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Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma)

 MK08_RAT                Reviewed;         411 AA.
P49185;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
13-NOV-2019, entry version 181.
RecName: Full=Mitogen-activated protein kinase 8;
Short=MAP kinase 8;
Short=MAPK 8;
EC=2.7.11.24 {ECO:0000269|PubMed:11121042, ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631, ECO:0000269|PubMed:9516415};
AltName: Full=SAPK gamma;
AltName: Full=Stress-activated protein kinase JNK1;
AltName: Full=c-Jun N-terminal kinase 1;
AltName: Full=p54 gamma;
Name=Mapk8; Synonyms=Jnk1, Prkm8;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8177321; DOI=10.1038/369156a0;
Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A.,
Ahmad M.F., Avruch J., Woodgett J.R.;
"The stress-activated protein kinase subfamily of c-Jun kinases.";
Nature 369:156-160(1994).
[2]
FUNCTION, CATALYTIC ACTIVITY, AND COFACTOR.
TISSUE=Heart;
PubMed=9516415; DOI=10.1074/jbc.273.13.7228;
Clerk A., Fuller S.J., Michael A., Sugden P.H.;
"Stimulation of 'stress-regulated' mitogen-activated protein kinases
(stress-activated protein kinases/c-Jun N-terminal kinases and p38-
mitogen-activated protein kinases) in perfused rat hearts by oxidative
and other stresses.";
J. Biol. Chem. 273:7228-7234(1998).
[3]
CATALYTIC ACTIVITY, S-NITROSYLATION AT CYS-116, AND MUTAGENESIS OF
CYS-116.
PubMed=11121042; DOI=10.1073/pnas.97.26.14382;
Park H.S., Huh S.H., Kim M.S., Lee S.H., Choi E.J.;
"Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-
activated protein kinase by means of S-nitrosylation.";
Proc. Natl. Acad. Sci. U.S.A. 97:14382-14387(2000).
[4]
IDENTIFICATION IN A COMPLEX WITH MAPK8IP1 AND ARHGEF28.
PubMed=14499478; DOI=10.1016/s0169-328x(03)00263-8;
Wu J., Zhai J., Lin H., Nie Z., Ge W.-W., Garcia-Bermejo L.,
Muschel R.J., Schlaepfer W.W., Canete-Soler R.;
"Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic
activity to an EGFP-tagged protein.";
Brain Res. Mol. Brain Res. 117:27-38(2003).
[5]
FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH MAPK8IP1; STMN2; STMN3
AND STMN4, AND SUBCELLULAR LOCATION.
PubMed=16618812; DOI=10.1083/jcb.200511055;
Tararuk T., Ostman N., Li W., Bjorkblom B., Padzik A., Zdrojewska J.,
Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T.;
"JNK1 phosphorylation of SCG10 determines microtubule dynamics and
axodendritic length.";
J. Cell Biol. 173:265-277(2006).
[6]
INTERACTION WITH GRIPAP1.
PubMed=17761173; DOI=10.1016/j.febslet.2007.08.008;
Ye B., Yu W.P., Thomas G.M., Huganir R.L.;
"GRASP-1 is a neuronal scaffold protein for the JNK signaling
pathway.";
FEBS Lett. 581:4403-4410(2007).
[7]
FUNCTION, AND CATALYTIC ACTIVITY.
PubMed=21297631; DOI=10.1038/nn.2755;
Westerlund N., Zdrojewska J., Padzik A., Komulainen E., Bjorkblom B.,
Rannikko E., Tararuk T., Garcia-Frigola C., Sandholm J., Nguyen L.,
Kallunki T., Courtney M.J., Coffey E.T.;
"Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit
and neuronal migration rate.";
Nat. Neurosci. 14:305-313(2011).
-!- FUNCTION: Serine/threonine-protein kinase involved in various
processes such as cell proliferation, differentiation, migration,
transformation and programmed cell death. Extracellular stimuli
such as proinflammatory cytokines or physical stress stimulate the
stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)
signaling pathway. In this cascade, two dual specificity kinases
MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1.
In turn, MAPK8/JNK1 phosphorylates a number of transcription
factors, primarily components of AP-1 such as JUN, JDP2 and ATF2
and thus regulates AP-1 transcriptional activity. Phosphorylates
the replication licensing factor CDT1, inhibiting the interaction
between CDT1 and the histone H4 acetylase HBO1 to replication
origins. Loss of this interaction abrogates the acetylation
required for replication initiation. Promotes stressed cell
apoptosis by phosphorylating key regulatory factors including
p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and
MAPK9 are required for polarized differentiation of T-helper cells
into Th1 cells. Contributes to the survival of erythroid cells by
phosphorylating the antagonist of cell death BAD upon EPO
stimulation. Mediates starvation-induced BCL2 phosphorylation,
BCL2 dissociation from BECN1, and thus activation of autophagy.
Phosphorylates STMN2 and hence regulates microtubule dynamics,
controlling neurite elongation in cortical neurons. In the
developing brain, through its cytoplasmic activity on STMN2,
negatively regulates the rate of exit from multipolar stage and of
radial migration from the ventricular zone (By similarity).
Phosphorylates several other substrates including heat shock
factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3
ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and
plays a role in the regulation of the circadian clock (By
similarity). Phosphorylates the heat shock transcription factor
HSF1, suppressing HSF1-induced transcriptional activity (By
similarity). Phosphorylates POU5F1, which results in the
inhibition of POU5F1's transcriptional activity and enhances its
proteosomal degradation (By similarity). Phosphorylates JUND and
this phosphorylation is inhibited in the presence of MEN1 (By
similarity). {ECO:0000250|UniProtKB:P45983,
ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:16618812,
ECO:0000269|PubMed:21297631, ECO:0000269|PubMed:9516415}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11121042,
ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631,
ECO:0000269|PubMed:9516415};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11121042,
ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631,
ECO:0000269|PubMed:9516415};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:9516415};
-!- ACTIVITY REGULATION: Activated by threonine and tyrosine
phosphorylation by either of two dual specificity kinases, MAP2K4
and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while
MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual
specificity phosphatases, such as DUSP1. Inhibited by SERPINB3 (By
similarity). Inhibited by IFN-gamma-induced S-nitrosylation.
{ECO:0000250|UniProtKB:P45983}.
-!- SUBUNIT: Binds to at least four scaffolding proteins,
MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and
SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of
the JNK signaling pathway. Interacts with TP53, WWOX and JAMP.
Interacts with NFATC4. Interacts (phosphorylated form) with NFE2;
the interaction phosphorylates NFE2 in undifferentiated cells.
Interacts with MECOM; regulates JNK signaling. Interacts with
PIN1; this interaction mediates MAPK8 conformational changes
leading to the binding of MAPK8 to its substrates (By similarity).
Interacts with HSF1 (via D domain and preferentially with
hyperphosphorylated form); this interaction occurs under both
normal growth conditions and immediately upon heat shock (By
similarity). Forms a complex with MAPK8IP1 and ARHGEF28
(PubMed:14499478). Interacts with STMN2, STMN3 and STMN4
(PubMed:16618812). Interacts with GRIPAP1 (PubMed:17761173).
Interacts with POU5F1; phosphorylates POU5F1 at 'Ser-347'. Found
in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAP2K7/MKK7 and
MAPK8IP1/JIP1. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1,
MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK9/JNK2 (By similarity).
{ECO:0000250|UniProtKB:P45983, ECO:0000250|UniProtKB:Q91Y86,
ECO:0000269|PubMed:14499478, ECO:0000269|PubMed:16618812,
ECO:0000269|PubMed:17761173}.
-!- INTERACTION:
P19491-3:Gria2; NbExp=2; IntAct=EBI-7456505, EBI-9118256;
P19493:Gria4; NbExp=2; IntAct=EBI-7456505, EBI-7761834;
P17325:Jun; NbExp=2; IntAct=EBI-7456505, EBI-7709365;
P50232:Syt4; NbExp=5; IntAct=EBI-7456505, EBI-540118;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16618812}.
Nucleus {ECO:0000250|UniProtKB:Q91Y86}. Note=In the cortical
neurons, predominantly cytoplasmic and associated with the Golgi
apparatus and endosomal fraction (PubMed:16618812). Colocalizes
with POU5F1 in the nucleus (By similarity).
{ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:16618812}.
-!- DOMAIN: The TXY motif contains the threonine and tyrosine residues
whose phosphorylation activates the MAP kinases.
-!- PTM: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and
MAP2K4, which activates the enzyme. Phosphorylated by TAOK2 (By
similarity). {ECO:0000250}.
-!- PTM: Nitrosylated upon IFN-gamma-induced endogenous NO production,
which inhibits the enzyme (PubMed:11121042). May be phosphorylated
at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (By similarity).
{ECO:0000250|UniProtKB:P45983, ECO:0000269|PubMed:11121042}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
Ser/Thr protein kinase family. MAP kinase subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L27129; AAA42111.1; -; mRNA.
PIR; S43970; S43970.
RefSeq; NP_446281.2; NM_053829.2.
SMR; P49185; -.
IntAct; P49185; 6.
MINT; P49185; -.
STRING; 10116.ENSRNOP00000062048; -.
BindingDB; P49185; -.
ChEMBL; CHEMBL5718; -.
iPTMnet; P49185; -.
PhosphoSitePlus; P49185; -.
jPOST; P49185; -.
PRIDE; P49185; -.
GeneID; 116554; -.
KEGG; rno:116554; -.
UCSC; RGD:621506; rat.
CTD; 5599; -.
RGD; 621506; Mapk8.
HOGENOM; HOG000233024; -.
InParanoid; P49185; -.
KO; K04440; -.
OrthoDB; 741207at2759; -.
PhylomeDB; P49185; -.
BRENDA; 2.7.11.24; 5301.
Reactome; R-RNO-111446; Activation of BIM and translocation to mitochondria.
Reactome; R-RNO-139910; Activation of BMF and translocation to mitochondria.
Reactome; R-RNO-193648; NRAGE signals death through JNK.
Reactome; R-RNO-2559580; Oxidative Stress Induced Senescence.
Reactome; R-RNO-2871796; FCERI mediated MAPK activation.
Reactome; R-RNO-376172; DSCAM interactions.
Reactome; R-RNO-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
Reactome; R-RNO-450341; Activation of the AP-1 family of transcription factors.
Reactome; R-RNO-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-RNO-9007892; Interleukin-38 signaling.
PRO; PR:P49185; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0032839; C:dendrite cytoplasm; IDA:RGD.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0031982; C:vesicle; IDA:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004705; F:JUN kinase activity; IDA:RGD.
GO; GO:0019894; F:kinesin binding; IPI:RGD.
GO; GO:0004707; F:MAP kinase activity; IBA:GO_Central.
GO; GO:1904646; P:cellular response to amyloid-beta; IEP:RGD.
GO; GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
GO; GO:0034349; P:glial cell apoptotic process; IEP:RGD.
GO; GO:0006954; P:inflammatory response; IDA:RGD.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0007254; P:JNK cascade; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
GO; GO:0048666; P:neuron development; IEP:RGD.
GO; GO:0031175; P:neuron projection development; IMP:RGD.
GO; GO:0097150; P:neuronal stem cell population maintenance; IMP:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; IEP:RGD.
GO; GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:RGD.
GO; GO:0030335; P:positive regulation of cell migration; IDA:RGD.
GO; GO:0045740; P:positive regulation of DNA replication; IMP:RGD.
GO; GO:0034352; P:positive regulation of glial cell apoptotic process; IMP:RGD.
GO; GO:0031116; P:positive regulation of microtubule polymerization; IMP:RGD.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:2001224; P:positive regulation of neuron migration; IMP:RGD.
GO; GO:0046605; P:regulation of centrosome cycle; IMP:RGD.
GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
GO; GO:0045664; P:regulation of neuron differentiation; IMP:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:RGD.
GO; GO:0009408; P:response to heat; IDA:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; IDA:RGD.
GO; GO:0006970; P:response to osmotic stress; IDA:RGD.
GO; GO:0048545; P:response to steroid hormone; IEP:RGD.
GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO; GO:0007165; P:signal transduction; IDA:RGD.
GO; GO:0097050; P:type B pancreatic cell apoptotic process; IMP:CACAO.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008351; MAPK_JNK.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01772; JNKMAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Biological rhythms; Complete proteome; Cytoplasm; Kinase;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
S-nitrosylation; Serine/threonine-protein kinase; Transferase.
CHAIN 1 411 Mitogen-activated protein kinase 8.
/FTId=PRO_0000186264.
DOMAIN 26 321 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 32 40 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOTIF 183 185 TXY.
ACT_SITE 151 151 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 55 55 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 116 116 S-nitrosocysteine; in inhibited form.
{ECO:0000269|PubMed:11121042}.
MOD_RES 183 183 Phosphothreonine; by MAP2K7.
{ECO:0000250|UniProtKB:P45983}.
MOD_RES 185 185 Phosphotyrosine; by MAP2K4.
{ECO:0000250|UniProtKB:P45983}.
MOD_RES 377 377 Phosphoserine.
{ECO:0000250|UniProtKB:Q91Y86}.
MUTAGEN 116 116 C->S: Abolished inhibitory effect of IFN-
gamma on JNK1 activity.
{ECO:0000269|PubMed:11121042}.
SEQUENCE 411 AA; 46807 MW; 04E388B4F94633D4 CRC64;
MSRSKRDNNF YSVEIADSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC LKILFPGRDY IDQWNKVIEQ
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
MDLEERTKNG VIRGQPSPLG AAVINGSQHP VSSPSVNDMS SMSTDPTLAS D


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WP2292: Chemokine signaling pathway
WP2199: Seed Development
WP1703: Streptomycin biosynthesis
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP1946: Cori Cycle
WP1701: Starch and sucrose metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1653: Galactose metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1681: Pantothenate and CoA biosynthesis
WP1844: MAP kinase cascade
WP253: Glycolysis
WP2152: BDNF
WP152: FGF signaling pathway
WP813: G Protein Signaling Pathways
WP1502: Mitochondrial biogenesis
WP1694: Pyrimidine metabolism
WP2272: Pathogenic Escherichia coli infection
WP525: Mitochondrial Unfolded-Protein Response
WP1224: EBV LMP1 signaling
WP1657: Glycerolipid metabolism

Related Genes :
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma)
[MAPK8 JNK1 PRKM8 SAPK1 SAPK1C] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[Mapk8 Jnk1 Prkm8] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (SAPK-alpha) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (p54-alpha)
[MAPK9 JNK2 PRKM9 SAPK1A] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[Mapk10 Jnk3 Prkm10] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta)
[MAPK10 JNK3 JNK3A PRKM10 SAPK1B] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk8ip3 Jip3 Jsap1 Syd2] C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Mitogen-activated protein kinase 8-interacting protein 3) (Sunday driver 2)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Mapk8ip1 Ib1 Jip1 Mapk8ip Prkm8ip] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[MAPK8IP1 IB1 JIP1 PRKM8IP] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[Mapk10 Jnk3 Prkm10 Serk2] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[Mapk8ip1 Ib1 Jip1 Mapk8ip] C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JIP-1-related protein) (JRP) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
[MAPK8IP2 IB2 JIP2 PRKM8IPL] C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[jnk-1 B0478.1] Stress-activated protein kinase jnk-1 (EC 2.7.11.24)
[Mapk8ip2 Ib2 Jip2] C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
[Mapk8ip2 Ib2 Jip2] C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK8IP3 JIP3 KIAA1066] C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)

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