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Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma)

 MK08_RAT                Reviewed;         411 AA.
P49185;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
12-AUG-2020, entry version 186.
RecName: Full=Mitogen-activated protein kinase 8;
Short=MAP kinase 8;
Short=MAPK 8;
EC=2.7.11.24 {ECO:0000269|PubMed:11121042, ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631, ECO:0000269|PubMed:9516415};
AltName: Full=SAPK gamma;
AltName: Full=Stress-activated protein kinase JNK1;
AltName: Full=c-Jun N-terminal kinase 1;
AltName: Full=p54 gamma;
Name=Mapk8; Synonyms=Jnk1, Prkm8;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8177321; DOI=10.1038/369156a0;
Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F.,
Avruch J., Woodgett J.R.;
"The stress-activated protein kinase subfamily of c-Jun kinases.";
Nature 369:156-160(1994).
[2]
FUNCTION, CATALYTIC ACTIVITY, AND COFACTOR.
TISSUE=Heart;
PubMed=9516415; DOI=10.1074/jbc.273.13.7228;
Clerk A., Fuller S.J., Michael A., Sugden P.H.;
"Stimulation of 'stress-regulated' mitogen-activated protein kinases
(stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-
activated protein kinases) in perfused rat hearts by oxidative and other
stresses.";
J. Biol. Chem. 273:7228-7234(1998).
[3]
CATALYTIC ACTIVITY, S-NITROSYLATION AT CYS-116, AND MUTAGENESIS OF CYS-116.
PubMed=11121042; DOI=10.1073/pnas.97.26.14382;
Park H.S., Huh S.H., Kim M.S., Lee S.H., Choi E.J.;
"Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated
protein kinase by means of S-nitrosylation.";
Proc. Natl. Acad. Sci. U.S.A. 97:14382-14387(2000).
[4]
IDENTIFICATION IN A COMPLEX WITH MAPK8IP1 AND ARHGEF28.
PubMed=14499478; DOI=10.1016/s0169-328x(03)00263-8;
Wu J., Zhai J., Lin H., Nie Z., Ge W.-W., Garcia-Bermejo L., Muschel R.J.,
Schlaepfer W.W., Canete-Soler R.;
"Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity
to an EGFP-tagged protein.";
Brain Res. Mol. Brain Res. 117:27-38(2003).
[5]
FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH MAPK8IP1; STMN2; STMN3 AND
STMN4, AND SUBCELLULAR LOCATION.
PubMed=16618812; DOI=10.1083/jcb.200511055;
Tararuk T., Ostman N., Li W., Bjorkblom B., Padzik A., Zdrojewska J.,
Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T.;
"JNK1 phosphorylation of SCG10 determines microtubule dynamics and
axodendritic length.";
J. Cell Biol. 173:265-277(2006).
[6]
INTERACTION WITH GRIPAP1.
PubMed=17761173; DOI=10.1016/j.febslet.2007.08.008;
Ye B., Yu W.P., Thomas G.M., Huganir R.L.;
"GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway.";
FEBS Lett. 581:4403-4410(2007).
[7]
FUNCTION, AND CATALYTIC ACTIVITY.
PubMed=21297631; DOI=10.1038/nn.2755;
Westerlund N., Zdrojewska J., Padzik A., Komulainen E., Bjorkblom B.,
Rannikko E., Tararuk T., Garcia-Frigola C., Sandholm J., Nguyen L.,
Kallunki T., Courtney M.J., Coffey E.T.;
"Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and
neuronal migration rate.";
Nat. Neurosci. 14:305-313(2011).
[8]
SUBCELLULAR LOCATION.
PubMed=29166604; DOI=10.1016/j.celrep.2017.10.084;
Bharat V., Siebrecht M., Burk K., Ahmed S., Reissner C.,
Kohansal-Nodehi M., Steubler V., Zweckstetter M., Ting J.T., Dean C.;
"Capture of Dense Core Vesicles at Synapses by JNK-Dependent
Phosphorylation of Synaptotagmin-4.";
Cell Rep. 21:2118-2133(2017).
-!- FUNCTION: Serine/threonine-protein kinase involved in various processes
such as cell proliferation, differentiation, migration, transformation
and programmed cell death. Extracellular stimuli such as
proinflammatory cytokines or physical stress stimulate the stress-
activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling
pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and
MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1
phosphorylates a number of transcription factors, primarily components
of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1
transcriptional activity. Phosphorylates the replication licensing
factor CDT1, inhibiting the interaction between CDT1 and the histone H4
acetylase HBO1 to replication origins. Loss of this interaction
abrogates the acetylation required for replication initiation. Promotes
stressed cell apoptosis by phosphorylating key regulatory factors
including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8
and MAPK9 are required for polarized differentiation of T-helper cells
into Th1 cells. Contributes to the survival of erythroid cells by
phosphorylating the antagonist of cell death BAD upon EPO stimulation.
Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation
from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and
hence regulates microtubule dynamics, controlling neurite elongation in
cortical neurons. In the developing brain, through its cytoplasmic
activity on STMN2, negatively regulates the rate of exit from
multipolar stage and of radial migration from the ventricular zone (By
similarity). Phosphorylates several other substrates including heat
shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3
ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays
a role in the regulation of the circadian clock (By similarity).
Phosphorylates the heat shock transcription factor HSF1, suppressing
HSF1-induced transcriptional activity (By similarity). Phosphorylates
POU5F1, which results in the inhibition of POU5F1's transcriptional
activity and enhances its proteosomal degradation (By similarity).
Phosphorylates JUND and this phosphorylation is inhibited in the
presence of MEN1 (By similarity). In neurons, phosphorylates SYT4 which
captures neuronal dense core vesicles at synapses (PubMed:29166604).
{ECO:0000250|UniProtKB:P45983, ECO:0000250|UniProtKB:Q91Y86,
ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631,
ECO:0000269|PubMed:29166604, ECO:0000269|PubMed:9516415}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;
Evidence={ECO:0000269|PubMed:11121042, ECO:0000269|PubMed:16618812,
ECO:0000269|PubMed:21297631, ECO:0000269|PubMed:9516415};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11121042,
ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631,
ECO:0000269|PubMed:9516415};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:9516415};
-!- ACTIVITY REGULATION: Activated by threonine and tyrosine
phosphorylation by either of two dual specificity kinases, MAP2K4 and
MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7
phosphorylates Tyr-183 preferentially. Inhibited by dual specificity
phosphatases, such as DUSP1. Inhibited by SERPINB3 (By similarity).
Inhibited by IFN-gamma-induced S-nitrosylation.
{ECO:0000250|UniProtKB:P45983}.
-!- SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1,
MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These
proteins also bind other components of the JNK signaling pathway.
Interacts with TP53, WWOX and JAMP. Interacts with NFATC4. Interacts
(phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in
undifferentiated cells. Interacts with MECOM; regulates JNK signaling.
Interacts with PIN1; this interaction mediates MAPK8 conformational
changes leading to the binding of MAPK8 to its substrates (By
similarity). Interacts with HSF1 (via D domain and preferentially with
hyperphosphorylated form); this interaction occurs under both normal
growth conditions and immediately upon heat shock (By similarity).
Forms a complex with MAPK8IP1 and ARHGEF28 (PubMed:14499478). Interacts
with STMN2, STMN3 and STMN4 (PubMed:16618812). Interacts with GRIPAP1
(PubMed:17761173). Interacts with POU5F1; phosphorylates POU5F1 at
'Ser-347'. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3,
MAP2K7/MKK7 and MAPK8IP1/JIP1. Found in a complex with SH3RF1, RAC2,
MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK9/JNK2 (By similarity).
{ECO:0000250|UniProtKB:P45983, ECO:0000250|UniProtKB:Q91Y86,
ECO:0000269|PubMed:14499478, ECO:0000269|PubMed:16618812,
ECO:0000269|PubMed:17761173}.
-!- INTERACTION:
P49185; P19491-3: Gria2; NbExp=2; IntAct=EBI-7456505, EBI-9118256;
P49185; P19493: Gria4; NbExp=2; IntAct=EBI-7456505, EBI-7761834;
P49185; P17325: Jun; NbExp=2; IntAct=EBI-7456505, EBI-7709365;
P49185; P50232: Syt4; NbExp=5; IntAct=EBI-7456505, EBI-540118;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16618812}. Nucleus
{ECO:0000250|UniProtKB:Q91Y86}. Cell junction, synapse
{ECO:0000269|PubMed:29166604}. Note=In the cortical neurons,
predominantly cytoplasmic and associated with the Golgi apparatus and
endosomal fraction (PubMed:16618812). Increased neuronal activity
increases phosphorylated form at synapses (PubMed:29166604).
Colocalizes with POU5F1 in the nucleus (By similarity).
{ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:16618812,
ECO:0000269|PubMed:29166604}.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
-!- PTM: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4,
which activates the enzyme. Phosphorylated by TAOK2 (By similarity).
Phosphorylated form is more concentrated at synapses than none-
phosphorylated (PubMed:29166604). {ECO:0000250,
ECO:0000269|PubMed:29166604}.
-!- PTM: Nitrosylated upon IFN-gamma-induced endogenous NO production,
which inhibits the enzyme (PubMed:11121042). May be phosphorylated at
Thr-183 and Tyr-185 by MAP3K1/MEKK1 (By similarity).
{ECO:0000250|UniProtKB:P45983, ECO:0000269|PubMed:11121042}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
protein kinase family. MAP kinase subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; L27129; AAA42111.1; -; mRNA.
PIR; S43970; S43970.
RefSeq; NP_446281.2; NM_053829.2.
SMR; P49185; -.
IntAct; P49185; 6.
MINT; P49185; -.
STRING; 10116.ENSRNOP00000062048; -.
BindingDB; P49185; -.
ChEMBL; CHEMBL5718; -.
iPTMnet; P49185; -.
PhosphoSitePlus; P49185; -.
jPOST; P49185; -.
PRIDE; P49185; -.
GeneID; 116554; -.
KEGG; rno:116554; -.
UCSC; RGD:621506; rat.
CTD; 5599; -.
RGD; 621506; Mapk8.
eggNOG; KOG0665; Eukaryota.
InParanoid; P49185; -.
KO; K04440; -.
OrthoDB; 741207at2759; -.
PhylomeDB; P49185; -.
BRENDA; 2.7.11.24; 5301.
Reactome; R-RNO-111446; Activation of BIM and translocation to mitochondria.
Reactome; R-RNO-139910; Activation of BMF and translocation to mitochondria.
Reactome; R-RNO-193648; NRAGE signals death through JNK.
Reactome; R-RNO-2559580; Oxidative Stress Induced Senescence.
Reactome; R-RNO-2871796; FCERI mediated MAPK activation.
Reactome; R-RNO-376172; DSCAM interactions.
Reactome; R-RNO-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-RNO-450341; Activation of the AP-1 family of transcription factors.
Reactome; R-RNO-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-RNO-9007892; Interleukin-38 signaling.
PRO; PR:P49185; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0097441; C:basal dendrite; ISO:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; ISO:RGD.
GO; GO:0032839; C:dendrite cytoplasm; IDA:RGD.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0002102; C:podosome; ISO:RGD.
GO; GO:0045202; C:synapse; IDA:UniProtKB.
GO; GO:0031982; C:vesicle; IDA:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019899; F:enzyme binding; ISO:RGD.
GO; GO:0042826; F:histone deacetylase binding; ISO:RGD.
GO; GO:0035033; F:histone deacetylase regulator activity; ISO:RGD.
GO; GO:0004705; F:JUN kinase activity; IDA:RGD.
GO; GO:0016301; F:kinase activity; ISO:RGD.
GO; GO:0019894; F:kinesin binding; IPI:RGD.
GO; GO:0004707; F:MAP kinase activity; IBA:GO_Central.
GO; GO:0004672; F:protein kinase activity; ISO:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:RGD.
GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; ISO:RGD.
GO; GO:0034198; P:cellular response to amino acid starvation; ISO:RGD.
GO; GO:1904646; P:cellular response to amyloid-beta; IEP:RGD.
GO; GO:0071276; P:cellular response to cadmium ion; ISO:RGD.
GO; GO:0070301; P:cellular response to hydrogen peroxide; ISO:RGD.
GO; GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD.
GO; GO:0071732; P:cellular response to nitric oxide; ISO:RGD.
GO; GO:0034614; P:cellular response to reactive oxygen species; ISO:RGD.
GO; GO:0048813; P:dendrite morphogenesis; ISO:RGD.
GO; GO:0034349; P:glial cell apoptotic process; IEP:RGD.
GO; GO:0006954; P:inflammatory response; IDA:RGD.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0007254; P:JNK cascade; ISS:UniProtKB.
GO; GO:0007258; P:JUN phosphorylation; ISO:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
GO; GO:0032091; P:negative regulation of protein binding; ISO:RGD.
GO; GO:0048666; P:neuron development; IEP:RGD.
GO; GO:0001764; P:neuron migration; ISO:RGD.
GO; GO:0031175; P:neuron projection development; IMP:RGD.
GO; GO:0097150; P:neuronal stem cell population maintenance; IMP:MGI.
GO; GO:0001503; P:ossification; ISO:RGD.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:RGD.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IEP:RGD.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISO:RGD.
GO; GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:RGD.
GO; GO:0030335; P:positive regulation of cell migration; IDA:RGD.
GO; GO:0031281; P:positive regulation of cyclase activity; ISO:RGD.
GO; GO:0090045; P:positive regulation of deacetylase activity; ISO:RGD.
GO; GO:2000017; P:positive regulation of determination of dorsal identity; ISO:RGD.
GO; GO:0045740; P:positive regulation of DNA replication; IMP:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0034352; P:positive regulation of glial cell apoptotic process; IMP:RGD.
GO; GO:0031116; P:positive regulation of microtubule polymerization; IMP:RGD.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:2001224; P:positive regulation of neuron migration; IMP:RGD.
GO; GO:0071803; P:positive regulation of podosome assembly; ISO:RGD.
GO; GO:0051247; P:positive regulation of protein metabolic process; ISO:RGD.
GO; GO:0031398; P:positive regulation of protein ubiquitination; ISO:RGD.
GO; GO:1901485; P:positive regulation of transcription factor catabolic process; ISO:RGD.
GO; GO:0097300; P:programmed necrotic cell death; ISO:RGD.
GO; GO:0061833; P:protein localization to tricellular tight junction; ISO:RGD.
GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
GO; GO:0046605; P:regulation of centrosome cycle; IMP:RGD.
GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO; GO:1904809; P:regulation of dense core granule transport; IDA:UniProtKB.
GO; GO:1902595; P:regulation of DNA replication origin binding; ISO:RGD.
GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
GO; GO:0045664; P:regulation of neuron differentiation; IMP:RGD.
GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:RGD.
GO; GO:0046686; P:response to cadmium ion; ISO:RGD.
GO; GO:0009408; P:response to heat; IDA:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; IDA:RGD.
GO; GO:0009612; P:response to mechanical stimulus; IBA:GO_Central.
GO; GO:0006970; P:response to osmotic stress; IDA:RGD.
GO; GO:0048545; P:response to steroid hormone; IEP:RGD.
GO; GO:0009411; P:response to UV; ISO:RGD.
GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO; GO:0007165; P:signal transduction; IDA:RGD.
GO; GO:0051403; P:stress-activated MAPK cascade; ISO:RGD.
GO; GO:0097050; P:type B pancreatic cell apoptotic process; IMP:CACAO.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008351; MAPK_JNK.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01772; JNKMAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Biological rhythms; Cell junction; Cytoplasm; Kinase;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
S-nitrosylation; Serine/threonine-protein kinase; Synapse; Transferase.
CHAIN 1..411
/note="Mitogen-activated protein kinase 8"
/id="PRO_0000186264"
DOMAIN 26..321
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 32..40
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 183..185
/note="TXY"
ACT_SITE 151
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 55
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 116
/note="S-nitrosocysteine; in inhibited form"
/evidence="ECO:0000269|PubMed:11121042"
MOD_RES 183
/note="Phosphothreonine; by MAP2K7"
/evidence="ECO:0000250|UniProtKB:P45983"
MOD_RES 185
/note="Phosphotyrosine; by MAP2K4"
/evidence="ECO:0000250|UniProtKB:P45983"
MOD_RES 377
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q91Y86"
MUTAGEN 116
/note="C->S: Abolished inhibitory effect of IFN-gamma on
JNK1 activity."
/evidence="ECO:0000269|PubMed:11121042"
SEQUENCE 411 AA; 46807 MW; 04E388B4F94633D4 CRC64;
MSRSKRDNNF YSVEIADSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC LKILFPGRDY IDQWNKVIEQ
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
MDLEERTKNG VIRGQPSPLG AAVINGSQHP VSSPSVNDMS SMSTDPTLAS D


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EIAAB24862 c-Jun N-terminal kinase 3,Jnk3,MAP kinase 10,MAPK 10,Mapk10,Mitogen-activated protein kinase 10,p54-beta,Prkm10,Rat,Rattus norvegicus,SAPK-beta,Stress-activated protein kinase JNK3
EIAAB24858 c-Jun N-terminal kinase 2,Jnk2,MAP kinase 9,MAPK 9,Mapk9,Mitogen-activated protein kinase 9,p54-alpha,Prkm9,Rat,Rattus norvegicus,SAPK-alpha,Stress-activated protein kinase JNK2
EIAAB24866 ERK-6,Extracellular signal-regulated kinase 6,MAP kinase 12,MAP kinase p38 gamma,MAPK 12,Mapk12,Mitogen-activated protein kinase 12,Mitogen-activated protein kinase p38 gamma,Mouse,Mus musculus,Sapk3,
EIAAB24868 ERK-6,Extracellular signal-regulated kinase 6,MAP kinase 12,MAP kinase p38 gamma,MAPK 12,Mapk12,Mitogen-activated protein kinase 12,Mitogen-activated protein kinase p38 gamma,Rat,Rattus norvegicus,Sap
EIAAB24861 c-Jun N-terminal kinase 3,Homo sapiens,Human,JNK3,JNK3A,MAP kinase 10,MAP kinase p49 3F12,MAPK 10,MAPK10,Mitogen-activated protein kinase 10,PRKM10,Stress-activated protein kinase JNK3
10-782-55060 Mitogen-activated protein kinase 12 - EC 2.7.11.24; Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 0.05 mg
10-782-55060 Mitogen-activated protein kinase 12 - EC 2.7.11.24; Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 0.02 mg
10-782-55059 Mitogen-activated protein kinase 12 - EC 2.7.11.24; Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 0.02 mg
10-782-55059 Mitogen-activated protein kinase 12 - EC 2.7.11.24; Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 0.001 mg
10-782-55059 Mitogen-activated protein kinase 12 - EC 2.7.11.24; Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 0.01 mg
10-782-55059 Mitogen-activated protein kinase 12 - EC 2.7.11.24; Extracellular signal-regulated kinase 6; ERK-6; ERK5; Stress-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 0.005 mg
EIAAB24863 c-Jun N-terminal kinase 3,Jnk3,MAP kinase 10,MAP kinase p49 3F12,MAPK 10,Mapk10,Mitogen-activated protein kinase 10,Mouse,Mus musculus,Prkm10,Serk2,Stress-activated protein kinase JNK3
EIAAB24870 Homo sapiens,Human,MAP kinase 13,MAP kinase p38 delta,MAPK 13,MAPK13,Mitogen-activated protein kinase 13,Mitogen-activated protein kinase p38 delta,PRKM13,SAPK4,Stress-activated protein kinase 4
EIAAB24860 c-Jun N-terminal kinase 2,Homo sapiens,Human,JNK2,JNK-55,MAP kinase 9,MAPK 9,MAPK9,Mitogen-activated protein kinase 9,PRKM9,Stress-activated protein kinase JNK2
EIAAB24864 Homo sapiens,Human,MAP kinase 11,MAP kinase p38 beta,MAPK 11,MAPK11,Mitogen-activated protein kinase 11,Mitogen-activated protein kinase p38 beta,p38-2,p38b,PRKM11,SAPK2,Stress-activated protein kinas
EIAAB24857 c-Jun N-terminal kinase 2,Jnk2,MAP kinase 9,MAPK 9,Mapk9,Mitogen-activated protein kinase 9,Mouse,Mus musculus,Prkm9,Stress-activated protein kinase JNK2
EIAAB24872 MAP kinase 13,MAP kinase p38 delta,MAPK 13,Mapk13,Mitogen-activated protein kinase 13,Mitogen-activated protein kinase p38 delta,Mouse,Mus musculus,Serk4,Stress-activated protein kinase 4
E1206r ELISA kit Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protei 96T
E1206m ELISA kit Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protei 96T
U1206m CLIA Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kina 96T
U1206r CLIA Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kina 96T
Pathways :
WP32: Translation Factors
WP1493: Carbon assimilation C4 pathway
WP2292: Chemokine signaling pathway
WP2199: Seed Development
WP1703: Streptomycin biosynthesis
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP1946: Cori Cycle
WP1701: Starch and sucrose metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1653: Galactose metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1844: MAP kinase cascade
WP253: Glycolysis
WP1681: Pantothenate and CoA biosynthesis
WP2152: BDNF
WP152: FGF signaling pathway
WP1657: Glycerolipid metabolism
WP1929: Thrombin signalling through proteinase activated receptors (PARs)
WP346: Protein Modifications
WP813: G Protein Signaling Pathways
WP1502: Mitochondrial biogenesis
WP1694: Pyrimidine metabolism
WP2272: Pathogenic Escherichia coli infection

Related Genes :
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma)
[MAPK8 JNK1 PRKM8 SAPK1 SAPK1C] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (SAPK-alpha) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (p54-alpha)
[MAPK9 JNK2 PRKM9 SAPK1A] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[Mapk10 Jnk3 Prkm10] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta)
[MAPK10 JNK3 JNK3A PRKM10 SAPK1B] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[Mapk8ip3 Jip3 Jsap1 Syd2] C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Mitogen-activated protein kinase 8-interacting protein 3) (Sunday driver 2)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Mapk8ip1 Ib1 Jip1 Mapk8ip Prkm8ip] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[MAPK8IP1 IB1 JIP1 PRKM8IP] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[Mapk10 Jnk3 Prkm10 Serk2] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[Mapk8ip1 Ib1 Jip1 Mapk8ip] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JIP-1-related protein) (JRP) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[MAPK8IP2 IB2 JIP2 PRKM8IPL] C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[jnk-1 B0478.1] Stress-activated protein kinase jnk-1 (EC 2.7.11.24)
[Mapk8ip2 Ib2 Jip2] C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
[Mapk8ip2 Ib2 Jip2] C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[MAPK8IP3 JIP3 KIAA1066] C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)

Bibliography :
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