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Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B)

 MK11_MOUSE              Reviewed;         364 AA.
Q9WUI1; Q569F1;
21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
12-AUG-2020, entry version 170.
RecName: Full=Mitogen-activated protein kinase 11;
Short=MAP kinase 11;
Short=MAPK 11;
EC=2.7.11.24;
AltName: Full=Mitogen-activated protein kinase p38 beta;
Short=MAP kinase p38 beta;
Short=p38B;
Name=Mapk11; Synonyms=Prkm11;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Han J.;
"The primary structure of murine p38beta.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION IN ACTIVATION OF RPS6KA5/MSK1 AND RPS6KA4/MSK2.
PubMed=11909979; DOI=10.1128/mcb.22.8.2871-2881.2002;
Wiggin G.R., Soloaga A., Foster J.M., Murray-Tait V., Cohen P.,
Arthur J.S.;
"MSK1 and MSK2 are required for the mitogen- and stress-induced
phosphorylation of CREB and ATF1 in fibroblasts.";
Mol. Cell. Biol. 22:2871-2881(2002).
[5]
PHOSPHORYLATION AT THR-180 AND TYR-182, AND ACTIVITY REGULATION.
PubMed=20004242; DOI=10.1016/j.cellsig.2009.11.020;
Remy G., Risco A.M., Inesta-Vaquera F.A., Gonzalez-Teran B., Sabio G.,
Davis R.J., Cuenda A.;
"Differential activation of p38MAPK isoforms by MKK6 and MKK3.";
Cell. Signal. 22:660-667(2010).
[6]
REVIEW ON FUNCTION.
PubMed=12452429; DOI=10.1515/bc.2002.173;
Shi Y., Gaestel M.;
"In the cellular garden of forking paths: how p38 MAPKs signal for
downstream assistance.";
Biol. Chem. 383:1519-1536(2002).
[7]
REVIEW ON ACTIVITY REGULATION, AND REVIEW ON FUNCTION.
PubMed=20626350; DOI=10.1042/bj20100323;
Cuadrado A., Nebreda A.R.;
"Mechanisms and functions of p38 MAPK signalling.";
Biochem. J. 429:403-417(2010).
-!- FUNCTION: Serine/threonine kinase which acts as an essential component
of the MAP kinase signal transduction pathway. MAPK11 is one of the
four p38 MAPKs which play an important role in the cascades of cellular
responses evoked by extracellular stimuli such as proinflammatory
cytokines or physical stress leading to direct activation of
transcription factors. Accordingly, p38 MAPKs phosphorylate a broad
range of proteins and it has been estimated that they may have
approximately 200 to 300 substrates each. MAPK11 functions are mostly
redundant with those of MAPK14. Some of the targets are downstream
kinases which are activated through phosphorylation and further
phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can
directly phosphorylate and activate transcription factors such as
CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but
can also phosphorylate histone H3 and the nucleosomal protein HMGN1.
RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid
induction of immediate-early genes in response to stress or mitogenic
stimuli, either by inducing chromatin remodeling or by recruiting the
transcription machinery. On the other hand, two other kinase targets,
MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene
expression mostly at the post-transcriptional level, by phosphorylating
ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is
important for the elongation of mRNA during translation. MKNK1/MNK1 and
MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein
synthesis by phosphorylating the initiation factor EIF4E2. In the
cytoplasm, the p38 MAPK pathway is an important regulator of protein
turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis
whose proteasome-mediated degradation is regulated by p38 MAPK
phosphorylation. Ectodomain shedding of transmembrane proteins is
regulated by p38 MAPKs as well. In response to inflammatory stimuli,
p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17.
Such phosphorylation is required for ADAM17-mediated ectodomain
shedding of TGF-alpha family ligands, which results in the activation
of EGFR signaling and cell proliferation. Additional examples of p38
MAPK substrates are the FGFR1. FGFR1 can be translocated from the
extracellular space into the cytosol and nucleus of target cells, and
regulates processes such as rRNA synthesis and cell growth. FGFR1
translocation requires p38 MAPK activation. In the nucleus, many
transcription factors are phosphorylated and activated by p38 MAPKs in
response to different stimuli. Classical examples include ATF1, ATF2,
ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs
are emerging as important modulators of gene expression by regulating
chromatin modifiers and remodelers. The promoters of several genes
involved in the inflammatory response, such as IL6, IL8 and IL12B,
display a p38 MAPK-dependent enrichment of histone H3 phosphorylation
on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
phosphorylation enhances the accessibility of the cryptic NF-kappa-B-
binding sites marking promoters for increased NF-kappa-B recruitment.
{ECO:0000269|PubMed:11909979}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.24;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Activated by phosphorylation on threonine and
tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and
MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by
environmental stress. HDAC3 interacts directly and selectively with
MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene
expression in LPS-stimulated cells. Inhibited by SB203580 and
pyridinyl-imidazole related compounds. {ECO:0000269|PubMed:20004242}.
-!- SUBUNIT: Interacts with HDAC3 and DUSP16. {ECO:0000250}.
-!- INTERACTION:
Q9WUI1; P47811: Mapk14; NbExp=10; IntAct=EBI-645081, EBI-298727;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
-!- PTM: Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3,
MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme.
{ECO:0000269|PubMed:20004242}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
protein kinase family. MAP kinase subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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---------------------------------------------------------------------------
EMBL; AF135185; AAD30116.1; -; mRNA.
EMBL; CH466550; EDL04368.1; -; Genomic_DNA.
EMBL; BC092526; AAH92526.1; -; mRNA.
CCDS; CCDS27741.1; -.
RefSeq; NP_035291.4; NM_011161.5.
SMR; Q9WUI1; -.
BioGRID; 202374; 5.
IntAct; Q9WUI1; 1.
MINT; Q9WUI1; -.
STRING; 10090.ENSMUSP00000086204; -.
BindingDB; Q9WUI1; -.
ChEMBL; CHEMBL4335; -.
iPTMnet; Q9WUI1; -.
PhosphoSitePlus; Q9WUI1; -.
MaxQB; Q9WUI1; -.
PaxDb; Q9WUI1; -.
PRIDE; Q9WUI1; -.
Antibodypedia; 28468; 506 antibodies.
Ensembl; ENSMUST00000088823; ENSMUSP00000086204; ENSMUSG00000053137.
GeneID; 19094; -.
KEGG; mmu:19094; -.
UCSC; uc007xfp.2; mouse.
CTD; 5600; -.
MGI; MGI:1338024; Mapk11.
eggNOG; KOG0660; Eukaryota.
GeneTree; ENSGT00940000160790; -.
HOGENOM; CLU_000288_181_1_1; -.
InParanoid; Q9WUI1; -.
KO; K04441; -.
OMA; IKPRVPF; -.
OrthoDB; 683132at2759; -.
TreeFam; TF105100; -.
Reactome; R-MMU-168638; NOD1/2 Signaling Pathway.
Reactome; R-MMU-171007; p38MAPK events.
Reactome; R-MMU-198753; ERK/MAPK targets.
Reactome; R-MMU-2559580; Oxidative Stress Induced Senescence.
Reactome; R-MMU-376172; DSCAM interactions.
Reactome; R-MMU-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-MMU-450302; activated TAK1 mediates p38 MAPK activation.
Reactome; R-MMU-450341; Activation of the AP-1 family of transcription factors.
Reactome; R-MMU-525793; Myogenesis.
Reactome; R-MMU-5668599; RHO GTPases Activate NADPH Oxidases.
Reactome; R-MMU-6804756; Regulation of TP53 Activity through Phosphorylation.
BioGRID-ORCS; 19094; 1 hit in 19 CRISPR screens.
PRO; PR:Q9WUI1; -.
Proteomes; UP000000589; Chromosome 15.
RNAct; Q9WUI1; protein.
Bgee; ENSMUSG00000053137; Expressed in midbrain and 210 other tissues.
Genevisible; Q9WUI1; MM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; ISO:MGI.
GO; GO:0004707; F:MAP kinase activity; ISS:UniProtKB.
GO; GO:0071347; P:cellular response to interleukin-1; ISO:MGI.
GO; GO:0098586; P:cellular response to virus; ISO:MGI.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IMP:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:2001184; P:positive regulation of interleukin-12 secretion; ISO:MGI.
GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; IGI:MGI.
GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
GO; GO:0051403; P:stress-activated MAPK cascade; ISS:UniProtKB.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008352; MAPK_p38-like.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01773; P38MAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
Stress response; Transcription; Transcription regulation; Transferase.
CHAIN 1..364
/note="Mitogen-activated protein kinase 11"
/id="PRO_0000186281"
DOMAIN 24..308
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 30..38
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 106..110
/note="Inhibitor-binding"
/evidence="ECO:0000250"
REGION 168..169
/note="Inhibitor-binding"
/evidence="ECO:0000250"
MOTIF 180..182
/note="TXY"
ACT_SITE 168
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 53
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 71
/note="Nilotinib"
/evidence="ECO:0000250"
MOD_RES 180
/note="Phosphothreonine; by MAP2K3, MAP2K4 and MAP2K6"
/evidence="ECO:0000305|PubMed:20004242"
MOD_RES 182
/note="Phosphotyrosine; by MAP2K3, MAP2K4 and MAP2K6"
/evidence="ECO:0000305|PubMed:20004242"
MOD_RES 323
/note="Phosphotyrosine; by ZAP70"
/evidence="ECO:0000250"
CONFLICT 173
/note="R -> P (in Ref. 1; AAD30116)"
/evidence="ECO:0000305"
CONFLICT 312
/note="H -> R (in Ref. 1; AAD30116)"
/evidence="ECO:0000305"
SEQUENCE 364 AA; 41397 MW; 75C16E9972508220 CRC64;
MSGPRAGFYR QELNKTVWEV PQRLQGLRPV GSGAYGSVCS AYDARLRQKV AVKKLSRPFQ
SLIHARRTYR ELRLLKHLKH ENVIGLLDVF TPATSIEDFS EVYLVTTLMG ADLNNIVKCQ
ALSDEHVQFL VYQLLRGLKY IHSAGIIHRD LKPSNVAVNE DCELRILDFG LARQADEEMT
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLQGK ALFPGNDYID QLKRIMEVVG
TPSPEVLAKI SSEHARTYIQ SLPPMPQKDL SSVFHGANPL AIDLLGRMLV LDSDQRVSAA
EALAHAYFSQ YHDPDDEPEA EPYDESVEAK ERTLEEWKEL TYQEVLSFKP LEPSQLPGTH
EIEQ


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Pathways :
WP1493: Carbon assimilation C4 pathway
WP32: Translation Factors
WP1566: Citrate cycle (TCA cycle)
WP1946: Cori Cycle
WP1703: Streptomycin biosynthesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1681: Pantothenate and CoA biosynthesis
WP210: Cytoplasmic Ribosomal Proteins
WP1653: Galactose metabolism
WP1701: Starch and sucrose metabolism
WP1844: MAP kinase cascade
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP253: Glycolysis
WP1567: Glycolysis and Gluconeogenesis
WP2218: sGC
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2292: Chemokine signaling pathway
WP187: Fatty Acid Beta Oxidation 2
WP2371: Parkinsons Disease Pathway
WP812: TGF Beta Signaling Pathway
WP1685: Peptidoglycan biosynthesis
WP211: BMP signaling pathway
WP35: G Protein Signaling Pathways
WP542: Electron Transport Chain
WP1644: DNA replication

Related Genes :
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Mapk11 Prkm11] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B)
[p38b CG7393] Mitogen-activated protein kinase p38b (MAP kinase p38b) (MAPK p38b) (EC 2.7.11.24)
[mapk14b mapk14] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b)
[mapk14b] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK14 CSBP1 CSBP2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[mapk14a mapk14] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a)
[mapk14a] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a)
[pmk-1 B0218.3] Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)
[pmk-3 F42G8.4] Mitogen-activated protein kinase pmk-3 (EC 2.7.11.24) (Stress-activated protein kinase pmk-3) (p38 MAP kinase 3)
[MAPK14 CSBP1] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a)
[MAPKAPK5 PRAK] MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[MAP3K5 ASK1 MAPKKK5 MEKK5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[MAP3K20 MLTK ZAK HCCS4] Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)

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