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Mitogen-activated protein kinase kinase 4 (AtMKK4) (MAP kinase kinase 4) (EC 2.7.12.2)

 M2K4_ARATH              Reviewed;         366 AA.
O80397;
11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
08-MAY-2019, entry version 144.
RecName: Full=Mitogen-activated protein kinase kinase 4;
Short=AtMKK4;
Short=MAP kinase kinase 4;
EC=2.7.12.2;
Name=MKK4; OrderedLocusNames=At1g51660; ORFNames=F19C24.26;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=cv. Columbia;
PubMed=10048483; DOI=10.1093/dnares/5.6.341;
Ichimura K., Mizoguchi T., Hayashida N., Seki M., Shinozaki K.;
"Molecular cloning and characterization of three cDNAs encoding
putative mitogen-activated protein kinase kinases (MAPKKs) in
Arabidopsis thaliana.";
DNA Res. 5:341-348(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
FUNCTION, AND MUTAGENESIS OF LYS-108; THR-224 AND SER-230.
PubMed=11687590; DOI=10.1074/jbc.M109495200;
Ren D., Yang H., Zhang S.;
"Cell death mediated by MAPK is associated with hydrogen peroxide
production in Arabidopsis.";
J. Biol. Chem. 277:559-565(2002).
[6]
FUNCTION, ACTIVITY REGULATION, PHOSPHORYLATION AT THR-224 AND SER-230,
AND MUTAGENESIS OF LYS-108; THR-224 AND SER-230.
PubMed=11875555; DOI=10.1038/415977a;
Asai T., Tena G., Plotnikova J., Willmann M.R., Chiu W.-L.,
Gomez-Gomez L., Boller T., Ausubel F.M., Sheen J.;
"MAP kinase signalling cascade in Arabidopsis innate immunity.";
Nature 415:977-983(2002).
[7]
GENE FAMILY, AND NOMENCLATURE.
PubMed=12119167; DOI=10.1016/S1360-1385(02)02302-6;
MAPK group;
"Mitogen-activated protein kinase cascades in plants: a new
nomenclature.";
Trends Plant Sci. 7:301-308(2002).
[8]
GENE FAMILY.
PubMed=16537113; DOI=10.1016/j.tplants.2006.02.007;
Hamel L.P., Nicole M.C., Sritubtim S., Morency M.J., Ellis M.,
Ehlting J., Beaudoin N., Barbazuk B., Klessig D., Lee J., Martin G.,
Mundy J., Ohashi Y., Scheel D., Sheen J., Xing T., Zhang S.,
Seguin A., Ellis B.E.;
"Ancient signals: comparative genomics of plant MAPK and MAPKK gene
families.";
Trends Plant Sci. 11:192-198(2006).
[9]
FUNCTION.
PubMed=17259259; DOI=10.1105/tpc.106.048298;
Wang H., Ngwenyama N., Liu Y., Walker J.C., Zhang S.;
"Stomatal development and patterning are regulated by environmentally
responsive mitogen-activated protein kinases in Arabidopsis.";
Plant Cell 19:63-73(2007).
[10]
SUBCELLULAR LOCATION.
PubMed=19516975; DOI=10.4161/psb.3.1.4856;
Samuel M.A., Chaal B.K., Lampard G., Green B.R., Ellis B.E.;
"Surviving the passage: Non-canonical stromal targeting of an
Arabidopsis mitogen-activated protein kinase kinase.";
Plant Signal. Behav. 3:6-12(2008).
[11]
INTERACTION WITH MPK6.
PubMed=19513235; DOI=10.4161/psb.3.12.6848;
Lee J.S., Huh K.W., Bhargava A., Ellis B.E.;
"Comprehensive analysis of protein-protein interactions between
Arabidopsis MAPKs and MAPK kinases helps define potential MAPK
signalling modules.";
Plant Signal. Behav. 3:1037-1041(2008).
[12]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=18809915; DOI=10.1073/pnas.0805539105;
Cho S.K., Larue C.T., Chevalier D., Wang H., Jinn T.-L., Zhang S.,
Walker J.C.;
"Regulation of floral organ abscission in Arabidopsis thaliana.";
Proc. Natl. Acad. Sci. U.S.A. 105:15629-15634(2008).
[13]
INTERACTION WITH P.SYRINGAE HOPF2.
PubMed=20571112; DOI=10.1105/tpc.110.075697;
Wang Y., Li J., Hou S., Wang X., Li Y., Ren D., Chen S., Tang X.,
Zhou J.M.;
"A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis
mitogen-activated protein kinase kinases.";
Plant Cell 22:2033-2044(2010).
[14]
FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
PubMed=21806969; DOI=10.1016/j.bbrc.2011.07.064;
Kim S.H., Woo D.H., Kim J.M., Lee S.Y., Chung W.S., Moon Y.H.;
"Arabidopsis MKK4 mediates osmotic-stress response via its regulation
of MPK3 activity.";
Biochem. Biophys. Res. Commun. 412:150-154(2011).
[15]
FUNCTION.
PubMed=23263767; DOI=10.1105/tpc.112.104695;
Meng X., Wang H., He Y., Liu Y., Walker J.C., Torii K.U., Zhang S.;
"A MAPK cascade downstream of ERECTA receptor-like protein kinase
regulates Arabidopsis inflorescence architecture by promoting
localized cell proliferation.";
Plant Cell 24:4948-4960(2012).
[16]
FUNCTION, ACTIVITY REGULATION, INTERACTION WITH ASK7/BIN2, MUTAGENESIS
OF SER-230 AND THR-234, IDENTIFICATION BY MASS SPECTROMETRY,
PHOSPHORYLATION AT SER-6; SER-230 AND THR-234, AND SUBCELLULAR
LOCATION.
PubMed=23341468; DOI=10.1074/jbc.M112.384453;
Khan M., Rozhon W., Bigeard J., Pflieger D., Husar S., Pitzschke A.,
Teige M., Jonak C., Hirt H., Poppenberger B.;
"Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate
mitogen-activated protein (MAP) kinase kinases, which control stomata
development in Arabidopsis thaliana.";
J. Biol. Chem. 288:7519-7527(2013).
[17]
INTERACTION WITH RACK1A; RACK1B AND RACK1C.
PubMed=25731164; DOI=10.1038/nature14243;
Cheng Z., Li J.F., Niu Y., Zhang X.C., Woody O.Z., Xiong Y.,
Djonovic S., Millet Y., Bush J., McConkey B.J., Sheen J.,
Ausubel F.M.;
"Pathogen-secreted proteases activate a novel plant immune pathway.";
Nature 521:213-216(2015).
[18]
INTERACTION WITH MAPKKK5, PHOSPHORYLATION BY MAPKKK5, AND MUTAGENESIS
OF LYS-108; THR-224 AND SER-230.
STRAIN=cv. Columbia;
PubMed=27679653; DOI=10.15252/embj.201694248;
Yamada K., Yamaguchi K., Shirakawa T., Nakagami H., Mine A.,
Ishikawa K., Fujiwara M., Narusaka M., Narusaka Y., Ichimura K.,
Kobayashi Y., Matsui H., Nomura Y., Nomoto M., Tada Y., Fukao Y.,
Fukamizo T., Tsuda K., Shirasu K., Shibuya N., Kawasaki T.;
"The Arabidopsis CERK1-associated kinase PBL27 connects chitin
perception to MAPK activation.";
EMBO J. 35:2468-2483(2016).
-!- FUNCTION: Involved in the second phase of hydrogen peroxide
generation during hypersensitive response-like cell death.
Involved in the innate immune MAP kinase signaling cascade (MEKK1,
MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin
receptor FLS2. Activates by phosphorylation the downstream MPK3
and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell
fate before the guard mother cell (GMC) is specified. This MAPK
cascade also functions downstream of the ER receptor in regulating
coordinated local cell proliferation, which shapes the morphology
of plant organs. MKK4 and MKK5 participate in the regulation of
floral organ abscission. Mediates osmotic-stress response via its
regulation of MPK3 activity. Target of the Pseudomonas syringae
type III effector HopF2. {ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555, ECO:0000269|PubMed:17259259,
ECO:0000269|PubMed:18809915, ECO:0000269|PubMed:21806969,
ECO:0000269|PubMed:23263767, ECO:0000269|PubMed:23341468}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
EC=2.7.12.2;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.12.2;
-!- ACTIVITY REGULATION: Activated through serine and threonine
phosphorylation by MEKK1. Inhibited through phosphorylation by
GSK3/Shaggy-like kinase ASKs. {ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468}.
-!- SUBUNIT: Interacts with ASK7/BIN2 (PubMed:23341468). Interacts
with P.syringae type III effector HopF2 (PubMed:20571112).
Interacts with MPK6 (PubMed:19513235). Interacts with RACK1A,
RACK1B and RACK1C (PubMed:25731164). Interacts with MAPKKK5 mainly
in the cytosol (PubMed:27679653). {ECO:0000269|PubMed:19513235,
ECO:0000269|PubMed:20571112, ECO:0000269|PubMed:23341468,
ECO:0000269|PubMed:25731164, ECO:0000269|PubMed:27679653}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Plastid, chloroplast
stroma.
-!- TISSUE SPECIFICITY: Expressed higher in stems and leaves than in
flowers and roots. {ECO:0000269|PubMed:10048483,
ECO:0000269|PubMed:21806969}.
-!- PTM: Phosphorylation at Thr-224 and Ser-230 by MAP kinase kinase
kinases positively regulates kinase activity. Phosphorylation at
Ser-230 and Thr-234 by GSK3/Shaggy-like kinase ASKs negatively
regulates kinase activity. Phosphorylated by MAPKKK5
(PubMed:27679653). {ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468, ECO:0000269|PubMed:27679653}.
-!- DISRUPTION PHENOTYPE: RNAi double mutants MKK4 and MKK5 have a
strong abscission defect. Higher sensitivity to high salt and
drought stresses. {ECO:0000269|PubMed:18809915,
ECO:0000269|PubMed:21806969}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. MAP kinase kinase subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB015315; BAA28830.1; -; mRNA.
EMBL; AC025294; AAG50863.1; -; Genomic_DNA.
EMBL; CP002684; AEE32696.1; -; Genomic_DNA.
EMBL; AF324667; AAG40018.1; -; mRNA.
EMBL; AF326878; AAG41460.1; -; mRNA.
EMBL; AF349517; AAK15564.1; -; mRNA.
EMBL; AF375398; AAK52982.1; -; mRNA.
EMBL; AY129469; AAM91055.1; -; mRNA.
PIR; T51339; T51339.
RefSeq; NP_175577.1; NM_104044.3.
SMR; O80397; -.
BioGrid; 26816; 15.
IntAct; O80397; 10.
STRING; 3702.AT1G51660.1; -.
iPTMnet; O80397; -.
PaxDb; O80397; -.
PRIDE; O80397; -.
EnsemblPlants; AT1G51660.1; AT1G51660.1; AT1G51660.
GeneID; 841591; -.
Gramene; AT1G51660.1; AT1G51660.1; AT1G51660.
KEGG; ath:AT1G51660; -.
Araport; AT1G51660; -.
TAIR; locus:2017662; AT1G51660.
eggNOG; KOG0581; Eukaryota.
eggNOG; ENOG410XQ5A; LUCA.
HOGENOM; HOG000234206; -.
InParanoid; O80397; -.
KO; K13413; -.
OMA; KFPYDSW; -.
OrthoDB; 688282at2759; -.
PhylomeDB; O80397; -.
PRO; PR:O80397; -.
Proteomes; UP000006548; Chromosome 1.
ExpressionAtlas; O80397; baseline and differential.
Genevisible; O80397; AT.
GO; GO:0009570; C:chloroplast stroma; IDA:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:TAIR.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004708; F:MAP kinase kinase activity; IBA:GO_Central.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
GO; GO:0009814; P:defense response, incompatible interaction; IMP:TAIR.
GO; GO:0010227; P:floral organ abscission; IMP:TAIR.
GO; GO:0010229; P:inflorescence development; IGI:TAIR.
GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Chloroplast; Complete proteome; Cytoplasm;
Hypersensitive response; Kinase; Nucleotide-binding; Nucleus;
Phosphoprotein; Plant defense; Plastid; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 366 Mitogen-activated protein kinase kinase
4.
/FTId=PRO_0000245823.
DOMAIN 79 334 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 85 93 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 196 196 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 108 108 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 6 6 Phosphoserine; by ASK7.
{ECO:0000269|PubMed:23341468}.
MOD_RES 224 224 Phosphothreonine.
{ECO:0000269|PubMed:11875555}.
MOD_RES 230 230 Phosphoserine.
{ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468}.
MOD_RES 230 230 Phosphoserine; by ASK7.
{ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468}.
MOD_RES 234 234 Phosphothreonine; by ASK7.
{ECO:0000269|PubMed:23341468}.
MUTAGEN 108 108 K->M: Loss of activity.
{ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555}.
MUTAGEN 108 108 K->R: Loss of activity. Phosphorylated by
MAPKKK5. {ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:27679653}.
MUTAGEN 224 224 T->A: Impaired phosphorylation by
MAPKKK5; when associated with A-230.
{ECO:0000269|PubMed:27679653}.
MUTAGEN 224 224 T->D: Constitutively active; when
associated with D-230 or E-230.
{ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555}.
MUTAGEN 230 230 S->A: Abolishes phosphorylation by
ASK7/BIN2. Impaired phosphorylation by
MAPKKK5; when associated with A-224.
{ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468,
ECO:0000269|PubMed:27679653}.
MUTAGEN 230 230 S->D: Constitutively active; when
associated with D-224.
{ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468}.
MUTAGEN 230 230 S->E: Constitutively active; when
associated with D-224.
{ECO:0000269|PubMed:11687590,
ECO:0000269|PubMed:11875555,
ECO:0000269|PubMed:23341468}.
MUTAGEN 234 234 T->A: Abolishes phosphorylation by
ASK7/BIN2. {ECO:0000269|PubMed:23341468}.
MUTAGEN 234 234 T->D,E: Abolishes activity of MKK4
against MPK6.
{ECO:0000269|PubMed:23341468}.
SEQUENCE 366 AA; 40117 MW; 34C1CA3EEA19D07C CRC64;
MRPIQSPPGV SVPVKSRPRR RPDLTLPLPQ RDVSLAVPLP LPPTSGGSGG SSGSAPSSGG
SASSTNTNSS IEAKNYSDLV RGNRIGSGAG GTVYKVIHRP SSRLYALKVI YGNHEETVRR
QICREIEILR DVNHPNVVKC HEMFDQNGEI QVLLEFMDKG SLEGAHVWKE QQLADLSRQI
LSGLAYLHSR HIVHRDIKPS NLLINSAKNV KIADFGVSRI LAQTMDPCNS SVGTIAYMSP
ERINTDLNQG KYDGYAGDIW SLGVSILEFY LGRFPFPVSR QGDWASLMCA ICMSQPPEAP
ATASPEFRHF ISCCLQREPG KRRSAMQLLQ HPFILRASPS QNRSPQNLHQ LLPPPRPLSS
SSSPTT


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E1358h ELISA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
U1358h CLIA Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
E1358h ELISA kit Apoptosis signal-regulating kinase 1,ASK1,ASK-1,Homo sapiens,Human,MAP3K5,MAPK_ERK kinase kinase 5,MAPKKK5,MEK kinase 5,MEKK 5,MEKK5,Mitogen-activated protein kinase kinase kinase 5 96T
18-662-20091 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20090 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20092 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 mg
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.05 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
EIAAB25228 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,Map2k1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,Mek1,Prkmk1,Rat,Rattus norvegicus
EIAAB25230 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,Map2k1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,Mek1,Mouse,Mus musculus,Prkmk1

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP1493: Carbon assimilation C4 pathway
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1653: Galactose metabolism
WP1681: Pantothenate and CoA biosynthesis
WP1701: Starch and sucrose metabolism
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1946: Cori Cycle
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP253: Glycolysis
WP32: Translation Factors
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication

Related Genes :
[MKK4 At1g51660 F19C24.26] Mitogen-activated protein kinase kinase 4 (AtMKK4) (MAP kinase kinase 4) (EC 2.7.12.2)
[MPK4 At4g01370 F2N1.1 F2N1_2-t] Mitogen-activated protein kinase 4 (AtMPK4) (MAP kinase 4) (EC 2.7.11.24)
[pmk-3 F42G8.4] Mitogen-activated protein kinase pmk-3 (EC 2.7.11.24) (Stress-activated protein kinase pmk-3) (p38 MAP kinase 3)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[Mapk13 Serk4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK13 PRKM13 SAPK4] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MKK1 MEK1 At4g26070 F20B18.180] Mitogen-activated protein kinase kinase 1 (AtMKK1) (MAP kinase kinase 1) (EC 2.7.12.2) (AtMEK1) (NMAPKK)
[sek-1 R03G5.2] Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2)
[Mapk12 Sapk3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAP3K20 MLTK ZAK HCCS4] Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[mekA MEK1 DDB_G0269152] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (DdMEK1) (MEK1) (MAPK/ERK kinase A) (MEKA)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[Mapk13] Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
[MAPK10 JNK3 JNK3A PRKM10 SAPK1B] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Mapk10 Jnk3 Prkm10 Serk2] Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAP2K2 MEK2 MKK2 PRKMK2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[MAP2K5 MEK5 MKK5 PRKMK5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[Map2k2 Mek2 Mkk2 Prkmk2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[pmk-1 B0218.3] Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1)

Bibliography :