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Meiotic recombination protein DMC1/LIM15 homolog

 DMC1_MOUSE              Reviewed;         340 AA.
Q61880;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
29-SEP-2021, entry version 156.
RecName: Full=Meiotic recombination protein DMC1/LIM15 homolog {ECO:0000305};
Name=Dmc1 {ECO:0000312|MGI:MGI:105393}; Synonyms=Dmc1h, Lim15;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=8581742; DOI=10.1093/dnares/2.3.147;
Sato S., Kobayashi T., Hotta Y., Tabata S.;
"Characterization of a mouse recA-like gene specifically expressed in
testis.";
DNA Res. 2:147-150(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129/Sv; TISSUE=Testis;
PubMed=8602360; DOI=10.1093/nar/24.3.470;
Habu T., Taki T., West A., Nishimune Y., Morita T.;
"The mouse and human homologs of DMC1, the yeast meiosis-specific
homologous recombination gene, have a common unique form of exon-skipped
transcript in meiosis.";
Nucleic Acids Res. 24:470-477(1996).
[3]
INTERACTION WITH MND1/PSMC3IP HETERODIMER.
PubMed=15834424; DOI=10.1038/nsmb923;
Petukhova G.V., Pezza R.J., Vanevski F., Ploquin M., Masson J.-Y.,
Camerini-Otero R.D.;
"The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic
recombination.";
Nat. Struct. Mol. Biol. 12:449-453(2005).
[4]
FUNCTION.
PubMed=17639081; DOI=10.1101/gad.1562907;
Pezza R.J., Voloshin O.N., Vanevski F., Camerini-Otero R.D.;
"Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous
pairing.";
Genes Dev. 21:1758-1766(2007).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[6]
SUBCELLULAR LOCATION.
PubMed=21307306; DOI=10.1073/pnas.1016454108;
Dray E., Dunlop M.H., Kauppi L., San Filippo J., Wiese C., Tsai M.S.,
Begovic S., Schild D., Jasin M., Keeney S., Sung P.;
"Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51
associated protein 1 (RAD51AP1).";
Proc. Natl. Acad. Sci. U.S.A. 108:3560-3565(2011).
[7]
SUBCELLULAR LOCATION.
PubMed=22549958; DOI=10.1101/gad.187559.112;
Wojtasz L., Cloutier J.M., Baumann M., Daniel K., Varga J., Fu J.,
Anastassiadis K., Stewart A.F., Remenyi A., Turner J.M., Toth A.;
"Meiotic DNA double-strand breaks and chromosome asynapsis in mice are
monitored by distinct HORMAD2-independent and -dependent mechanisms.";
Genes Dev. 26:958-973(2012).
[8]
SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
PubMed=30760716; DOI=10.1038/s41467-019-08676-2;
Zhang J., Fujiwara Y., Yamamoto S., Shibuya H.;
"A meiosis-specific BRCA2 binding protein recruits recombinases to DNA
double-strand breaks to ensure homologous recombination.";
Nat. Commun. 10:722-722(2019).
[9]
SUBCELLULAR LOCATION.
PubMed=30949703; DOI=10.1093/nar/gkz226;
Liu H., Huang T., Li M., Li M., Zhang C., Jiang J., Yu X., Yin Y.,
Zhang F., Lu G., Luo M.C., Zhang L.R., Li J., Liu K., Chen Z.J.;
"SCRE serves as a unique synaptonemal complex fastener and is essential for
progression of meiosis prophase I in mice.";
Nucleic Acids Res. 47:5670-5683(2019).
[10]
SUBCELLULAR LOCATION.
PubMed=30746471; DOI=10.1126/sciadv.aau9780;
Zhang Q., Ji S.Y., Busayavalasa K., Yu C.;
"SPO16 binds SHOC1 to promote homologous recombination and crossing-over in
meiotic prophase I.";
Sci. Adv. 5:eaau9780-eaau9780(2019).
[11]
SUBCELLULAR LOCATION.
PubMed=32463460; DOI=10.1093/nar/gkaa406;
Shang Y., Huang T., Liu H., Liu Y., Liang H., Yu X., Li M., Zhai B.,
Yang X., Wei Y., Wang G., Chen Z., Wang S., Zhang L.;
"MEIOK21: a new component of meiotic recombination bridges required for
spermatogenesis.";
Nucleic Acids Res. 48:6624-6639(2020).
-!- FUNCTION: Participates in meiotic recombination, specifically in
homologous strand assimilation, which is required for the resolution of
meiotic double-strand breaks. {ECO:0000269|PubMed:17639081}.
-!- SUBUNIT: Double stacked ring-shaped homooctamer (By similarity).
Interacts with BRCA2 (By similarity). Interacts with the MND1-PSMC3IP
heterodimer (PubMed:15834424). Interacts with RAD51AP1; the interaction
is direct and stimulates DMC1-mediated homologous recombination (By
similarity). {ECO:0000250|UniProtKB:Q14565,
ECO:0000269|PubMed:15834424}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21307306}. Chromosome
{ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22549958,
ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30760716,
ECO:0000269|PubMed:30949703, ECO:0000269|PubMed:32463460}.
-!- TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:30760716,
ECO:0000269|PubMed:8581742}.
-!- DEVELOPMENTAL STAGE: In spermatocytes, shows punctate localization
along chromosome axes specifically in early meiotic prophase I cells.
Foci start to appear from the leptotene stage, reach their greatest
number in the zygotene stage, in the early pachytene stage, the DMC1
foci mostly disappeared from autosomes and became restricted to the sex
chromosomes. {ECO:0000269|PubMed:30760716}.
-!- SIMILARITY: Belongs to the RecA family. DMC1 subfamily. {ECO:0000305}.
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EMBL; D58419; BAA09590.1; -; mRNA.
EMBL; D64107; BAA10969.1; -; mRNA.
CCDS; CCDS27644.1; -.
PIR; JC4191; JC4191.
RefSeq; NP_034189.1; NM_010059.3.
SMR; Q61880; -.
BioGRID; 199244; 1.
CORUM; Q61880; -.
STRING; 10090.ENSMUSP00000023065; -.
iPTMnet; Q61880; -.
PhosphoSitePlus; Q61880; -.
PaxDb; Q61880; -.
PRIDE; Q61880; -.
ProteomicsDB; 277345; -.
Antibodypedia; 246; 408 antibodies.
Ensembl; ENSMUST00000023065; ENSMUSP00000023065; ENSMUSG00000022429.
GeneID; 13404; -.
KEGG; mmu:13404; -.
UCSC; uc007wtu.2; mouse.
CTD; 11144; -.
MGI; MGI:105393; Dmc1.
VEuPathDB; HostDB:ENSMUSG00000022429; -.
eggNOG; KOG1434; Eukaryota.
GeneTree; ENSGT00760000119398; -.
HOGENOM; CLU_041732_0_0_1; -.
InParanoid; Q61880; -.
OMA; GGINDPD; -.
OrthoDB; 877394at2759; -.
PhylomeDB; Q61880; -.
TreeFam; TF300698; -.
BioGRID-ORCS; 13404; 0 hits in 98 CRISPR screens.
PRO; PR:Q61880; -.
Proteomes; UP000000589; Chromosome 15.
RNAct; Q61880; protein.
Bgee; ENSMUSG00000022429; Expressed in female gonad and 198 other tissues.
ExpressionAtlas; Q61880; baseline and differential.
Genevisible; Q61880; MM.
GO; GO:0005694; C:chromosome; IDA:UniProtKB.
GO; GO:0000781; C:chromosome, telomeric region; IDA:MGI.
GO; GO:0000794; C:condensed nuclear chromosome; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0008094; F:ATPase, acting on DNA; IBA:GO_Central.
GO; GO:0000150; F:DNA strand exchange activity; ISS:UniProtKB.
GO; GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IBA:GO_Central.
GO; GO:0000730; P:DNA recombinase assembly; IBA:GO_Central.
GO; GO:0007276; P:gamete generation; IMP:MGI.
GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:MGI.
GO; GO:0007141; P:male meiosis I; IMP:MGI.
GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
GO; GO:0001556; P:oocyte maturation; IMP:MGI.
GO; GO:0048477; P:oogenesis; IMP:MGI.
GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
GO; GO:0007286; P:spermatid development; IMP:MGI.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
GO; GO:0042148; P:strand invasion; IBA:GO_Central.
CDD; cd01123; Rad51_DMC1_radA; 1.
Gene3D; 3.40.50.300; -; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR011940; Dmc1.
InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
InterPro; IPR016467; DNA_recomb/repair_RecA-like.
InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033925; Rad51_DMC1_RadA.
InterPro; IPR020588; RecA_ATP-bd.
InterPro; IPR020587; RecA_monomer-monomer_interface.
Pfam; PF08423; Rad51; 1.
PIRSF; PIRSF005856; Rad51; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF47794; SSF47794; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR02238; recomb_DMC1; 1.
PROSITE; PS50162; RECA_2; 1.
PROSITE; PS50163; RECA_3; 1.
1: Evidence at protein level;
ATP-binding; Cell cycle; Chromosome; DNA-binding; Meiosis;
Nucleotide-binding; Nucleus; Reference proteome.
CHAIN 1..340
/note="Meiotic recombination protein DMC1/LIM15 homolog"
/id="PRO_0000122919"
NP_BIND 126..133
/note="ATP"
/evidence="ECO:0000305"
BINDING 230
/note="ssDNA or dsDNA"
/evidence="ECO:0000250|UniProtKB:Q14565"
BINDING 233
/note="ssDNA"
/evidence="ECO:0000250|UniProtKB:Q14565"
BINDING 236
/note="ssDNA or dsDNA"
/evidence="ECO:0000250|UniProtKB:Q14565"
BINDING 242
/note="ssDNA or dsDNA"
/evidence="ECO:0000250|UniProtKB:Q14565"
BINDING 311
/note="ssDNA"
/evidence="ECO:0000250|UniProtKB:Q14565"
SEQUENCE 340 AA; 37821 MW; 23EAB08D6E668637 CRC64;
MKEDQVVQEE SGFQDDEESL FQDIDLLQKH GINMADIKKL KSVGICTIKG IQMTTRRALC
NVKGLSEAKV EKIKEAANKL IEPGFLTAFQ YSERRKMVFH ITTGSQEFDK LLGGGIESMA
ITEAFGEFRT GKTQLSHTLC VTAQLPGTGG YSGGKIIFID TENTFRPDRL RDIADRFNVD
HEAVLDNVLY ARAYTSEHQM ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA
ERQQKLAQML SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR
ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE


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Pathways :
WP1663: Homologous recombination
WP1676: Non-homologous end-joining
WP1576: Homologous recombination
WP1205: Homologous recombination
WP1258: Homologous recombination
WP1362: Homologous recombination
WP1234: Homologous recombination
WP917: Homologous recombination
WP186: Homologous recombination
WP377: Genes of Meiotic Recombination
WP1036: Homologous recombination
WP1153: Homologous recombination
WP741: Homologous recombination
WP804: Homologous recombination
WP1216: Homologous recombination
WP1296: Homologous recombination
WP1502: Mitochondrial biogenesis
WP1892: Protein folding
WP525: Mitochondrial Unfolded-Protein Response
WP1003: Ovarian Infertility Genes
WP1672: Mismatch repair
WP263: Ovarian Infertility Genes
WP1097: Non-homologous end joining
WP2032: TSH signaling pathway
WP739: Non-homologous end joining

Related Genes :
[DMC1 DMC1H LIM15] Meiotic recombination protein DMC1/LIM15 homolog
[Dmc1 Dmc1h Lim15] Meiotic recombination protein DMC1/LIM15 homolog
[DMC1 LIM15 At3g22880 F5N5.6] Meiotic recombination protein DMC1 homolog (AtDMC1)
[DMC1 ISC2 YER179W] Meiotic recombination protein DMC1
[DMC1A DMC1 Os12g0143800 LOC_Os12g04980] Meiotic recombination protein DMC1 homolog A (OsDMC1A) (OsDMC1) (RiLIM15A)
[dmc1 dmp1 SPAC8E11.03c] Meiotic recombination protein dmc1
[RDH54 TID1 YBR073W YBR0715] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[MND1 At4g29170 F19B15.200] Meiotic nuclear division protein 1 homolog (AtMND1) (Meiotic nuclear division 1-like protein)
[DMC1B DMC1 Os11g0146800 LOC_Os11g04954] Meiotic recombination protein DMC1 homolog B (OsDMC1B) (RiLIM15B)
[LIM15] Meiotic recombination protein DMC1 homolog
[DMC1A DMC1 OsI_37443] Meiotic recombination protein DMC1 homolog A (OsDMC1A) (OsDMC1) (RiLIM15A)
[HID1 C17orf28 DMC1] Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog)
[NDC80 HEC1 TID3 YIL144W] Kinetochore protein NDC80 (80 kDa spindle component protein) (Nuclear division cycle protein 80) (Two-hybrid interaction with DMC1 protein 3)
[rdh54 mug34 tid1 SPAC22F3.03c] Meiotic recombination protein rdh54 (EC 3.6.4.12) (ATP-dependent helicase rdh54) (Meiotically up-regulated gene 34 protein) (RAD54 protein homolog 2)
[RDH54 TID1 SCRG_02893] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[RDH54 TID1 SCY_0287] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[RDH54 TID1 C1Q_02585] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[MRE11 HNGS1 MRE11A] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[RDH54 TID1 AWRI1631_21610] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[Dmc1 rCG_59573] Meiotic recombination protein
[] Meiotic recombination protein DMC1 homolog
[DMC1 GW7_02580] Meiotic recombination protein DMC1/LIM15 homolog (Meiotic recombination protein DMC1/LIM15-like protein)
[Rec8 Mei8 Rec8L1] Meiotic recombination protein REC8 homolog (Cohesin Rec8p)
[REC8 REC8L1] Meiotic recombination protein REC8 homolog (Cohesin Rec8p)
[BRME1 C19orf57] Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3)
[Rec8 Rec8L1] Meiotic recombination protein REC8 homolog (Cohesin Rec8p)
[DMC1 Dmc1] Meiotic recombination protein
[Mre11 Mre11a] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (MmMRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[Mre11 Mre11a] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[DMC1] meiotic recombination protein DMC1/LIM15 homolog

Bibliography :
[10048487] Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination.