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Mitogen-activated protein kinase kinase 2

 A0A2K5YI82_MANLE        Unreviewed;       389 AA.
A0A2K5YI82;
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
17-JUN-2020, entry version 15.
RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
Name=MAP2K2 {ECO:0000313|Ensembl:ENSMLEP00000015252};
Mandrillus leucophaeus (Drill) (Papio leucophaeus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Mandrillus.
NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000015252, ECO:0000313|Proteomes:UP000233140};
[1] {ECO:0000313|Ensembl:ENSMLEP00000015252, ECO:0000313|Proteomes:UP000233140}
NUCLEOTIDE SEQUENCE.
Murali S., Hughes D.S., Raveendran M., Korchina V., Bandaranaike D.,
Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H.,
Gnanaolivu R., Gross S., Jayaseelan J., Khan Z., Kovar C., Kurapati P.,
Le B., Lee S., Mathew T., Narasimhan A., Okwuonu G., Ongeri F., Osuji N.,
Qu C., Quiroz J., Rajbhandari K., Reid J.G., Santibanez J., Skinner E.,
Wang Y., Xin Y., Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J.,
Gibbs R.A.;
"Drill reference genome project.";
Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMLEP00000015252}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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Ensembl; ENSMLET00000038708; ENSMLEP00000015252; ENSMLEG00000031781.
GeneTree; ENSGT00940000153487; -.
OMA; CHDMYER; -.
Proteomes; UP000233140; Whole Genome Shotgun Assembly.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0005874; C:microtubule; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004708; F:MAP kinase kinase activity; IEA:Ensembl.
GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:Ensembl.
GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0060324; P:face development; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0036289; P:peptidyl-serine autophosphorylation; IEA:Ensembl.
GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
GO; GO:2000147; P:positive regulation of cell motility; IEA:Ensembl.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0048679; P:regulation of axon regeneration; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Reference proteome {ECO:0000313|Proteomes:UP000233140};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 61..358
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..20
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 275..298
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 389 AA; 43217 MW; 2B183C7917DC4275 CRC64;
LTINPTIAEG PSPTSEGASE ANLVDLQKKL EELELDEQQK KRLEAFLTQK AKVGELKDDD
FERISELGAG NGGVVTKVQH RPSGLIMARK LIHLEIKPAI RNQIIRELQV LHECNSPYIV
GFYGAFYSDG EISICMEHMD GGSLDQVLKE AKRIPEEILG KVSIAVLRGL AYLREKHQIM
HRDVKPSNIL VNSRGEIKLC DFGVSGQLID SMANSFVGTR SYMAPERLQG THYSVQSDVW
SMGLSLVELA IGRYPIPPPD AKELEAIFGR PVVDGEEGEP HSISPRPRPP GRPISGHGMD
SRPAMAIFEL LDYIVNEPPP KLPNGVFTPD FQEFVNKCLI KNPAERADLK MLTNHIFIKR
SEVEEVDFAG WLCKTLRLNQ PGTPTRTAV


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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1653: Galactose metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1681: Pantothenate and CoA biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1371: G Protein Signaling Pathways
WP253: Glycolysis
WP1703: Streptomycin biosynthesis
WP1567: Glycolysis and Gluconeogenesis
WP1844: MAP kinase cascade
WP1619: Amino sugar and nucleotide sugar metabolism
WP1946: Cori Cycle
WP1701: Starch and sucrose metabolism
WP32: Translation Factors
WP1039: Glutathione metabolism
WP2075: Alzheimers Disease
WP240: Alanine and aspartate metabolism
WP1642: D-Arginine and D-ornithine metabolism
WP1049: G Protein Signaling Pathways
WP1692: Protein export
WP1370: TGF Beta Signaling Pathway
WP1362: Homologous recombination
WP1438: Influenza A virus infection
WP1700: Selenoamino acid metabolism
WP270: Tryptophan metabolism

Related Genes :
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[MAP3K20 MLTK ZAK HCCS4] Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
[pmk-2 F42G8.3] Mitogen-activated protein kinase pmk-2 (EC 2.7.11.24) (Stress-activated protein kinase pmk-2) (p38 MAP kinase 2)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[pmk-1 B0218.3] Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)
[Map3k20 Mltk Zak] Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif kinase ZAK) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[pmk-3 F42G8.4] Mitogen-activated protein kinase pmk-3 (EC 2.7.11.24) (Stress-activated protein kinase pmk-3) (p38 MAP kinase 3)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[sek-1 R03G5.2] Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[mek-2 Y54E10BL.6] Dual specificity mitogen-activated protein kinase kinase mek-2 (MAP kinase kinase mek-2) (EC 2.7.12.2)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[map2k6 map2k3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (Mitogen-activated protein kinase kinase 3) (zMKK3)
[NPK1] Mitogen-activated protein kinase kinase kinase NPK1 (EC 2.7.11.25) (Nicotiana protein kinase 1)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[dlk-1 F33E2.2] Mitogen-activated protein kinase kinase kinase dlk-1 (EC 2.7.11.25) (DAP kinase-like kinase) (Death-associated protein kinase-like kinase)
[jkk-1 F35C8.3] Dual specificity mitogen-activated protein kinase kinase jkk-1 (MAP kinase kinase jkk-1) (EC 2.7.12.2) (JNK-1 activator kinase) (JNK kinase)
[Mapk14 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4] Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
[MAPK14 CSBP1 CSBP2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[nsy-1 F59A6.1] Mitogen-activated protein kinase kinase kinase nsy-1 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (Neuronal symmetry kinase 1)
[MPK4 At4g01370 F2N1.1 F2N1_2-t] Mitogen-activated protein kinase 4 (AtMPK4) (MAP kinase 4) (EC 2.7.11.24)

Bibliography :
[32471307] Phosphorylation Sites in Protein Kinases and Phosphatases Regulated by Formyl Peptide Receptor 2 Signaling.
[32231305] Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.
[32100585] An overview of binimetinib for the treatment of melanoma.
[31901897] Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer.
[31870556] EMR 20006-012: A phase II randomized double-blind placebo controlled trial comparing the combination of pimasertib (MEK inhibitor) with SAR245409 (PI3K inhibitor) to pimasertib alone in patients with previously treated unresectable borderline or low grade ovarian cancer.
[31804822] Design, Synthesis, and Biological Evaluation of MEK PROTACs.
[31702027] MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells.
[31682623] Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells.
[31562895] Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles of MEK2 in neurogenesis and induction of astrocytogenesis by PD98059.
[31491405] The CO-releasing molecule CORM-3 protects adult cardiomyocytes against hypoxia-reoxygenation by modulating pH restoration.