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Melatonin-related receptor (G protein-coupled receptor 50) (H9)

 MTR1L_SHEEP             Reviewed;         575 AA.
Q28558; O46624;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
26-FEB-2020, entry version 83.
RecName: Full=Melatonin-related receptor;
AltName: Full=G protein-coupled receptor 50;
AltName: Full=H9;
Name=GPR50;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9744482; DOI=10.1046/j.1365-2826.1998.00229.x;
Drew J.E., Barrett P., Williams L.M., Conway S., Morgan P.J.;
"The ovine melatonin-related receptor: cloning and preliminary distribution
and binding studies.";
J. Neuroendocrinol. 10:651-661(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 128-245.
PubMed=8647286; DOI=10.1016/0014-5793(96)00437-1;
Reppert S.M., Weaver D.R., Ebisawa T., Mahle C.D., Kolakowski L.F. Jr.;
"Cloning of a melatonin-related receptor from human pituitary.";
FEBS Lett. 386:219-224(1996).
-!- FUNCTION: Does not bind melatonin. {ECO:0000250}.
-!- SUBUNIT: Homodimer, and heterodimer with MTNR1A and MTNR1B.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AF047829; AAC04275.1; -; mRNA.
EMBL; U52221; AAC48609.1; -; mRNA.
RefSeq; NP_001009726.1; NM_001009726.1.
SMR; Q28558; -.
STRING; 9940.ENSOARP00000009392; -.
GeneID; 443023; -.
KEGG; oas:443023; -.
CTD; 9248; -.
KO; K04287; -.
OrthoDB; 907115at2759; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002280; Mel_rcpt_1X.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01151; MELATONIN1XR.
PRINTS; PR00857; MELATONINR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1..575
/note="Melatonin-related receptor"
/id="PRO_0000069881"
TOPO_DOM 1..30
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 31..51
/note="Helical; Name=1"
/evidence="ECO:0000255"
TOPO_DOM 52..64
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 65..85
/note="Helical; Name=2"
/evidence="ECO:0000255"
TOPO_DOM 86..103
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 104..124
/note="Helical; Name=3"
/evidence="ECO:0000255"
TOPO_DOM 125..143
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 144..164
/note="Helical; Name=4"
/evidence="ECO:0000255"
TOPO_DOM 165..188
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 189..209
/note="Helical; Name=5"
/evidence="ECO:0000255"
TOPO_DOM 210..239
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 240..260
/note="Helical; Name=6"
/evidence="ECO:0000255"
TOPO_DOM 261..273
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 274..294
/note="Helical; Name=7"
/evidence="ECO:0000255"
TOPO_DOM 295..575
/note="Cytoplasmic"
/evidence="ECO:0000255"
DISULFID 101..178
/evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
CONFLICT 138
/note="R -> L (in Ref. 2; AAC48609)"
/evidence="ECO:0000305"
CONFLICT 158
/note="L -> M (in Ref. 2; AAC48609)"
/evidence="ECO:0000305"
CONFLICT 218..219
/note="Missing (in Ref. 2; AAC48609)"
/evidence="ECO:0000305"
SEQUENCE 575 AA; 62810 MW; E2CA1C11FFE7DEF8 CRC64;
MGRTLAVPTP YGCIGCKLPQ PDYPPALIVF MFCAMVITIV VDLIGNSMVI LAVSKNKKLR
NSGNVFVVSL SVADMLVAIY PYPLMLHAMA IGGWDLSKLQ CQMVGFITGL SVVGSIFNIM
AIAINRYCYI CHSLQYERIF SVRNTCIYLA VTWIMTVLAV LPNMYIGTIE YDPRTYTCIF
NYVNNPAFAV TIVCIHFVLP LLIVGFCYVK IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
VIFLLFAVCW CPINALTVLV AVNPKEMAGK IPNWVYLAAY FIAYFNSCLN AVIYGVLNEN
FRREYWTIFH AMRHPVLFLS GLLTDVREMQ EAQAHTHARA RARTQAHEQD HAHACPAVEE
IPMSVRNVPL PGHGAAGQPE CVSGHPKPAS GHSRSVSARR KSASAHPKSA SGQSKSATVY
PKPTSVHFKP SSVYFKADSV YFKPSSSHPK PITGPSKTAI SPATSFPKPT TGYTQHATIH
SEPTTLDYLE PITTSHSKPV IASHSELAAS CHLECNIFDL SDPTSSPASD SSNSAASLLD
PTAAAAATVN PTVVTTDYHE IVLIDVDADS DEMAV


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Related Genes :
[Gpr50] Melatonin-related receptor (G protein-coupled receptor 50) (H9)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
[scd-2 T10H9.2] ALK tyrosine kinase receptor homolog scd-2 (EC 2.7.10.1) (Suppressor of constitutive dauer formation protein 2)
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[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
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[OR51E2 PSGR] Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor)
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[GPR183 EBI2] G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)
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[KISS1R AXOR12 GPR54] KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)
[Adgrg6 Dreg Gm222 Gpr126] Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)]
[NPFFR2 GPR74 NPFF2 NPGPR] Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)
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Bibliography :