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Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)

 MK12_RAT                Reviewed;         367 AA.
Q63538;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-APR-2021, entry version 168.
RecName: Full=Mitogen-activated protein kinase 12;
Short=MAP kinase 12;
Short=MAPK 12;
EC=2.7.11.24;
AltName: Full=Extracellular signal-regulated kinase 6;
Short=ERK-6;
AltName: Full=Mitogen-activated protein kinase p38 gamma;
Short=MAP kinase p38 gamma;
AltName: Full=Stress-activated protein kinase 3;
Name=Mapk12; Synonyms=Sapk3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
PubMed=8925912; DOI=10.1016/0014-5793(96)00255-4;
Mertens S., Craxton M., Goedert M.;
"SAP kinase-3, a new member of the family of mammalian stress-activated
protein kinases.";
FEBS Lett. 383:273-276(1996).
[2]
INTERACTION WITH SNTA1, FUNCTION IN PHOSPHORYLATION OF SNTA1, AND
SUBCELLULAR LOCATION.
PubMed=19135240; DOI=10.1016/j.cell.2008.11.018;
Sumara G., Formentini I., Collins S., Sumara I., Windak R., Bodenmiller B.,
Ramracheya R., Caille D., Jiang H., Platt K.A., Meda P., Aebersold R.,
Rorsman P., Ricci R.;
"Regulation of PKD by the MAPK p38delta in insulin secretion and glucose
homeostasis.";
Cell 136:235-248(2009).
[3]
FUNCTION, PHOSPHORYLATION AT THR-183 AND TYR-185, AND MUTAGENESIS OF
THR-183 AND TYR-185.
PubMed=10438538; DOI=10.1074/jbc.274.33.23570;
Conrad P.W., Rust R.T., Han J., Millhorn D.E., Beitner-Johnson D.;
"Selective activation of p38alpha and p38gamma by hypoxia. Role in
regulation of cyclin D1 by hypoxia in PC12 cells.";
J. Biol. Chem. 274:23570-23576(1999).
[4]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=11991731; DOI=10.1006/jmcc.2001.1523;
Court N.W., dos Remedios C.G., Cordell J., Bogoyevitch M.A.;
"Cardiac expression and subcellular localization of the p38 mitogen-
activated protein kinase member, stress-activated protein kinase-3
(SAPK3).";
J. Mol. Cell. Cardiol. 34:413-426(2002).
[5]
SUBCELLULAR LOCATION, AND INTERACTION WITH SH3BP5.
PubMed=15158451; DOI=10.1016/j.bbrc.2004.04.148;
Court N.W., Kuo I., Quigley O., Bogoyevitch M.A.;
"Phosphorylation of the mitochondrial protein Sab by stress-activated
protein kinase 3.";
Biochem. Biophys. Res. Commun. 319:130-137(2004).
[6]
INTERACTION WITH LIN7C; SCRIB AND SYNJ2BP, AND ACTIVITY REGULATION.
PubMed=15878399; DOI=10.1016/j.bbamcr.2004.11.008;
Court N.W., Ingley E., Klinken S.P., Bogoyevitch M.A.;
"Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-
activated protein kinase-3.";
Biochim. Biophys. Acta 1744:68-75(2005).
[7]
REVIEW ON ACTIVITY REGULATION, AND REVIEW ON FUNCTION.
PubMed=20626350; DOI=10.1042/bj20100323;
Cuadrado A., Nebreda A.R.;
"Mechanisms and functions of p38 MAPK signalling.";
Biochem. J. 429:403-417(2010).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14 different rat
organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Serine/threonine kinase which acts as an essential component
of the MAP kinase signal transduction pathway. MAPK12 is one of the
four p38 MAPKs which play an important role in the cascades of cellular
responses evoked by extracellular stimuli such as proinflammatory
cytokines or physical stress leading to direct activation of
transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs
phosphorylate a broad range of proteins and it has been estimated that
they may have approximately 200 to 300 substrates each. Some of the
targets are downstream kinases such as MAPKAPK2, which are activated
through phosphorylation and further phosphorylate additional targets.
Plays a role in myoblast differentiation and also in the down-
regulation of cyclin D1 in response to hypoxia in adrenal cells
suggesting MAPK12 may inhibit cell proliferation while promoting
differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12
in the cell nucleus increases its association with nuclear DLG1,
thereby causing dissociation of DLG1-SFPQ complexes. This function is
independent of its catalytic activity and could affect mRNA processing
and/or gene transcription to aid cell adaptation to osmolarity changes
in the environment. Regulates UV-induced checkpoint signaling and
repair of UV-induced DNA damage and G2 arrest after gamma-radiation
exposure. MAPK12 is involved in the regulation of SLC2A1 expression and
basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4
expression and contraction-mediated glucose uptake in adult skeletal
muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and
inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is
required for the normal kinetochore localization of PLK1, prevents
chromosomal instability and supports mitotic cell viability. MAPK12-
signaling is also positively regulating the expansion of transient
amplifying myogenic precursor cells during muscle growth and
regeneration. {ECO:0000269|PubMed:10438538,
ECO:0000269|PubMed:19135240}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.24;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Note=Binds 2 magnesium ions.;
-!- ACTIVITY REGULATION: Activated by phosphorylation on threonine and
tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the
activation of MAPK12 induced by environmental stress, whereas
MAP2K6/MKK6 is the major MAPK12 activator in response to TNF-alpha.
{ECO:0000269|PubMed:15878399}.
-!- SUBUNIT: Monomer. Interacts with the PDZ domain of the syntrophin
SNTA1. Interacts with LIN7C, SCRIB, SYNJ2BP and SH3BP5. Interacts with
PTPN4; this interaction induces the activation of PTPN4 phosphatase
activity. {ECO:0000250|UniProtKB:P53778, ECO:0000269|PubMed:15158451,
ECO:0000269|PubMed:15878399, ECO:0000269|PubMed:19135240}.
-!- INTERACTION:
Q63538; Q13424: SNTA1; Xeno; NbExp=5; IntAct=EBI-783937, EBI-717191;
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}. Mitochondrion.
Note=Mitochondrial when associated with SH3BP5. In skeletal muscle
colocalizes with SNTA1 at the neuromuscular junction and throughout the
sarcolemma.
-!- TISSUE SPECIFICITY: Highly expressed in skeletal muscle, lung and
testes and also in the heart and thymus of both adult and neonatal
rats. {ECO:0000269|PubMed:11991731}.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
-!- PTM: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and
MAP2K6/MKK6, which activates the enzyme. {ECO:0000269|PubMed:10438538}.
-!- PTM: Ubiquitinated. Ubiquitination leads to degradation by the
proteasome pathway (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
protein kinase family. MAP kinase subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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---------------------------------------------------------------------------
EMBL; X96488; CAA65342.1; -; mRNA.
PIR; S68680; S68680.
RefSeq; NP_068514.1; NM_021746.1.
SMR; Q63538; -.
BioGRID; 248795; 2.
DIP; DIP-37835N; -.
IntAct; Q63538; 3.
STRING; 10116.ENSRNOP00000046455; -.
iPTMnet; Q63538; -.
PhosphoSitePlus; Q63538; -.
jPOST; Q63538; -.
PaxDb; Q63538; -.
PRIDE; Q63538; -.
Ensembl; ENSRNOT00000044376; ENSRNOP00000046455; ENSRNOG00000031233.
GeneID; 60352; -.
KEGG; rno:60352; -.
CTD; 6300; -.
RGD; 70975; Mapk12.
eggNOG; KOG0660; Eukaryota.
GeneTree; ENSGT00940000156189; -.
HOGENOM; CLU_000288_181_1_1; -.
InParanoid; Q63538; -.
OMA; PGRDYGH; -.
OrthoDB; 683132at2759; -.
PhylomeDB; Q63538; -.
TreeFam; TF105100; -.
Reactome; R-RNO-168638; NOD1/2 Signaling Pathway.
Reactome; R-RNO-376172; DSCAM interactions.
Reactome; R-RNO-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-RNO-525793; Myogenesis.
Reactome; R-RNO-5675221; Negative regulation of MAPK pathway.
PRO; PR:Q63538; -.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000031233; Expressed in skeletal muscle tissue and 21 other tissues.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IDA:RGD.
GO; GO:0000287; F:magnesium ion binding; ISO:RGD.
GO; GO:0004707; F:MAP kinase activity; IDA:RGD.
GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO; GO:0106311; F:protein threonine kinase activity; IEA:RHEA.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0045445; P:myoblast differentiation; ISO:RGD.
GO; GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:RGD.
GO; GO:0006468; P:protein phosphorylation; IDA:RGD.
GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
CDD; cd07880; STKc_p38gamma; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008352; MAPK_p38-like.
InterPro; IPR038786; p38gamma.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01773; P38MAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding; Cell cycle; Cytoplasm; Kinase; Magnesium; Metal-binding;
Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Stress response;
Transcription; Transcription regulation; Transferase; Ubl conjugation.
CHAIN 1..367
/note="Mitogen-activated protein kinase 12"
/id="PRO_0000186284"
DOMAIN 27..311
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 33..41
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 183..185
/note="TXY"
ACT_SITE 153
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
BINDING 56
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 183
/note="Phosphothreonine; by MAP2K3 and MAP2K6"
/evidence="ECO:0000269|PubMed:10438538"
MOD_RES 185
/note="Phosphotyrosine; by MAP2K3 and MAP2K6"
/evidence="ECO:0000269|PubMed:10438538"
MUTAGEN 183
/note="T->A: Loss of kinase activity."
/evidence="ECO:0000269|PubMed:10438538"
MUTAGEN 185
/note="Y->A: Loss of kinase activity."
/evidence="ECO:0000269|PubMed:10438538"
SEQUENCE 367 AA; 41985 MW; B77193D9F45E1D4E CRC64;
MSSPPPARKG FYRQEVTKTA WEVRAVYQDL QPVGSGAYGA VCSAVDSRTG NKVAIKKLYR
PFQSELFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD DFTDFYLVMP FMGTDLGKLM
KHETLSEDRI QFLVYQMLKG LKYIHAAGVI HRDLKPGNLA VNEDCELKIL DFGLARQADS
EMTGYVVTRW YRAPEVILNW MRYTQTVDIW SVGCIMAEMI TGKILFKGND HLDQLKEIMK
VTGTPPPEFV QKLQSAEAKN YMEGLPELEK KDFASVLTNA SPQAVNLLEK MLVLDAEQRV
TAAEALAHPY FESLRDTEDE PKAQKYDDSF DDVDRTLEEW KRVTYKEVLS FKPPRQLGAR
VPKETAL


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Pathways :
WP1493: Carbon assimilation C4 pathway
WP32: Translation Factors
WP1567: Glycolysis and Gluconeogenesis
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP1844: MAP kinase cascade
WP1946: Cori Cycle
WP1701: Starch and sucrose metabolism
WP2292: Chemokine signaling pathway
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP253: Glycolysis
WP1653: Galactose metabolism
WP1681: Pantothenate and CoA biosynthesis
WP2199: Seed Development
WP1703: Streptomycin biosynthesis
WP1654: gamma-Hexachlorocyclohexane degradation
WP1909: Signal regulatory protein (SIRP) family interactions
WP1673: Naphthalene and anthracene degradation
WP1678: Nucleotide excision repair
WP211: BMP signaling pathway
WP1644: DNA replication
WP1888: Post-translational protein modification
WP731: Sterol regulatory element binding protein related
WP1438: Influenza A virus infection
WP1689: Porphyrin and chlorophyll metabolism

Related Genes :
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Mapk11 Prkm11] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK14 CSBP1 CSBP2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[mapk14a mapk14] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a)
[mapk14b mapk14] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b)
[mapk14b] Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b)
[MAPK14 CSBP1] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a)
[pmk-1 B0218.3] Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[mapk14a] Mitogen-activated protein kinase 14A (MAP kinase 14A) (MAPK 14A) (EC 2.7.11.24) (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[p38b CG7393] Mitogen-activated protein kinase p38b (MAP kinase p38b) (MAPK p38b) (EC 2.7.11.24)
[pmk-3 F42G8.4] Mitogen-activated protein kinase pmk-3 (EC 2.7.11.24) (Stress-activated protein kinase pmk-3) (p38 MAP kinase 3)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPKAPK5 PRAK] MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Mapk7 Bmk1 Erk5] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)

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