO_0000065582.
MOTIF 128 132 LXXLL motif 1.
MOTIF 344 348 LXXLL motif 2.
MOTIF 448 452 LXXLL motif 3.
MOTIF 557 561 LXXLL motif 4.
MOTIF 788 792 LXXLL motif 5.
MOTIF 857 861 LXXLL motif 6.
MOD_RES 862 862 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 873 873 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
VAR_SEQ 72 84 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_041125.
VARIANT 204 204 A -> T (in dbSNP:rs34585432).
{ECO:0000269|PubMed:8590280}.
/FTId=VAR_053969.
CONFLICT 20 20 D -> Y (in Ref. 3; BAA09479).
{ECO:0000305}.
CONFLICT 476 476 Missing (in Ref. 8; AA sequence).
{ECO:0000305}.
CONFLICT 555 555 E -> G (in Ref. 2; AAF78764).
{ECO:0000305}.
CONFLICT 710 710 V -> E (in Ref. 4; BAG51081).
{ECO:0000305}.
CONFLICT 741 741 V -> A (in Ref. 4; BAG51081).
{ECO:0000305}.
CONFLICT 969 969 A -> P (in Ref. 4; BAG51081).
{ECO:0000305}.
SEQUENCE 989 AA; 110305 MW; CCEDE7D4E74D890C CRC64;
MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLADALLEQA MIGPSPNPLI
LSYLKYAISS QMVSYSSVLT AISKFDDFSR DLCVQALLDI MDMFCDRLSC HGKAEECIGL
CRALLSALHW LLRCTAASAE RLREGLEAGT PAAGEKQLAM CLQRLEKTLS STKNRALLHI
AKLEEASSWT AIEHSLLKLG EILANLSNPQ LRSQAEQCGT LIRSIPTMLS VHAEQMHKTG
FPTVHAVILL EGTMNLTGET QSLVEQLTMV KRMQHIPTPL FVLEIWKACF VGLIESPEGT
EELKWTAFTF LKIPQVLVKL KKYSHGDKDF TEDVNCAFEF LLKLTPLLDK ADQRCNCDCT
NFLLQECGKQ GLLSEASVNN LMAKRKADRE HAPQQKSGEN ANIQPNIQLI LRAEPTVTNI
LKTMDADHSK SPEGLLGVLG HMLSGKSLDL LLAAAAATGK LKSFARKFIN LNEFTTYGSE
ESTKPASVRA LLFDISFLML CHVAQTYGSE VILSESRTGA EVPFFETWMQ TCMPEEGKIL
NPDHPCFRPD STKVESLVAL LNNSSEMKLV QMKWHEACLS ISAAILEILN AWENGVLAFE
SIQKITDNIK GKVCSLAVCA VAWLVAHVRM LGLDEREKSL QMIRQLAGPL FSENTLQFYN
ERVVIMNSIL ERMCADVLQQ TATQIKFPST GVDTMPYWNL LPPKRPIKEV LTDIFAKVLE
KGWVDSRSIH IFDTLLHMGG VYWFCNNLIK ELLKETRKEH TLRAVELLYS IFCLDMQQVT
LVLLGHILPG LLTDSSKWHS LMDPPGTALA KLAVWCALSS YSSHKGQAST RQKKRHREDI
EDYISLFPLD DVQPSKLMRL LSSNEDDANI LSSPTDRSMS SSLSASQLHT VNMRDPLNRV
LANLFLLISS ILGSRTAGPH TQFVQWFMEE CVDCLEQGGR GSVLQFMPFT TVSELVKVSA
MSSPKVVLAI TDLSLPLGRQ VAAKAIAAL


Related products :

Catalog number Product name Quantity
18-003-42176 Thyroid hormone receptor-associated protein complex 95 kDa component - Trap95; Thyroid hormone receptor-associated protein 5; Vitamin D3 receptor-interacting protein complex component DRIP92 Polyclona 0.1 mg Protein A
10-288-22393F Cofactor required for Sp1 transcriptional activation subunit 9 - Transcriptional coactivator CRSP33; RNA polymerase transcriptional regulation mediator subunit 7 homolog; hMED7; Activator-recruited co 0.05 mg
18-003-43107 Cofactor required for Sp1 transcriptional activation subunit 9 - Transcriptional coactivator CRSP33; RNA polymerase transcriptional regulation mediator subunit 7 homolog; hMED7; Activator-recruited co 0.05 mg Aff Pur
10-288-22393F Cofactor required for Sp1 transcriptional activation subunit 9 - Transcriptional coactivator CRSP33; RNA polymerase transcriptional regulation mediator subunit 7 homolog; hMED7; Activator-recruited co 0.1 mg
18-003-43214 CRSP complex subunit 8 - Cofactor required for Sp1 transcriptional activation subunit 8; Transcriptional coactivator CRSP34; P37 TRAP_SMCC_PC2 subunit Polyclonal 0.1 mg Protein A
28-735 MED21 belongs to the Mediator complex subunit 21 family. It is the component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent ge 0.05 mg
10-288-22355F RNA polymerase transcriptional regulation mediator. subunit 6 homolog - Activator-recruited cofactor 33 kDa component; ARC33; NY-REN-28 antigen 0.1 mg
10-288-22355F RNA polymerase transcriptional regulation mediator. subunit 6 homolog - Activator-recruited cofactor 33 kDa component; ARC33; NY-REN-28 antigen 0.05 mg
27-934 CRSP9 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. CRSP9 is also a component of other multisubunit com 0.05 mg
EIAAB08492 COG complex subunit 1,Cog1,Component of oligomeric Golgi complex 1,Conserved oligomeric Golgi complex subunit 1,Ldlb,Low density lipoprotein receptor defect B-complementing protein,Mouse,Mus musculus
EIAAB08495 COG complex subunit 2,Cog2,Component of oligomeric Golgi complex 2,Conserved oligomeric Golgi complex subunit 2,Ldlc,Low density lipoprotein receptor defect C-complementing protein,Mouse,Mus musculus
EIAAB08494 COG complex subunit 2,COG2,Component of oligomeric Golgi complex 2,Conserved oligomeric Golgi complex subunit 2,Homo sapiens,Human,LDLC,Low density lipoprotein receptor defect C-complementing protein
EIAAB43730 Homo sapiens,Human,THRAP3,Thyroid hormone receptor-associated protein 3,Thyroid hormone receptor-associated protein complex 150 kDa component,Trap150,TRAP150
EIAAB43728 Rat,Rattus norvegicus,Thrap3,Thyroid hormone receptor-associated protein 3,Thyroid hormone receptor-associated protein complex 150 kDa component,Trap150,Trap150
EIAAB43729 Mouse,Mus musculus,Thrap3,Thyroid hormone receptor-associated protein 3,Thyroid hormone receptor-associated protein complex 150 kDa component,Trap150,Trap150
ARP32301_T200 Anti-Thyroid hormone receptor-associated protein complex 95 kDa component(THRAP5) Species_Reactivity: Human
EIAAB09602 Alien homolog,COP9 signalosome complex subunit 2,Cops2,Csn2,JAB1-containing signalosome subunit 2,Mouse,Mus musculus,SGN2,Signalosome subunit 2,Thyroid receptor-interacting protein 15,TR-interacting p
18-003-43113 COP9 signalosome complex subunit 2 - Signalosome subunit 2; SGN2; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; Alien homolog Polyclonal 0.1 mg Protein A
18-001-30018 COP9 signalosome complex subunit 2 - Signalosome subunit 2; SGN2; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; Alien homolog Polyclonal 0.1 mg
18-003-43113 COP9 signalosome complex subunit 2 - Signalosome subunit 2; SGN2; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; Alien homolog Polyclonal 0.05 mg Aff Pur
EIAAB09601 Alien homolog,COP9 signalosome complex subunit 2,COPS2,CSN2,Homo sapiens,Human,JAB1-containing signalosome subunit 2,SGN2,Signalosome subunit 2,Thyroid receptor-interacting protein 15,TR-interacting p
EIAAB09600 Alien homolog,COP9 signalosome complex subunit 2,Cops2,Csn2,JAB1-containing signalosome subunit 2,Rat,Rattus norvegicus,SGN2,Signalosome subunit 2,Thyroid receptor-interacting protein 15,TR-interactin
EIAAB08503 13S Golgi transport complex 90 kDa subunit,Bos taurus,Bovine,COG complex subunit 5,COG5,Component of oligomeric Golgi complex 5,Conserved oligomeric Golgi complex subunit 5,GTC-90
EIAAB08496 COG complex subunit 3,COG3,Component of oligomeric Golgi complex 3,Conserved oligomeric Golgi complex subunit 3,Homo sapiens,Human,p94,SEC34,Vesicle-docking protein SEC34 homolog
EIAAB06531 Cdk8,Cell division protein kinase 8,Cyclin-dependent kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Mouse,Mus musculus

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1566: Citrate cycle (TCA cycle)
WP1531: Vitamin D synthesis
WP1624: Bacterial secretion system
WP1692: Protein export
WP1713: Two-component system
WP1718: Vitamin B6 metabolism
WP1963: The effect of Glucocorticoids on target gene expression
WP2355: Corticotropin-releasing hormone
WP474: Endochondral Ossification
WP1102: EBV LMP1 signaling
WP1122: Blood Clotting Cascade
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1243: EBV LMP1 signaling
WP1278: EBV LMP1 signaling
WP1328: EBV LMP1 signaling
WP1438: Influenza A virus infection
WP1571: EBV LMP1 signaling

Related Genes :
[MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100] Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
[MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170] Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
[MED17 ARC77 CRSP6 DRIP77 DRIP80 TRAP80] Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
[Med24 D11Ertd307e Thrap4 Trap100] Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (mTRAP100)
[MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2] Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
[MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2] Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
[MED13 ARC250 KIAA0593 THRAP1 TRAP240] Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
[MED16 DRIP92 THRAP5] Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)
[MED7 ARC34 CRSP9] Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
[MED4 ARC36 DRIP36 VDRIP HSPC126] Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
[Med14 Crsp2 Gm641 Trap170] Mediator of RNA polymerase II transcription subunit 14 (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170)
[MED26 ARC70 CRSP7] Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[Med17 Crsp6 Trap80] Mediator of RNA polymerase II transcription subunit 17 (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component)
[MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230] Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
[MED30 THRAP6 TRAP25] Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
[MED27 CRSP34 CRSP8] Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)
[Med30 Thrap6 Trap25] Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
[MED13L KIAA1025 PROSIT240 THRAP2 TRAP240L] Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
[Med12 Kiaa0192 Mopa Tnrc11 Trap230] Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
[MED25 ACID1 ARC92 PTOV2 TCBAP0758] Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)
[Med23 Crsp3 Kiaa1216 Sur2] Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (mSur-2)
[MED15 ARC105 CTG7A PCQAP TIG1 TNRC7] Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
[MED6 ARC33] Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)
[Med16 Thrap5] Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)
[med12 kto mot trap230] Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Protein kohtalo) (Protein motionless) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230)
[MED8] Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
[Med13 Kiaa0593 Thrap1 Trap240] Mediator of RNA polymerase II transcription subunit 13 (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240)
[NCOA6 AIB3 KIAA0181 RAP250 TRBP] Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
[NCOA3 AIB1 BHLHE42 RAC3 TRAM1] Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)

Bibliography :